Characterization of cellular senescence in doxorubicin-induced aging mice

The Hallmarks of Aging

López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982 · see citing works

Cellular Senescence: Defining a Path Forward

Gorgoulis, V., Adams, P. D., Alimonti, A., Bennett, D. C., Bischof, O., Bishop, C., Campisi, J., Collado, M., Evangelou, K., Ferbeyre, G., et al. (2019) · Cell · doi:10.1016/j.cell.2019.10.005 · Cited by 3,225 · see citing works

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

Baker, D. J., Childs, B. G., Durik, M., Wijers, M. E., Sieben, C. J., Zhong, J., A. Saltness, R., Jeganathan, K. B., Verzosa, G. C., Pezeshki, A., et al. (2016) · Nature · doi:10.1038/nature16932 · Cited by 2,891 · see citing works

A DNA damage checkpoint response in telomere-initiated senescence

Fagagna, F. D. D., Reaper, P. M., Clay-Farrace, L., Fiegler, H., Carr, P., von Zglinicki, T., Saretzki, G., Carter, N. P., & Jackson, S. P. (2003) · Nature · doi:10.1038/nature02118 · Cited by 2,855 · see citing works

The genetics of ageing

Kenyon, C. J. (2010) · Nature · doi:10.1038/nature08980 · Cited by 2,739 · see citing works

A complex secretory program orchestrated by the inflammasome controls paracrine senescence

Acosta, J. C., Banito, A., Wuestefeld, T., Georgilis, A., Janich, P., Morton, J. P., Athineos, D., Kang, T.-W., Lasitschka, F., Andrulis, M., et al. (2013) · Nature Cell Biology · doi:10.1038/ncb2784 · Cited by 2,278 · see citing works

Ageing as a Risk Factor for Disease

Niccoli, T., & Partridge, L. (2012) · Current Biology · doi:10.1016/j.cub.2012.07.024 · Cited by 1,831 · see citing works

Senescence in Health and Disease

He, S., & Sharpless, N. E. (2017) · Cell · doi:10.1016/j.cell.2017.05.015 · Cited by 1,766 · see citing works

Protocols to detect senescence-associated beta-galactosidase (SA-βgal) activity, a biomarker of senescent cells in culture and in vivo

Debacq-Chainiaux, F., Erusalimsky, J. D., Campisi, J., & Toussaint, O. (2009) · Nature Protocols · doi:10.1038/nprot.2009.191 · Cited by 1,668 · see citing works

Reversal of human cellular senescence: roles of the p53 and p16 pathways

Beauséjour, C. M., Krtolica, A., Galimi, F., Narita, M., Lowe, S. W., Yaswen, P., & Campisi, J. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg417 · Cited by 1,457 · see citing works

Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging

Baar, M. P., Brandt, R. M. C., Putavet, D. A., Klein, J. D. D., Derks, K. W. J., Bourgeois, B. R. M., Stryeck, S., Rijksen, Y., van Willigenburg, H., Feijtel, D. A., et al. (2017) · Cell · doi:10.1016/j.cell.2017.02.031 · Cited by 1,454 · see citing works

Cellular senescence promotes adverse effects of chemotherapy and cancer relapse

Demaria, M., O'Leary, M. N., Chang, J., Shao, L., Liu, S., Alimirah, F., Koenig, K., Le, C., Mitin, N., Deal, A. M., et al. (2017) · Cancer Discovery · doi:10.1158/2159-8290.cd-16-0241 · Cited by 1,338 · see citing works

IKKβ Couples Hepatocyte Death to Cytokine-Driven Compensatory Proliferation that Promotes Chemical Hepatocarcinogenesis

Maeda, S., Kamata, H., Luo, J., Leffert, H. L., & Karin, M. (2005) · Cell · doi:10.1016/j.cell.2005.04.014 · Cited by 1,165 · see citing works

Senescence-associated β-galactosidase reflects an increase in lysosomal mass during replicative ageing of human endothelial cells

Kurz, D. J., Decary, S., Hong, Y., & Erusalimsky, J. D. (2000) · Journal of Cell Science · doi:10.1242/jcs.113.20.3613 · Cited by 899 · see citing works

Benefits of Metformin in Attenuating the Hallmarks of Aging

Kulkarni, A. S., Gubbi, S., & Barzilai, N. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.04.001 · Cited by 766 · see citing works

d-Galactose-induced accelerated aging model: an overview

Azman, K. F., & Zakaria, R. (2019) · Biogerontology · doi:10.1007/s10522-019-09837-y · Cited by 553 · see citing works

The role of nuclear lamin B1 in cell proliferation and senescence

Shimi, T., Butin-Israeli, V., Adam, S. A., Hamanaka, R. B., Goldman, A. E., Lucas, C. A., Shumaker, D. K., Kosak, S. T., Chandel, N. S., & Goldman, R. D. (2011) · Genes & Development · doi:10.1101/gad.179515.111 · Cited by 547 · see citing works

Lipofuscin: Formation, Distribution, and Metabolic Consequences

JUNG, T., BADER, N., & GRUNE, T. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1404.008 · Cited by 415 · see citing works

Specific lipofuscin staining as a novel biomarker to detect replicative and stress-induced senescence. A method applicable in cryo-preserved and archival tissues

Georgakopoulou, E., Tsimaratou, K., Evangelou, K., Fernandez, M.-P., Zoumpourlis, V, Trougakos, I., Kletsas, D., Bartek, J., Serrano, M., & Gorgoulis, V. (2012) · Aging · doi:10.18632/aging.100527 · Cited by 390 · see citing works

Senolytics and senomorphics: Natural and synthetic therapeutics in the treatment of aging and chronic diseases

Lagoumtzi, S. M., & Chondrogianni, N. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.05.003 · Cited by 279 · see citing works

New molecular and biochemical insights of doxorubicin-induced hepatotoxicity

Prasanna, P. L., Renu, K., & Gopalakrishnan, A. V. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.117599 · Cited by 271 · see citing works

Persistent γH2AX: A promising molecular marker of DNA damage and aging

Siddiqui, M. S., François, M., Fenech, M. F., & Leifert, W. R. (2015) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2015.07.001 · Cited by 266 · see citing works

Induction of premature senescence in cardiomyocytes by doxorubicin as a novel mechanism of myocardial damage

Maejima, Y., Adachi, S., Ito, H., Hirao, K., & Isobe, M. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00358.x · Cited by 220 · see citing works

Metformin extends C. elegans lifespan through lysosomal pathway

Chen, J., Ou, Y., Li, Y., Hu, S., Shao, L.-W., & Liu, Y. (2017) · eLife · doi:10.7554/elife.31268 · Cited by 202 · see citing works

Bleomycin induces cellular senescence in alveolar epithelial cells

Aoshiba, K., Tsuji, T., & Nagai, A. (2003) · European Respiratory Journal · doi:10.1183/09031936.03.00011903 · Cited by 197 · see citing works

Metformin‐mediated increase in DICER1 regulates microRNA expression and cellular senescence

Noren Hooten, N., Martin‐Montalvo, A., Dluzen, D. F., Zhang, Y., Bernier, M., Zonderman, A. B., Becker, K. G., Gorospe, M., Cabo, R., & Evans, M. K. (2016) · Aging Cell · doi:10.1111/acel.12469 · Cited by 196 · see citing works

Algorithmic assessment of cellular senescence in experimental and clinical specimens

Kohli, J., Wang, B., Brandenburg, S. M., Basisty, N., Evangelou, K., Varela-Eirin, M., Campisi, J., Schilling, B., Gorgoulis, V., & Demaria, M. (2021) · Nature Protocols · doi:10.1038/s41596-021-00505-5 · Cited by 196 · see citing works

Molecular and phenotypic biomarkers of aging

Xia, X., Chen, W., McDermott, J., & Han, J.-D. J. (2017) · F1000Research · doi:10.12688/f1000research.10692.1 · Cited by 187 · see citing works

Induction of senescence with doxorubicin leads to increased genomic instability of HCT116 cells

Śliwińska, M. A., Mosieniak, G., Wolanin, K., Babik, A., Piwocka, K., Magalska, A., Szczepanowska, J., Fronk, J., & Sikora, E. (2008) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2008.04.011 · Cited by 179 · see citing works

Physiological hypoxia restrains the senescence-associated secretory phenotype via AMPK-mediated mTOR suppression

van Vliet, T., Varela-Eirin, M., Wang, B., Borghesan, M., Brandenburg, S. M., Franzin, R., Evangelou, K., Seelen, M., Gorgoulis, V., & Demaria, M. (2021) · Molecular Cell · doi:10.1016/j.molcel.2021.03.018 · Cited by 172 · see citing works

Doxorubicin induces senescence or apoptosis in rat neonatal cardiomyocytes by regulating the expression levels of the telomere binding factors 1 and 2.

Spallarossa, P., Altieri, P., Aloi, C., Garibaldi, S., Barisione, C., Ghigliotti, G., Fugazza, G., Barsotti, A., & Brunelli, C. (2009) · American Journal of Physiology. Heart and Circulatory Physiology · doi:10.1152/ajpheart.00068.2009 · Cited by 154 · see citing works

SILAC Analysis Reveals Increased Secretion of Hemostasis-Related Factors by Senescent Cells

Wiley, C. D., Liu, S., Limbad, C., Zawadzka, A. M., Beck, J., Demaria, M., Artwood, R., Alimirah, F., Lopez-Dominguez, J.-A., Kuehnemann, C., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.08.049 · Cited by 137 · see citing works

Berberine ameliorates cellular senescence and extends the lifespan of mice via regulating p16 and cyclin protein expression

Dang, Y., An, Y., He, J., Huang, B., Zhu, J., Gao, M., Zhang, S., Wang, X., Yang, B., & Xie, Z. (2019) · Aging Cell · doi:10.1111/acel.13060 · Cited by 112 · see citing works

Different Stages of Quiescence, Senescence, and Cell Stress Identified by Molecular Algorithm Based on the Expression of Ki67, RPS6, and Beta-Galactosidase Activity

Alessio, N., Aprile, D., Cappabianca, S., Peluso, G., Bernardo, G. D., & Galderisi, U. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22063102 · Cited by 94 · see citing works

An NIR‐Responsive DNA‐Mediated Nanotetrahedron Enhances the Clearance of Senescent Cells

Qu, A., Wu, X., Li, S., Sun, M., Xu, L., Kuang, H., & Xu, C. (2020) · Advanced Materials · doi:10.1002/adma.202000184 · Cited by 93 · see citing works

Activation of DNA damage response pathways as a consequence of anthracycline-DNA adduct formation

Forrest, R. A., Swift, L. P., Rephaeli, A., Nudelman, A., Kimura, K., Phillips, D. R., & Cutts, S. M. (2012) · Biochemical Pharmacology · doi:10.1016/j.bcp.2012.02.026 · Cited by 78 · see citing works

Senescent cells as promising targets to tackle age-related diseases

Prašnikar, E., Borišek, J., & Perdih, A. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101251 · Cited by 74 · see citing works

Alleviation of the doxorubicin-induced nephrotoxicity by fasudil in vivo and in vitro

Xiang, C., Yan, Y., & Zhang, D. (2020) · Journal of Pharmacological Sciences · doi:10.1016/j.jphs.2020.10.002 · Cited by 61 · see citing works

Aspirin ameliorates the long‐term adverse effects of doxorubicin through suppression of cellular senescence

Feng, M., Kim, J., Field, K. P., Reid, C., Chatzistamou, I., & Shim, M. (2019) · FASEB BioAdvances · doi:10.1096/fba.2019-00041 · Cited by 42 · see citing works

DNA Damage, Liver Injury, and Tumorigenesis: Consequences of DDX3X Loss

Chan, C.-H., Chen, C., Lee, Y. W., & You, L. (2018) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-18-0551 · Cited by 41 · see citing works

An Optimized Protocol for Histochemical Detection of Senescence-associated Beta-galactosidase Activity in Cryopreserved Liver Tissue

Jannone, G., Rozzi, M., Najimi, M., Decottignies, A., & Sokal, E. M. (2020) · Journal of Histochemistry & Cytochemistry · doi:10.1369/0022155420913534 · Cited by 34 · see citing works

Growth arrest and DNA damage-inducible protein (GADD34) enhanced liver inflammation and tumorigenesis in a diethylnitrosamine (DEN)-treated murine model

Chen, N., Nishio, N., Ito, S., Tanaka, Y., Sun, Y., & Isobe, K. (2015) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-015-1690-8 · Cited by 28 · see citing works

Finding Ponce de Leon’s Pill: Challenges in Screening for Anti-Aging Molecules

Kumar, S., & Lombard, D. B. (2016) · F1000Research · doi:10.12688/f1000research.7821.1 · Cited by 24 · see citing works

The anti-aging promise of p21

Papismadov, N., Gal, H., & Krizhanovsky, V. (2017) · Cell Cycle · doi:10.1080/15384101.2017.1377500 · Cited by 22 · see citing works

Evaluation of senescent cells in intervertebral discs by lipofuscin staining

Veroutis, D., Kouroumalis, A., Lаgopati, N., Polyzou, A., Chamilos, C., Papadodima, S. A., Evangelou, K., Gorgoulis, V. G., & Kletsas, D. (2021) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2021.111564 · Cited by 22 · see citing works

Characterization of acetaminophen-induced cytotoxicity in target tissues.

Guo, C., Xie, G., Su, M., Wu, X., Lu, X., Wu, K., & Wei, C. (2016) · PubMed Central · Cited by 17 · see citing works

Dynamic Scaling of Lipofuscin Deposition in Aging Cells

Family, F., Mazzitello, K. I., Arizmendi, C. M., & GROSSNIKLAUS, H. E. (2011) · Journal of Statistical Physics · doi:10.1007/s10955-011-0178-y · Cited by 5 · see citing works

Inflammation and aging: signaling pathways and intervention therapies

Li, X., Li, C., Zhang, W., Wang, Y., Qian, P., & Huang, H. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01502-8 · Cited by 1,443 · see citing works

The role of p21 in cellular senescence and aging-related diseases

Yan, J., Chen, S., Yi, Z., Zhao, R., Zhu, J., Shuwen, D., & Wu, J. (2024) · Molecules and Cells · doi:10.1016/j.mocell.2024.100113 · Cited by 181 · see citing works

Inflammaging and Brain Aging

Jurcău, M. C., Jurcău, A., Cristian, A., Hogea, V. O., Diaconu, R. G., & Nunkoo, V. S. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms251910535 · Cited by 90 · see citing works

Biomarkers of Cellular Senescence and Aging: Current State‐of‐the‐Art, Challenges and Future Perspectives

Muthamil, S., Kim, H., Jang, H., Lyu, J., Shin, U. C., Go, Y., Park, S., Lee, H. G., & Park, J. H. (2024) · Advanced Biology · doi:10.1002/adbi.202400079 · Cited by 79 · see citing works

Pregnane X receptor agonist nomilin extends lifespan and healthspan in preclinical models through detoxification functions

Fan, S., Yan, Y., Xia, Y., Zhou, Z., Luo, L., Zhu, M., Han, Y., Yao, D., Zhang, L., Fang, M., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-39118-9 · Cited by 67 · see citing works

Geroscience and pathology: a new frontier in understanding age-related diseases

Fekete, M., Major, D., Fehér, Á., Fazekas‐Pongor, V., & Lehoczki, A. (2024) · Pathology & Oncology Research · doi:10.3389/pore.2024.1611623 · Cited by 64 · see citing works

Impaired ketogenesis in Leydig Cells drives testicular aging

Liu, C., Peng, H. Y., Yu, J., Luo, P., Xiong, C., Chen, H., Fan, H., Ma, Y., Ou, W., Zhang, S., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-59591-8 · Cited by 38 · see citing works

Cellular senescence triggers intracellular acidification and lysosomal pH alkalinized via ATP6AP2 attenuation in breast cancer cells

Li, W., Kawaguchi, K., Tanaka, S., He, C., Maeshima, Y., Suzuki, E., & Toi, M. (2023) · Communications Biology · doi:10.1038/s42003-023-05433-6 · Cited by 33 · see citing works

Senolytic treatment alleviates doxorubicin‐induced chemobrain

Budamagunta, V., Kumar, A., Rani, A., Sindhu, S. M., Yang, Y., Zhou, D., & Foster, T. C. (2024) · Aging Cell · doi:10.1111/acel.14037 · Cited by 35 · see citing works

Uncovering key mechanisms and intervention therapies in aging skin

Zhang, Y., Liu, L., Yue, L., Huang, Y., Wang, B., & Liu, P. (2024) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2024.07.009 · Cited by 30 · see citing works

A Senomorphlytic Three‐Drug Combination Discovered in Salsola collina for Delaying Aging Phenotypes and Extending Healthspan

Wang, J., Liu, W., Huang, Y., Wang, G., Guo, X., Shi, D., Sun, T., Xiao, C., Zhang, C., Jiang, B., et al. (2024) · Advanced Science · doi:10.1002/advs.202401862 · Cited by 24 · see citing works

Application of mesenchymal stem cells for anti-senescence and clinical challenges

Wang, Y., Gao, T., & Wang, B. (2023) · Stem Cell Research & Therapy · doi:10.1186/s13287-023-03497-z · Cited by 27 · see citing works

Targeting the redox system for cardiovascular regeneration in aging

Allemann, M., Lee, P., Beer, J. H., & Saravi, S. S. S. (2023) · Aging Cell · doi:10.1111/acel.14020 · Cited by 22 · see citing works

Anthracycline-induced cardiotoxicity and senescence

Booth, L. K., Redgrave, R. E., Folaranmi, O., Gill, J. H., & Richardson, G. D. (2022) · Frontiers in Aging · doi:10.3389/fragi.2022.1058435 · Cited by 23 · see citing works

Doxorubicin-induced modulation of TGF-β signaling cascade in mouse fibroblasts: insights into cardiotoxicity mechanisms

Patricelli, C., Lehmann, P., Oxford, J. T., & Pu, X. (2023) · Scientific Reports · doi:10.1038/s41598-023-46216-7 · Cited by 20 · see citing works

Piezo1-Mediated Ferroptosis Delays Wound Healing in Aging Mice by Regulating the Transcriptional Activity of SLC7A11 through Activating Transcription Factor 3

Chen, J., Zhang, D., Lin, Z. N., Lin, Y., Shi, Y., Dong, X., Jin, M.-Q., Song, F.-Q., Du, S.-T., Feng, Y.-Z., et al. (2025) · Research · doi:10.34133/research.0718 · Cited by 19 · see citing works

Intercellular flow dominates the poroelasticity of multicellular tissues

Liu, F., Gao, B., Lei, L., Liu, S., Li, H., & Guo, M. (2025) · Nature Physics · doi:10.1038/s41567-025-02947-0 · Cited by 18 · see citing works

Ligustilide prevents thymic immune senescence by regulating Thymosin β15-dependent spatial distribution of thymic epithelial cells

Xu, X., Tao, N., Sun, C., Hoffman, R. D., Shi, D., Ying, Y., Dong, S., & Gao, J. (2023) · Phytomedicine · doi:10.1016/j.phymed.2023.155216 · Cited by 17 · see citing works

Mechanisms of endothelial senescence and vascular aging

Qiao, L., Qian, Z., Huang, Y., Yang, X. F., Yang, J., Xiao, N., Liang, G., Zhang, H., Fu, Y., Yan, L., et al. (2025) · Biogerontology · doi:10.1007/s10522-025-10279-y · Cited by 17 · see citing works

Acyl-CoA-binding protein as a driver of pathological aging

Montégut, L., Lambertucci, F., Moledo-Nodar, L., Fiuza‐Luces, C., Rodríguez-López, C., Rexach, J. A. S., Lachkar, S., Motiño, O., Abdellatif, M., Durand, S., et al. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2501584122 · Cited by 16 · see citing works

Sex-related differences in delayed doxorubicin-induced cardiac dysfunction in C57BL/6 mice

Abdelgawad, I. Y., George, B., Grant, M. K. O., Huang, Y., Shan, Y., Huang, R. S., & Zordoky, B. N. M. (2024) · Archives of Toxicology · doi:10.1007/s00204-023-03678-y · Cited by 15 · see citing works

Ohwia caudata aqueous extract attenuates doxorubicin‐induced mitochondrial dysfunction in Wharton 's jelly‐derived mesenchymal stem cells

Lee, P., Tsai, B. C., Sitorus, M. A., Lin, P., Lin, S., Shih, C.-Y., Lu, S., Lin, Y., Ho, T., & Huang, C. (2023) · Environmental Toxicology · doi:10.1002/tox.23880 · Cited by 13 · see citing works

Inhibition of Polyamine Catabolism Reduces Cellular Senescence

Uemura, T., Matsunaga, M., Yokota, Y., Takao, K., & Furuchi, T. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241713397 · Cited by 13 · see citing works

An antibiotic that mediates immune destruction of senescent cancer cells

Raffi, G. C., Chen, J., Feng, X., Chen, Z., Lieftink, C., Deng, S., Mo, J., Zeng, C., Steur, M., Wang, J., et al. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2417724121 · Cited by 13 · see citing works

Nicandra physalodes Extract Exerts Antiaging Effects in Multiple Models and Extends the Lifespan of Caenorhabditis elegans via DAF‐16 and HSF‐1

Wang, J., Huang, Y., Shi, K., Bao, L., Xiao, C., Sun, T., Mao, Z., Feng, J., Hu, Z., Guo, Z., et al. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/3151071 · Cited by 11 · see citing works

Iron retardation in lysosome protects senescent cells from ferroptosis

Feng, Y., Wei, H., Lyu, M., Yu, Z., Chen, J., Lyu, X., & Zhuang, F. (2024) · Aging · doi:10.18632/aging.205777 · Cited by 12 · see citing works

Cellular senescence mediates doxorubicin chemotherapy-induced vascular endothelial dysfunction: translational evidence of prevention with senolytic treatment

Venkatasubramanian, R., Mahoney, S. A., Hutton, D. A., VanDongen, N. S., Brunt, V. E., Greenberg, N., Longtine, A. G., Brandt, L., Beyer, A., Melov, S., et al. (2025) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00712.2025 · Cited by 11 · see citing works

Cytoprotective Properties of Citronella Oil (Cymbopogon nardus (L.) Rendl.) and Lemongrass Oil (Cymbopogon citratus (DC.) Stapf) through Attenuation of Senescent-Induced Chemotherapeutic Agent Doxorubicin on Vero and NIH-3T3 Cells

Salsabila, D. U., Wardani, R., Hasanah, N. U., Tafrihani, A. S., Zulfin, U. M., Ikawati, M., & Meiyanto, E. (2023) · Asian Pacific Journal of Cancer Prevention · doi:10.31557/apjcp.2023.24.5.1667 · Cited by 10 · see citing works

Targeting farnesoid X receptor as aging intervention therapy

Zhang, L., Yu, J., Gao, X., Yan, Y., Wang, X., Shi, H., Fang, M., Liu, Y., Kim, Y., Zhu, H., et al. (2025) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2025.01.006 · Cited by 12 · see citing works

Methylglyoxal-induced glycation stress promotes aortic stiffening: putative mechanistic roles of oxidative stress and cellular senescence

Singh, P., Venkatasubramanian, R., Mahoney, S. A., Darrah, M. A., Ludwig, K. R., Zhang, A., Kaneshiro, K. R., Najera, L. E., Wimer, L. A., Shanmugam, M. M., et al. (2025) · Aging · doi:10.18632/aging.206335 · Cited by 8 · see citing works

Exploring the potential anti-senescence effects of soybean-derived peptide Soymetide in mice hippocampal neurons via the Wnt/β-catenin pathway

Garg, A., Saroj, J., Tiwari, S., Das, U., Shukla, N., Ghosh, J. K., & Bandyopadhyay, S. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1510337 · Cited by 7 · see citing works

Cellular Senescence Mediates Doxorubicin Chemotherapy-Induced Aortic Stiffening: Role of Glycation Stress

Venkatasubramanian, R., Darrah, M., Mahoney, S. A., Hutton, D. A., Maurer, G. S., Ludwig, K. R., VanDongen, N. S., Greenberg, N., Longtine, A. G., Brunt, V. E., et al. (2025) · Hypertension · doi:10.1161/hypertensionaha.125.25408 · Cited by 7 · see citing works

Dasabuvir alleviates 5-fluorouracil-induced intestinal injury through anti-senescence and anti-inflammatory

He, S., Wang, Z., Xia, J., Jia, H., Dai, Q., Cui, C., He, F., Wang, X., & Zhou, M. (2024) · Scientific Reports · doi:10.1038/s41598-024-66771-x · Cited by 8 · see citing works

Molecular engineering development of β-galactosidase-activatable fluorogenic probes for precise senescence tracking in cells, tissues and a mouse model of psoriasis

Lv, X., Yu, Y., Chen, Z., Wang, G., Li, X., Wu, L., Wu, L., Wu, J., Li, J., Guo, Y., et al. (2025) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2025.138406 · Cited by 6 · see citing works

LncRNA Gm15232 Promotes Lipogenesis in Aging Mice Through the miR-192-3p/GCR Pathway

Hu, Y., Zhang, Y., Wang, S., Wang, R., Yuan, Q., Wu, W., Gui, Y., Zhao, J., Li, X., He, Y., et al. (2024) · The Journals of Gerontology Series A · doi:10.1093/gerona/glae066 · Cited by 6 · see citing works

Ohwia caudata aqueous extract attenuates senescence in aging adipose-derived mesenchymal stem cells

Ho, T., Tsai, B. C., Goswami, D., Shibu, M. A., Kuo, C., Lin, C.-H., Lin, P., Lin, S., Kuo, W., & Huang, C. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e29729 · Cited by 6 · see citing works

Lactiplantibacillus plantarum CCFM8610 mitigates oxidative stress-related intestinal aging through its metabolite indole-3-lactic acid

Fang, J., Dai, Y., Chen, J., Zhang, H., Li, H., & Chen, W. (2025) · Food Bioscience · doi:10.1016/j.fbio.2024.105822 · Cited by 5 · see citing works

The Expression Pattern of tRNA-Derived Small RNAs in Adult Drosophila and the Function of tRF-Trp-CCA-014-H3C4 Network Analysis

Yang, D., Xiao, F., Yuan, Y., Li, J., Wang, S., Fan, X., Ni, Q., Li, Y., Zhang, M., Gu, X., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076169 · Cited by 5 · see citing works

Platycodi radix aqueous extract salvages doxorubicin‐induced senescence by mitochondrial reactive oxygen species reduction in umbilical cord matrix stem cells

Lee, P., Sitorus, M. A., Kuo, C., Tsai, B. C., Kuo, W., Lin, K., Lu, S., Lin, Y., Ho, T., & Huang, C. (2024) · Environmental Toxicology · doi:10.1002/tox.24240 · Cited by 5 · see citing works

H 2 S Donor SPRC Ameliorates Cardiac Aging by Suppression of JMJD3, a Histone Demethylase

Li, S., Li, Q., Xiang, H., Wang, C., Zhu, Q., Ruan, D., Zhu, Y. Z., & Mao, Y. (2024) · Antioxidants and Redox Signaling · doi:10.1089/ars.2024.0605 · Cited by 5 · see citing works

Impact of Aging and Cellular Senescence in the Pathophysiology of Preeclampsia

Suvakov, S. R., Kattah, A. G., Gojković, T., Enninga, E. A. L., Pruett, J. E., Jayachandran, M., Sousa, C., Santos, J., Hassan, C. A., Suarez, M. L. G., et al. (2023) · Comprehensive physiology · doi:10.1002/cphy.c230003 · Cited by 6 · see citing works

Cancerous Conditions Accelerate the Aging of Skeletal Muscle via Mitochondrial DNA Damage

Luo, Y., Fujiwara‐Tani, R., Kawahara, I., Goto, K., Nukaga, S., Nishida, R., Nakashima, C., Sasaki, T., Miyagawa, Y., Ogata, R., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25137060 · Cited by 4 · see citing works

Indole-3-Carboxylic Acid Enhanced Anti-cancer Potency of Doxorubicin via Induction of Cellular Senescence in Colorectal Cells

Zhou, Y., Yi, T., Luo, Q., HU, Y., & Peng, W. (2024) · Acta Poloniae Pharmaceutica - Drug Research · doi:10.32383/appdr/178491 · Cited by 5 · see citing works

Research progress of cell senescence in Alzheimer's disease: mechanisms and therapy.

Cai, J., Yang, L., Xu, Y., Wang, L., Zhang, M., Qiao, J.-W., Xu, Q., Zhu, H., & Cai, M. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.177697 · Cited by 6 · see citing works

Activation of Nuclear Receptor CAR: A Pathway to Delay Aging through Enhanced Capacity for Xenobiotic Resistance

Yu, J., Gao, X., Shi, H., Zhang, L., Nie, W., Zhang, R., Fang, M., Liu, Y., Yan, Y., Fan, B., et al. (2025) · Advanced Science · doi:10.1002/advs.202416823 · Cited by 3 · see citing works

Senescence in the bone marrow microenvironment: A driver in development of therapy-related myeloid neoplasms

Guilatco, A. J., Shah, M. V., & Weivoda, M. M. (2024) · Journal of bone oncology · doi:10.1016/j.jbo.2024.100620 · Cited by 3 · see citing works

Machine learning-based identification and validation of aging-related genes in cardiomyocytes from patients with atrial fibrillation

Liu, K., Yang, Z., Ye, Z., & Han, L. (2024) · Minerva Cardiology and Angiology · doi:10.23736/s2724-5683.24.06492-5 · Cited by 3 · see citing works

Effect of Benzo[a]pyrene on Cellular Senescence in MCF7 Breast Cancer Cells

Kitamoto, N., Haga, Y., Tsujii, Y., Kubo, M., Higashisaka, K., & Tsutsumi, Y. M. (2025) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b25-00309 · Cited by 2 · see citing works

MiR-668-5p targets ZNRF3, an E3 ubiquitin ligase to enhance osteoblast function and alleviate senescence in doxorubicin-induced age-related bone loss

Singh, D. P., Tripathi, A., Paul, A., Kaushal, S. K., Dixit, M., & Singh, D. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1693659 · Cited by 2 · see citing works

Design and Optimization of Lysosome-Targeted β-Galactoside Senolytic Prodrugs: Harnessing the Aromatic Ring of Self-Immolative Linkers

Liu, J., Liu, X., Fu, H., Yu, C., Jing Hua, H. U., Fu, J., & Yin, J. (2026) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5c01922 · Cited by 2 · see citing works

Telomere Length of Cardiomyocytes in Wistar Rat Treated with Doxorubicin: In Vivo Experimental Study

Асанов, М. А., Олеговна, П. А., Sinitskaya, A. V., Khutornaya, M. V., Khryachkova, O. V., & Sinitsky, M. Y. (2025) · Bulletin of Experimental Biology and Medicine · doi:10.1007/s10517-025-06381-3 · Cited by 2 · see citing works

Glucomannogalactan inhibits senescence by promoting nuclear translocation of NRF2

Liang, Z., Tang, Q., Liang, H., Liang, X., Fu, C., Kang, W., Zhang, Y., & Lv, P. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.141059 · Cited by 1 · see citing works

Discovery of Non-antibacterial Enrofloxacin Derivatives with Emerging Antiaging Effects through Drug Repurposing and Secondary Development

Qiao, S., Chen, X., Chen, Y., Song, Y., Shi, D., Mao, Z., Li, J., Huang, Y., & Liú, W. (2025) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5c00021 · Cited by 1 · see citing works

Accumulation Kinetics and Biological Action of Doxorubicin in Rabbit Intervertebral Discs

Mavrogonatou, E., Kouroumalis, A., Khaldi, L., Christophoridis, C., & Kletsas, D. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26157386 · Cited by 1 · see citing works

Reversible ALKBH5 cytosolic aggregation accelerates cellular senescence

Chen, L., Chen, Z., Mo, J., Xie, Q., Lin, W., Zheng, H., Zou, Y., Chen, Y., Bian, X., Zhou, Z., et al. (2025) · Cell Death and Differentiation · doi:10.1038/s41418-025-01560-1 · Cited by 1 · see citing works

Quansanqi (derived from Panax notoginseng (Burk.) F. H. Chen) tablets extend the lifespan and ameliorate cellular inflammaging via regulating CD38 and senescence-associated secretory phenotype

Guo, Y. J., Yan, H., Zhong, C., Gong, L., Yang, W., Zi, Z.-D., Li, T., Xu, Y., Wu, D., Wei, S., et al. (2025) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2025.120959 · Cited by 1 · see citing works

Ganoderma lucidum -Derived Nanovesicles Attenuate Multiorgan Senescence via Modulation of Oxidative Stress and Inflammation

Fan, Q., Zhang, Y., Xie, H., Guo, X., & Zhang, Y. (2025) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.5c00862 · Cited by 1 · see citing works

Structural evolution of carbon frameworks realizes in vitro interfacial transport in metabolically reprogrammed senescent cells for senolysis

Wang, X., Ma, H., Li, Y., Chen, L., Ye, C., Zhao, Y., Wang, H., Fu, W., Yu, C., Wang, F., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-70810-8 · Cited by 1 · see citing works

Small molecule activators of the mitochondrial protease ClpP induce senescence in triple-negative breast cancer cells and sensitize cells to the Bcl-2 inhibitor venetoclax

Daglish, S., Canterbury, O. G., Graves, P. R., Carter, S. A., Beese, S. M., Mouery, B. L., Hynek, M. A., Moorman, E. C., Mistreanu, A., Bhatt, A. P., et al. (2026) · Cell Death and Disease · doi:10.1038/s41419-026-09061-w · Cited by 2 · see citing works

Impact of Aging and Cellular Senescence in the Pathophysiology of Preeclampsia

Suvakov, S. R., Kattah, A. G., Gojković, T., Enninga, E. A. L., Pruett, J. E., Jayachandran, M., Sousa, C., Santos, J., Hassan, C. A., Suarez, M. L. G., et al. (2023) · Comprehensive physiology · doi:10.1002/j.2040-4603.2023.tb00282.x · Cited by 1 · see citing works

Mechanotransduction is the Janus-faced regulator of cell agingPreprint

Liu, X., Liao, L., Wang, P., Ye, Y., Dong, X., Xing, X., Li, Z., Wei, Q., & Tian, W. (2022) · Research Square · doi:10.21203/rs.3.rs-2208259/v1

Chronically disrupted sleep induces senescence in the visceral adipose tissue of C57BL/6 micePreprint

Timonina, D., Hormazabal, G. V., Heckenbach, I., Anderton, E., Haky, L., Floro, A., Riley, R. R., Kwok, R., Breslin, S., Ingle, H., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.10.17.562803

Antibiotics and Cellular Senescence: An Unexplored Territory

Zinovkin, R. A., & Kondratenko, N. (2025) · Biochemistry (Moscow) · doi:10.1134/s0006297925602758

HTR2B Upregulation induces Adipose Aging and Is Attenuated by HederageninPreprint

Li, M., Wu, X., Huang, Y., Lin, J., Wu, Z., Pang, M., Zhao, X., & Zhang, J. (2026) · Research Square · doi:10.21203/rs.3.rs-8390928/v1

Effects of Ritonavir, Lopinavir, and Alcohol on ABC Transporters and Secretion of Bile Acid and Bilirubin in Senescent Hepatocytes

Chen, L., Duran, E., Headrick, D., & Ji, C. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27031189

P2Y12-AMPKα2 signaling contributes to cardiomyocyte senescence in doxorubicin-induced heart failure

Niu, Q., Wang, H. W., Zhao, M., Zhang, H., Hao, R., Liu, P., Guo, L., Chen, B., Xi, Y., Li, P., et al. (2026) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-026-05593-z

mRNA-LNP delivery of individual longevity genes mitigates doxorubicin-induced progeroid phenotypes

Ju, Y., Zhang, Y., Zhao, X., Lin, J., & Wei, Y. (2026) · Protein & Cell · doi:10.1093/procel/pwag044

Indoxyl Sulfate-Mediated Blood–Brain Barrier Damage in Chronic Kidney Disease

Hernandez, L. N., Strizzi, C. T., Rosina, M., Schwarz, A., Kronqvist, N., Arefin, S., Stenvinkel, P., & Kublickiene, K. R. (2026) · Toxins · doi:10.3390/toxins18080334

Mechanisms of Doxorubicin-Induced Cardiac Senescence and Potential Therapeutic Strategies

Bai, Y., Yang, W., Wang, Z., Yang, Q., Zhang, Z., Liu, J., Qi, Y., & Liu, D. (2026) · Biomolecules · doi:10.3390/biom16081180

Identification of Senescence‐Associated β‐Galactosidase With Single‐Molecule Resolution

Wang, G., Chen, X., Ge, Y., Duan, K., Wu, S., Qiao, Q., Shi, D., Shen, J., Zhang, J., James, T. D., et al. (2026) · Angewandte Chemie · doi:10.1002/ange.5443283

Identification of Senescence‐Associated β‐Galactosidase With Single‐Molecule Resolution

Wang, G., Chen, X., Ge, Y., Duan, K., Wu, S., Qiao, Q., Shi, D., Shen, J., Zhang, J., James, T. D., et al. (2026) · Angewandte Chemie International Edition · doi:10.1002/anie.5443283

Ciprofloxacin-Induced Oxidative Stress Promotes a Senescence-like Phenotype in Human Fibroblasts In Vitro

Kondratenko, N. D., Chelombitko, M. A., Zinovkina, L. A., Dashkevich, A. A., Prikhodko, A. S., Kuptsova, R. Y., Ziubina, E. P., Lyamzaev, K. G., & Zinovkin, R. A. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27198696

An environment-sensitive fluorescent probe activated by senescence-associated β-galactosidase for tracking cellular senescence

Zhang, J., Yu, H., Gao, L.-L., Du, J., Wang, G., Tian, X., Shi, D., Zhang, J., & Guo, Y. (2026) · Chinese Chemical Letters · doi:10.1016/j.cclet.2026.113529

Doxorubicin‐induced senescence through NF‐κB affected by the age of mouse mesenchymal stem cells

Dezfouli, A. B., Amoli, J. S., Pourfathollah, A. A., Yazdi, M., Nikougoftar‐Zarif, M., Khosravi, M., & Hassan, J. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.29140 · Cited by 18 · see citing works

Metformin Modulates Doxorubicin‐induced Senescence Phenotype in Endothelial Cells

Abdelgawad, I. Y., Grant, M. K. O., & Zordoky, B. N. M. (2021) · The FASEB Journal · doi:10.1096/fasebj.2021.35.s1.02786 · Cited by 1 · see citing works

Doxorubicin and liposomal doxorubicin induce senescence by enhancing nuclear factor kappa B and mitochondrial membrane potential

Fallah, M., Mohammadi, H., Shaki, F., Hosseini‐khah, Z., Moloudizargari, M., Dashti, A., Ziar, A., Mohammadpour, A., Mirshafa, A., Modanloo, M., et al. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.116677 · Cited by 28 · see citing works

A Comprehensive Multiomics Signature of Doxorubicin‐Induced Cellular Senescence in the Postmenopausal Human Ovary

Devrukhkar, P. R., Watson, M. A., Soygur, B., Wu, F., Bons, J., Anvari, H., Atazhanova, T., Martin, N., Tran, T., Schneider, K., et al. (2025) · Aging Cell · doi:10.1111/acel.70111 · Cited by 15 · see citing works

Modulation of senescence-related changes in the small and large intestine of experimental animals with induced aging

Yakovlev, A. A., Vasil’ev, Y. G., Shumikhina, G. V., Berestov, D. S., Korepanova, Y. B., & Владиславовна, К. О. (2025) · Вестник Новгородского государственного университета им. Ярослава Мудрого · doi:10.34680/2076-8052.2025.2(140).223-230