Peptides from sesame cake extend healthspan of Caenorhabditis elegans via upregulation of skn-1 and inhibition of intracellular ROS levels
Abstract
The peptides from sesame cake (PSC) which are the main by-product of agricultural processing of sesame were prepared. To evaluate benefits of PSC for health and longevity, antioxidant activity and anti-aging effects were studied in vitro and in a Caenorhabditis elegans (C. elegans) model system. PSC exhibited antioxidant activity in vitro, and induced beneficial effects on lifespan and several health parameters of C.elegans, including pharyngeal pumping rate, locomotion and lipofuscin accumulation. In a mev-1 mutant, PSC increased lifespan, and it enhanced oxidative stress tolerance in wild-type nematodes. After treatment with PSC, SOD activity, GSH content, and GSH/GSSG ratio were increased, leading to low intracellular ROS levels in C. elegans. PSC up-regulated skn-1 mRNA, and its target gene gcs-1, and abolished the extension of lifespan in skn-1 mutant, indicating that PSC-mediated longevity is dependent on activation of the skn-1/Nrf-2 transcription factor. Current results warrant research into the use of PSC as nutraceuticals for overall health improvement.
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C. elegans intestinal autofluorescence is an indicator of health in terms of aging and oxidative stress in many species, including C. elegans.
“C.elegans intestinal autofluorescence is an indicator of health in terms of aging and oxidative stress in many species, including C.elegans.”
From Bacopa monnieri (L.) wettst. Extract protects against glutamate toxicity and increases the longevity of Caenorhabditis elegans (2020) · cites this paper as [25]
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- Authors
- Wang, Z., Ma, X., Li, J., & Cui, X.
- Affiliations
- Shanxi University (CN)
- Corresponding author
- Wang, Zhuanhua
- Cui, Xiaodong
- Venue
- Experimental Gerontology
- Publisher
- Elsevier BV
- Published
- 2016-09
- Volume
- 82
- Pages
- 139-149
- ISSN
- 0531-5565 (ISSN-L)
- OpenAlex
- W2473171234
- Cited by
- 39
- References
- 56
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 3 · 2023: 1 · 2022: 2 · 2021: 7 · 2020: 2 · 2019: 10 · 2018: 5 · 2017: 2
- FWCI
- 3.05
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Experimental Gerontology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Sciences Foundation of China (31171659, 31300653)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Keywords
- healthspan extension, longevity, Caenorhabditis elegans, oxidative stress resistance, reactive oxygen species, antioxidant activity, lipofuscin accumulation, glutathione, superoxide dismutase, nutraceuticals, agricultural by-products
- MeSH terms
- Animals, Antioxidants, DNA-Binding Proteins, Longevity, Peptides, Transcription Factors, Signal Transduction, Up-Regulation, Caenorhabditis elegans, Reactive Oxygen Species, Oxidative Stress, Dietary Supplements, Caenorhabditis elegans Proteins, Sesamum
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