The DOI matches its Crossref record; 57 of the 58 references it cites were found in a registry or an index.
The effects of aging, physical training, and a single bout of exercise on mitochondrial protein expression in human skeletal muscle
Open accessAbstract
Aging results in a significant decline in aerobic capacity and impaired mitochondrial function. We have tested the effects of moderate physical activity on aerobic capacity and a single bout of exercise on the expression profile of mitochondrial biogenesis, and fusion and fission related genes in skeletal muscle of human subjects. Physical activity attenuated the aging-associated decline in VO2 max (p<0.05). Aging increased and a single exercise bout decreased the expression of nuclear respiratory factor-1 (NRF1), while the transcription factor A (TFAM) expression showed a strong relationship with VO(2max) and increased significantly in the young physically active group. Mitochondrial fission representing FIS1 was induced by regular physical activity, while a bout of exercise decreased fusion-associated gene expression. The expression of polynucleotide phosphorylase (PNPase) changed inversely in young and old groups and decreased with aging. The A2 subunit of cyclic AMP-activated protein kinase (AMPK) was induced by a single bout of exercise in skeletal muscle samples of both young and old subjects (p<0.05). Our data suggest that moderate levels of regular physical activity increases a larger number of mitochondrial biogenesis-related gene expressions in young individuals than in aged subjects. Mitochondrial fission is impaired by aging and could be one of the most sensitive markers of the age-associated decline in the adaptive response to physical activity.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“While Konopka et al. (25) and Bori et al. (36) have found no differences in mitochondrial fusion and fission between young and older subjects”
From Chronological Age Does not Influence Ex-vivo Mitochondrial Respiration and Quality Control in Skeletal Muscle (2016) · cites this paper as [36]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“However, Bori et al. (36) showed that in contrast to the higher FIS1 mRNA observed in active young subjects versus young sedentary, old active subjects did not have higher FIS1 than old sedentary subjects”
From Chronological Age Does not Influence Ex-vivo Mitochondrial Respiration and Quality Control in Skeletal Muscle (2016) · cites this paper as [36]
The cited source says what the claim attributes to it.
In the citing paper
“Recent studies have investigated whether mitochondrial quality control is influenced by aging, but the results are not conclusive and remain to be elucidated (1,2,25,35,36).”
From Chronological Age Does not Influence Ex-vivo Mitochondrial Respiration and Quality Control in Skeletal Muscle (2016) · cites this paper as [36]
The cited source says what the claim attributes to it.
In the citing paper
“Studies that included an exercise intervention have also been performed and reported both similar and distinct quality control responses in young and older adults (25,35,36).”
From Chronological Age Does not Influence Ex-vivo Mitochondrial Respiration and Quality Control in Skeletal Muscle (2016) · cites this paper as [36]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
1 retracted
Safdar, A., Bourgeois, J. M., Ogborn, D. I., Little, J. P., Hettinga, B. P., Akhtar, M., Thompson, J. E., Melov, S., Mocellin, N. J., Kujoth, G. C., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1019581108 · Cited by 320
RetractedInternational physical activity questionnaire: 12-country reliability and validity
CRAIG, C. L., MARSHALL, A. L., SJ??STR??M, M., BAUMAN, A. E., BOOTH, M. L., AINSWORTH, B. E., PRATT, M., EKELUND, U., YNGVE, A., SALLIS, J. F., et al. (2003) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000078924.61453.fb · Cited by 21,619
(2014) · Medical Entomology and Zoology · Cited by 9,400
Fission and selective fusion govern mitochondrial segregation and elimination by autophagy
Twig, G., Elorza, A., Molina, A. J. A., Mohamed, H., Wikstrom, J. D., Walzer, G., Stiles, L., Haigh, S. E., Katz, S., Las, G., et al. (2008) · The EMBO Journal · doi:10.1038/sj.emboj.7601963 · Cited by 3,082
Mitochondrial fusion and fission in cell life and death
Westermann, B. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3013 · Cited by 2,002 · cited 2×
“The mitochondrial network is a dynamic system which can be altered by outer membrane mitofusions 1 and 2 proteins (Mfn1 and Mfn2) (Westermann, 2010) and mitochondrial fission proteins (FIS1 and 2) (Ding et al.”
A Mitochondrial Protein Compendium Elucidates Complex I Disease Biology
Pagliarini, D. J., Calvo, S. E., Chang, B., Sheth, S. A., Vafai, S. B., Ong, S.-E., Walford, G. A., Sugiana, C., Boneh, A., Chen, W. K., et al. (2008) · Cell · doi:10.1016/j.cell.2008.06.016 · Cited by 1,994
Free radicals and tissue damage produced by exercise
Davies, K. J. A., Quintanilha, A. T., Brooks, G. A., & Packer, L. (1982) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(82)80124-1 · Cited by 1,739
Transcriptional paradigms in mammalian mitochondrial biogenesis and function
Scarpulla, R. C. (2008) · Physiological Reviews · doi:10.1152/physrev.00025.2007 · Cited by 1,666
Disruption of Fusion Results in Mitochondrial Heterogeneity and Dysfunction
Chen, H., Chomyn, A., & Chan, D. C. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m503062200 · Cited by 1,376 · cited 1×
“PNPase knockdown results in impaired mitochondrial membrane potential, which can readily affect fusion and fission (Chen et al., 2005).”
Telomere dysfunction induces metabolic and mitochondrial compromise
Sahin, E., Colla, S., Liesa, M., Moslehi, J., Müller, F. L., Guo, M., Cooper, M., Kotton, D., Fabian, A. J., Walkey, C., et al. (2011) · Nature · doi:10.1038/nature09787 · Cited by 1,319
Flagged first, then by citations
1 of the 58 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- Bergström, 1962, Muscle electrolytes in man, Scand. J. Clin. Lab. Invest., 14, 1
- Radak, 2011, Age-dependent changes in 8-oxoguanine-DNA-glycosylase activity is modulated by adaptive responses to physical exercise in human skeletal muscle, Free Radic. Biol. Med., 51, 417, 10.1016/j.freeradbiomed.2011.04.018 · DOI
Cited by
Sorted by citations
Items 101–108 of 108
Farooqui, A. A. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-821711-5.00010-3
Recarey-Rodríguez, A. E. (2021) · Academica-e (Universidad Pública de Navarra) · doi:10.48035/tesis/2454/39685
Therapeutic Exercise in Sarcopenia
Senda, M., Hamada, M., Katayama, Y., Ise, M., Hongo, M., & Hamasaki, H. (2021) · リハビリテーション医学 : 日本リハビリテーション医学会誌 · doi:10.2490/jjrmc.58.605
Skeletal muscle health in aging
Grevendonk, L. (2021) · Research Publications (Maastricht University) · doi:10.26481/dis.20211006lg
de Freitas, J. A. N. L. F. (2020) · theses.fr (ABES) · doi:10.70675/0e6e3614z3915z4fb8za2cdz24b40b9679b2
Constans, A. (2019) · theses.fr (ABES) · doi:10.70675/93486891z6065z449cz992az7390677dca22
Yousaf, F., Kao, S., Ishaq, S., Shah, I. A., & Lee, S. (2026) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2026.106435
Metadata
- Authors
- Bori, Z., Zhao, Z., Koltai, E., Fatouros, I. G., Jamurtas, A. Z., Douroudos, I. I., Terzis, G., Chatzinikolaou, A., Sovatzidis, A., Draganidis, D., Boldogh, I., & Radak, Z.
- Affiliations
- Semmelweis University (HU)
- Democritus University of Thrace (GR)
- University of Thessaly (GR)
- National and Kapodistrian University of Athens (GR)
- The University of Texas Medical Branch at Galveston (US)
- Corresponding author
- Radak, Zsolt
- ORCID
- Venue
- Experimental Gerontology
- Publisher
- Elsevier BV
- Published
- 2012-06
- Volume
- 47
- Issue
- 6
- Pages
- 417-424
- ISSN
- 0531-5565 (ISSN-L)
- PMC
- PMC4915826
- OpenAlex
- W2060172951
- Cited by
- 108
- References
- 58
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 5 · 2023: 5 · 2022: 4 · 2021: 13 · 2020: 9 · 2019: 7 · 2018: 11 · 2017: 16 · 2016: 6 · 2015: 9 · 2014: 7 · 2013: 3 · 2012: 4
- FWCI
- 2.95
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Experimental Gerontology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- University of Thessaly Institutional Repository (University of Thessaly) (submittedVersion)
- Funders
- ETT (38388)
- OTKA (K75702)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Keywords
- aging, exercise training, single bout exercise, mitochondrial protein expression, skeletal muscle, mitochondrial biogenesis, mitochondrial fusion, mitochondrial fission, NRF1, TFAM, Fis1, polynucleotide phosphorylase, AMPK, VO2max, cardiorespiratory fitness, mitochondrial function
- MeSH terms
- Adult, Aged, Aging, Gene Expression Regulation, Humans, Male, Middle Aged, Mitochondria, Muscle, Muscle Proteins, Oxygen Consumption, RNA, Messenger, Exercise, Muscle, Skeletal, Mitochondrial Proteins, Young Adult, Real-Time Polymerase Chain Reaction
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
