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Cited by 201Treatment of Major DepressionAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesMental Health Treatment and Access

The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.

Anhedonia predicts poor psychosocial functioning: Results from a large cohort of patients treated for major depressive disorder by general practitioners

Vinckier, F., Gourion, D., Mouchabac, S.·2017·European Psychiatry
DOI 10.1016/j.eurpsy.2017.02.485
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Abstract

BACKGROUND: Anhedonia is a core symptom of major depression and a key prognostic factor that is often poorly explored in clinical trials of major depressive disorder (MDD). Beyond symptomatic remission, psychosocial functioning also reveals difficulty in achieving remission in patients with MDD. The main objective of this study was to explore the interrelationships between social functioning and anhedonia on a longitudinal basis. METHODS: In total, 1570 outpatients treated for MDD with agomelatine were included. Severity of depression and levels of anhedonia and of psychosocial functioning were assessed at inclusion and at 10-14 weeks, with specific standardized scales (MADRS, QFS, SHAPS, CGI). Multivariate regression and mediation analyses were performed. RESULTS: Using multivariate regression, we showed that improvement of anhedonia was the strongest predictor of improvement in psychosocial functioning (odds ratio=7.3 [4.3-12.1] P<0.0001). In addition, mediation tests confirmed that the association between improvement of depressive symptoms and improvement of social functioning was significantly underpinned by the improvement of anhedonia over time. Finally, we explored the determinants of the dissociation of the response, i.e., the persistence of psychosocial dysfunctioning despite a symptomatic response to antidepressant treatment, which remains a widespread situation in clinical practice. We showed that this dissociation was strongly predicted by persistence of anhedonia. CONCLUSION: Our results suggest that anhedonia is one of the strongest predictors of psychosocial functioning, along with symptomatic remission, and should be carefully assessed by health professionals, in order to optimize pharmacological as well as non-pharmacological management of depression.

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  1. Loas, 1997, Étude de validation de la version française de l’échelle de plaisir de Snaith et Hamilton (Snaith-Hamilton Pleasure Scale, SHAPS, Snaith et al., 1995): détermination des paramètres métrologiques chez 208 sujets sains et chez 103 malades hospitalisés présentant une dépression ou une schizophrénie, Encephale, 23, 454

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Metadata

Authors
Vinckier, F., Gourion, D., & Mouchabac, S.
Affiliations
  • Sorbonne Paris Cité (FR)
  • Sorbonne Université (FR)
Corresponding author
Vinckier, F.
ORCID
Venue
European Psychiatry
Publisher
Cambridge University Press (CUP)
Published
2017-07
Volume
44
Pages
1-8
ISSN
  • 0924-9338 (ISSN-L)
  • 1778-3585
DOI
10.1016/j.eurpsy.2017.02.485
OpenAlex
W2592834759
Cited by
201
References
43
Citations by year
2026: 22 · 2025: 44 · 2024: 29 · 2023: 22 · 2022: 35 · 2021: 16 · 2020: 13 · 2019: 14 · 2018: 4 · 2017: 2
FWCI
6.30
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • European Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
  • Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
Keywords
anhedonia, major depressive disorder, psychosocial functioning, social functioning, agomelatine, antidepressant response, prognostic factors, general practitioners, mediation analysis
MeSH terms
Adaptation, Psychological, Adult, Antidepressive Agents, Major Depressive Disorder, Female, Humans, Male, Middle Aged, Outpatients, Severity of Illness Index, Social Adjustment, Cohort Studies, Treatment Outcome, General Practitioners, Anhedonia

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