d-Galactose-induced accelerated aging model: an overview
Abstract
To facilitate the process of aging healthily and prevent age-related health problems, efforts to properly understand aging mechanisms and develop effective and affordable anti-aging interventions are deemed necessary. Systemic administration of D-galactose has been established to artificially induce senescence in vitro and in vivo as well as for anti-aging therapeutic interventions studies. The aim of this article is to comprehensively discuss the use of D-galactose to generate a model of accelerated aging and its possible underlying mechanisms involved in different tissues/organs.
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When mice are treated with certain concentrations of D-galactose, they exhibit increased levels of ROS and inflammatory cytokines such as NOS-2, IL-1β, IL-6, TNF-α, and NF-κB.
“When mice are treated with certain concentrations of D-galactose, they exhibit increased levels of ROS and inflammatory cytokines such as NOS-2, IL-1β, IL-6, TNF-α, and NF-κB.”
From Inflammation and aging: signaling pathways and intervention therapies (2023) · cites this paper as [299]
The D-galactose-induced aging model effectively mimics aging in vivo by inducing changes in various tissues and organs.
“This model effectively mimics aging in vivo by inducing changes in various tissues and organs.”
From Inflammation and aging: signaling pathways and intervention therapies (2023) · cites this paper as [299]
These alterations contribute to the aging-like phenotype observed in this model.
“These alterations contribute to the aging-like phenotype observed in this model.”
From Inflammation and aging: signaling pathways and intervention therapies (2023) · cites this paper as [299]
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Inflammation and aging: signaling pathways and intervention therapies
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- Authors
- Azman, K. F., & Zakaria, R.
- Affiliations
- Universiti Sains Malaysia (MY)
- Corresponding author
- Azman, Khairunnuur Fairuz
- Venue
- Biogerontology
- Published
- 2019-09-20
- Volume
- 20
- Issue
- 6
- Pages
- 763-782
- ISSN
- 1389-5729 (ISSN-L)
- 1573-6768
- OpenAlex
- W2974795043
- Cited by
- 553
- References
- 148
- Citations by year
- 2026: 112 · 2025: 111 · 2024: 109 · 2023: 83 · 2022: 75 · 2021: 46 · 2020: 16 · 2019: 1
- FWCI
- 3.02
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biogerontology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Universiti Sains Malaysia (304/PPSP/6315093)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Antioxidants, Aging, Portulaca oleracea
- Keywords
- galactose, accelerated aging, aging models, cellular senescence, anti-aging interventions, aging mechanisms, age-related diseases
- MeSH terms
- Aging, Animals, Galactose, Humans, Models, Biological
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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