Conservation of neuronal number and size in the entorhinal cortex of behaviorally characterized aged rats

Merrill, David A.; Chiba, Andrea A.; Tuszynski, Mark H.

doi:10.1002/cne.1327

Cited by 118Memory and Neural MechanismsNeurogenesis and neuroplasticity mechanismsNeuroscience and Neuropharmacology Research

Conservation of neuronal number and size in the entorhinal cortex of behaviorally characterized aged rats

Merrill, David A., Chiba, Andrea A., Tuszynski, Mark H.·2001·Journal of Comparative Neurology

DOI 10.1002/cne.1327

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Abstract

Despite abundant evidence of behavioral and electrophysiological dysfunction of the rodent hippocampal formation with aging, the structural basis of age‐related cognitive decline remains unclear. Recently, unbiased stereological studies of the mammalian hippocampus have found little evidence to support the dogma that cellular loss accompanies hippocampal aging, thereby supporting an alternative hypothesis that aging is marked by widespread conservation of neuronal number. However, to date, the effects of aging have not been reported in another key component of memory systems in the rodent brain, the entorhinal cortex. In the present study, we stereologically estimated total neuronal number and size (cross‐sectional area and cell volume) in the subdivisions and cellular layers of the rat entorhinal cortex, using the optical fractionator and nucleator, respectively. Comparisons were made among Fischer 344 rats that were young, aged‐impaired, and aged‐unimpaired (based on functional analysis in the Morris water maze). No significant differences in cell number or size were observed in any of the entorhinal subdivisions or laminae examined in each group. Thus, aging is associated with widespread conservation of neuronal number, despite varying degrees of cognitive decline, in all memory‐related systems examined to date. These data suggest that mechanisms of age‐related cognitive decline are to be found in parameters other than neuronal number or size in the cortex of the mammalian brain. J. Comp. Neurol. 438:445–456, 2001. © 2001 Wiley‐Liss, Inc.

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Cell death is not a mechanism underlying age-related cognitive decline.
“cell death is not a mechanism underlying this decline16,17.”
From Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease (2009) · cites this paper as [16]
Extensive cell death does not occur in the aged primate entorhinal cortex with aging, consistent with findings in aged rodents.
“Extensive cell death does not occur in the aged primate entorhinal cortex with aging17,26, consistent with findings in aged rodents16.”
From Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease (2009) · cites this paper as [16]

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Herman (2000) · doi:10.1002/1096-9861(20000703)422:3
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Authors: Merrill, D. A., Chiba, A. A., & Tuszynski, M. H.
Affiliations: University of California San Diego (US)
Corresponding author: Tuszynski, Mark H.
ORCID: Merrill, David A.
Chiba, Andrea A.
Tuszynski, Mark H.
Venue: Journal of Comparative Neurology
Publisher: Wiley
Published: 2001-09-04
Volume: 438
Issue: 4
Pages: 445-456
ISSN: 0021-9967 (ISSN-L)
1096-9861
DOI: 10.1002/cne.1327
OpenAlex: W2128340731
Cited by: 118
References: 73
Citations by year: 2026: 3 · 2025: 5 · 2024: 7 · 2023: 2 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 4 · 2018: 7 · 2017: 1 · 2016: 2 · 2015: 10 · 2014: 7 · 2013: 4 · 2012: 8
FWCI: 2.45
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: The Journal of Comparative Neurology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Aging (P01AG010435, AG05131, P50AG005131, AG10435)
National Institute of General Medical Sciences (GM-07198, T32GM007198)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: entorhinal cortex, aging, neuron number, neuron size, cell volume, cross-sectional area, age-related cognitive decline, hippocampal aging, memory systems, F344 rats, Morris water maze, stereology
MeSH terms: Aging, Animals, Behavior, Animal, Cell Count, Female, Memory Disorders, Nerve Degeneration, Neurons, Rats, Inbred F344, Cell Death, Entorhinal Cortex, Maze Learning, Cell Size, Rats

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Conservation of neuronal number and size in the entorhinal cortex of behaviorally characterized aged rats

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