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Cited by 25Advanced Glycation End Products researchCollagen: Extraction and CharacterizationGenetics, Aging, and Longevity in Model Organisms

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Age‐related expression, enzymatic solubility and modification with advanced glycation end‐products of fibrillar collagens in mouse lung

Rolewska, Paulina, Al-Robaiy, Samiya, Navarrete Santos, Alexander, Simm, Andreas, Silber, Rolf-Edgar, Bartling, Babett·2013·Experimental Gerontology
DOI 10.1016/j.exger.2012.04.012
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Abstract

Changes in the expression of fibrillar collagens and post-translational modifications with advanced glycation end-products (AGEs) are often associated with tissue aging. Less is known about age-related changes in mouse lung tissue. Therefore, we studied the expression level and AGE load of fibrillar collagens in lungs from young (≤6 months), adult (15 months) and old (≥25 months) mice. The mRNA expression level was reduced in adult and old mice compared with the young. Old mice also showed a reduced protein level, whereas the adults even had more collagen protein. Fractionating of the fibrillar collagens into enzyme-soluble and insoluble collagens revealed a reduced solubility of collagens in old age. The enzymatic solubility of fibrillar collagens correlated inversely with the AGE load in the insoluble collagen as detected by the AGE-related fluorescence. While the intensity of the AGE-related fluorescence was increased in fibrillar collagens in response to age, the fluorescing AGE variant argpyrimidine was less affected. In summary, aging causes a reduced expression, lower enzymatic solubility and increased AGE load of fibrillar collagens in mouse lung tissue, but not all changes occur gradually with age.

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Metadata

Authors
Rolewska, P., Al-Robaiy, S., Navarrete Santos, A., Simm, A., Silber, R.-E., & Bartling, B.
Affiliations
University Hospital in Halle (DE)
Corresponding author
Bartling, Babett
ORCID
Venue
Experimental Gerontology
Publisher
Elsevier BV
Published
2013-01
Volume
48
Issue
1
Pages
29-37
ISSN
0531-5565 (ISSN-L)
DOI
10.1016/j.exger.2012.04.012
OpenAlex
W1987081805
Cited by
25
References
0
Citations by year
2025: 2 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 1 · 2019: 1 · 2018: 1 · 2017: 3 · 2015: 6 · 2014: 1 · 2013: 4
FWCI
2.45
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Experimental Gerontology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Wilhelm Roux program at the Medical Faculty Halle (Saale) (VFI/A7)
  • Deutsche Forschungsgemeinschaft (DFG (BA 2077/4-1)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
  • Physical Sciences › Materials Science › Biomaterials › Collagen: Extraction and Characterization
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Keywords
fibrillar collagen, advanced glycation end products, lung aging, tissue aging, collagen expression, collagen solubility, post-translational modification, argpyrimidine, mouse lung
MeSH terms
Aging, Animals, Cells, Cultured, Female, Gene Expression Regulation, Lung, Male, Mice, Inbred C57BL, Protein Processing, Post-Translational, RNA, Messenger, Solubility, Glycation End Products, Advanced, Fibrillar Collagens, Mice

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