The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
POxylation as an alternative stealth coating for biomedical applications
Open accessAbstract
Polyethylene glycol (PEG) polymers are currently used in a variety of medical formulations to reduce toxicity, minimize immune interactions and improve pharmacokinetics. Despite its widespread use however, the presence of anti-PEG antibodies indicates that this polymer has the potential to be immunogenic and antigenic. Here we present an alternative polymer, poly(2-oxazoline) (POx) for stealth applications, specifically shielding of a proteinaceous nanoparticle from recognition by the immune system. Tobacco mosaic virus (TMV) was used as our testbed due to its potential for use as a nanocarrier for drug delivery and molecular imaging applications.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“This study, along with others, indicate that PMeOx may actually have superior anti-fouling properties to that of PEG [89].”
From Polymeric micelles for the delivery of poorly soluble drugs: From nanoformulation to clinical approval. (2020) · cites this paper as [89]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Armstrong, J. K., Hempel, G., Koling, S., Chan, L. S., Fisher, T., Meiselman, H. J., & Garratty, G. (2007) · Cancer · doi:10.1002/cncr.22739 · Cited by 699
Engineering targeted viral vectors for gene therapy
Waehler, R., Russell, S. J., & Curiel, D. T. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2141 · Cited by 687
Perry, J. L., Reuter, K. G., Kai, M. P., Herlihy, K. P., Jones, S. W., Luft, J. C., Napier, M. A., Bear, J. E., & DeSimone, J. M. (2012) · Nano Letters · doi:10.1021/nl302638g · Cited by 622
Garay, R. P., El-Gewely, R., Armstrong, J. K., Garratty, G., & Richette, P. (2012) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2012.720969 · Cited by 587
In situ vaccination with cowpea mosaic virus nanoparticles suppresses metastatic cancer
Lizotte, P. H., Wen, A. M., Sheen, M. R., Fields, J., Rojanasopondist, P., Steinmetz, N. F., & Fiering, S. (2015) · Nature Nanotechnology · doi:10.1038/nnano.2015.292 · Cited by 487
Self-citationChauhan, V. P., Popović, Z., Chen, O., Cui, J., Fukumura, D., Bawendi, M. G., & Jain, R. K. (2011) · Angewandte Chemie International Edition · doi:10.1002/anie.201104449 · Cited by 474
Poly (2-oxazoline) s as polymer therapeutics
Luxenhofer, R., Han, Y., Schulz, A., Tong, J., He, Z., Kabanov, A. V., & Jordan, R. (2012) · Macromolecular Rapid Communications · doi:10.1002/marc.201200354 · Cited by 470
Self-citationPolyoxazoline: Chemistry, Properties, and Applications in Drug Delivery
Viegas, T. X., Bentley, M. D., Harris, J. M., Fang, Z., Yoon, K., Dizman, B., Weimer, R., Mero, A., Pasut, G., & Veronese, F. M. (2011) · Bioconjugate Chemistry · doi:10.1021/bc200049d · Cited by 432
Viral Vectors for Gene Therapy: Translational and Clinical Outlook
Kotterman, M. A., Chalberg, T. W., & Schaffer, D. V. (2015) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-071813-104938 · Cited by 424
Characterization of Nanoparticles for Therapeutics
Hall, J. B., Dobrovolskaia, M. A., Patri, A. K., & McNeil, S. E. (2007) · Nanomedicine · doi:10.2217/17435889.2.6.789 · Cited by 413
Kenworthy, A. K., Hristova, K. A., Needham, D., & McIntosh, T. J. (1995) · Biophysical Journal · doi:10.1016/s0006-3495(95)80369-3 · Cited by 408
Woodle, M. C., Engbers, C. M., & Zalipsky, S. (1994) · Bioconjugate Chemistry · doi:10.1021/bc00030a001 · Cited by 361
Poly-2-methyl-2-oxazoline: A Peptide-like Polymer for Protein-Repellent Surfaces
Konradi, R., Pidhatika, B., Mühlebach, A., & Textor, M. (2008) · Langmuir · doi:10.1021/la702917z · Cited by 356
Surface Initiated Living Cationic Polymerization of 2-Oxazolines
Jordan, R., & Ulman, A. (1998) · Journal of the American Chemical Society · doi:10.1021/ja973392r · Cited by 344
Self-citationEvaluation of Blood Clearance Rates and Biodistribution of Poly(2-oxazoline)-Grafted Liposomes§
Zalipsky, S., Hansen, C. B., Oaks, J. M., & Allen, T. M. (1996) · Journal of Pharmaceutical Sciences · doi:10.1021/js9504043 · Cited by 317
Virus-mediated gene delivery for human gene therapy
Giacca, M., & Zacchigna, S. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2012.04.008 · Cited by 302
Wiesbrock, F., Hoogenboom, R., Leenen, M. A. M., Meier, M. A. R., & Schubert, U. S. (2005) · Macromolecules · doi:10.1021/ma0474170 · Cited by 288
Doubly amphiphilic poly(2-oxazoline)s as high-capacity delivery systems for hydrophobic drugs
Luxenhofer, R., Schulz, A., Roques, C., Li, S., Bronich, T. K., Batrakova, E. V., Jordan, R., & Kabanov, A. V. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.02.057 · Cited by 287
Self-citationGanson, N. J., Povsic, T. J., Sullenger, B. A., Alexander, J. H., Zelenkofske, S. L., Sailstad, J. M., Rusconi, C. P., & Hershfield, M. S. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.10.034 · Cited by 275
Comparative stability studies of poly(2-methyl-2-oxazoline) and poly(ethylene glycol) brush coatings
Pidhatika, B., Rodenstein, M., Chen, Y., Rakhmatullina, E., Mühlebach, A., Acikgöz, C., Textor, M., & Konradi, R. (2012) · Biointerphases · doi:10.1007/s13758-011-0001-y · Cited by 251
PEGylated Protein Drugs: Basic Science and Clinical Applications
(2009) · doi:10.1007/978-3-7643-8679-5 · Cited by 241
Richter, A. W., & Akerblom, E. B. (2009) · International Archives of Allergy and Applied Immunology · doi:10.1159/000233512 · Cited by 229
Croyle, M. A., Chirmule, N. B., Zhang, Y., & Wilson, J. M. (2001) · Journal of Virology · doi:10.1128/jvi.75.10.4792-4801.2001 · Cited by 229
Wiesbrock, F., Hoogenboom, R., Abeln, C. H., & Schubert, U. S. (2004) · Macromolecular Rapid Communications · doi:10.1002/marc.200400369 · Cited by 193
Bruckman, M. A., Randolph, L. N., VanMeter, A., Hern, S., Shoffstall, A. J., Taurog, R. E., & Steinmetz, N. F. (2013) · Virology · doi:10.1016/j.virol.2013.10.035 · Cited by 180
Self-citationThe Impact of Aspect Ratio on the Biodistribution and Tumor Homing of Rigid Soft‐Matter Nanorods
Shukla, S., Eber, F. J., Nagarajan, A. S., DiFranco, N. A., Schmidt, N., Wen, A. M., Eiben, S., Twyman, R. M., Wege, C., & Steinmetz, N. F. (2015) · Advanced Healthcare Materials · doi:10.1002/adhm.201400641 · Cited by 177
Self-citationTobacco Mosaic Virus Delivery of Phenanthriplatin for Cancer therapy
Czapar, A. E., Zheng, Y., Riddell, I. A., Shukla, S., Awuah, S. G., Lippard, S. J., & Steinmetz, N. F. (2016) · ACS Nano · doi:10.1021/acsnano.5b07360 · Cited by 173
Self-citationTailored poly(2-oxazoline) polymer brushes to control protein adsorption and cell adhesion
Zhang, N., Pompe, T., Amin, I., Luxenhofer, R., Werner, C., & Jordan, R. (2012) · Macromolecular Bioscience · doi:10.1002/mabi.201200026 · Cited by 171
Self-citationPEG conjugation moderately protects adeno‐associated viral vectors against antibody neutralization
Lee, G. K., Maheshri, N., Kaspar, B., & Schaffer, D. V. (2005) · Biotechnology and Bioengineering · doi:10.1002/bit.20562 · Cited by 169
Bruckman, M. A., Jiang, K., Simpson, E. J., Randolph, L. N., Luyt, L. G., Yu, X., & Steinmetz, N. F. (2014) · Nano Letters · doi:10.1021/nl404816m · Cited by 165
Self-citationShukla, S., Ablack, A. L., Wen, A. M., Lee, K. L., Lewis, J. D., & Steinmetz, N. F. (2012) · Molecular Pharmaceutics · doi:10.1021/mp300240m · Cited by 154
Self-citationShukla, R. K., Kumar, A., Vallabani, N. V. S., et al. (2013) · Nanomedicine · doi:10.2217/nnm.13.100 · Cited by 143
"Characterization of Nanoparticles Intended for Drug Delivery"
Gabor, F. (2011) · Scientia Pharmaceutica · doi:10.3797/scipharm.br-11-01 · Cited by 142
Long-term safety of pegloticase in chronic gout refractory to conventional treatment
Becker, M. A., Baraf, H. S. B., Yood, R. A., Dillon, A., Vázquez‐Mellado, J., Ottery, F. D., Khanna, D., & Sundy, J. S. (2012) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2012-201795 · Cited by 107
Humans Have Antibodies against a Plant Virus: Evidence from Tobacco Mosaic Virus
Liu, R., Vaishnav, R., Roberts, A. M., & Friedland, R. P. (2013) · PLoS ONE · doi:10.1371/journal.pone.0060621 · Cited by 95
Interior Engineering of a Viral Nanoparticle and Its Tumor Homing Properties
Wen, A. M., Shukla, S., Saxena, P., Aljabali, A. A. A., Yıldız, İ., Dey, S. K., Mealy, J. E., Yang, A. C., Evans, D. J., Lomonossoff, G. P., et al. (2012) · Biomacromolecules · doi:10.1021/bm301278f · Cited by 95
Self-citationPitek, A. S., Wen, A. M., Shukla, S., & Steinmetz, N. F. (2016) · Small · doi:10.1002/smll.201502458 · Cited by 92
Self-citationLee, K. L., Shukla, S., Wu, M., Ayat, N. R., Sanadi, C. E. E., Wen, A. M., Edelbrock, J. F., Pokorski, J. K., Commandeur, U., Dubyak, G., et al. (2015) · Acta Biomaterialia · doi:10.1016/j.actbio.2015.03.001 · Cited by 89
Self-citationOncolytic Viruses as Anticancer Vaccines
Woller, N., rlevik, E. G. ⁄., Ureche, C.-I., Schumacher, A., & hnel, F. K. ⁄. (2014) · Frontiers in Oncology · doi:10.3389/fonc.2014.00188 · Cited by 87
Stabilization of Virus‐like Particles with Poly(2‐oxazoline)s
Manzenrieder, F., Luxenhofer, R., Retzlaff, M., Jordan, R., & Finn, M. G. (2011) · Angewandte Chemie International Edition · doi:10.1002/anie.201006134 · Cited by 86
Self-citationTong, J., Yi, X., Luxenhofer, R., Banks, W. A., Jordan, R., Zimmerman, M. C., & Kabanov, A. V. (2012) · Molecular Pharmaceutics · doi:10.1021/mp300496x · Cited by 77
Self-citationBiodistribution and Clearance of A Filamentous Plant Virus in Healthy and Tumor-Bearing Mice
Shukla, S., Wen, A. M., Ayat, N. R., Commandeur, U., Gopalkrishnan, R., Broome, A., Lozada, K. W., Keri, R. A., & Steinmetz, N. F. (2013) · Nanomedicine · doi:10.2217/nnm.13.75 · Cited by 72
Self-citationClick‐Chemistry: An Alternative Way to Functionalize Poly(2‐methyl‐2‐oxazoline)
Volet, G., Lav, T., Babinot, J., & Amiel, C. (2010) · Macromolecular Chemistry and Physics · doi:10.1002/macp.201000556 · Cited by 67
Wen, A. M., Lee, K. L., Cao, P., Pangilinan, K. D., Carpenter, B. L., Lam, P. M. W., Veliz, F. A., Ghiladi, R. A., Advíncula, R. C., & Steinmetz, N. F. (2016) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.6b00075 · Cited by 58
Self-citationForeman, M. B., Coffman, J. P., Murcia, M. J., Cesana, S., Jordan, R., Smith, G. S., & Naumann, C. A. (2002) · Langmuir · doi:10.1021/la0261390 · Cited by 56
Self-citationA Low Protein Binding Cationic Poly(2‐oxazoline) as Non‐Viral Vector
He, Z., Miao, L., Jordan, R., Manickam, D. S., Luxenhofer, R., & Kabanov, A. V. (2015) · Macromolecular Bioscience · doi:10.1002/mabi.201500021 · Cited by 46
Self-citationShukla, S., Dorand, R. D., Myers, J., Woods, S. E., Gulati, N. M., Stewart, P. L., Commandeur, U., Huang, A. Y.-C., & Steinmetz, N. F. (2016) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.6b00060 · Cited by 22
Self-citationWen, A. M., Le, N., Zhou, X., Steinmetz, N. F., & Popkin, D. L. (2015) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.5b00344 · Cited by 22
Self-citation
Flagged first, then by citations
Research works printed but not linked: 3
- Hall, 2014, Nanomedicine, 1
- Woller, 2014, Front. Oncol., 1
- Bruckman, 2013, vol. 1108, 173
Cited by
Sorted by citations
Hwang, D., Ramsey, J. D., & Kabanov, A. V. (2020) · Advanced drug delivery reviews · doi:10.1016/j.addr.2020.09.009 · Cited by 699
“This study, alongwith others, indicate that PMeOx may actually have superior anti-fouling properties to that of PEG [89].”
ResultStealth Coating of Nanoparticles in Drug-Delivery Systems
Fam, S. Y., Chee, C. F., Yong, C. Y., Ho, K. L., Mariatulqabtiah, A. R., & Tan, W. S. (2020) · Nanomaterials · doi:10.3390/nano10040787 · Cited by 430
Poly(2-oxazoline)s based biomaterials: a comprehensive and critical update
Lorson, T., Lübtow, M. M., Wegener, E., Haider, M. S., Borova, S., Nahm, D., Jordan, R., Sokolski-Papkov, M., Kabanov, A. V., & Luxenhofer, R. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.05.022 · Cited by 391
Self-citationCell membrane coated nanocarriers - an efficient biomimetic platform for targeted therapy
Dash, P., Piras, A. M., & Dash, M. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.09.012 · Cited by 267
The in vivo fate of polymeric micelles
Cai, Y., Qi, J., Lu, Y., He, H., & Wu, W. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114463 · Cited by 154
Metadata
- Authors
- Bludau, H., Czapar, A. E., Pitek, A. S., Shukla, S., Jordan, R., & Steinmetz, N. F.
- Affiliations
- Technische Universität Dresden (DE)
- Case Western Reserve University (US)
- Case Comprehensive Cancer Center (US)
- Corresponding author
- Jordan, Rainer
- Steinmetz, Nicole F.
- Venue
- European Polymer Journal
- Publisher
- Elsevier BV
- Published
- 2017-03
- Volume
- 88
- Pages
- 679-688
- ISSN
- 0014-3057 (ISSN-L)
- PMC
- PMC5510027
- OpenAlex
- W2547204128
- Cited by
- 112
- References
- 47
- Citations by year
- 2026: 13 · 2025: 9 · 2024: 8 · 2023: 15 · 2022: 13 · 2021: 7 · 2020: 16 · 2019: 14 · 2018: 10 · 2017: 6
- FWCI
- 4.08
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- European Polymer Journal (acceptedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (R03 EB020602, T32 GM007250, TL1 TR000441)
- Case Western Reserve University
- Deutscher Akademischer Austauschdienst France
- National Science Foundation (CHE 1306447)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
- Physical Sciences › Chemistry › Organic Chemistry › Advanced Polymer Synthesis and Characterization
- Keywords
- poly(2-oxazoline), stealth coatings, anti-PEG antibodies, tobacco mosaic virus, drug delivery nanocarriers, molecular imaging
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
