Anhedonia predicts poorer recovery among youth with selective serotonin reuptake inhibitor treatment-resistant depression
Open accessAbstract
Objective To identify symptom dimensions of depression that predict recovery among selective serotonin reuptake inhibitor (SSRI) treatment-resistant adolescents undergoing second-step treatment.Method The Treatment of Resistant Depression in Adolescents (TORDIA) trial included 334 SSRI treatment-resistant youth randomized to a medication switch, or a medication switch plus CBT. This study examined five established symptom dimensions (Child Depression Rating Scale-Revised) at baseline as they predicted recovery over 24 weeks of acute and continuation treatment. The two indices of recovery that were evaluated were time to remission and number of depression-free days.Results Multivariate analyses examining all five depression symptom dimensions simultaneously indicated that anhedonia was the only dimension to predict a longer time to remission, and also the only dimension to predict fewer depression-free days. In addition, when anhedonia and CDRS-total score were evaluated simultaneously, anhedonia continued to uniquely predict longer time to remission and fewer depression-free days.Conclusions Anhedonia may represent an important negative prognostic indicator among treatment-resistant depressed adolescents. Further research is needed to elucidate neurobehavioral underpinnings of anhedonia, and to test treatments that target anhedonia in the context of overall treatment of depression.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Anhedonia is a negative prognostic factor for treatment outcome in adolescents and adults.
“Furthermore, it was shown that anhedonia is a negative prognostic factor for treatment outcome both in adolescents (McMakin et al., 2012) and adults (Spijker et al., 2001; Vrieze et al., 2014).”
From Circuit Mechanisms of Reward, Anhedonia, and Depression (2019) · cites this paper as McMakin et al., 2012
Anhedonia typically does not respond to first-line pharmacotherapies.
“Anhedonia typically does not respond to first-line pharmacotherapies [5, 7, 8]”
From Chronic unpredictable stress induces depression-related behaviors by suppressing AgRP neuron activity (2021) · cites this paper as [7]
Persistent, trait-like social anhedonia in early adolescence predicts increased severity of, and poorer recovery from, depression, above and beyond other illness features.
“Indeed, persistent, trait-like social anhedonia in early adolescence predicts increased severity of, and poorer recovery from, depression, above and beyond other illness features (184)”
From A transdiagnostic perspective on social anhedonia (2019) · cites this paper as [184]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
KAUFMAN, J., BIRMAHER, B., BRENT, D., RAO, U., FLYNN, C., MORECI, P., WILLIAMSON, D., & RYAN, N. (1997) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199707000-00021 · Cited by 10,148 · see citing works
Fredrickson, B. L. (2001) · American Psychologist · doi:10.1037//0003-066x.56.3.218 · Cited by 3,512 · see citing works
Reconsidering anhedonia in depression: Lessons from translational neuroscience
Treadway, M. T., & Zald, D. H. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.06.006 · Cited by 1,579 · see citing works
Pizzagalli, D. A., Holmes, A. J., Dillon, D. G., Goetz, E. L., Birk, J. L., Bogdan, R., Dougherty, D. D., Iosifescu, D. V., Rauch, S. L., & Fava, M. (2009) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2008.08081201 · Cited by 1,232 · see citing works
Can people feel happy and sad at the same time?
Larsen, J. T., McGraw, A. P., & Cacioppo, J. T. (2001) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.81.4.684 · Cited by 1,083 · see citing works
The teen brain: insights from neuroimaging
Giedd, J. N. (2008) · Journal of Adolescent Health · doi:10.1016/j.jadohealth.2008.01.007 · Cited by 775 · see citing works
(2007) · Archives of General Psychiatry · doi:10.1001/archpsyc.64.10.1132 · Cited by 752 · see citing works
Report by the ACNP Task Force on Response and Remission in Major Depressive Disorder
Rush, A. J., Kraemer, H. C., Sackeim, H. A., Fava, M., Trivedi, M. H., Frank, E., Ninan, P. T., Thase, M. E., Gelenberg, A. J., Kupfer, D. J., et al. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301131 · Cited by 707 · see citing works
Brent, D. A., Emslie, G. J., Clarke, G. N., Wagner, K. D., Asarnow, J. R., Keller, M., Vitiello, B., Ritz, L., Iyengar, S., Abebe, K. Z., et al. (2008) · JAMA · doi:10.1001/jama.299.8.901 · Cited by 705 · see citing works
Behavioral activation and inhibition systems and the severity and course of depression.
Kasch, K. L., Rottenberg, J., Arnow, B. A., & Gotlib, I. H. (2002) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.111.4.589 · Cited by 551 · see citing works
Curry, J. F., Rohde, P., Simons, A. D., Silva, S. G., Vitiello, B., Kratochvil, C. J., Reinecke, M. A., Feeny, N. C., Wells, K., Pathak, S., et al. (2006) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/01.chi.0000240838.78984.e2 · Cited by 432 · see citing works
Wacker, J., Dillon, D. G., & Pizzagalli, D. A. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.01.058 · Cited by 405 · see citing works
Davey, C. G., Yücel, M., & Allen, N. B. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2007.04.016 · Cited by 377 · see citing works
Clinical Outcome After Short-term Psychotherapy for Adolescents With Major Depressive Disorder
Birmaher, B. B., Brent, D. A., Kolko, D. J., BAUGHER, M., Bridge, J. A., Holder, D., Iyengar, S., & Ulloa, R. E. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.1.29 · Cited by 374 · see citing works
Brent, D. A., Kolko, D. J., Birmaher, B. B., BAUGHER, M., Bridge, J. A., ROTH, C., & Holder, D. (1998) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199809000-00010 · Cited by 372 · see citing works
Rottenberg, J. A., Kasch, K. L., Gross, J. J., & Gotlib, I. H. (2002) · Emotion · doi:10.1037/1528-3542.2.2.135 · Cited by 360 · see citing works
Kennard, B. D., Silva, S. G., Vitiello, B., Curry, J. F., Kratochvil, C. J., Simons, A. D., Hughes, J. L., Feeny, N. C., Weller, E. B., SWEENEY, M., et al. (2006) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/01.chi.0000242228.75516.21 · Cited by 280 · see citing works
The current status of research on the structure of evaluative space
Norris, C. J., Gollan, J. K., Berntson, G. G., & Cacioppo, J. T. (2010) · Biological Psychology · doi:10.1016/j.biopsycho.2010.03.011 · Cited by 227 · see citing works
Treatment of Selective Serotonin Reuptake Inhibitor-Resistant Depression in Adolescents
Asarnow, J. R., Emslie, G. J., Clarke, G. N., Wagner, K. D., Spirito, A., Vitiello, B., Iyengar, S., Shamseddeen, W. A., Ritz, L., Birmaher, B. B., et al. (2009) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/chi.0b013e3181977476 · Cited by 218 · see citing works
Treatment of Resistant Depression in Adolescents (TORDIA): week 24 outcomes
Emslie, G. J., Mayes, T., Porta, G., Vitiello, B., Clarke, G., Wagner, K. D., Asarnow, J. R., Spirito, A., Birmaher, B., Ryan, N., et al. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2010.09040552 · Cited by 217 · see citing works
Daily emotional dynamics in depressed youth: A cell phone ecological momentary assessment study
Silk, J. S., Forbes, E. E., Whalen, D. J., Jakubcak, J. L., Thompson, W. K., Ryan, N. D., Axelson, D., Birmaher, B. B., & Dahl, R. E. (2010) · Journal of Experimental Child Psychology · doi:10.1016/j.jecp.2010.10.007 · Cited by 215 · see citing works
Kennard, B. D., Silva, S. G., Tonev, S. T., Rohde, P., Hughes, J. L., Vitiello, B., Kratochvil, C. J., Curry, J. F., Emslie, G. J., Reinecke, M. A., et al. (2009) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/chi.0b013e31819176f9 · Cited by 187 · see citing works
Forbes, E. E., Olino, T. M., Ryan, N. D., Birmaher, B., Axelson, D., Moyles, D. L., & Dahl, R. E. (2010) · Cognitive, Affective, & Behavioral Neuroscience · doi:10.3758/cabn.10.1.107 · Cited by 178 · see citing works
Cognitive-behavioral group treatment of adolescent depression: Prediction of outcome
Clarke, G., Hops, H., Lewinsohn, P., Andrews, J., Seeley, J., & Williams, J. (1992) · Behavior Therapy · doi:10.1016/s0005-7894(05)80162-5 · Cited by 176 · see citing works
Clinical Evidence and Potential Neurobiological Underpinnings of Unresolved Symptoms of Depression
Trivedi, M. H., Hollander, E., Nutt, D., & Blier, P. (2008) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v69n0211 · Cited by 153 · see citing works
Vitiello, B., Emslie, G. J., Clarke, G., Wagner, K. D., Asarnow, J. R., Keller, M. B., Birmaher, B. B., Ryan, N. D., Kennard, B. D., Mayes, T. L., et al. (2010) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.09m05885blu · Cited by 128 · see citing works
Kennard, B. D., Clarke, G. N., Weersing, V. R., Asarnow, J. R., Shamseddeen, W. A., Porta, G., Berk, M. S., Hughes, J. L., Spirito, A., Emslie, G. J., et al. (2009) · Journal of Consulting and Clinical Psychology · doi:10.1037/a0017411 · Cited by 121 · see citing works
Asarnow, J. R., Emslie, G. J., Clarke, G. N., Wagner, K. D., Spirito, A., Vitiello, B., Iyengar, S., Shamseddeen, W. A., Ritz, L., Birmaher, B. B., et al. (2009) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/chi.ob013e3181977476 · Cited by 120 · see citing works
Where’s the fun in that? Broadening the focus on reward function in depression
Forbes, E. E. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.05.001 · Cited by 98 · see citing works
Cost-Effectiveness of Treatments for Adolescent Depression: Results From TADS
Domino, M. E., Burns, B. J., Silva, S. G., Kratochvil, C. J., Vitiello, B., Reinecke, M. A., Mario, J., & March, J. S. (2008) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2008.07101610 · Cited by 92 · see citing works
Rohde, P., Seeley, J., Kaufman, N., Clarke, G., & Stice, E. (2006) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.74.1.80 · Cited by 78 · see citing works
Substance Use and the Treatment of Resistant Depression in Adolescents
Goldstein, B. I., Shamseddeen, W. A., Spirito, A., Emslie, G. J., Clarke, G. N., Wagner, K. D., Asarnow, J. R., Vitiello, B., Ryan, N. D., Birmaher, B. B., et al. (2009) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/chi.0b013e3181bef6e8 · Cited by 66 · see citing works
Lynch, F. L., Dickerson, J. F., Clarke, G. N., Vitiello, B., Porta, G., Wagner, K. D., Emslie, G. J., Asarnow, J. R., Keller, M. B., Birmaher, B. B., et al. (2011) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.9 · Cited by 51 · see citing works
Tao, R., Emslie, G. J., Mayes, T. L., Nakonezny, P. A., Kennard, B. D., & Hughes, C. W. (2008) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/chi.0b013e318190043e · Cited by 51 · see citing works
Pediatric depression: is there evidence to improve evidence‐based treatments?
Brent, D. A., & Maalouf, F. T. (2009) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2008.02037.x · Cited by 40 · see citing works
Mallick, R., Chen, J., Entsuah, R., & Schatzberg, A. F. (2003) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v64n0315 · Cited by 30 · see citing works
Tao, R., Emslie, G. J., Mayes, T. L., Nakonezny, P. A., & Kennard, B. D. (2010) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2009.0116 · Cited by 27 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Depression, Stress, and Anhedonia: Toward a Synthesis and Integrated Model
Pizzagalli, D. A. (2014) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-050212-185606 · Cited by 1,155 · see citing works
Dopamine system dysregulation in major depressive disorders
Belujon, P., & Grace, A. A. (2017) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyx056 · Cited by 754 · see citing works
Assessing anhedonia in depression: potentials and pitfalls
Rizvi, S. J., Pizzagalli, D. A., Sproule, B. A., & Kennedy, S. H. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.03.004 · Cited by 571 · see citing works
Craske, M. G., Meuret, A. E., Ritz, T., Treanor, M., Dour, H., & Rosenfield, D. (2019) · Journal of Consulting and Clinical Psychology · doi:10.1037/ccp0000396 · Cited by 451 · see citing works
Craske, M. G., Meuret, A. E., Ritz, T., Treanor, M., & Dour, H. J. (2016) · Depression and Anxiety · doi:10.1002/da.22490 · Cited by 387 · see citing works
Motivation and cognitive control in depression
Grahek, I., Shenhav, A., Musslick, S., Krebs, R. M., & Koster, E. H. W. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.04.011 · Cited by 360 · see citing works
Stringaris, A., Vidal-Ribas Belil, P., Artiges, E., Lemaitre, H., Gollier-Briant, F., Wolke, S., Vulser, H., Miranda, R., Penttilä, J., Struve, M., et al. (2015) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2015.14101298 · Cited by 322 · see citing works
Childhood Trauma Exposure Disrupts the Automatic Regulation of Emotional Processing
Marusak, H. A., Martin, K. R., Etkin, A., & Thomason, M. E. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2014.311 · Cited by 343 · see citing works
Fettes, P., Schulze, L., & Downar, J. (2017) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2017.00025 · Cited by 299 · see citing works
McAllister-Williams, R. H., Arango, C., Blier, P., Demyttenaere, K., Falkai, P., Gorwood, P., Hopwood, M., Javed, A., Kasper, S., Malhi, G. S., et al. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.02.023 · Cited by 278 · see citing works
Lally, N., Nugent, A. C., Luckenbaugh, D. A., Ameli, R., Roiser, J. P., & Zarate, C. A. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.105 · Cited by 271 · see citing works
Rizvi, S. J., Quilty, L. C., Sproule, B. A., Cyriac, A., Michael Bagby, R., & Kennedy, S. H. (2015) · Psychiatry Research · doi:10.1016/j.psychres.2015.07.062 · Cited by 274 · see citing works
Circuit Mechanisms of Reward, Anhedonia, and Depression
Höflich, A., Michenthaler, P., Kasper, S., & Lanzenberger, R. (2019) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyy081 · Cited by 253 · see citing works
Vanderlind, W. M., Millgram, Y., Baskin-sommers, A. R., Clark, M. S., & Joormann, J. (2020) · Clinical Psychology Review · doi:10.1016/j.cpr.2020.101826 · Cited by 256 · see citing works
Anhedonia and the Brain Reward Circuitry in Depression
Heshmati, M., & Russo, S. J. (2015) · Current Behavioral Neuroscience Reports · doi:10.1007/s40473-015-0044-3 · Cited by 236 · see citing works
Striatum-Based Circuitry of Adolescent Depression and Anhedonia
Gabbay, V., Ely, B. A., Li, Q., Bangaru, S. D., Panzer, A. M., Alonso, C. M., Castellanos, F. X., & Milham, M. P. (2013) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2013.04.003 · Cited by 222 · see citing works
Protecting Adolescents From Self-Harm: A Critical Review of Intervention Studies
Brent, D. A., McMakin, D. L., Kennard, B. D., Goldstein, T. R., Mayes, T. L., & Douaihy, A. B. (2013) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2013.09.009 · Cited by 223 · see citing works
Disrupted habenula function in major depression
Lawson, R. P., Nord, C. L., Seymour, B., Thomas, D. L., Dayan, P., Pilling, S., & Roiser, J. P. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.81 · Cited by 206 · see citing works
Borsini, A., Wallis, A. S. J., Zunszain, P., Pariante, C. M., & Kempton, M. J. (2020) · Cognitive, Affective, & Behavioral Neuroscience · doi:10.3758/s13415-020-00804-6 · Cited by 207 · see citing works
Vinckier, F., Gourion, D., & Mouchabac, S. (2017) · European Psychiatry · doi:10.1016/j.eurpsy.2017.02.485 · Cited by 201 · see citing works
Networks of major depressive disorder: A systematic review
Malgaroli, M., Calderon, A., & Bonanno, G. A. (2021) · Clinical Psychology Review · doi:10.1016/j.cpr.2021.102000 · Cited by 204 · see citing works
Blunted reward responsiveness in remitted depression
Pechtel, P., Dutra, S. J., Goetz, E. L., & Pizzagalli, D. A. (2013) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2013.08.011 · Cited by 192 · see citing works
Key role of gut microbiota in anhedonia-like phenotype in rodents with neuropathic pain
Yang, C., Fang, X., Zhan, G., Huang, N., Li, S., Bi, J., Jiang, R., Yang, L., Miao, L., Zhu, B., et al. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0379-8 · Cited by 176 · see citing works
Role of Reward Sensitivity and Processing in Major Depressive and Bipolar Spectrum Disorders
Alloy, L. B., Olino, T. M., Freed, R. D., & Nusslock, R. (2016) · Behavior Therapy · doi:10.1016/j.beth.2016.02.014 · Cited by 169 · see citing works
Personalized prediction of antidepressant v. placebo response: evidence from the EMBARC study
Webb, C. A., Trivedi, M. H., Cohen, Z. D., Dillon, D. G., Fournier, J. C. J., Goer, F., D, M. F. M., McGrath, P. J., Weissman, M. M., Parsey, R. V., et al. (2018) · Psychological Medicine · doi:10.1017/s0033291718001708 · Cited by 172 · see citing works
Stringaris, A. K., Maughan, B., Copeland, W., Costello, E. J., & Angold, A. C. (2013) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2013.05.017 · Cited by 165 · see citing works
A transdiagnostic perspective on social anhedonia
Barkus, E., & Badcock, J. C. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00216 · Cited by 165 · see citing works
Dwyer, J. B., Landeros‐Weisenberger, A., Johnson, J. A., Tobón, A. L., Flores, J. M., Nasir, M., Couloures, K. G., Sanacora, G., & Bloch, M. H. (2021) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2020.20010018 · Cited by 172 · see citing works
Wang, S., Leri, F., & Rizvi, S. J. (2021) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2021.110289 · Cited by 164 · see citing works
Anhedonia in depression and schizophrenia: A transdiagnostic challenge
Lambert, C. M., Silva, S. D., Ceniti, A. K., Rizvi, S. J., Foussias, G., & Kennedy, S. H. (2018) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12854 · Cited by 156 · see citing works
Reduced reward anticipation in youth at high-risk for unipolar depression: A preliminary study
Olino, T. M., McMakin, D. L., Morgan, J. K., Silk, J. S., Birmaher, B. B., Axelson, D., Williamson, D. E., Dahl, R. E., Ryan, N. D., & Forbes, E. E. (2013) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2013.11.005 · Cited by 149 · see citing works
Gabbay, V., Johnson, A. R., Alonso, C. M., Evans, L. K., Babb, J. S., & KLEIN, R. G. (2015) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2014.0105 · Cited by 148 · see citing works
Annual Research Review: Defining and treating pediatric treatment‐resistant depression
Dwyer, J. B., Stringaris, A. K., Brent, D. A., & Bloch, M. H. (2020) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.13202 · Cited by 152 · see citing works
Der‐Avakian, A., Mazei‐Robison, M. S., Kesby, J. P., Nestler, E. J., & Markou, A. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.01.013 · Cited by 147 · see citing works
Reduced neural response to reward and pleasant pictures independently relate to depression
Klawohn, J., Burani, K., Bruchnak, A., Santopetro, N. J., & Hajcak, G. (2020) · Psychological Medicine · doi:10.1017/s0033291719003659 · Cited by 142 · see citing works
Watson, R., Harvey, K., McCabe, C., & Reynolds, S. A. (2019) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-019-01364-y · Cited by 135 · see citing works
Sheth, C. S., McGlade, E., & Yurgelun-Todd, D. A. (2017) · Chronic Stress · doi:10.1177/2470547017715645 · Cited by 136 · see citing works
Mapping inflammation onto mood: inflammatory mediators of anhedonia
Swardfager, W., Rosenblat, J. D., Benlamri, M., & McIntyre, R. S. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.02.017 · Cited by 125 · see citing works
Anhedonia revisited: Is there a role for dopamine-targeting drugs for depression?
Argyropoulos, S. V., & Nutt, D. (2013) · Journal of Psychopharmacology · doi:10.1177/0269881113494104 · Cited by 122 · see citing works
McCauley, E., Gudmundsen, G. R., Schloredt, K. A., Martell, C. R., Rhew, I. C., Hubley, S. H., & Dimidjian, S. (2015) · Journal of Clinical Child & Adolescent Psychology · doi:10.1080/15374416.2014.979933 · Cited by 125 · see citing works
Markov, D. D. (2022) · Brain Sciences · doi:10.3390/brainsci12101287 · Cited by 125 · see citing works
Olino, T. M., Silk, J. S., Osterritter, C., & Forbes, E. E. (2015) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2014.0165 · Cited by 122 · see citing works
The Co-occurrence of Pediatric Chronic Pain and Depression
Soltani, S., Kopala‐Sibley, D. C., & Noel, M. E. (2019) · Clinical Journal of Pain · doi:10.1097/ajp.0000000000000723 · Cited by 118 · see citing works
Murphy, S. E., Capitão, L. P., Giles, S. L. C., Cowen, P. J., Stringaris, A., & Harmer, C. J. (2021) · The Lancet Psychiatry · doi:10.1016/s2215-0366(21)00154-1 · Cited by 112 · see citing works
Anhedonia in depression symptomatology: appetite dysregulation and defective brain reward processing
Coccurello, R. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.112041 · Cited by 106 · see citing works
The Comorbidity of PTSD and MDD: Implications for Clinical Practice and Future Research
Angelakis, S., & Nixon, R. D. V. (2015) · Behaviour Change · doi:10.1017/bec.2014.26 · Cited by 109 · see citing works
Positive affect and reward processing in the treatment of depression, anxiety and trauma
Craske, M. G., Dunn, B. D., Meuret, A. E., Rizvi, S. J., & Taylor, C. T. (2024) · Nature Reviews Psychology · doi:10.1038/s44159-024-00355-4 · Cited by 105 · see citing works
Disentangling reward anticipation with simultaneous pupillometry / fMRI
Schneider, M., Leuchs, L., Czisch, M., Sämann, P. G., & Spoormaker, V. I. (2018) · NeuroImage · doi:10.1016/j.neuroimage.2018.04.078 · Cited by 100 · see citing works
van Roekel, E., Bennik, E. C., Bastiaansen, J. A., Verhagen, M., Ormel, J., Engels, R. C. M. E., & Oldehinkel, A. J. (2015) · Research on Child and Adolescent Psychopathology · doi:10.1007/s10802-015-0090-z · Cited by 102 · see citing works
Irritability as a Transdiagnostic Vulnerability Trait:Current Issues and Future Directions
Beauchaine, T. P., & Tackett, J. L. (2019) · Behavior Therapy · doi:10.1016/j.beth.2019.10.009 · Cited by 101 · see citing works
Crockett, M. A., Martínez, V., & Jiménez-Molina, Á. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.03.111 · Cited by 100 · see citing works
Roles of the medial and lateral orbitofrontal cortex in major depression and its treatment
Zhang, B., Rolls, E. T., Wang, X., Xie, C., Cheng, W., & Feng, J. (2024) · Molecular Psychiatry · doi:10.1038/s41380-023-02380-w · Cited by 104 · see citing works
Whitton, A. E., Reinen, J., Slifstein, M., Ang, Y., McGrath, P. J., Iosifescu, D. V., Abi‐Dargham, A., Pizzagalli, D. A., & Schneier, F. R. (2020) · Brain · doi:10.1093/brain/awaa002 · Cited by 100 · see citing works
Targeting opioid dysregulation in depression for the development of novel therapeutics
Browne, C. A., & Lucki, I. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.04.009 · Cited by 97 · see citing works
Khazanov, G. K., Xu, C., Dunn, B. D., Cohen, Z. D., DeRubeis, R. J., & Hollon, S. D. (2019) · Behaviour Research and Therapy · doi:10.1016/j.brat.2019.103507 · Cited by 96 · see citing works
Fang, X., Jiang, S., Wang, J., Bai, Y., Kim, C. S., Blake, D., Weintraub, N. L., Lei, Y., & Lu, X.-Y. (2021) · Molecular Psychiatry · doi:10.1038/s41380-020-01004-x · Cited by 95 · see citing works
Carl, H., Walsh, E. C., Eisenlohr-Moul, T. A., Minkel, J. D., Crowther, A., Moore, T. M., Gibbs, D. E., Petty, C., Bizzell, J., Dichter, G. S., et al. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.06.005 · Cited by 95 · see citing works
Depressive disorders in childhood and adolescence
Brent, D. A., & Maalouf, F. (2015) · Wiley eBooks · doi:10.1002/9781118381953.ch63 · Cited by 94 · see citing works
Dunn, B. D., German, R. E., Khazanov, G., Xu, C., Hollon, S. D., & DeRubeis, R. J. (2020) · Clinical Psychological Science · doi:10.1177/2167702619863427 · Cited by 92 · see citing works
The promise of ketamine for treatment‐resistant depression: current evidence and future directions
DeWilde, K. E., Levitch, C. F., Murrough, J. W., Mathew, S. J., & Iosifescu, D. V. (2015) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12646 · Cited by 90 · see citing works
Nielson, D. M., Keren, H., O’Callaghan, G., Jackson, S. M., Douka, I., Vidal‐Ribas, P., Pornpattananangkul, N., Camp, C., Gorham, L. S., Wei, C. Y., et al. (2020) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.06.012 · Cited by 87 · see citing works
Positive emotion in daily life: Emotion regulation and depression.
Vanderlind, W. M., Everaert, J., & Joormann, J. (2021) · Emotion · doi:10.1037/emo0000944 · Cited by 87 · see citing works
Ironside, M., Amemori, K.-I., McGrath, C. L., Pedersen, M. L., Kang, M. S., Amemori, S., Frank, M. J., Graybiel, A. M., & Pizzagalli, D. A. (2020) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.08.022 · Cited by 75 · see citing works
Forbes, C. N. (2020) · Clinical Psychology Review · doi:10.1016/j.cpr.2020.101860 · Cited by 88 · see citing works
McIntyre, R. S., Loft, H., & Christensen, M. C. (2021) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s296451 · Cited by 87 · see citing works
Depression and employment status in primary and tertiary care settings
Rizvi, S. J., Cyriac, A., Grima, E., Tan, M., Lin, P., Gallaugher, L. A., McIntyre, R. S., & Kennedy, S. H. (2015) · The Canadian Journal of Psychiatry · doi:10.1177/070674371506000105 · Cited by 80 · see citing works
Katzman, M., & Sternat, T. (2016) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s111818 · Cited by 83 · see citing works
Fan, J., Liu, W., Xia, J., Li, S., Gao, F., Zhu, J., Han, Y., Zhou, H., Liao, H., Yi, J., et al. (2020) · Human Brain Mapping · doi:10.1002/hbm.25222 · Cited by 83 · see citing works
Ho, N., & Sommers, M. S. (2013) · Archives of Psychiatric Nursing · doi:10.1016/j.apnu.2013.02.001 · Cited by 81 · see citing works
Liu, W., Valton, V., Wang, L.-Z., Zhu, Y., & Roiser, J. P. (2017) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsx074 · Cited by 81 · see citing works
Liu, R., Wang, Y., Chen, X., Zhang, Z., Xiao, L., & Zhou, Y. (2021) · NeuroImage Clinical · doi:10.1016/j.nicl.2021.102599 · Cited by 79 · see citing works
Cross-sectional networks of depressive symptoms before and after antidepressant medication treatment
Bos, F. M., Fried, E. I., Hollon, S. D., Bringmann, L. F., Dimidjian, S., DeRubeis, R. J., & Bockting, C. (2018) · Social Psychiatry and Psychiatric Epidemiology · doi:10.1007/s00127-018-1506-1 · Cited by 80 · see citing works
The Different Facets of Anhedonia and Their Associations with Different Psychopathologies
Shankman, S. A., Katz, A. C., DeLizza, A. A., Sarapas, C., Gorka, S. M., & Campbell, M. L. (2014) · Springer eBooks · doi:10.1007/978-94-017-8591-4_1 · Cited by 77 · see citing works
A Pilot SMART for Developing an Adaptive Treatment Strategy for Adolescent Depression
Gunlicks‐Stoessel, M., Mufson, L. H., Westervelt, A., Almirall, D., & Murphy, S. A. (2015) · Journal of Clinical Child & Adolescent Psychology · doi:10.1080/15374416.2015.1015133 · Cited by 77 · see citing works
Hird, E. J., Slanina-Davies, A., Lewis, G., Hamer, M., & Roiser, J. P. (2024) · Translational Psychiatry · doi:10.1038/s41398-024-02922-y · Cited by 79 · see citing works
Anhedonia in Depression and Schizophrenia: Brain Reward and Aversion Circuits
Liang, S., Wu, Y. Z., Hanxiaoran, L., Greenshaw, A. J., & Li, T. (2022) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s367839 · Cited by 72 · see citing works
Anhedonia in depression and bipolar disorder
Whitton, A. E., & Pizzagalli, D. A. (2022) · Current topics in behavioral neurosciences · doi:10.1007/7854_2022_323 · Cited by 80 · see citing works
Linalool-rich essential oils from the Amazon display antidepressant-type effect in rodents
dos Santos, É. R. Q., Maia, C. D. S. F., Fontes-Júnior, E. A., Melo, A. S., Pinheiro, B. G., & Maia, J. G. S. (2017) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2017.10.013 · Cited by 71 · see citing works
Courtney, D. B., Watson, P., Krause, K. R., Chan, B. W. C., Bennett, K., Gunlicks-Stoessel, M., Rodak, T., Neprily, K., Zentner, T., & Szatmari, P. (2022) · JAMA Network Open · doi:10.1001/jamanetworkopen.2021.46331 · Cited by 63 · see citing works
Dunn, B. D., Widnall, E., Reed, N., Owens, C., Campbell, J., & Kuyken, W. (2019) · Behaviour Research and Therapy · doi:10.1016/j.brat.2019.103418 · Cited by 70 · see citing works
Thomas, R. K., Baker, G., Lind, J., & Dursun, S. (2018) · Journal of Psychopharmacology · doi:10.1177/0269881118793104 · Cited by 69 · see citing works
Neuroanatomical Prediction of Anhedonia in Adolescents
Auerbach, R. P., Pisoni, A., Bondy, E., Kumar, P., Stewart, J. G., Yendiki, A., & Pizzagalli, D. A. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2017.28 · Cited by 69 · see citing works
Inflammation as a Pathophysiologic Pathway to Anhedonia: Mechanisms and Therapeutic Implications
Bekhbat, M., Treadway, M. T., & Felger, J. C. (2022) · Current topics in behavioral neurosciences · doi:10.1007/7854_2021_294 · Cited by 67 · see citing works
Johnston, J. N., Kadriu, B., Allen, J., Gilbert, J. R., Henter, I. D., & Zarate, C. A. (2023) · Neuropharmacology · doi:10.1016/j.neuropharm.2023.109422 · Cited by 68 · see citing works
Reward-Related Neural Circuitry in Depressed and Anxious Adolescents: A Human Connectome Project
Auerbach, R. P., Pagliaccio, D., Hubbard, N. A., Frosch, I. R., Kremens, R., Cosby, E. A., Jones, R. J., Siless, V., Lo, N., Henin, A., et al. (2021) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2021.04.014 · Cited by 64 · see citing works
Social anhedonia in major depressive disorder: a symptom-specific neuroimaging approach
Enneking, V., Krüssel, P., Zaremba, D., Dohm, K., Grotegerd, D., Förster, K., Meinert, S. L., Bürger, C., Dzvonyar, F., Leehr, E. J., et al. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0283-6 · Cited by 64 · see citing works
Anhedonia as a Key Clinical Feature in the Maintenance and Treatment of Opioid Use Disorder
Kiluk, B. D., Yip, S. W., DeVito, E. E., Carroll, K. M., & Sofuoglu, M. (2019) · Clinical Psychological Science · doi:10.1177/2167702619855659 · Cited by 63 · see citing works
Henje, E., Duncan, L. G., Ho, T. C., Connolly, C. G., LeWinn, K. Z., Chesney, M. A., Hecht, F. M., & Yang, T. T. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2014.00630 · Cited by 63 · see citing works
Alsayednasser, B., Widnall, E., O’Mahen, H., Wright, K. A., Warren, F. C., Ladwa, A., Khazanov, G. K., Byford, S., Kuyken, W., Watkins, E. R., et al. (2022) · Behaviour Research and Therapy · doi:10.1016/j.brat.2022.104185 · Cited by 62 · see citing works
Szczypiński, J., & Gola, M. K. (2018) · Reviews in the Neurosciences · doi:10.1515/revneuro-2017-0091 · Cited by 60 · see citing works
Becker, S. P., Langberg, J. M., Evans, S. W., Girio-Herrera, E. L., & Vaughn, A. J. (2014) · Journal of Clinical Child & Adolescent Psychology · doi:10.1080/15374416.2014.930689 · Cited by 56 · see citing works
Whitton, A. E., Kumar, P., Treadway, M. T., Rutherford, A. V., Ironside, M. L., Foti, D., Fitzmaurice, G. M., Du, F., & Pizzagalli, D. A. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02165-1 · Cited by 55 · see citing works
Social anhedonia and medial prefrontal response to mutual liking in late adolescents
Healey, K. L., Morgan, J., Musselman, S. C., Olino, T. M., & Forbes, E. E. (2014) · Brain and Cognition · doi:10.1016/j.bandc.2013.12.004 · Cited by 53 · see citing works
Nogo, D., Jasrai, A. K., Kim, H., Nasri, F., Ceban, F., Lui, L. M. W., Rosenblat, J. D., Vinberg, M., Ho, R., & McIntyre, R. S. (2022) · Psychopharmacology · doi:10.1007/s00213-022-06105-9 · Cited by 54 · see citing works
Multimodal Investigations of Reward Circuitry and Anhedonia in Adolescent Depression
Ely, B. A., Nguyen, T. N. B., Tobe, R. H., Walker, A., & Gabbay, V. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.678709 · Cited by 56 · see citing works
Hedonic sensitivity to low-dose ketamine is modulated by gonadal hormones in a sex-dependent manner
Saland, S. K., Schoepfer, K. J., & Kabbaj, M. (2016) · Scientific Reports · doi:10.1038/srep21322 · Cited by 54 · see citing works
Schmidt, M. E., Kezic, I., Popova, V., Melkote, R., van der Ark, P. D., Pemberton, D. J., Mareels, G., Canuso, C. M., D, M. F. M., & Drevets, W. C. (2024) · Neuropsychopharmacology · doi:10.1038/s41386-024-01862-x · Cited by 53 · see citing works
Anhedonia was associated with the dysregulation of hippocampal HTR4 and microRNA Let-7a in rats
Bai, M., Zhu, X., Zhang, Y., Zhang, S., Zhang, L., Xue, L., Zhong, M., & Zhang, X. (2014) · Physiology & Behavior · doi:10.1016/j.physbeh.2014.02.035 · Cited by 53 · see citing works
Intolerance of uncertainty mediates reduced reward anticipation in major depressive disorder
Nelson, B. D., Shankman, S. A., & Proudfit, G. H. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.02.014 · Cited by 53 · see citing works
Disrupted reward and cognitive control networks contribute to anhedonia in depression
Gong, L., He, C., Zhang, H., Zhang, H., Zhang, Z., & Xie, C. (2018) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2018.05.010 · Cited by 53 · see citing works
- Authors
- McMakin, D. L., Olino, T. M., Porta, G., Dietz, L. J., Emslie, G., Clarke, G., Wagner, K. D., Asarnow, J. R., Ryan, N. D., Birmaher, B., Shamseddeen, W., Mayes, T., Kennard, B., Spirito, A., Keller, M., Lynch, F. L., Dickerson, J. F., & Brent, D. A.
- Affiliations
- University of Pittsburgh (US)
- The University of Texas Southwestern Medical Center (US)
- Kaiser Permanente (US)
- The University of Texas Medical Branch at Galveston (US)
- University of California, Los Angeles (US)
- Rosalind Franklin University of Medicine and Science (US)
- Brown University (US)
- Corresponding author
- McMakin, Dana L.
- ORCID
- Venue
- Journal of the American Academy of Child & Adolescent Psychiatry
- Publisher
- Elsevier BV
- Published
- 2012-04
- Volume
- 51
- Issue
- 4
- Pages
- 404-411
- ISSN
- 0890-8567 (ISSN-L)
- PMC
- PMC3536476
- OpenAlex
- W2065796254
- Cited by
- 448
- References
- 37
- Citations by year
- 2026: 23 · 2025: 50 · 2024: 52 · 2023: 33 · 2022: 45 · 2021: 53 · 2020: 39 · 2019: 41 · 2018: 23 · 2017: 18 · 2016: 18 · 2015: 17 · 2014: 23 · 2013: 11 · 2012: 2
- FWCI
- 12.45
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of the American Academy of Child & Adolescent Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Department of Health and Human Services
- Bristol-Myers Squibb
- Eli Lilly and Company
- Pfizer
- GlaxoSmithKline
- Kaiser Permanente
- University of Pittsburgh
- Melissa Institute for Violence Prevention and Treatment
- Valeant Pharmaceuticals International
- Rosalind Franklin University of Medicine and Science
- H. Lundbeck A/S
- National Institutes of Health
- University of California, Los Angeles (MH61958, MH66371, MH61869, MH62014)
- National Institute of Mental Health (MH61958, U01MH061856, MH-66371, U01MH061835, U01MH061869, MH-61869, U01MH062014, K01MH092603, MH61856, MH-61835, MH61864, K23MH092400, U01MH061958, P30MH066371, T32MH018951, U01MH061864, MH62014)
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Keywords
- anhedonia, treatment-resistant depression, adolescent depression, selective serotonin reuptake inhibitors, prognostic factors, remission, cognitive behavioral therapy
- MeSH terms
- Venlafaxine Hydrochloride, Adolescent, Affect, Combined Modality Therapy, Cyclohexanols, Major Depressive Disorder, Double-Blind Method, Drug Resistance, Female, Humans, Longitudinal Studies, Male, Personality Assessment, Psychometrics, Psychotherapy, Cognitive Behavioral Therapy, Selective Serotonin Reuptake Inhibitors, Antidepressive Agents, Second-Generation, Drug Substitution, Anhedonia, Depressive Disorder, Treatment-Resistant
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
