Changes in parvalbumin immunoreactivity with aging in the central auditory system of the rat.

Ouda, Ladislav; Druga, Rastislav; Syka, Josef

doi:10.1016/j.exger.2008.04.001

Cited by 83Hearing, Cochlea, Tinnitus, GeneticsHearing Loss and RehabilitationVestibular and auditory disorders

Changes in parvalbumin immunoreactivity with aging in the central auditory system of the rat.

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Ouda, Ladislav, Druga, Rastislav, Syka, Josef·2008·Experimental Gerontology

DOI 10.1016/j.exger.2008.04.001

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Abstract

Changes in the levels of calcium binding proteins are known to occur in different parts of the brain during aging. In our study we attempted to define the effect that aging has on the parvalbumin-expressing system of neurons in the higher parts of the central auditory system. Age-related changes in parvalbumin immunoreactivity were investigated in the inferior colliculus (IC), medial geniculate body (MGB) and auditory cortex (AC) in two rat strains, normally aging Long-Evans (LE) and fast aging Fischer 344 (F344). The results demonstrate that the changes in PV-immunoreactivity are strain-dependent with an increase in the number of PV-immunoreactive (PV-ir) neurons occurring in the inferior colliculus of old LE rats and a pronounced decline in the number of PV-ir neurons appearing in the auditory cortex of aged F344 animals. In some parts of the AC of old F344 animals no PV-ir neurons were present at all. The number of PV-ir neurons in the MGB in all examined animals was very low independent of the strain and age. The loss of PV-ir neurons in the auditory cortex of Fischer 344 rats with aging may contribute to the substantial deterioration of hearing function in this strain.

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Reduced GABAergic signaling has been demonstrated in the aged auditory system of rodents and humans.
“several studies have demonstrated reduced GABAergic signaling in the aged auditory system of rodents and humans (Caspary et al., 1990; Ouda et al., 2008; Martin del Campo et al., 2012; Gao et al., 2015).”
From The Perineuronal ‘Safety’ Net? Perineuronal Net Abnormalities in Neurological Disorders (2018) · cites this paper as Ouda et al., 2008

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Authors: Ouda, L., Druga, R., & Syka, J.
Affiliations: Czech Academy of Sciences (CZ)
Charles University (CZ)
Corresponding author: Ouda, Ladislav
ORCID: Druga, Rastislav
Syka, Josef
Venue: Experimental Gerontology
Publisher: Elsevier BV
Published: 2008-08
Volume: 43
Issue: 8
Pages: 782-789
ISSN: 0531-5565 (ISSN-L)
DOI: 10.1016/j.exger.2008.04.001
OpenAlex: W2172265909
Cited by: 83
References: 60
Citations by year: 2026: 4 · 2025: 4 · 2022: 3 · 2021: 2 · 2020: 7 · 2019: 6 · 2018: 5 · 2017: 2 · 2016: 6 · 2015: 9 · 2014: 9 · 2013: 10 · 2012: 8
FWCI: 1.27
Type: journal article
Language: en
Open access: green
hal.science
Licence: other-oa
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Experimental Gerontology (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion, other-oa)
Trinity's Access to Research Output (TARA) (Trinity College Dublin) (submittedVersion)
Funders: Grantová Agentura České Republiky (GA309/07/1336)
Ministerstvo Zdravotnictví Ceské Republiky
Topics: Life Sciences › Neuroscience › Sensory Systems › Hearing, Cochlea, Tinnitus, Genetics
Life Sciences › Neuroscience › Cognitive Neuroscience › Hearing Loss and Rehabilitation
Life Sciences › Neuroscience › Neurology › Vestibular and auditory disorders
Keywords: parvalbumin, aging, central auditory system, inferior colliculus, medial geniculate body, auditory cortex, calcium-binding proteins, strain differences, Long-Evans rats, F344 rats, age-related hearing loss, neuronal loss
MeSH terms: Aging, Animals, Auditory Cortex, Calcium-Binding Proteins, Geniculate Bodies, Inferior Colliculi, Male, Neurons, Parvalbumins, Rats, Inbred F344, Species Specificity, Rats, Long-Evans, Rats

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Changes in parvalbumin immunoreactivity with aging in the central auditory system of the rat.

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