Healthspan, Translation, and New Outcomes for Animal Studies of Aging
Open accessAbstract
Dramatic advances in understanding mechanisms of aging have recently been made in model systems. Interventions have been devised that successfully enhance survival. Major issues still in need of resolution include whether these interventions not only increase survival but also enhance function, delay frailty, and can be translated into clinical application. It seems there are basic biologic findings close to being ready for translation. However, a number of barriers exist to translating these findings into realistic clinical interventions. Steps and resources needed include measuring not only survival but also impact of interventions on age-related disability, frailty, and onset of disease in model systems; development of clinically relevant measures of disability, frailty, and disease for each animal model and genetically tractable animal models of frailty; training and career-long funding mechanisms for geriatricians in basic science research and for basic scientists in geriatric issues; translationally capable review and funding mechanisms; emphasis on studies of interventions that can be initiated in later life for preventing or reversing disability; genetic association studies in humans to identify new candidate genes and pathways that correlate with disability, frailty, and age-related disease onset as well as longevity; study of exposure to environmental agents or toxins early in life on survival, disability, frailty, and disease in later life.
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The geroscience hypothesis predicts that targeting fundamental ageing mechanisms, such as cellular senescence, could have a large impact on increasing health span and decreasing chronic disease burden.
“The geroscience hypothesis leverages the fact that ageing is the major risk factor for most chronic diseases, including diabetes, and predicts that targeting fundamental ageing mechanisms, such as cellular senescence, could have a large impact on increasing health span and decreasing chronic disease burden.”
From Cellular senescence: at the nexus between ageing and diabetes (2019) · cites this paper as [7]
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- Authors
- Kirkland, J. L., & Peterson, C.
- Affiliations
- Mayo Clinic (US)
- University of Kentucky (US)
- Venue
- The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-02-01
- Volume
- 64A
- Issue
- 2
- Pages
- 209-212
- ISSN
- 1079-5006 (ISSN-L)
- 1758-535X
- PMC
- PMC2655038
- OpenAlex
- W2162568242
- Cited by
- 98
- References
- 8
- Citations by year
- 2026: 1 · 2025: 7 · 2024: 2 · 2023: 5 · 2022: 4 · 2021: 3 · 2020: 3 · 2019: 9 · 2018: 3 · 2017: 7 · 2016: 6 · 2015: 8 · 2014: 8 · 2013: 7 · 2012: 6
- FWCI
- 2.56
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journals of Gerontology Series A (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
- Keywords
- healthspan, aging interventions, clinical translation, animal models of aging, frailty, age-related disability, geriatrician training, genetic association studies
- MeSH terms
- Aging, Animals, Forecasting, Geriatrics, Humans, Longevity, Sensitivity and Specificity, Models, Animal, Biomedical Research
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