The DOI matches its Crossref record; 53 of the 76 references it cites were found in a registry or an index.
The Th17/Treg balance is disturbed during aging
Abstract
Aging is associated with multiple changes in the proliferative and functional abilities of the immune system which are not related to any pathology but consequences in immunosenescence and inflammaging. T helper (TH) 17 cells have been implicated in the development of autoimmune and chronic inflammatory diseases in humans. Additionally, a reciprocal relationship between these pro-inflammatory TH17 and the anti-inflammatory regulatory T cells (Tregs) has been described. Recent studies reported an increase of TH17 cells in aged humans and aged mice, but the role of TH17 cells and their relation to Tregs is poorly understood in human aging. This study investigated the proportion of TH17 (CD4+ IL23 receptor(R)+) cells and Tregs (CD4+ Foxp3+) as well as Interleukin (IL)-17 and IL-10 production in four different age groups from human healthy donors. The data revealed a continual increase of basal CD4+ IL23R+ cell amounts in the different age groups. By analyzing the balance of both T-cell subsets it was observed that, on a basal resting level, TH17 cells were significantly increased in older individuals whereas Tregs were reduced. However, the TH17/Treg ratio decreased age-dependently after stimulation and was accompanied by elevated Foxp3 mRNA and IL-10 protein expressions. In conclusion, changes of the TH17/Treg ratios in combination with altered cytokine expression during aging may contribute to an imbalance between the pro-inflammatory and the anti-inflammatory immune response. This indicates a higher susceptibility to develop inflammatory diseases with increasing age.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“However, more recent focus has been on a possible accumulation of Th17 cells with age (i.e., IL-17 producing cells that are associated with autoimmunity and inflammatory disease) (Schmitt et al. 2013).”
From Is immunosenescence influenced by our lifetime “dose” of exercise? (2016) · cites this paper as Schmitt et al. 2013
Citations
Cites
Control of Regulatory T Cell Development by the Transcription Factor Foxp3
Hori, S., Nomura, T., & Sakaguchi, S. (2003) · Science · doi:10.1126/science.1079490 · Cited by 8,187
Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
Fontenot, J. D., Gavin, M. A., & Rudensky, A. Y. (2003) · Nature Immunology · doi:10.1038/ni904 · Cited by 7,745
Bettelli, E., Carrier, Y., Gao, W., Korn, T., Strom, T. B., Oukka, M., Weiner, H. L., & Kuchroo, V. K. (2006) · Nature · doi:10.1038/nature04753 · Cited by 6,992
Inflamm‐aging: An Evolutionary Perspective on Immunosenescence
FRANCESCHI, C., BONAFÈ, M., VALENSIN, S., OLIVIERI, F., DE LUCA, M., OTTAVIANI, E., & DE BENEDICTIS, G. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06651.x · Cited by 5,358
Harrington, L. E., Hatton, R. D., Mangan, P. R., Turner, H., Murphy, T. L., Murphy, K. M., & Weaver, C. T. (2005) · Nature Immunology · doi:10.1038/ni1254 · Cited by 4,742
Development, cytokine profile and function of human interleukin 17-producing helper T cells
Wilson, N. J., Boniface, K., Chan, J. R., McKenzie, B. S., Blumenschein, W. M., Mattson, J. D., Basham, B., Smith, K., Chen, T., Morel, F., et al. (2007) · Nature Immunology · doi:10.1038/ni1497 · Cited by 2,035
TGF-β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORγt function
Zhou, L., Lopes, J. E., Chong, M. M. W., Ivanov, I. I., Min, R., Victora, G. D., Shen, Y., Du, J., Rubtsov, Y. P., Rudensky, A. Y., et al. (2008) · Nature · doi:10.1038/nature06878 · Cited by 1,928
Phenotypic and functional features of human Th17 cells
Annunziato, F., Cosmi, L., Santarlasci, V., Maggi, L., Liotta, F., Mazzinghi, B., Parente, E., Filì, L., Ferri, S., Frosali, F., et al. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070663 · Cited by 1,861
Aggarwal, S., Ghilardi, N., Xie, M.-H., de Sauvage, F. J., & Gurney, A. L. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m207577200 · Cited by 1,848
Surface phenotype and antigenic specificity of human interleukin 17–producing T helper memory cells
Acosta-Rodriguez, E. V., Rivino, L., Geginat, J., Jarrossay, D., Gattorno, M., Lanzavecchia, A., Sallusto, F., & Napolitani, G. (2007) · Nature Immunology · doi:10.1038/ni1467 · Cited by 1,828
Flagged first, then by citations
23 of the 76 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- Franceschi, 2000, Inflammaging. An evolutionary perspective on immunosenescence, Ann. N. Y. Acad. Sci., 908, 254
- Ligthart, 1984, Admission criteria for immunogerontological studies — the SENIEUR protocol, Mech. Ageing. Dev., 28, 55
Cited by
Sorted by citations
Items 201–235 of 235
Jiang, P. (2021) · Revista Brasileira de Medicina do Esporte · doi:10.1590/1517-8692202127012020_0118 · Cited by 1
Age-Related Changes in Type 1 and Type 2 Cytokine Production in Humans
Gardner, E. M., & Murasko, D. M. (2019) · Springer eBooks · doi:10.1007/978-3-319-99375-1_39 · Cited by 1
Yamamoto, T. (2024) · The Journal of Dermatology · doi:10.1111/1346-8138.17538
Germinal center immune dynamics: challenges for effective vaccination in the elderly
Brenna, C., & Petrovas, C. (2025) · Immunotherapy · doi:10.1080/1750743x.2025.2546279 · Cited by 1
Hvor effektive er covid-19-vaksinene hos eldre?
Vaksdal, H. H., & Grødeland, G. (2021) · Tidsskrift for Den norske legeforening · doi:10.4045/tidsskr.21.0748 · Cited by 1
Pathophysiology of pneumococcal meningitis
Geldhoff, M. (2016) · Data Archiving and Networked Services (DANS) · Cited by 1
Turner, J. E. (2016) · Springer eBooks · doi:10.1007/978-1-4614-6439-6_101906-1 · Cited by 1
Hanania, N. A., & Busse, P. J. (2015) · Springer eBooks · doi:10.1007/978-3-319-23246-1_14
Tang, D., Guo, J., & Zhang, J. (2017) · Nephrology - Open Journal · doi:10.17140/npoj-3-117
Age-Related Dysfunction in the Innate Immune Response to Lung Infections
Boe, D. M., Chen, M. M., & Kovacs, E. J. (2018) · Springer eBooks · doi:10.1007/978-3-319-64597-1_91-1
Characteristics of the Immunoresponse in Elderly People and Autoimmunity
Moskalets, O. V. (2020) · Advances in Gerontology · doi:10.1134/s2079057020040153
Navarro-Zorraquino, M. (2021) · Biomedical Journal of Scientific & Technical Research · doi:10.26717/bjstr.2021.39.006232
Lymphocyte Subtypes and Functions in Centenarians as Models for Successful Aging
Bianchini, E., Pecorini, S., Biasi, S. D., Gibellini, L., Nasi, M., Cossarizza, A., & Pinti, M. (2019) · Springer eBooks · doi:10.1007/978-3-319-99375-1_2
Lymphocyte Subtypes and Functions in Centenarians as Models for Successful Aging
Bianchini, E., Pecorini, S., Biasi, S. D., Gibellini, L., Nasi, M., Cossarizza, A., & Pinti, M. (2017) · Springer eBooks · doi:10.1007/978-3-319-64597-1_2-1
Turner, J. E. (2020) · Springer eBooks · doi:10.1007/978-3-030-39903-0_101906
Vučić, M., Milenković, J., Djindjić, B., Stojiljković, V., Stojanović, D. R., Djordjevic, B., Milojković, M., & Veličković, S. (2024) · Hematology · doi:10.1080/16078454.2024.2311006
Mohanty, S. K., Veerabhadrappa, B., Majhi, A., Suchiang, K., & Dyavaiah, M. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15500-0.00003-7 · Cited by 1
Campanari, D. D. (2024) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.17.2024.tde-13052024-155734
Naderi, N., Montazerghaem, H., & Rahimzadeh, M. (2023) · Bimonthly Journal of Hormozgan University of Medical Sciences · doi:10.34172/hmj.2023.917
Dynamic microbiotal changes in the human lung
Zhang, C., Georgian, E. M., & Pinkerton, K. E. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-91824-4.00018-6
Molecular Mechanism of VSV-Vectored ASFV Vaccine Activating Immune Response in DCs
Ma, Y., Shao, J., Liu, W., Gao, S., Zhou, G., Qi, X., & Chang, H. (2025) · Veterinary Sciences · doi:10.3390/vetsci12010036
Cheng, X., Liu, J., Guan, Y., Jing, B., Zhao, J., & Cao, Y. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1629276
Wang, W., Zha, S.-Y., Sun, L., & Zhou, D. (2026) · Psoriasis Targets and Therapy · doi:10.2147/ptt.s604199
Associations of IL-17 and TGF-β1 with physical frailty in older adults
Ceolin, C., RUI, M. D., Musso, G., Sturani, S., Ravelli, A., Simonato, C., Villanova, F., Pigozzo, S., Busetto, L., Antonini, A., et al. (2026) · GeroScience · doi:10.1007/s11357-026-02397-3
Ageing-driven periodontitis: molecular mechanisms and emerging anti-ageing interventions
Li, M. M., Peng, Z., Wang, R., Zheng, Y., Li, S., Kreher, D., Schmalz, G., Han, Q., & Tang, H. (2026) · European journal of medical research · doi:10.1186/s40001-026-04846-3
Green, R. S., Morales, D., Schott, E. M., Charbonneau, M. R., & Ballok, A. E. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27146369
БРОНХІАЛЬНА АСТМА В АСПЕКТІ ФЕНОТИПІВ, ЕНДОТИПІВ І ПАТОГЕНЕЗУ (Повідомлення друге)
Khodosh, E. M., Yakovenko, О. К., & Nartov, P. (2026) · Immunology and Allergy Science and Practice · doi:10.37321/immunology.2026.2-02
Placido, D. D., Ciaramella, A., Riccomi, A., Trombetta, C. M., Dorrucci, M., Farchi, F., Giuseppetti, R., Marchi, S., Sanarico, N., Pezzotti, P., et al. (2026) · Vaccines · doi:10.3390/vaccines14080680
Сlinical features of Т2-low asthma in real practice
Sergeeva, G. R., Emelyanov, A. V., Leshenkova, E. V., Tsukanova, I. V., & Александровна, З. А. (2026) · PULMONOLOGIYA · doi:10.18093/0869-0189-2026-36-4-645-653
Erythroderma: A Retrospective Study From a Single Institution
Irie, K., Oura, Y., & Yamamoto, T. (2026) · Cureus · doi:10.7759/cureus.115265
Zhang, Y., Yang, Z., Zhao, Y., Gu, H., & Tu, Y. (2026) · Frontiers in Medicine · doi:10.3389/fmed.2026.1905694
Qiu, H., Luo, Y., Pu, L., Luo, X., Jiang, X., Nasser, M. I., Liu, C., & Yalikun, K. (2026) · Journal of Oral Microbiology · doi:10.1080/20002297.2026.2728747
Wu, N., Li, Y., Wang, X., Wu, Y., & Yin, W. (2026) · Immunity Inflammation and Disease · doi:10.1002/iid3.70528
Metadata
- Authors
- Schmitt, V., Rink, L., & Uciechowski, P.
- Affiliations
- RWTH Aachen University (DE)
- Corresponding author
- Uciechowski, Peter
- Venue
- Experimental Gerontology
- Publisher
- Elsevier BV
- Published
- 2013-12
- Volume
- 48
- Issue
- 12
- Pages
- 1379-1386
- ISSN
- 0531-5565 (ISSN-L)
- OpenAlex
- W2009341839
- Cited by
- 235
- References
- 76
- Citations by year
- 2026: 16 · 2025: 21 · 2024: 20 · 2023: 16 · 2022: 29 · 2021: 39 · 2020: 22 · 2019: 12 · 2018: 9 · 2017: 16 · 2016: 12 · 2015: 14 · 2014: 9
- FWCI
- 6.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Experimental Gerontology (publishedVersion)
- PubMed (publishedVersion)
- RWTH Publications (RWTH Aachen) (submittedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
- Keywords
- Th17/Treg balance, aging, immunosenescence, inflammaging, regulatory T cells, Th17 cells, IL23R, Foxp3, IL-17, IL-10, CD4+ T cells
- MeSH terms
- Adult, Age Factors, Aged, Aged, 80 and over, Aging, Cells, Cultured, Female, Humans, Male, Middle Aged, Phenotype, Phytohemagglutinins, RNA, Messenger, Interleukin-10, Receptors, Interleukin, Th1 Cells, Inflammation Mediators, Interleukin-17, T-Lymphocytes, Regulatory, Forkhead Transcription Factors, Young Adult, Nuclear Receptor Subfamily 1, Group F, Member 3, Healthy Volunteers
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
