Aging is characterized by a profound reduction in anti-inflammatory lipoxin A4 levels
Abstract
Ongoing low-grade chronic inflammation represents a pathogenetic background for age-related diseases. In this report, we tested the hypothesis that endogenous anti-inflammatory mechanisms may become less efficient with age, resulting in increased susceptibility to inflammatory disorders. Using previously validated ELISA assays, we evaluated urinary levels of the anti-inflammatory, pro-resolution, arachidonic acid (AA) metabolite, lipoxin (LX)A(4) and of the pro-inflammatory cysteinyl leukotrienes (cysLTs) in volunteers aged from 26 to over 100 years. (i) LXA(4) excretion was decreased in elderly people, resulting in a profound unbalance of the LXA(4)/cysLTs ratio, which may be considered an index of the endogenous anti-inflammatory potential. A significant inverse correlation was denoted between age and the LXA(4)/cysLTs ratio (rho = -0.41, P = 0.0026). We conclude that aging is associated with a switch in arachidonic acid metabolism that prevents formation of key 'stop signals' of the inflammatory reaction. This may contribute to promote the development of disease in elderly.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Adipocytes can secrete MIF.
“In this context, it is of interest that adipocytes are able to secrete MIF (33) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [33]
Cites
Lipid mediator class switching during acute inflammation: signals in resolution
Levy, B. D., Clish, C. B., Schmidt, B., Gronert, K., & Serhan, C. N. (2001) · Nature Immunology · doi:10.1038/89759 · Cited by 1,453 · see citing works
Age-Associated Increased Interleukin-6 Gene Expression, Late-Life Diseases, and Frailty
Ershler, W. B., & Keller, E. T. (2000) · Annual Review of Medicine · doi:10.1146/annurev.med.51.1.245 · Cited by 1,282 · see citing works
Inflammatory Resolution: new opportunities for drug discovery
Gilroy, D. W., Lawrence, T., Perretti, M., & Rossi, A. G. (2004) · Nature Reviews Drug Discovery · doi:10.1038/nrd1383 · Cited by 772 · see citing works
Arachidonate 5-Lipoxygenase Promoter Genotype, Dietary Arachidonic Acid, and Atherosclerosis
Dwyer, J. H., Allayee, H., Dwyer, K. M., Fan, J., Wu, H., Mar, R., Lusis, A. J., & Mehrabian, M. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa025079 · Cited by 614 · see citing works
Takano, T., Fiore, S., Maddox, J. F., Brady, H. R., Petasis, N. A., & Serhan, C. N. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.185.9.1693 · Cited by 433 · see citing works
Kanaoka, Y., & Boyce, J. A. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.3.1503 · Cited by 352 · see citing works
Defective lipoxin-mediated anti-inflammatory activity in the cystic fibrosis airway
Karp, C. L., Flick, L. M., Park, K. W., Softic, S., Greer, T. M., Keledjian, R., Yang, R., Uddin, J., Guggino, W. B., Atabani, S. F., et al. (2004) · Nature Immunology · doi:10.1038/ni1056 · Cited by 344 · see citing works
Ariel, A., Chiang, N., Arita, M., Petasis, N. A., & Serhan, C. N. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.12.6266 · Cited by 175 · see citing works
Gronert, K., Niskanen, T. M., Ravasi, S., Chiang, N., & Serhan, C. N. (2001) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63937-5 · Cited by 167 · see citing works
Severe asthma is associated with a loss of LX4, an endogenous anti-inflammatory compound
Vachier, I., Bonnans, C., Chavis, C., Farce, M., Godard, P., Bousquet, J., & Chanez, P. (2005) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2004.09.038 · Cited by 154 · see citing works
Lipoxins: endogenous regulators of inflammation
McMahon, B. A., & Godson, C. (2004) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00224.2003 · Cited by 148 · see citing works
Immunoproteasomes and immunosenescence
Mishto, M., Santoro, A., Bellavista, E., Bonafè, M., Monti, D., & Franceschi, C. (2003) · Ageing Research Reviews · doi:10.1016/s1568-1637(03)00030-8 · Cited by 86 · see citing works
Romano, M., Luciotti, G., Gangemi, S., Marinucci, F., Prontera, C., D’Urbano, E., & Davı̀, G. (2002) · Laboratory Investigation · doi:10.1097/01.lab.0000028823.53486.4a · Cited by 30 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Dietary factors and low-grade inflammation in relation to overweight and obesity
Calder, P. C., Ahluwalia, N., Brouns, F., Buetler, T., Clement, K., Cunningham, K., Esposito, K., Jönsson, L. S., Kolb, H., Lansink, M., et al. (2011) · British Journal of Nutrition · doi:10.1017/s0007114511005460 · Cited by 1,098 · see citing works
Inflammaging and Anti-Inflammaging: The Role of Cytokines in Extreme Longevity
Minciullo, P. L., Catalano, A., Mandraffino, G., Casciaro, M., Crucitti, A., Maltese, G., Morabito, N., Lasco, A., Gangemi, S., & Basile, G. (2016) · Archivum Immunologiae et Therapiae Experimentalis · doi:10.1007/s00005-015-0377-3 · Cited by 433 · see citing works
Self-citationSelf-defense of macrophages against oxidative injury: Fighting for their own survival
Virág, L., Jaén, R. I., Regdon, Z., Boscá, L., & Prieto, P. (2019) · Redox Biology · doi:10.1016/j.redox.2019.101261 · Cited by 121 · see citing works
- Authors
- Gangemi, S., Pescara, L., D'Urbano, E., Basile, G., Nicita-Mauro, V., Davì, G., & Romano, M.
- Affiliations
- University of Messina (IT)
- University of Chieti-Pescara (IT)
- Corresponding author
- Romano, Mario
- Venue
- Experimental Gerontology
- Publisher
- Elsevier BV
- Published
- 2005-07
- Volume
- 40
- Issue
- 7
- Pages
- 612-614
- ISSN
- 0531-5565 (ISSN-L)
- OpenAlex
- W2081899977
- Cited by
- 74
- References
- 13
- Citations by year
- 2026: 3 · 2024: 2 · 2023: 4 · 2022: 5 · 2021: 10 · 2020: 5 · 2019: 7 · 2018: 3 · 2017: 5 · 2016: 4 · 2015: 2 · 2014: 4 · 2013: 1 · 2012: 5
- FWCI
- 1.83
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Experimental Gerontology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
- Health Sciences › Medicine › Pharmacology › Inflammatory mediators and NSAID effects
- Keywords
- aging, lipoxin A4, cysteinyl leukotrienes, arachidonic acid metabolism, low-grade inflammation, urinary biomarkers, age-related diseases, older adults
- MeSH terms
- Adult, Aging, Anti-Inflammatory Agents, Non-Steroidal, Female, Humans, Male, Middle Aged, Leukotrienes, Arachidonic Acid, Lipoxins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
