Cited by 117Bipolar Disorder and TreatmentSubstance Abuse Treatment and OutcomesPersonality Disorders and Psychopathology

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Alcohol misuse in bipolar disorder. A systematic review and meta-analysis of comorbidity rates

Di Florio, A., Craddock, N., van den Bree, M.·2014·European Psychiatry

DOI 10.1016/j.eurpsy.2013.07.004

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Abstract

AIMS: To assess the comorbidity rates of alcohol use disorders (AUDs) in bipolar disorder (BD) and to explore possible sources of heterogeneity. METHODS: Studies were identified through database searches. Meta-analytic techniques were employed to aggregate data on lifetime comorbidity and to explore possible sources of heterogeneity. Funnel plots were used to detect publication bias. RESULTS: In clinical studies, AUDs affected more than one in three subjects with BD. Significant heterogeneity was found, which was largely explained by the geographical location of study populations and gender ratio of participants. AUDs affected more than one in five women and two in five men. CONCLUSION: AUDs are highly prevalent in BD. Our study revealed a substantial heterogeneity across studies. Further research including control groups is needed. Patients with BD should be assessed for current and previous AUDs.

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Higgins, J. P. T., Thompson, S. G., Deeks, J. J., & Altman, D. G. (2003) · BMJ · doi:10.1136/bmj.327.7414.557 · Cited by 63,139
Meta-analysis of Observational Studies in Epidemiology<SUBTITLE>A Proposal for Reporting</SUBTITLE>
Stroup, D. F. (2000) · JAMA · doi:10.1001/jama.283.15.2008 · Cited by 20,623
Conducting Meta-Analyses in R with the metafor Package
Viechtbauer, W. (2010) · Journal of Statistical Software · doi:10.18637/jss.v036.i03 · Cited by 20,464
Comorbidity of Mental Disorders With Alcohol and Other Drug Abuse: Results From the Epidemiologic Catchment Area (ECA) Study
Regier, D. A. (1990) · JAMA · doi:10.1001/jama.1990.03450190043026 · Cited by 3,962
Bipolar Disorder
Yatham, L. N., & Malhi, G. S. (2011) · Oxford University Press eBooks · doi:10.1093/med/9780199562305.001.0001 · Cited by 3,515
Lifetime Co-occurrence of DSM-III-R Alcohol Abuse and Dependence With Other Psychiatric Disorders in the National Comorbidity Survey
Kessler, R. C. (1997) · Archives of General Psychiatry · doi:10.1001/archpsyc.1997.01830160031005 · Cited by 2,085
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Knapp, G., & Hartung, J. (2003) · Statistics in Medicine · doi:10.1002/sim.1482 · Cited by 2,075
Manic-Depressive Insanity and Paranoia.
(1921) · JAMA · doi:10.1001/jama.1921.02630330070026 · Cited by 1,612
Meta-analysis Spurious precision? Meta-analysis of observational studies
Egger, M., Schneider, M., & Smith, G. D. (1998) · BMJ · doi:10.1136/bmj.316.7125.140 · Cited by 997
The emerging epidemiology of hypomania and bipolar II disorder
Angst, J. (1998) · Journal of Affective Disorders · doi:10.1016/s0165-0327(98)00142-6 · Cited by 758

Show all 71 references

Research works printed but not linked: 1

Suzanne, 2001, Course and socio-familial outcome of bipolar mood disorders, Ann Med Psychol, 554

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Comorbidity of Alcohol Use Disorders with Substance Use Disorders and Psychiatric Disorders
Zaorska, J., & Wojnar, M. (2023) · Springer eBooks · doi:10.1007/978-3-031-32483-3_17 · Cited by 7
Which comes first? New insights on comorbidity between eating disorders and bipolar disorders
Craba, A., Mazza, M., Marano, G., Rinaldi, L., Sani, G., & Janiri, L. (2021) · Emerging Trends in Drugs Addictions and Health · doi:10.1016/j.etdah.2021.100023 · Cited by 7
Peer victimization and associated alcohol and substance use: Prospective pathways for negative outcomes
Tretyak, V., Huffman, A., & Lippard, E. (2022) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2022.173409 · Cited by 9
Monitoring of alcohol consumption in primary care among adults with bipolar disorder: A cross-sectional and retrospective cohort study
Hardoon, S. L., Khadjesari, Z., Nazareth, I., Hamilton, F. L., & Petersen, I. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.03.019 · Cited by 5
Coping drinking motives, neural functional coupling during emotion processing, and alcohol use in young adults with bipolar disorder
Tretyak, V., Kirsch, D. E., Le, V., Fromme, K., Strakowski, S. M., & Lippard, E. T. C. (2022) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.14885 · Cited by 6
Alcohol use is associated with affective and interoceptive network alterations in bipolar disorder
Martyn, F. M., McPhilemy, G., Nabulsi, L., Quirke, J., Hallahan, B. P., McDonald, C., & Cannon, D. M. (2022) · Brain and Behavior · doi:10.1002/brb3.2832 · Cited by 8
“Most research examining the associations between resting state functional connectivity and alcohol use in BD has been undertaken in those with an AUD; however, this does not represent a complete spectrum of alcohol use by people with a diagnosis of BD (di Florio et al., 2014).”
Background
A Multimethod Examination of Sensitivity to Reward and Sensitivity to Punishment in Bipolar Disorder and Alcohol Dependence: Results from a 2 × 2 Factorial Design
Mellick, W. H., Prisciandaro, J. J., Brenner, H. M., Brown, D. G., & Tolliver, B. K. (2021) · Psychopathology · doi:10.1159/000512661 · Cited by 7
Subjective response to alcohol in young adults with bipolar disorder and recent alcohol use: a within-subject randomized placebo-controlled alcohol administration study
Lippard, E., Kirsch, D. E., Kosted, R., Le, V., Almeida, J., Fromme, K., & Strakowski, S. M. (2023) · Psychopharmacology · doi:10.1007/s00213-023-06315-9 · Cited by 5
Identification and management of bipolar disorder
Scrandis, D. A. (2014) · The Nurse Practitioner · doi:10.1097/01.npr.0000453642.51780.97 · Cited by 5
Does the number of previous mood episodes moderate the relationship between alcohol use, smoking and mood in bipolar outpatients?
ter Meulen, W. G., van Zaane, J., Draisma, S., Beekman, A. T. F., & Kupka, R. (2017) · BMC Psychiatry · doi:10.1186/s12888-017-1341-z · Cited by 6
Alcohol use in bipolar disorder: A neurobiological model to help predict susceptibility, select treatments and attenuate cortical insult
Chitty, K. M., Lagopoulos, J., Hickie, I. B., & Hermens, D. F. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.07.004 · Cited by 5
“Decades later with a wealth of information regarding the impact of this destructive comorbidity, it is still highly prevalent (Di Florio et al, 2014), which indicates there is room for improvement in prevention, early intervention and treatment strategies.”
Background
Challenges in the development of treatment guidelines for bipolar disorder
Fountoulakis, K. Ν., Fountoulakis, N. K., & Antoniadis, D. (2025) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2025.1564004 · Cited by 4
Differentiation between alcohol-associated cirrhosis and hepatitis B-associated cirrhosis based on hepatic complications and psychological symptoms
Liang, Y., Wang, S., Pan, Z.-Y., Deng, Z., & Xie, W.-R. (2023) · Journal of Research in Medical Sciences · doi:10.4103/jrms.jrms_187_22 · Cited by 4
AUD in perspective
de Bejczy, A., Addolorato, G., Aubin, H., Guiraud, J., Korpi, E. R., Nutt, D. J., Witkiewitz, K. A., & Söderpalm, B. (2024) · International review of neurobiology · doi:10.1016/bs.irn.2024.03.003 · Cited by 4
Associations between dietary habits and bipolar disorder: a diet-wide mendelian randomization study
Li, J., Hu, R., Luo, H., Guo, Y., Zhang, Z., Luo, Q., & Xia, P. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1388316 · Cited by 6
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The Relationship between Selected Factors (Temperament, Bipolar Traits, Sleep Quality, Severity of Addiction) and Depressive Symptoms in Alcohol-Dependent Men
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“Most of the previous research in this area has examined co-occurring alcohol abuse as a consequence of bipolar disorder [1,11].”
Background
Influence of Alcohol Dependence on the Clinical and Dynamic Characteristics of Bipolar Disorder with Their Comorbidity in Psychiatric Hospital Patients
Васильева, С. Н., Simutkin, G. G., Schastnyy, E. D., Лебедева, Е. В., & Bokhan, N. A. (2024) · Psikhiatriya · doi:10.30629/2618-6667-2023-21-6-42-49 · Cited by 3
Alcohol and Substance Use in BD Patients
Fountoulakis, K. N. (2014) · Springer eBooks · doi:10.1007/978-3-642-37216-2_9 · Cited by 3
Incidence of and risk factors for alcohol dependence in bipolar disorder: A population-based cohort and nested case–control study
Hsu, H.-E., Chen, P., Chang, H., Pan, C., Su, S., Tsai, S., Chen, C.-C., & Kuo, C. (2022) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/00048674221100153 · Cited by 4
“A previous study reported a difference in the pattern of cooccurrence among patients in North America, Europe and Asia, indicating that the comorbidity estimates of AD were significantly lower in Asia than in North America and Europe (Di Florio et al., 2014).”
BackgroundResult
Alcoholism in Bipolar Disorders: An Overview of Epidemiology, Common Pathogenetic Pathways, Course of Disease, and Implications for Treatment
Nicola, M. D., Moccia, L., Ferri, V. R., Panaccione, I., & Janiri, L. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813125-1.00038-6 · Cited by 2
Risk of developing avascular necrosis of the femoral head and neck among patients with bipolar disorder: A nationwide cohort study
Li, D., Yeh, T., Tsai, S., Chen, T., Liang, C., & Chen, M. (2023) · The European Journal of Psychiatry · doi:10.1016/j.ejpsy.2023.100224 · Cited by 2
Evaluation of 2D:4D digit ratio in bipolar 1 disorder patients and its relationship with treatment response
Cansız, A., & İnce, B. (2020) · Early Human Development · doi:10.1016/j.earlhumdev.2020.104971 · Cited by 2
Bipolar Disorder
Fears, S. C., & Reus, V. I. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-410529-4.00104-2 · Cited by 2
Screening for alcohol use disorder among individuals with comorbid psychiatric disorders: Diagnostic accuracy in a sample of young Swiss men
Baggio, S., Baudat, S., Daeppen, J., Gmel, G. E., Heller, P., Perroud, N. A., Rothen, S., Sporkert, F., Studer, J., Wolff, H. J., et al. (2020) · Addictive Behaviors · doi:10.1016/j.addbeh.2020.106354 · Cited by 2
Mental Health and SDG3.3, 3d, 3.4 and 3.5
Mphande, F. A. (2023) · Sustainable development goals series · doi:10.1007/978-981-99-4254-1_7 · Cited by 1
Low Psychological Resilience Predict the Risk for Alcohol Use Disorder in General Population: National Mental Health Survey of Korea 2021
Lee, S., Kim, J., & Han, C. (2024) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.24.1171 · Cited by 3
Unveiling the Gender Gap in Alcohol Misuse: Fear, Anger, and the “Game of Secrets”
Uscola, C. J. (2025) · Socius Sociological Research for a Dynamic World · doi:10.1177/23780231251369154 · Cited by 2
“Past work shows that stress, mental health (Di Florio, Craddock, and Van den Bree 2014; St. John, Montgomery, and Tyas 2009; Temmen and Crockett 2020), and complex gender roles and expectations for women effect alcohol use (Caluzzi et al. 2022).”
Alcohol abuse by mood disorder patients
Tondo, L., Miola, A., & Baldessarini, R. J. (2026) · Psychiatry Research · doi:10.1016/j.psychres.2026.117129 · Cited by 1
Genetics of bipolar disorder
O’Connell, K. S., Smeland, O. B., & Andreassen, O. A. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-819602-1.00003-6 · Cited by 1
Could reasons for admission help to screen unhealthy alcohol use in emergency departments? A multicenter French study
Chabert, J., Lambert, C., Cabé, J., CHERPITEL, C. J. S., Rolland, B., Moustafa, F., Lesage, P., Ragonnet, D., Geneste, J., Poulet, E., et al. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1271076 · Cited by 1
Nucleus accumbens functional connectivity changes underlying alcohol expectancies in bipolar disorder and prospective alcohol outcomes: a within-subject randomized placebo-controlled alcohol administration fMRI study
Lippard, E., Kirsch, D. E., Le, V., Lee, S.-H., Bibb, N., Meek, K., Kosted, R., Huffman, A., Almeida, J., Fromme, K., et al. (2025) · Frontiers in Neuroscience · doi:10.3389/fnins.2025.1549295 · Cited by 1
“While a 20%–40% prevalence of AUD in bipolar disorder is suggested (Di Florio et al., 2014; Hunt et al., 2016; Nery et al., 2014; Simhandl et al., 2016), estimates as high as 60% prevalence of lifetime AUD in bipolar disorder have been reported (Regier et al., 1990).”
Cardiometabolic comorbidity in bipolar disorder
Martin, D. J., & Smıth, D. J. (2013) · Dusunen Adam The Journal of Psychiatry and Neurological Sciences · doi:10.5350/dajpn20132604001 · Cited by 2
“Of all DSM-IV disorders, bipolar disorder has the highest rate of alcohol abuse (35).”
Background
Alcohol use disorders and psychiatric diseases in Colombia Desórdenes y enfermedad psiquiátrica causada por el uso de alcohol en Colombia
Rincón-Hoyos, H. G., Castillo, A., Prada, S. I., & Administrativas, F. C. (2016)
Epidemiological studies of medication use and effectiveness in bipolar disorder
Wingård, L. (2017) · Figshare
Ethical Issues in the Diagnosis and Treatment of Bipolar Disorders
Ostacher, M. J. (2019) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/appi.focus.20190010

Authors: Di Florio, A., Craddock, N., & van den Bree, M.
Affiliations: Cardiff University (GB)
ORCID: Craddock, N.
Venue: European Psychiatry
Publisher: Cambridge University Press (CUP)
Published: 2014-03
Volume: 29
Issue: 3
Pages: 117-124
ISSN: 0924-9338 (ISSN-L)
1778-3585
DOI: 10.1016/j.eurpsy.2013.07.004
OpenAlex: W1974477361
Cited by: 117
References: 71
Citations by year: 2026: 6 · 2025: 9 · 2024: 6 · 2023: 13 · 2022: 11 · 2021: 11 · 2020: 13 · 2019: 9 · 2018: 5 · 2017: 8 · 2016: 9 · 2015: 7 · 2014: 8
FWCI: 1.19
Type: journal article
Language: en
Open access: closed
Licence: www.cambridge.org/core/terms (unspecified, 2237 d)
Locations: European Psychiatry (publishedVersion)
PubMed (publishedVersion)
ORCA Online Research @Cardiff (Cardiff University) (submittedVersion)
Funders: Medical Research Council (MR/L010305/1, MR/K023233/1)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Social Sciences › Psychology › Clinical Psychology › Personality Disorders and Psychopathology
Keywords: bipolar disorder, alcoholism, alcohol abuse, psychiatric comorbidity, lifetime prevalence, sex differences, publication bias, heterogeneity sources
MeSH terms: Alcoholism, Bipolar Disorder, Humans, Comorbidity

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Alcohol misuse in bipolar disorder. A systematic review and meta-analysis of comorbidity rates

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