Oxidative status of red blood cells, neutrophils, and platelets in paroxysmal nocturnal hemoglobinuria
Open accessAbstract
Objective Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired stem-cell disorder associated with intravascular hemolysis and thrombosis. Hemolysis is caused by the hypersensitivity of PNH-red blood cells (RBC) to complement-mediated lysis due to deficiency in the surface glycosyl phosphatidylinositol-anchored antigens, CD55 and CD59. Thrombosis may be related to the platelet tendency to undergo hyperactivation. We previously suggested that hemolysis and thrombosis in other hemolytic anemias are related to oxidative stress. In the present study, we assessed the oxidative status of blood cells in PNH and tested the potential protective effects of antioxidants.Materials and methods Blood samples were obtained from 11 PNH patients and 11 normal control donors. Flow cytometry was used to measure oxidative stress markers in conjunction with the PNH immunophenotype.Results Results indicated that abnormal, CD55/CD59-negative, RBC, neutrophils, and platelets are under oxidative stress. Their intracellular reactive oxygen species, membrane lipid peroxides, and external phosphatidylserine were higher and their reduced glutathione was lower than CD55/CD59-positive cells of the same patient or cells of normal controls. PNH-RBC were hypersensitive to an oxidative insult (e.g., hydrogen peroxide) and their oxidative status increased following interaction with complement, prior to hemolysis. Antioxidants reduced this hemolysis as well as activation of PNH platelets.Conclusion We propose that oxidative stress mediates the symptoms of PNH and suggest that antioxidants might be considered as a therapeutic modality.
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Cites
Free Radicals in the Physiological Control of Cell Function
Dröge, W. (2002) · Physiological Reviews · doi:10.1152/physrev.00018.2001 · Cited by 9,855 · see citing works
Walport, M. J. (2001) · New England Journal of Medicine · doi:10.1056/nejm200104053441406 · Cited by 2,921 · see citing works
Kohen, R., & Nyska, A. (2002) · Toxicologic Pathology · doi:10.1080/01926230290166724 · Cited by 2,178 · see citing works
Wiklund, R. A., & Rosenbaum, S. H. (1997) · New England Journal of Medicine · doi:10.1056/nejm199710163371606 · Cited by 2,159 · see citing works
Takeda, J., Miyata, T., Kawagoe, K., Iida, Y., Endo, Y., Fujita, T., Takahashi, M., Kitani, T., & Kinoshita, T. (1993) · Cell · doi:10.1016/0092-8674(93)90250-t · Cited by 1,059 · see citing works
Hillmen, P., Hall, C., Marsh, J. C. W., Elebute, M. O., Bombara, M. P., Petro, B. E., Cullen, M. J., Richards, S. J., Rollins, S. A., Mojcik, C. F., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa031688 · Cited by 632 · see citing works
[35] Comparative studies on different methods of malonaldehyde determination
Bird, R. P., & Draper, H. H. (1984) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(84)05038-2 · Cited by 557 · see citing works
The hypercoagulable state in thalassemia
Eldor, A., & Rachmilewitz, E. A. (2002) · Blood · doi:10.1182/blood.v99.1.36 · Cited by 535 · see citing works
Paroxysmal nocturnal haemoglobinuria: long-term follow-up and prognostic factors
Socié, G., Mary, J., de Gramont, A., Rio, B., Leporrier, M., Rose, C., Heudier, P., Rochant, H., Cahn, J.-Y. Y., & Gluckman, É. (1996) · The Lancet · doi:10.1016/s0140-6736(95)12360-1 · Cited by 512 · see citing works
Holguin, M. H., Fredrick, L. R., Bernshaw, N. J., Wilcox, L., & Parker, C. J. (1989) · Journal of Clinical Investigation · doi:10.1172/jci114172 · Cited by 402 · see citing works
Inhibition of complement activity by humanized anti-C5 antibody and single-chain Fv
Thomas, T. C., Rollins, S. A., Rother, R. P., Giannoni, M. A., Hartman, S. L., Elliott, E. A., Nye, S. H., Matis, L. A., Squinto, S. P., & Evans, M. J. (1996) · Molecular Immunology · doi:10.1016/s0161-5890(96)00078-8 · Cited by 363 · see citing works
Walter, P. B., Fung, E. B., Killilea, D. W., Jiang, Q., Hudes, M. L., Madden, J., Porter, J. B., Evans, P., Vichinsky, E. P., & Harmatz, P. (2006) · British Journal of Haematology · doi:10.1111/j.1365-2141.2006.06277.x · Cited by 288 · see citing works
Hanson, S. R., & Harker, L. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.9.3184 · Cited by 266 · see citing works
Blockmans, D., Deckmyn, H., & Vermylen, J. (1995) · Blood Reviews · doi:10.1016/0268-960x(95)90020-9 · Cited by 246 · see citing works
Eidt, J. F., Allison, P. M., Noble, S., Ashton, J. H., Golino, P., McNatt, J. M., Buja, L. M., & Willerson, J. T. (1989) · Journal of Clinical Investigation · doi:10.1172/jci114138 · Cited by 234 · see citing works
Wiedmer, T., Hall, S. E., Ortel, T. L., Kane, W., Rosse, W., & Sims, P. (1993) · Blood · doi:10.1182/blood.v82.4.1192.1192 · Cited by 225 · see citing works
Amer, J., Ghoti, H., Rachmilewitz, E. A., Koren, A., Levin, C., & Fibach, E. (2005) · British Journal of Haematology · doi:10.1111/j.1365-2141.2005.05834.x · Cited by 219 · see citing works
Phosphatidylinositol-linked proteins and paroxysmal nocturnal hemoglobinuria
Rosse, W. (1990) · Blood · doi:10.1182/blood.v75.8.1595.1595 · Cited by 187 · see citing works
Amer, J., Goldfarb, A. W., & Fibach, E. (2003) · European Journal Of Haematology · doi:10.1034/j.1600-0609.2003.00011.x · Cited by 149 · see citing works
Flow cytometric analysis of the oxidative status of normal and thalassemic red blood cells
Amer, J., Goldfarb, A. W., & Fibach, E. (2004) · Cytometry Part A · doi:10.1002/cyto.a.20017 · Cited by 114 · see citing works
The pathophysiology of paroxysmal nocturnal hemoglobinuria
Parker, C. J. (2007) · Experimental Hematology · doi:10.1016/j.exphem.2007.01.046 · Cited by 108 · see citing works
Activated platelets in paroxysmal nocturnal haemoglobinuria
Gralnick, H. R., Vail, M., McKeown, L. P., Merryman, P. K., Wilson, O. J., Chu, I. W. T., & Kimball, J. (1995) · British Journal of Haematology · doi:10.1111/j.1365-2141.1995.tb05371.x · Cited by 93 · see citing works
Free radical-mediated platelet activation by hemoglobin released from red blood cells
Iuliano, L., Violi, F., Pedersen, J. Z., Praticò, D., Rotilio, G., & BALSANO, F. (1992) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(92)90267-z · Cited by 82 · see citing works
Shingu, M., NONAKA, S., Nishimukai, H., Nobunaga, M., Kitamura, H., & Tomooka, K. (1992) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.1992.tb05834.x · Cited by 77 · see citing works
Oxidative status of platelets in normal and thalassemic blood
Amer, J., & Fibach, E. (2004) · Thrombosis and Haemostasis · doi:10.1160/th04-04-0234 · Cited by 71 · see citing works
Amer, J., & Fibach, E. (2005) · British Journal of Haematology · doi:10.1111/j.1365-2141.2005.05463.x · Cited by 66 · see citing works
Molecular Genetics of Paroxysmal Nocturnal Hemoglobinuria
Inoue, N., Murakami, Y., & Kinoshita, T. (2003) · International Journal of Hematology · doi:10.1007/bf02983208 · Cited by 54 · see citing works
New insights into paroxysmal nocturnal hemoglobinuria
Rosse, W. F. (2001) · Current Opinion in Hematology · doi:10.1097/00062752-200103000-00001 · Cited by 47 · see citing works
Fujioka, S., & Yamada, T. (1994) · American Journal of Hematology · doi:10.1002/ajh.2830450205 · Cited by 31 · see citing works
Recent insights into the pathophysiology of paroxysmal nocturnal hemoglobinuria.
Meletis, J., & Terpos, E. (2003) · PubMed · Cited by 31 · see citing works
The Glycosylphosphatidylinositol Anchor and Paroxysmal Nocturnal Haemoglobinuria/Aplasia Model
Hall, C., Richards, S. J., & Hillmen, P. (2002) · Acta Haematologica · doi:10.1159/000065658 · Cited by 28 · see citing works
Ninomiya, H., Kawashima, Y., Hasegawa, Y., & Nagasawa, T. (1999) · British Journal of Haematology · doi:10.1046/j.1365-2141.1999.01483.x · Cited by 28 · see citing works
Paroxysmal Nocturnal Hemoglobinuria
Paudyal, B. P., Zimmerman, M., Karki, A., Neupane, H. C., & Kayastha, G. K. (2005) · Journal of Nepal Medical Association · doi:10.31729/jnma.425 · Cited by 28 · see citing works
Paroxysmal nocturnal hemoglobinuria: current issues in pathophysiology and treatment.
Young, N. S. (2005) · PubMed · Cited by 26 · see citing works
Paroxysmal nocturnal hemoglobinuria.
Smith, L. J. (2004) · PubMed · Cited by 17 · see citing works
Marsh, J. C. W., & Elebute, M. O. (2003) · Transfusion Medicine · doi:10.1111/j.1365-3148.2003.00465.x · Cited by 14 · see citing works
Filosa, A., Valgimigli, L., Pedulli, G. F., Sapone, A., Maggio, A., Renda, D., Scazzone, C., Malizia, R., Pitrolo, L., Pinto, C. L., et al. (2005) · British Journal of Haematology · doi:10.1111/j.1365-2141.2005.05734.x · Cited by 13 · see citing works
Oxidative status of valinomycin-resistant normal, β-thalassemia and sickle red blood cells
Amer, J., Etzion, Z., Bookchin, R. M., & Fibach, E. (2006) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2006.01.012 · Cited by 12 · see citing works
Biochemistry of PNH cells: nature of the membrane defect.
Mengel, C. E., Ebbert, L., Stickney, D. G., Essig, L. L., & Brubaker, L. (1972) · PubMed · Cited by 8 · see citing works
Moraleja, J. G., Pérez, P. R., Carro, J. C., García-Casasola, G., & Álvarez-Sala, J. L. (1994) · PubMed · Cited by 4 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- Walport MJ. Complement. First of two parts. N Engl J Med. 2001;344: 1058-1066.
- Blockmans D, Deckmyn H, Vermylen J. Platelet activation. Blood Rev. 1995;9:143-156.
Cited by
Sorted by citations
Vitamin C-Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination
Doseděl, M., Jirkovský, E., Macáková, K., Krčmová, L., Javorská, L., Pourová, J., Mercolini, L., Remião, F., Nováková, L., Mladěnka, P., et al. (2021) · Nutrients · doi:10.3390/nu13020615 · Cited by 553 · see citing works
Thrombosis in paroxysmal nocturnal hemoglobinuria
Hill, A., Kelly, R., & Hillmen, P. (2013) · Blood · doi:10.1182/blood-2012-09-311381 · Cited by 510 · see citing works
Oxidative stress, eryptosis and anemia: a pivotal mechanistic nexus in systemic diseases
Bissinger, R., Bhuyan, A. A. M., Qadri, S. M., & Lang, F. (2019) · The FEBS Journal · doi:10.1111/febs.14606 · Cited by 239 · see citing works
The Worst Things in Life are Free: The Role of Free Heme in Sickle Cell Disease
Gbotosho, O. T., Kapetanaki, M. G., & Kato, G. J. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.561917 · Cited by 117 · see citing works
Roh, H., Kim, A., Kim, N., Lee, Y., & Kim, D. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21239198 · Cited by 54 · see citing works
Ferraris, J. R., Ferraris, V., Acquier, A. B., Sorroche, P. B., Saez, M. S., Ginaca, A., & Méndez, C. F. (2015) · Clinical & Experimental Immunology · doi:10.1111/cei.12601 · Cited by 47 · see citing works
The prothrombotic state in paroxysmal nocturnal hemoglobinuria: a multifaceted source
Peacock‐Young, B., Macrae, F. L., Newton, D. J., Hill, A., & Ariëns, R. A. S. (2017) · Haematologica · doi:10.3324/haematol.2017.177618 · Cited by 46 · see citing works
Arruda, M. M. D. A. S., Mecabô, G., Rodrigues, C. A., Matsuda, S. S., Rabelo, I. B., & Figueiredo, M. S. (2012) · British Journal of Haematology · doi:10.1111/bjh.12185 · Cited by 44 · see citing works
α-Tocopheryl phosphate: Uptake, hydrolysis, and antioxidant action in cultured cells and mouse
Nishio, K., Ishida, N., Saito, Y., Ogawa, Y., Shichiri, M., Yoshida, Y., Hagihara, Y., Noguchi, N., Chirico, J., Atkinson, J., et al. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.03.021 · Cited by 37 · see citing works
Thrombosis in Paroxysmal Nocturnal Hemoglobinuria (PNH): From Pathogenesis to Treatment
Kokoris, S. I., Polyviou, A., Evangelidis, P., Grouzi, E., Valsami, S. I., Tragiannidis, K., Gialeraki, A. E., Tsakiris, D. A., & Gavriilaki, E. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252212104 · Cited by 30 · see citing works
Potential utility of melatonin as an antioxidant therapy in the management of sickle cell anemia
da Silva, D. G. H., Ricci, O., de Almeida, E. A., & Bonini-Domingos, C. R. (2014) · Journal of Pineal Research · doi:10.1111/jpi.12204 · Cited by 29 · see citing works
The Redox Balance and Membrane Shedding in RBC Production, Maturation, and Senescence
Fibach, E. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.604738 · Cited by 28 · see citing works
Mimura, E. C. M., Favoreto, J. P. M., Fávero, M. E., Bonifácio, K. L., Peixe, T. S., Morita, A. A., Barbosa, D. S., Yabe, M. J. S., & Carrilho, A. J. F. (2019) · Burns · doi:10.1016/j.burns.2019.11.012 · Cited by 25 · see citing works
Basu, S., Banerjee, D., Ghosh, M., & Chakrabarti, A. (2010) · Hematology · doi:10.1179/102453309x12583347114095 · Cited by 21 · see citing works
Sakamoto, T. M., Canalli, A. A., Traina, F., Franco‐Penteado, C. F., Gambero, S., Saad, S. T. O., Conran, N., & Costa, F. F. (2013) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2013.09.011 · Cited by 20 · see citing works
Ghoti, H., Rosenbaum, H., Fibach, E., & Rachmilewitz, E. A. (2009) · Annals of Hematology · doi:10.1007/s00277-009-0821-8 · Cited by 20 · see citing works
The plasma membrane redox system in human platelet functions and platelet-leukocyte interactions
Frega, G., Savini, I., Catani, V., Rossi, A., Avigliano, L., & Principe, D. D. (2009) · Thrombosis and Haemostasis · doi:10.1160/th08-05-0300 · Cited by 19 · see citing works
Fibach, E., & Dana, M. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.04.027 · Cited by 18 · see citing works
Freikman, I., Amer, J., Ringel, I., & Fibach, E. (2009) · Analytical Biochemistry · doi:10.1016/j.ab.2009.06.011 · Cited by 18 · see citing works
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Woolcock, A. D., Serpa, P. B. S., dos Santos, A. P., Christian, J. A., & Moore, G. E. (2020) · Journal of Veterinary Internal Medicine · doi:10.1111/jvim.15926 · Cited by 18 · see citing works
A mouse model to study thrombotic complications of thalassemia
Kalish, Y., Malyutin, Z., Shai, E., Dana, M., Avraham, L., Jahshan, N., Rachmilewitz, E. A., Fibach, E., & Varon, D. (2015) · Thrombosis Research · doi:10.1016/j.thromres.2014.12.023 · Cited by 16 · see citing works
Vallejo, F., Yuste, J. E., Teruel‐Montoya, R., Luengo‐Gil, G., Bohdan, N., Espín, S., García‐Barberá, N., Martı́nez, C., Vicente, V., Espı́n, J. C., et al. (2019) · Thrombosis Research · doi:10.1016/j.thromres.2019.10.001 · Cited by 16 · see citing works
Sharma, S., Zingde, S. M., & Gokhale, S. M. (2013) · The Journal of Membrane Biology · doi:10.1007/s00232-013-9569-0 · Cited by 12 · see citing works
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Amer, J., Frankenburg, S., & Fibach, E. (2009) · Therapeutic Apheresis and Dialysis · doi:10.1111/j.1744-9987.2009.00746.x · Cited by 10 · see citing works
Chiou, E., & Zennadi, R. (2015) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2015.05.013 · Cited by 10 · see citing works
Effect of osmotic shock and urea on phosphatidylserine scrambling in thrombocyte cell membranes
Gatidis, S., Borst, O., Föller, M., & Lang, F. J. W. (2010) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00477.2009 · Cited by 9 · see citing works
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Fibach, E., & Rachmilewitz, E. A. (2015) · Radiation Research · doi:10.1667/rr14000.1 · Cited by 8 · see citing works
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Fibach, E. (2014) · Springer eBooks · doi:10.1007/978-3-642-30018-9_95 · Cited by 7 · see citing works
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Guerrero‐Hue, M., Rubio‐Navarro, A., Sevillano, Á., Yuste, C., Gutiérrez, E., Palomino‐Antolín, A., de Román, E. M., Praga, M., Egido, J., & Moreno, J. A. (2018) · Nefrología (English Edition) · doi:10.1016/j.nefroe.2018.01.003 · Cited by 7 · see citing works
α-Tocopheryl Phosphate as a Bioactive Derivative of Vitamin E: A Review of the Literature
Ghayour‐Mobarhan, M., Zahra, S., Ferns, G. A., & Sahebkar, A. (2014) · Journal of Dietary Supplements · doi:10.3109/19390211.2014.952859 · Cited by 7 · see citing works
Protein Susceptibility to Peroxidation by 4-Hydroxynonenal in Hereditary Hemochromatosis
Sánchez-Jaut, S., Pérez-Benavente, S., Abad, P., Méndez-Cuadro, D., Puyet, A., Díez, A., Galicia‐Poblet, G., Domínguez, E. G., Morán‐Jiménez, M., Bautista, J. M., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032922 · Cited by 5 · see citing works
Glutathione metabolism of erythrocytes in the paroxysmal nocturnal hemoglobinuria
Alexandrova, L. A., Mironova, J. A., Agafonova, U. I., Филиппова, Н. А., & Трофимов, В. И. (2015) · Regional blood circulation and microcirculation · doi:10.24884/1682-6655-2015-14-4-60-65 · Cited by 5 · see citing works
Case Report: Paroxysmal nocturnal hemoglobinuria in a woman heterozygous for G6PD A-
Perdigones, N., Morales, M., Mason, P. J., & Bessler, M. (2014) · F1000Research · doi:10.12688/f1000research.4980.1 · Cited by 4 · see citing works
Eisa, M. S., Mohamed, S., Ibrahim, F. A., Shariff, M., Sadik, N. D., Nashwan, A. J., & Yassin, M. A. (2019) · Case Reports in Oncology · doi:10.1159/000503817 · Cited by 4 · see citing works
Woolcock, A. D., Serpa, P. B. S., dos Santos, A. P., Christian, J. A., & Moore, G. E. (2021) · American Journal of Veterinary Research · doi:10.2460/ajvr.82.5.343 · Cited by 3 · see citing works
Sica, M., Pellecchia, A., Angioletti, M. D., Caocci, G., Nannelli, C., Nasa, G. L., Luzzatto, L., & Notaro, R. (2020) · Blood · doi:10.1182/blood.2020007780 · Cited by 2 · see citing works
Neeekantappa, V. M., Kamath, A., & Rajaduraivelpandian, P. B. (2024) · Medicina · doi:10.3390/medicina60030379 · Cited by 2 · see citing works
Mandibular osteomyelitis associated with paroxysmal nocturnal hemoglobinuria
Kharazmi, M., Carlson, K., Björnstad, L., Petersson, A. R., & Warfvinge, G. (2011) · International Journal of Oral and Maxillofacial Surgery · doi:10.1016/j.ijom.2011.06.016 · Cited by 2 · see citing works
Das, M., Mondal, S., Ghosh, R., Roy, L., Das, A. K., Bhattacharya, S. S., Pal, D., Bhattacharya, D., Chakrabarti, P., Mallick, A. K., et al. (2024) · ChemMedChem · doi:10.1002/cmdc.202400698 · Cited by 1 · see citing works
Kao, Y.-F., dos Santos, A. P., Serpa, P. B. S., Moore, G. E., & Woolcock, A. D. (2025) · American Journal of Veterinary Research · doi:10.2460/ajvr.24.09.0273 · Cited by 1 · see citing works
Phosphatidylserine Shedding from RBCs – A Mechanism of Membrane Modulation and Damage Control
Fibach, E. (2012) · InTech eBooks · doi:10.5772/30575
Ninomiya, H., & Hill, A. (2017) · Springer eBooks · doi:10.1007/978-4-431-56003-6_9
- Authors
- Amer, J., Zelig, O., & Fibach, E.
- Affiliations
- Hadassah Medical Center (IL)
- Hebrew University of Jerusalem (IL)
- Corresponding author
- Fibach, Eitan
- Venue
- Experimental Hematology
- Publisher
- Elsevier BV
- Published
- 2008-04
- Volume
- 36
- Issue
- 4
- Pages
- 369-377
- ISSN
- 0301-472X (ISSN-L)
- OpenAlex
- W2036760054
- Cited by
- 44
- References
- 40
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 1 · 2021: 4 · 2020: 3 · 2019: 3 · 2018: 2 · 2017: 3 · 2015: 6 · 2014: 4 · 2013: 4 · 2012: 2
- FWCI
- 1.11
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Experimental Hematology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Complement system in diseases
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Physiology › Erythrocyte Function and Pathophysiology
- Keywords
- paroxysmal nocturnal hemoglobinuria, oxidative stress, erythrocytes, neutrophils, platelets, CD55, CD59, complement-mediated hemolysis, reactive oxygen species, lipid peroxidation, phosphatidylserine, reduced glutathione, antioxidants, platelet activation, thrombosis
- MeSH terms
- Acetylcysteine, Anemia, Antioxidants, Ascorbic Acid, Blood Platelets, Erythrocytes, Female, Flow Cytometry, Hemoglobinuria, Paroxysmal, Humans, Hydrogen Peroxide, Male, Neutrophils, Reference Values, Thrombosis, Biomarkers, Oxidants, Oxidative Stress, Tocopherols
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