Cited by 201Treatment of Major DepressionAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesMental Health Treatment and Access

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Anhedonia predicts poor psychosocial functioning: Results from a large cohort of patients treated for major depressive disorder by general practitioners

Vinckier, F., Gourion, D., Mouchabac, S.·2017·European Psychiatry

DOI 10.1016/j.eurpsy.2017.02.485

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Abstract

BACKGROUND: Anhedonia is a core symptom of major depression and a key prognostic factor that is often poorly explored in clinical trials of major depressive disorder (MDD). Beyond symptomatic remission, psychosocial functioning also reveals difficulty in achieving remission in patients with MDD. The main objective of this study was to explore the interrelationships between social functioning and anhedonia on a longitudinal basis. METHODS: In total, 1570 outpatients treated for MDD with agomelatine were included. Severity of depression and levels of anhedonia and of psychosocial functioning were assessed at inclusion and at 10-14 weeks, with specific standardized scales (MADRS, QFS, SHAPS, CGI). Multivariate regression and mediation analyses were performed. RESULTS: Using multivariate regression, we showed that improvement of anhedonia was the strongest predictor of improvement in psychosocial functioning (odds ratio=7.3 [4.3-12.1] P<0.0001). In addition, mediation tests confirmed that the association between improvement of depressive symptoms and improvement of social functioning was significantly underpinned by the improvement of anhedonia over time. Finally, we explored the determinants of the dissociation of the response, i.e., the persistence of psychosocial dysfunctioning despite a symptomatic response to antidepressant treatment, which remains a widespread situation in clinical practice. We showed that this dissociation was strongly predicted by persistence of anhedonia. CONCLUSION: Our results suggest that anhedonia is one of the strongest predictors of psychosocial functioning, along with symptomatic remission, and should be carefully assessed by health professionals, in order to optimize pharmacological as well as non-pharmacological management of depression.

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The Effect of Electroconvulsive Therapy on Positive Affect and Hedonism in Patients With Depression
Crauwels, B., Vansteelandt, K., Obbels, J., Lambrichts, S., Pilato, E., Demyttenaere, K., & Sienaert, P. A. (2021) · Journal of Ect · doi:10.1097/yct.0000000000000818 · Cited by 1
“Finally, anhedonia has previously been associated with poor self-rated QoL in depression.(32,34,35) A discussion of the literature on QoL in ECT goes beyond the scope of the present investigation,(21,22,36,37) but the broaden-and-build theory implies that PA and hedonism may contribute to QoL by promoting flexible, cr…”
Background
About Treatments That Work
(2022) · Oxford University Press eBooks · doi:10.1093/med-psych/9780197548523.002.0006
Actions Toward Feeling Better
Craske, M. G., Dour, H. J., Treanor, M., & Meuret, A. E. (2022) · Oxford University Press eBooks · doi:10.1093/med-psych/9780197548523.003.0005
Client Exercises
Craske, M. G., Dour, H. J., Treanor, M., & Meuret, A. E. (2022) · Oxford University Press eBooks · doi:10.1093/med-psych/9780197548523.005.0001
Continuing the Journey After Treatment
Craske, M. G., Dour, H. J., Treanor, M., & Meuret, A. E. (2022) · Oxford University Press eBooks · doi:10.1093/med-psych/9780197548523.003.0008
Psychoeducation
Craske, M. G., Dour, H. J., Treanor, M., & Meuret, A. E. (2022) · Oxford University Press eBooks · doi:10.1093/med-psych/9780197548523.003.0004
Forms and Worksheets
Craske, M. G., Dour, H. J., Treanor, M., & Meuret, A. E. (2022) · Oxford University Press eBooks · doi:10.1093/med-psych/9780197548523.005.0002
Copyright Page
(2022) · Oxford University Press eBooks · doi:10.1093/med-psych/9780197548523.002.0004
Attending to the Positive
Craske, M. G., Dour, H. J., Treanor, M., & Meuret, A. E. (2022) · Oxford University Press eBooks · doi:10.1093/med-psych/9780197548523.003.0006
Introductory Information for Therapists
Craske, M. G., Dour, H. J., Treanor, M., & Meuret, A. E. (2022) · Oxford University Press eBooks · doi:10.1093/med-psych/9780197548523.003.0001
Behavioral Science and Neuroscience Identify Targets for Treatment of Anhedonia
Craske, M. G., Dour, H. J., Treanor, M., & Meuret, A. E. (2022) · Oxford University Press eBooks · doi:10.1093/med-psych/9780197548523.003.0002
General Treatment Format and Guiding Therapy Principles
Craske, M. G., Dour, H. J., Treanor, M., & Meuret, A. E. (2022) · Oxford University Press eBooks · doi:10.1093/med-psych/9780197548523.003.0003
About the Authors
(2022) · Oxford University Press eBooks · doi:10.1093/med-psych/9780197548523.002.0007
Building Positivity
Craske, M. G., Dour, H. J., Treanor, M., & Meuret, A. E. (2022) · Oxford University Press eBooks · doi:10.1093/med-psych/9780197548523.003.0007
A Preliminary Study for the Development of Data-Driven Screening Tool for Mental Health Using Self-Report Questionnaires Reflecting General Functional Status
Choi, W., Hwang, W. J., Kim, H., Kim, M., & Kwon, J. S. (2022) · 신경정신의학 · doi:10.4306/jknpa.2022.61.4.297
The Factorial Structure of the Anhedonia List and its mediating role between Mindfulness and both Anxiety and Depression among University Students
Abouzaid, A. M. G., & Abdelhamid, H. G. (2023) · Sohag University International Journal of Educational Research (SUIJER) /Sohag University International Journal of Educational Research (SUIJER) · doi:10.21608/suijer.2023.305894 · Cited by 1
“This is confirmed by several researchers, as Vinckier et al. (2017) found that using multivariate regression improvement in anhedonia was the strongest predictor of improvement in psychosocial functioning.”
Method
أدبيات انعدام التلذذ في الاضطرابات النفسية (نحو مدخل علاجي جديد "خفض انعدام التلذذ القائم على اليقظة العقلية) بحث نظري
(2023) · Al-Maǧallaẗ Al-Dawliyyaẗ Lil Buḥūṯ wa Al-Dirāsāt fi Al-Tarbiyyaẗ Al-H̲āṣaẗ · doi:10.21608/adba.2023.324391
أدبيات انعدام التلذذ في الاضطرابات النفسية (نحو مدخل علاجي جديد "خفض انعدام التلذذ القائم على اليقظة العقلية) بحث نظري
(2023) · Al-Maǧallaẗ Al-Dawliyyaẗ Lil Buḥūṯ wa Al-Dirāsāt fi Al-Tarbiyyaẗ Al-H̲āṣaẗ · doi:10.21608/adba.2023.324400
Study protocol for a randomized controlled trial of the RASPERA project: recalling and anticipating specific positive events to boost resilience in adolescents
Loyen, E., Bogaert, L., Hallford, D. J., D’Argembeau, A., & Raes, F. (2023) · Frontiers in Public Health · doi:10.3389/fpubh.2023.1216988
Mobile Cognitive Interventions in Mental Disorders
Blomberg, M. (2024) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-10652
Assessing social anhedonia in a transdiagnostic sample: Insights from a computational psychiatry lens.
Harlé, K. M., Dun, D., Spadoni, A. D., Howlett, J. R., & Simmons, A. N. (2024) · Journal of Mood and Anxiety Disorders · doi:10.1016/j.xjmad.2024.100088
“While not limited to the social domain, anhedonia often manifests as a marked avoidance of social interactions and altered sense of belong-ingness promoting social isolation, i.e., “ social anhedonia ” , which has in turn been associated with poorer functional outcomes [1,2,14].”
Audios
Craske, M. G., Dour, H. J., Treanor, M., & Meuret, A. E. (2022) · Oxford University Press eBooks · doi:10.1093/med-psych/9780197548523.005.0003
Anhedonia: a unifying symptom and a transdiagnostic therapeutic target
Rosso, G., Pesci, N. R., PERACCHIA, S., Garrone, C., Salvo, G. D., & Maina, G. (2025) · Minerva Psychiatry · doi:10.23736/s2724-6612.24.02572-7
Depression Remission Over Six Months Characterized by Elevated Target‐Locked P300 ERP Component: Prospective Evidence Employing an Affective Visual Oddball Task
Santopetro, N. J., Thompson, B., Albanese, B. J., Brush, C. J., & Schmidt, N. B. (2025) · Psychophysiology · doi:10.1111/psyp.70067
“…suggesting that P300-related impairments in depression reflect symptoms of an-hedonia (Urretavizcaya et al. 2003; Santopetro, Brush, Burani, et al. 2021; Santopetro et al. 2022), which is also associated with chronic and treatment-resistant presentations of depression (Vinckier et al. 2017).”
Approche dimensionnelle des symptômes négatifs dans les troubles psychiatriques
Mallet, J., Pignon, B., Kaiser, S., & Cevoli, F. (2025) · médecine/sciences · doi:10.1051/medsci/2025068
Childhood P300 predicts development of depressive disorders into adolescence
Santopetro, N. J., Nelson, B. D., Hajcak, G., & Klein, D. N. (2025) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/s13415-025-01327-8
“…been associated with anhedonia symptoms in adults experiencing clinical levels of depression (Santopetro et al., 2021), which is a pernicious core symptom of the disorder linked to worse clinical outcomes, such as a more chronic and recurrent trajectory of depression (Vinckier et al., 2017).”
Cognition–Emotion Interactions
Armony, J., & Vuilleumier, P. (2025) · Cambridge University Press eBooks · doi:10.1017/9781009342919.024
Smartphone-Based Approach-Avoidance Bias Modification Training for Depression: Randomized Clinical Trial
Blomberg, M., Zech, H., Kluge, M., Böhmert, N., Platte, H., & Brockmeyer, T. (2025) · JMIR mhealth and uhealth · doi:10.2196/69033
“Anhedonia predicts psychosocial functioning, depression severity, and treatment response [31, 32] and has been proposed as a potential target of change in approach-avoidance bias modification [23].”
Additional file 1 of Sex-specific immune-inflammatory markers and lipoprotein profile in patients with anhedonia with unipolar and bipolar depression
Lin, S., Liu, R., Zhang, Z., Liu, F., Qin, S., Wei, Y., & Wang, F. (2023) · Figshare · doi:10.6084/m9.figshare.24647146
Development and Validation of the Multidimensional Adolescent Anhedonia Scale
Grocott, B. B., Zareian, B., Hewitt, J. M. A., Ge, S. Y. J., Hewitt, P. L., Hong, S., Smith, M. M., Chi, X., & LeMoult, J. (2026) · Assessment · doi:10.1177/10731911261423154
“For example, anticipatory anhedonia has been more strongly linked to depressive symptoms (Sherdell et al., 2012), whereas consummatory anhedonia is more closely related to impaired psychosocial functioning (Vinckier et al., 2017).”
Development of a baseline battery to optimize depression treatment assignment in primary care: Balancing breadth and brevity
Pozuelo, J. R., Kessler, R. C., Patel, V., Lahiri, A., Parashar, Y., Herzallah, M. M., Khanduri, M., O’Neill, K., Martinez, A., Bhan, A., et al. (2026) · Journal of Affective Disorders · doi:10.1016/j.jad.2026.121674
Examining the malleability of research domain criteria positive valence system constructs in mood disorders: A systematic review and meta-analysis
Ambalavanar, N., Tang, B., Galinato, D. J. A., Spoelma, M. J., Newby, J. M., & Whitton, A. E. (2026) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2026.106667
Caractérisation neuro-computationnelle des troubles de la motivation dans la dépression : vers une médecine personnalisée en psychiatrie
Jaffré, C. (2023) · theses.fr (ABES) · doi:10.70675/43b0f664ze3e9z438eza225zb06ccd201945
Caractérisation neuro-computationnelle de l'humeur : causes et conséquences
Carrillo, P. (2024) · theses.fr (ABES) · doi:10.70675/181aec0cz429dz4bccz83f0za479cbef52f7
Patient perspectives on the challenges, obstacles, and opportunities in discussing and managing anhedonia in major depressive disorder (MDD): a focus group study
Portela, R., Brister, T. S., Mattingly, G. W., Drissen, T., & Bowrey, H. E. (2026) · Annals of General Psychiatry · doi:10.1186/s12991-026-00662-5 · Cited by 1
Comparative multidimensional psychosocial profiles of major depressive disorder patients with higher versus lower anhedonia burden: a cross-sectional study
Zhu, C., Hu, R., Du, W., Ye, Y., Mu, Q., Chen, Y., Xu, Y., Zhang, K., & Lu, S. (2026) · BMC Psychiatry · doi:10.1186/s12888-026-08169-9
“Given that anhedonia is not only a core symptomatic dimen-sion of MDD [8] but is also associated with poorer functional outcomes and quality of life [10, 13], systematic identification and longitudinal monitoring in routine assessment are clinically warranted [49, 50].”
Influential
Baseline Anhedonia Phenotypes Reveal Divergent Neurophysiological Effects of Intermittent Theta Burst Stimulation in Major Depressive Disorder
Wu, J., Deng, Z., Cheng, X., Qiu, N., Hu, L., Chen, Z., Yi, C., Pu, L., Yao, D., & Yan, H. (2026) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2026.05.004
PHENOTYPIC CHARACTERISTICS OF MAJOR DEPRESSIVE DISORDER AND CEREBRAL GRAY MATTER ABNORMALITIES ACCORDING TO VOXEL-BASED MORPHOMETRY DATA
Levada, O. A., Troian, O., Myshakivska, O., & Пінчук, І. (2026) · Proceedings of the Shevchenko Scientific Society Medical Sciences · doi:10.25040/ntsh2026.01.23
Identifying distinct trajectories of change in anhedonia during psychological treatment for depression
Pugh, D., Saunders, R., Jones, A., Dunn, B., Suh, J. W., Stott, J. C. H., Wheatley, J., Pilling, S., & Buckman, J. E. J. (2026) · Psychological Medicine · doi:10.1017/s0033291726104875
Anticipate, experience, strengthen: a network analysis of daily life positive affect dynamics
Pacheco-Romero, A. M., Hoorelbeke, K., Vázquez, C., & Sánchez-López, Á. (2026) · Motivation and Emotion · doi:10.1007/s11031-026-10259-w
Common and disorder-specific aberrant activation during reward and loss processing in major depressive disorder and addiction: a meta-analysis of fMRI studies
Yang, X., Huang, Y., Liu, W., Wu, T., Liu, Z., Gao, S., Zheng, Q., Dou, Z., Zheng, J., Meng, S., et al. (2026) · Molecular Psychiatry · doi:10.1038/s41380-026-03794-y
Effects of acute inflammatory challenge on anhedonia and social reward processing: A randomized controlled trial of endotoxin
Boyle, C. C., Blandl, F., Eisenberger, N. I., Olmstead, R., Cho, J. H., Piber, D., & Irwin, M. R. (2026) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2026.107987
Correspondence in emotionality between spoken words and ecological momentary assessment in individuals varying in depression and anhedonia
Losiewicz, O. M., Zbozinek, T. D., Cohen, Z. D., Akre, S., Bui, A. A. T., & Craske, M. G. (2026) · Journal of Affective Disorders Reports · doi:10.1016/j.jadr.2026.101163
Verbal memory impairments predict social connection via anhedonia: a transdiagnostic, population-based study
Matteo, I. D., Lavigne, K. M., & Raucher‐Chéné, D. (2026) · Psychiatry Research · doi:10.1016/j.psychres.2026.117532

Authors: Vinckier, F., Gourion, D., & Mouchabac, S.
Affiliations: Sorbonne Paris Cité (FR)
Sorbonne Université (FR)
Corresponding author: Vinckier, F.
ORCID: Vinckier, F.
Mouchabac, S.
Venue: European Psychiatry
Publisher: Cambridge University Press (CUP)
Published: 2017-07
Volume: 44
Pages: 1-8
ISSN: 0924-9338 (ISSN-L)
1778-3585
DOI: 10.1016/j.eurpsy.2017.02.485
OpenAlex: W2592834759
Cited by: 201
References: 43
Citations by year: 2026: 22 · 2025: 44 · 2024: 29 · 2023: 22 · 2022: 35 · 2021: 16 · 2020: 13 · 2019: 14 · 2018: 4 · 2017: 2
FWCI: 6.30
Type: journal article
Language: en
Open access: closed
Licence: www.cambridge.org/core/terms (unspecified, 996 d)
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: European Psychiatry (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
Keywords: anhedonia, major depressive disorder, psychosocial functioning, social functioning, agomelatine, antidepressant response, prognostic factors, general practitioners, mediation analysis
MeSH terms: Adaptation, Psychological, Adult, Antidepressive Agents, Major Depressive Disorder, Female, Humans, Male, Middle Aged, Outpatients, Severity of Illness Index, Social Adjustment, Cohort Studies, Treatment Outcome, General Practitioners, Anhedonia

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Anhedonia predicts poor psychosocial functioning: Results from a large cohort of patients treated for major depressive disorder by general practitioners

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