The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Stress, genetics and epigenetic effects on the neurobiology of suicidal behavior and depression
Open accessAbstract
Alterations in a number of neurobiological systems have been associated with suicidal behavior including the serotonergic and noradrenergic systems and the hypothalamic-pituitary-adrenal axis. Altered functioning of these systems may stem from both genetic and developmental causes. Adversity in early-life has developmental consequences on these systems that persist into adulthood. Genetic differences may also contribute to alterations in functioning of neurobiological systems. Moreover, the interaction of early-life experiences of adversity and genetic vulnerability is increasingly thought to play a role, including via epigenetic mechanisms.
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“Stress affects human society by increasing suicide1 and reducing work efficiency2.”
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Cited by
Sorted by citations
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“So-called distal risk factors include genetic loading, trait impulsivity and early traumatic life events, whereas proximal risk factors include psychological crisis or acute stress (Mann and Currier 2010); Gradus et al, 2010; Hawton and van Heerningen, 2009).”
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“Post-translational histone modifications, such as acetylation, methylation, phosphorylation, and ubiquitination of histone tails, are another important mechanism responsible for epigenetic regulation of transcription (Wang and Higgins, 2013).”
Background
Metadata
- Authors
- Mann, J. J., & Currier, D. M.
- Affiliations
- Columbia University (US)
- Corresponding author
- Mann, J.J.
- Venue
- European Psychiatry
- Publisher
- Cambridge University Press (CUP)
- Published
- 2010-06
- Volume
- 25
- Issue
- 5
- Pages
- 268-271
- ISSN
- 0924-9338 (ISSN-L)
- 1778-3585
- PMC
- PMC2896004
- OpenAlex
- W2034761715
- Cited by
- 169
- References
- 29
- Citations by year
- 2026: 2 · 2025: 8 · 2024: 4 · 2023: 6 · 2022: 11 · 2021: 16 · 2020: 4 · 2019: 9 · 2018: 14 · 2017: 13 · 2016: 13 · 2015: 13 · 2014: 20 · 2013: 11 · 2012: 16
- FWCI
- 12.68
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- European Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (MH 62185, R10MH056390, MH48514, R01MH082041, MH56390, R01MH048514, MH82041, R01MH056390, P50MH062185)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- suicidal behavior, depression, stress, epigenetics, genetics, neurobiology, serotonergic system, noradrenergic system, hypothalamic-pituitary-adrenal axis, childhood adversity, genetic susceptibility, gene-environment interaction
- MeSH terms
- Depressive Disorder, Humans, Stress, Psychological, Suicide, Epigenesis, Genetic
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