Cited by 108Mitochondrial Function and PathologyAdipose Tissue and MetabolismCardiovascular and exercise physiology

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The effects of aging, physical training, and a single bout of exercise on mitochondrial protein expression in human skeletal muscle

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Bori, Zoltan, Zhao, Zhongfu, Koltai, Erika, Fatouros, Ioannis G., Jamurtas, Athanasios Z., Douroudos, Ioannis I., Terzis, Gerasimos, Chatzinikolaou, Athanasios, Sovatzidis, Apostolos, Draganidis, Dimitrios, Boldogh, Istvan, Radak, Zsolt·2012·Experimental Gerontology

DOI 10.1016/j.exger.2012.03.004PMC PMC4915826

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Abstract

Aging results in a significant decline in aerobic capacity and impaired mitochondrial function. We have tested the effects of moderate physical activity on aerobic capacity and a single bout of exercise on the expression profile of mitochondrial biogenesis, and fusion and fission related genes in skeletal muscle of human subjects. Physical activity attenuated the aging-associated decline in VO2 max (p<0.05). Aging increased and a single exercise bout decreased the expression of nuclear respiratory factor-1 (NRF1), while the transcription factor A (TFAM) expression showed a strong relationship with VO(2max) and increased significantly in the young physically active group. Mitochondrial fission representing FIS1 was induced by regular physical activity, while a bout of exercise decreased fusion-associated gene expression. The expression of polynucleotide phosphorylase (PNPase) changed inversely in young and old groups and decreased with aging. The A2 subunit of cyclic AMP-activated protein kinase (AMPK) was induced by a single bout of exercise in skeletal muscle samples of both young and old subjects (p<0.05). Our data suggest that moderate levels of regular physical activity increases a larger number of mitochondrial biogenesis-related gene expressions in young individuals than in aged subjects. Mitochondrial fission is impaired by aging and could be one of the most sensitive markers of the age-associated decline in the adaptive response to physical activity.

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Authors: Bori, Z., Zhao, Z., Koltai, E., Fatouros, I. G., Jamurtas, A. Z., Douroudos, I. I., Terzis, G., Chatzinikolaou, A., Sovatzidis, A., Draganidis, D., Boldogh, I., & Radak, Z.
Affiliations: Semmelweis University (HU)
Democritus University of Thrace (GR)
University of Thessaly (GR)
National and Kapodistrian University of Athens (GR)
The University of Texas Medical Branch at Galveston (US)
Corresponding author: Radak, Zsolt
ORCID: Koltai, Erika
Fatouros, Ioannis G.
Jamurtas, Athanasios Z.
Terzis, Gerasimos
Chatzinikolaou, Athanasios
Sovatzidis, Apostolos
Draganidis, Dimitrios
Boldogh, Istvan
Radak, Zsolt
Venue: Experimental Gerontology
Publisher: Elsevier BV
Published: 2012-06
Volume: 47
Issue: 6
Pages: 417-424
ISSN: 0531-5565 (ISSN-L)
DOI: 10.1016/j.exger.2012.03.004
PMC: PMC4915826
OpenAlex: W2060172951
Cited by: 108
References: 58
Citations by year: 2026: 4 · 2025: 5 · 2024: 5 · 2023: 5 · 2022: 4 · 2021: 13 · 2020: 9 · 2019: 7 · 2018: 11 · 2017: 16 · 2016: 6 · 2015: 9 · 2014: 7 · 2013: 3 · 2012: 4
FWCI: 2.95
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Experimental Gerontology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
University of Thessaly Institutional Repository (University of Thessaly) (submittedVersion)
Funders: ETT (38388)
OTKA (K75702)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
Keywords: aging, exercise training, single bout exercise, mitochondrial protein expression, skeletal muscle, mitochondrial biogenesis, mitochondrial fusion, mitochondrial fission, NRF1, TFAM, Fis1, polynucleotide phosphorylase, AMPK, VO2max, cardiorespiratory fitness, mitochondrial function
MeSH terms: Adult, Aged, Aging, Gene Expression Regulation, Humans, Male, Middle Aged, Mitochondria, Muscle, Muscle Proteins, Oxygen Consumption, RNA, Messenger, Exercise, Muscle, Skeletal, Mitochondrial Proteins, Young Adult, Real-Time Polymerase Chain Reaction

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The effects of aging, physical training, and a single bout of exercise on mitochondrial protein expression in human skeletal muscle

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