The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Stress, genetics and epigenetic effects on the neurobiology of suicidal behavior and depression
Open accessAbstract
Alterations in a number of neurobiological systems have been associated with suicidal behavior including the serotonergic and noradrenergic systems and the hypothalamic-pituitary-adrenal axis. Altered functioning of these systems may stem from both genetic and developmental causes. Adversity in early-life has developmental consequences on these systems that persist into adulthood. Genetic differences may also contribute to alterations in functioning of neurobiological systems. Moreover, the interaction of early-life experiences of adversity and genetic vulnerability is increasingly thought to play a role, including via epigenetic mechanisms.
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“Stress affects human society by increasing suicide1 and reducing work efficiency2.”
From A Flexible and Wearable Human Stress Monitoring Patch (2016) · cites this paper as [1]
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Cites
Heim, C., & Nemeroff, C. B. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01157-x · Cited by 2,791
Neurobiology of suicidal behaviour
Mann, J. J. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1220 · Cited by 1,260
Self-citationPhysiology and pharmacology of corticotropin-releasing factor.
Owens, M. J., & Nemeroff, C. B. (1991) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06673-6 · Cited by 1,147
Long story short: the serotonin transporter in emotion regulation and social cognition
Canli, T., & Lesch, K.-P. (2007) · Nature Neuroscience · doi:10.1038/nn1964 · Cited by 1,034
Weaver, I. C. G., Champagne, F. A., Brown, S. E., Dymov, S., Sharma, S., Meaney, M. J., & Szyf, M. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.3652-05.2005 · Cited by 905
Early experience and serotonin transporter gene variation interact to influence primate CNS function
Bennett, A. J., Lesch, K., Heils, A., Long, J. C., Lorenz, J. G., Shoaf, S. E., Champoux, M. C., Suomi, S. J., Linnoila, M., & Higley, J. D. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4000949 · Cited by 659
Bradley, R. G., Binder, E. B., Epstein, M. P., Tang, Y., Nair, H. P., Liu, W., Gillespie, C. F., Berg, T., Evces, M., Newport, D. J., et al. (2008) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2007.26 · Cited by 643
Knoch, D., Gianotti, L. R. R., Pascual-Leone, A., Treyer, V., Regard, M., Hohmann, M., & Brugger, P. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0804-06.2006 · Cited by 517
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Frodl, T., & O'Keane, V. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.03.012 · Cited by 555
The European Psychiatric Association (EPA) guidance on suicide treatment and prevention
Wasserman, D., Ríhmer, Z., Rujescu, D., Sarchiapone, M., Sokolowski, M., Titelman, D., Zalsman, G., Zemishlany, Z., & Carli, V. (2011) · European Psychiatry · doi:10.1016/j.eurpsy.2011.06.003 · Cited by 390
“In the stress-vulnerability model [89,149,152] (Fig.”
Connecting inflammation with glutamate agonism in suicidality
Erhardt, S., Lim, C. K., Linderholm, K. R., Janelidze, S., Lindqvist, D., Samuelsson, M., Lundberg, K., Postolache, T. T., Träskman-Bendz, L., Guillemin, G. J., et al. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2012.248 · Cited by 345
“So-called distal risk factors include genetic loading, trait impulsivity and early traumatic life events, whereas proximal risk factors include psychological crisis or acute stress (Mann and Currier 2010); Gradus et al, 2010; Hawton and van Heerningen, 2009).”
BackgroundPassos, I. C., Mwangi, B., Cao, B., Hamilton, J. E., Wu, M., Zhang, X., Zunta‐Soares, G. B., Quevedo, J., Kauer‐Sant’Anna, M., Kapczinski, F. P., et al. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.12.066 · Cited by 199
“Consequently, a growing body of knowledge has put forward several risk factors associated with patients that attempt suicide (Brundin et al., 2015; Mann and Currier, 2010; Maria A Oquendo et al., 2014; Turecki, 2014).”
BackgroundEpigenetic programming by early‐life stress: Evidence from human populations
Vaiserman, A. M. (2014) · Developmental Dynamics · doi:10.1002/dvdy.24211 · Cited by 193
“Post-translational histone modifications, such as acetylation, methylation, phosphorylation, and ubiquitination of histone tails, are another important mechanism responsible for epigenetic regulation of transcription (Wang and Higgins, 2013).”
Background
Metadata
- Authors
- Mann, J. J., & Currier, D. M.
- Affiliations
- Columbia University (US)
- Corresponding author
- Mann, J.J.
- Venue
- European Psychiatry
- Publisher
- Cambridge University Press (CUP)
- Published
- 2010-06
- Volume
- 25
- Issue
- 5
- Pages
- 268-271
- ISSN
- 0924-9338 (ISSN-L)
- 1778-3585
- PMC
- PMC2896004
- OpenAlex
- W2034761715
- Cited by
- 169
- References
- 29
- Citations by year
- 2026: 2 · 2025: 8 · 2024: 4 · 2023: 6 · 2022: 11 · 2021: 16 · 2020: 4 · 2019: 9 · 2018: 14 · 2017: 13 · 2016: 13 · 2015: 13 · 2014: 20 · 2013: 11 · 2012: 16
- FWCI
- 12.68
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- European Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (MH 62185, R10MH056390, MH48514, R01MH082041, MH56390, R01MH048514, MH82041, R01MH056390, P50MH062185)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- suicidal behavior, depression, stress, epigenetics, genetics, neurobiology, serotonergic system, noradrenergic system, hypothalamic-pituitary-adrenal axis, childhood adversity, genetic susceptibility, gene-environment interaction
- MeSH terms
- Depressive Disorder, Humans, Stress, Psychological, Suicide, Epigenesis, Genetic
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