The DOI matches its Crossref record; 93 of the 93 references it cites were found in a registry or an index.
Multipotent mesenchymal stromal cells obtained from diverse human tissues share functional properties and gene-expression profile with CD146(+) perivascular cells and fibroblasts
Open accessAbstract
Objective The relationship of multipotent mesenchymal stromal cells (MSC) with pericytes and fibroblasts has not been established thus far, although they share many markers of primitive marrow stromal cells and the osteogenic, adipogenic, and chondrogenic differentiation potentials.Materials and methods We compared MSCs from adult or fetal tissues, MSC differentiated in vitro, fibroblasts and cultures of retinal pericytes obtained either by separation with anti-CD146 or adhesion. The characterizations included morphological, immunophenotypic, gene-expression profile, and differentiation potential.Results Osteogenic, adipocytic, and chondrocytic differentiation was demonstrated for MSC, retinal perivascular cells, and fibroblasts. Cell morphology and the phenotypes defined by 22 markers were very similar. Analysis of the global gene expression obtained by serial analysis of gene expression for 17 libraries and by reverse transcription polymerase chain reaction of 39 selected genes from 31 different cell cultures, revealed similarities among MSC, retinal perivascular cells, and hepatic stellate cells. Despite this overall similarity, there was a heterogeneous expression of genes related to angiogenesis, in MSC derived from veins, artery, perivascular cells, and fibroblasts. Evaluation of typical pericyte and MSC transcripts, such as NG2, CD146, CD271, and CD140B on CD146 selected perivascular cells and MSC by real-time polymerase chain reaction confirm the relationship between these two cell types. Furthermore, the inverse correlation between fibroblast-specific protein-1 and CD146 transcripts observed on pericytes, MSC, and fibroblasts highlight their potential use as markers of this differentiation pathway.Conclusion Our results indicate that human MSC and pericytes are similar cells located in the wall of the vasculature, where they function as cell sources for repair and tissue maintenance, whereas fibroblasts are more differentiated cells with more restricted differentiation potential.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
A new mathematical model for relative quantification in real-time RT-PCR
Pfaffl, M. W. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.9.e45 · Cited by 34,610
THE USE OF LEAD CITRATE AT HIGH pH AS AN ELECTRON-OPAQUE STAIN IN ELECTRON MICROSCOPY
Reynolds, E. S. (1963) · The Journal of Cell Biology · doi:10.1083/jcb.17.1.208 · Cited by 24,938
Cluster analysis and display of genome-wide expression patterns
Eisen, M. B., Spellman, P. T., Brown, P. O., & Botstein, D. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.25.14863 · Cited by 16,184
Jaffe, E. A., Nachman, R., Becker, C. G., & Minick, C. (1973) · Journal of Clinical Investigation · doi:10.1172/jci107470 · Cited by 7,146
Marrow Stromal Cells as Stem Cells for Nonhematopoietic Tissues
Prockop, D. J. (1997) · Science · doi:10.1126/science.276.5309.71 · Cited by 4,629
Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo
Gronthos, S., Mankani, M. H., Brahim, J. S., Robey, P. G., & Shi, S. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.240309797 · Cited by 4,580
Open source clustering software
de Hoon, M., Imoto, S., Nolan, J., & Miyano, S. (2004) · Bioinformatics · doi:10.1093/bioinformatics/bth078 · Cited by 3,047
Epithelial-mesenchymal transition and its implications for fibrosis
Kalluri, R., & Neilson, E. G. (2003) · Journal of Clinical Investigation · doi:10.1172/jci20530 · Cited by 2,715
Molecular regulation of angiogenesis and lymphangiogenesis
Adams, R. H., & Alitalo, K. K. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2183 · Cited by 2,086
Horwitz, E. M., Blanc, K. L., Dominici, M., Mueller, I., Slaper‐Cortenbach, I., Marini, F. C., Deans, R. J., Krause, D. S., & Keating, A. (2005) · Cytotherapy · doi:10.1080/14653240500319234 · Cited by 2,071
Cited by
Sorted by citations
Items 401–500 of 610
Stem cells for tissue engineered vascular bypass grafts
Askari, F., Solouk, A., Shafieian, M., & Seifalian, A. M. (2016) · Artificial Cells Nanomedicine and Biotechnology · doi:10.1080/21691401.2016.1198366 · Cited by 10
“Pericytes have recently been recognized as distinct cellular entities that have the ability to yield MSCs in culture, which mirrors the broad developmental potential of pericytes (Covas et al. 2008, Murray et al. 2014).”
BackgroundKwiecień, E., Kot, M., Czyz, L., Drabik, L., Mazurek, A., Sikorska, M., Skubera, M., Tekieli, Ł. M., Majka, M., & Musiałek, P. (2025) · Current Cardiology Reviews · doi:10.2174/011573403x372908250117092252 · Cited by 9
“With their high plasticity, high proliferation capacity, and absence of tumorigenic potential, WJMSCs are today a particularly promising tool for the next-generation cardiovascular regenerative approaches [62, 70, 77, 78].”
Virotherapy as Potential Adjunct Therapy for Graft-Vs-Host Disease
Villa, N., & McFadden, G. (2018) · Current Pathobiology Reports · doi:10.1007/s40139-018-0186-6 · Cited by 9
Comparative Analysis of Human Adipose-Derived Stromal/Stem Cells and Dermal Fibroblasts
Zanata, F. C., Curley, L., Martin, E. C., Bowles, A. C., Bunnell, B. A., Wu, X., Ferreira, L. M., & Gimble, J. M. (2021) · Stem Cells and Development · doi:10.1089/scd.2021.0164 · Cited by 9
“Consequently, fibroblasts, MSCs, and pericytes may be related cells present within the vascular wall, constituting an MSC compartment that extends throughout the entire organism [5].”
InfluentialAdult Stem and Progenitor Cells
Geraerts, M., & Verfaillie, C. M. (2009) · Springer eBooks · doi:10.1007/10_2008_21 · Cited by 9
Shi, Q. S., Cox, L. A., Hodara, V. L., Wang, X. L., & VandeBerg, J. L. (2011) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2011.01501.x · Cited by 9
Current view of mesenchymal stem cells biology (brief review)
Maslova, O. (2012) · Biopolymers and Cell · doi:10.7124/bc.00004c · Cited by 9
Amend, B., Vaegler, M., Fuchs, K., Mannheim, J. G., Will, S., Krämer, U., Hart, M. L., Feitz, W., Chapple, C. R., Stenzl, A., et al. (2015) · Cell Transplantation · doi:10.3727/096368915x686229 · Cited by 9
“Possible candidates are multipotent MSCs abundantly available from bone marrow (BM-MSCs) (12,28,79,104), AT-MSCs (84,111,112), or other sources (18,19).”
BackgroundStem Cell Considerations for the Clinician
Hasty, K. A., & Cho, H. (2016) · Physical Medicine and Rehabilitation Clinics of North America · doi:10.1016/j.pmr.2016.06.004 · Cited by 9
“Another report observed that the MSC population derived from veins, artery, perivascular cells, and fibroblasts showed similarity of cell morphology and phenotypes established with 22 markers with heterogeneous expression of genes related to angiogenesis (8).”
BackgroundIsolation, culture, and characterization of chicken lung-derived mesenchymal stem cells.
Wang, X., C, F. H., Wang, J. J., Ji, H., Guan, W., & Zhao, Y. (2018) · Europe PMC (PubMed Central) · Cited by 9
Root, Z. D., Gould, C., Brewer, M., Jandzík, D., & Medeiros, D. M. (2021) · Diversity · doi:10.3390/d13090435 · Cited by 11
Pignatti, E., Maccaferri, M., Pisciotta, A., Carnevale, G., & Salvarani, C. (2024) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2023.2299729 · Cited by 10
Sibov, T. T., Pavon, L. F., de Oliveira, D. M., Marti, L. C., Guilhen, D. D., Amaro, E., & Gamarra, L. F. (2010) · Cellular Reprogramming · doi:10.1089/cell.2009.0087 · Cited by 8
“CD146 is involved in a cell-to-cell junction, and it is present in primitive MSCs (Bardin et al., 2001; Covas et al., 2008; Shi and Gronthos, 2003; Yoshimura et al., 2006).”
Andreeva, E. R., Andrianova, I. V., Sotnezova, E. V., Gornostaeva, A. N., Khorkova, S., & Buravkova, L. B. (2018) · Journal of Bioscience and Bioengineering · doi:10.1016/j.jbiosc.2018.10.017 · Cited by 8
Kim, K. H., Kim, Y. M., Lee, M. J., Ko, H., Kim, M.-B., & Kim, J. H. (2012) · Experimental & Molecular Medicine · doi:10.3858/emm.2012.44.2.011 · Cited by 8
Characterization of mesenchymal progenitor cell populations from non‐epithelial oral mucosa
Matsumura, S., Higa, K., Igarashi, T., Takaichi, S., Tonogi, M., Shinozaki, N., Shimazaki, J., & Yamane, G. (2014) · Oral Diseases · doi:10.1111/odi.12288 · Cited by 8
CD146/MCAM Surface Marker for Identifying Human Periodontal Ligament-derived Mesenchymal Stem Cells
Saitō, Y., Watanabe, E., Mayahara, K., Watanabe, N., Morokuma, M., Isokawa, K., Shimizu, N., & Honda, M. J. (2013) · Journal of Hard Tissue Biology · doi:10.2485/jhtb.22.115 · Cited by 8
Wittig, D., Jászai, J., Corbeil, D., & Funk, R. H. W. (2013) · Cells Tissues Organs · doi:10.1159/000346661 · Cited by 8
“Interestingly, its expression has been linked to multipotency [Sacchetti et al., 2007; Covas et al., 2008; Crisan et al., 2008; Sorrentino et al., 2008; Tormin et al., 2011].”
BackgroundInfluentialOstrakhovitch, E. A., Akakura, S., Sanokawa‐Akakura, R., & TABIBZADEH, S. S. (2019) · Experimental Cell Research · doi:10.1016/j.yexcr.2019.111683 · Cited by 8
Adult Dermal Stem Cells for Scaffold-Free Cartilage Tissue Engineering: Exploration of Strategies
Vapniarsky, N., Kwon, H., Paschos, N. K., Haudenschild, A. K., Brown, W. E., DuRaine, G. D., Hu, J. C. Y., & Athanasiou, K. A. (2020) · Tissue Engineering Part C Methods · doi:10.1089/ten.tec.2020.0207 · Cited by 8
“A high percentage of hDIAS cells expressed CD146, a surface glycoprotein, which, although not considered a classical MSC marker, has been observed on MSCs and pericytes.(31) Therefore, it is plausible for the hDIAS cells to be associated with the perivascular niche due to CD146 expression.”
Miyauchi, J. (2024) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2024.104382 · Cited by 7
Stockwin, L. H. (2020) · PeerJ · doi:10.7717/peerj.9394 · Cited by 7
Bahrawy, M. A. (2021) · Stem Cells International · doi:10.1155/2021/5583421 · Cited by 7
“Comparing the 3 cells genetically, they concluded that the gene expression pattern of MSC is similar to pericytes and stellate hepatic cells, not fibroblast which showed the gene expression pattern of myofibroblasts and smooth muscle cells [14].”
BackgroundSarangthem, V., Sharma, H., Mendiratta, M., Sahoo, R., Park, R., Kumar, L., Singh, T. D., & Mohanty, S. (2022) · Biomedicines · doi:10.3390/biomedicines10051151 · Cited by 7
Characterization of deciduous teeth stem cells isolated from crown dental pulp
Debeljak-Martačić, J., Andrić, J. F., Božinovski, T. L., Vukovic, N., Mojsilović, S. B., Drndarević, N., Petakov, M., Glibetić, M., Marković, D., Radovanović, A., et al. (2014) · Vojnosanitetski pregled · doi:10.2298/vsp1408735d · Cited by 7
Gentile, A., Toietta, G., Pazzano, V., Tsiopoulos, V., Giglio, A. F., Crea, F., Pompilio, G., Capogrossi, M. C., & Rocco, G. D. (2011) · Molecular Biology of the Cell · doi:10.1091/mbc.e10-06-0537 · Cited by 7
“In this regard, it is interesting to note that, as only recently emphasized, MSCs, fibroblasts , and pericytes share many phenotypical markers (Covas et al., 2008) and are probably considered variations of a unique phenotype (Bianco et al., 2008; da Silva Meirelles et al., 2008; Haniffa et al.,…”
Origin and Regenerative Potential of Vertebrate Mechanoreceptor-Associated Stem Cells
Widera, D., Hauser, S., Kaltschmidt, C., & Kaltschmidt, B. (2012) · Anatomy Research International · doi:10.1155/2012/837626 · Cited by 7
“Concerning their morphological and immunocytochemical properties, as well as the expression profile, MSCs show high degree of similarity to fibroblasts, making them nearly indistinguishable in vivo [68–71].”
Background[Localization and functions of mesenchymal stromal cells in vivo].
Payushina, V. (2015) · PubMed · Cited by 7
Tarusin, D. N., Kireev, V. A., Kovalenko, S. Y., Kovalenko, I., Rozanov, L. F., & Petrenko, A. Y. (2016) · Problems of Cryobiology and Cryomedicine · doi:10.15407/cryo26.02.133 · Cited by 7
Biological Augmentation of Anterior Cruciate Ligament Grafts
Takayama, K., & Kuroda, R. (2017) · Operative Techniques in Orthopaedics · doi:10.1053/j.oto.2017.01.007 · Cited by 8
Pericytes in the Umbilical Cord
Gauthier-Fisher, A., Száraz, P., & Librach, C. L. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-11093-2_12 · Cited by 7
Bergeron, L., Busuttil, V., & Botto, J.-M. (2019) · International Journal of Cosmetic Science · doi:10.1111/ics.12587 · Cited by 7
“Further publications revealed that a perivascular niche containing precursors feeds other tissues such as skeletal muscle [22], retina [23], kidney [24] and bone marrow [25]; using FACS technology, the authors hypothesized and confirmed that perivascular cells are at the origin of non-follicular SKPs.”
BackgroundVolinsky, E., Hailu, A., Cohen, N., Adani, B., Faroja, M., Grunewald, M., & Gorodetsky, R. (2020) · Stem Cell Research & Therapy · doi:10.1186/s13287-020-01850-0 · Cited by 7
“Mesenchymal stromal cells (MSCs) isolated from different tissues, primarily from the bone marrow, have raised interest in the field of regenerative medicine in the last decades [6–8].”
InfluentialPericytes: a Ubiquitous Source of Multipotent Adult Tissue Stem Cells
Zimmerlin, L., Park, T. S., Donnenberg, V. S., Zambidis, E. T., & Donnenberg, A. D. (2014) · Springer eBooks · doi:10.1007/978-3-642-45207-9_9 · Cited by 7
Adipose-Derived Stem Cells: Characterization and Application in Urology
Lin, C., & Lue, T. F. (2011) · Springer eBooks · doi:10.1007/978-3-642-20012-0_18 · Cited by 7
“The vascular connection appears to apply to other types of mesenchymal stem cells (MSC) as well, including bone marrow stem cells (BMSC) [2, 9, 20 , 22, 92].”
BackgroundMiyaki, L. A. M., Sibov, T. T., Pavon, L. F., Mamani, J. B., & Gamarra, L. F. (2012) · Einstein (São Paulo) · doi:10.1590/s1679-45082012000200012 · Cited by 7
“However, there are studies showing that MSCs from the wall of human umbilical cord (WHUC) have morphological features, immunophenotypes and the ability to differentiate in cell from mesodermal lineages, similar to MSCs from BM(2,4,12-14).”
BackgroundLocalization and functions of mesenchymal stromal cells in vivo
Payushina, O. V. (2016) · Biology Bulletin Reviews · doi:10.1134/s2079086416010059 · Cited by 7
“…periosteum (Ghilzon et al., 1999), cartilaginous primordia of bones (Mir malek Sani et al., 2006), skin dermis and muscle fas cia (Covas et al., 2008), heart (Srikanth et al., 2013), lung (Anker et al., 2003), kidney (Lai et al., 2010a), pancreas (Hu et al., 2003), and testes (Covas et al., 2008).”
BackgroundInfluentialSaleh, M., Shamsasenjan, K., Movassaghpour, A. A., Akbarzadehlaleh, P., & Molaeipour, Z. (2017) · PubMed Central · doi:10.22074/cellj.2016.4133 · Cited by 7
“It is commonly thought that BMMSCs do not express hematopoietic cell markers CD14 and CD34 (3, 6-9).”
BackgroundUnraveling the role of cancer-associated fibroblasts in B cell lymphoma
Mukherjee, P., Ansell, S. M., & Mondello, P. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1451791 · Cited by 6
Yuan, Y., & Liu, T. (2024) · Experimental Cell Research · doi:10.1016/j.yexcr.2024.114263 · Cited by 6
Lutz, J. B. K. (2014) · Journal of Tissue Science & Engineering · doi:10.4172/2157-7552.1000135 · Cited by 6
“However, it became clear that Mesenchymal Stem/Stromal Cells (MSC)1, also residing for instance in bone marrow, could not be sufficiently defined this way since they i) are detected in and isolated from many different types of tissues [1], ii) MSC share many cellular and molecular characteristics with other mesenchyma…”
BackgroundThongprasom, K. (2017) · Acta Stomatologica Croatica · doi:10.15644/asc51/3/8 · Cited by 6
“CD146+ cells have been shown to be mesenchymal stromal cells capable of multilineage differentiation (28-30).”
BackgroundEpigenetic mechanisms driving lineage commitment in mesenchymal stem cells
Yianni, V., & Sharpe, P. T. (2020) · Bone · doi:10.1016/j.bone.2020.115309 · Cited by 6
de Souza, L. E. B., de Almeida, D. C., Yaochite, J. N. U., Covas, D. T., & Fontes, A. M. (2015) · Experimental Cell Research · doi:10.1016/j.yexcr.2015.05.021 · Cited by 6
“The adipogenic and osteogenic potential of BM-MSCs were tested after culture in specific differentiation inductive medium as previously described [18].”
MethodSelf-citationQuesada, B. A. O., Chauvin, C., Martin, E. C., & Melvin, A. T. (2025) · Lab on a Chip · doi:10.1039/d5lc00320b · Cited by 5
Mora, A., Girolamo, F., Marzullo, A., Annese, T., Giorgis, M. D., Signorelli, F., Messina, R., Ingravallo, G., Virgintino, D., Errede, M., et al. (2025) · Fluids and Barriers of the CNS · doi:10.1186/s12987-025-00707-z · Cited by 5
Mohammed, R. N., Aziz, S. A., Hassan, S. M. A., Mohammed, H. F., & Ramzi, D. O. M. (2023) · Journal of Burn Care & Research · doi:10.1093/jbcr/irad080 · Cited by 5
Rikitake, K., Kunimatsu, R., Yoshimi, Y., & Tanimoto, K. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26030974 · Cited by 5
“Some researchers have proposed that pericytes may be the origin of MSCs, with CD146 + MSCs exhibiting properties closely resembling those of pericytes [25–27].”
Challenges in Mesenchymal Stromal Cell-based Therapies
Kavianpour, M., Meirelles, L. D. S., & Ahmadbeigi, N. (2022) · Current Stem Cell Research & Therapy · doi:10.2174/1574888x17666220831104747 · Cited by 5
Bispo, E. C. I., Argañaraz, E. R., Neves, F. D. A. R., Carvalho, J. L., & Saldanha‐Araújo, F. (2024) · Scientific Reports · doi:10.1038/s41598-024-75776-5 · Cited by 6
Multipotential Mesenchymal Stromal/Stem Cells in Skeletal Tissue Repair
Arthur, A., Zannettino, A. C. W., & Gronthos, S. (2013) · CRC Press eBooks · doi:10.1201/b14590-7 · Cited by 5
Takada, M., Suzuki, M., Haga‐Tsujimura, M., & Shinkai, K. (2016) · Odontology · doi:10.1007/s10266-016-0278-x · Cited by 5
“[50] reported that CD146 has been used as a marker of mesenchymal stem cells isolated from multiple adult and fetal organs.”
BackgroundRationale for the Use of Orthobiologics in Sports Medicine
Makaram, N. S., Safran, M. R., Abrams, G. D., Sherman, S. L., & Murray, I. R. (2020) · Operative Techniques in Sports Medicine · doi:10.1016/j.otsm.2020.150753 · Cited by 5
Growth characteristics and expression of CD 73 and CD 146 in cells cultured from dental pulp
Sivasankar, V., & Ranganathan, K. (2015) · Journal of Investigative and Clinical Dentistry · doi:10.1111/jicd.12155 · Cited by 5
Allogeneic stem cell transplantation for ischemic myocardial dysfunction
Ting, A. E., & Sherman, W. (2012) · Current Opinion in Organ Transplantation · doi:10.1097/mot.0b013e32835a66a1 · Cited by 5
“MSCs, sometimes referred to as mesenchymal stromal cells, are an adult cell derived from bone marrow but that has also been isolated from other tissues including adipose, placenta, and umbilical cord [18,19].”
BackgroundTian, L., Wang, Y., Shen, L., Zong, M., Fan, J., Lu, Y., Cheng, X., Du, L., Zhang, L., & Xiao, F. (2025) · Stem Cell Research & Therapy · doi:10.1186/s13287-025-04695-7 · Cited by 4
“CD146 is a mesenchymal marker of MSCs [26–28 , 35 ].”
Mikšiūnas, R., Labeit, S., & Bironaitė, D. (2022) · Cells · doi:10.3390/cells11203209 · Cited by 5
“The CD146 was also detected on skeletal muscle progenitor cells (SMPC) derived from pluripotent stem cells (PSCs) [45] and was shown to be associated with multipotency of MSCs and a greater differential potential [46,47].”
BackgroundFunctional fingerprinting of human mesenchymal stem cells using high-throughput RNAi screening
Erdmann, G., Suchánek, M., Horn, P., Graf, F., Volz, C. H., Horn, T., Zhang, X., Wagner, W., Ho, A., & Boutros, M. (2015) · Genome Medicine · doi:10.1186/s13073-015-0170-2 · Cited by 4
“This supports the notion that MSCs are actually different from fibroblasts [12, 41, 42].”
BackgroundCaplan, A. I. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-381422-7.10014-8 · Cited by 4
Yağcı, B. G., & Çelebi‐Saltik, B. (2017) · Cell and Tissue Banking · doi:10.1007/s10561-017-9656-z · Cited by 4
Ferreira-Silva, V., Primo, F. L., Baqui, M. M. A., Magalhães, D. A., Orellana, M. D., Castilho–Fernandes, A., Cruz, M. C., Câmara, N. O. S., Covas, D. T., & Tedesco, A. C. (2018) · Stem Cell Reviews and Reports · doi:10.1007/s12015-017-9796-3 · Cited by 4
Self-citationHein, R. F. C., Okarski, K. M., & Szivek, J. A. (2018) · Journal of Investigative Surgery · doi:10.1080/08941939.2017.1423420 · Cited by 4
Zeb2: A novel regulator of cardiac fibroblast to myofibroblast transition
Jahan, F., Rattan, S. G., Dixon, I., & Wigle, J. T. (2015) · The FASEB Journal · doi:10.1096/fasebj.29.1_supplement.556.1 · Cited by 4
Searching for In Vivo Traces of Mesenchymal Stem Cells and Their Ancestors
Can, A. (2012) · Humana Press eBooks · doi:10.1007/978-1-61779-630-2_2 · Cited by 4
Bone Marrow Mesenchymal Stem Cells
Shi, S., & Gronthos, S. (2013) · doi:10.1002/9781118498026.ch11 · Cited by 4
Sawicki, S., Bugno‐Poniewierska, M., Żurowski, J., Szmatoła, T., Semik‐Gurgul, E., Bochenek, M., Karnas, E., & Gurgul, A. (2025) · Genes · doi:10.3390/genes16080936 · Cited by 3
“In 2008, Covas et al. [73] found that MSCs, pericytes, and fibroblasts exhibited a similar gene expression pattern, but their immunophenotype and differentiation experiments led to the conclusion that fibroblasts are differentiated cells with limited differentiation potential.”
Cho, I. S., Yaghmour, A., Joshi, A., Gupta, P., Sanborn, M. A., Zappia, M. P., Wong, S. W., Cheng, G., Frolov, M. V., Rehman, J., et al. (2025) · Advanced Materials · doi:10.1002/adma.202504590 · Cited by 4
Basu, J., Genheimer, C. W., Guthrie, K., Sangha, N., Quinlan, S. F., Bruce, A. T., Reavis, B., Halberstadt, C. R., Ilagan, R. M., & Ludlow, J. W. (2011) · Tissue Engineering Part C Methods · doi:10.1089/ten.tea.2010.0697 · Cited by 3
Cremona, M., Rusconi, G., Ferrario, A., Mariotta, L., Gola, M., & Soldati, G. (2023) · Biomedicines · doi:10.3390/biomedicines11092533 · Cited by 7
Qubi, W., Zheng, J., Wang, Y., Xu, G., Li, Y., Xiong, Y., Wang, Y., Liu, W., & Lin, Y. (2023) · Genes · doi:10.3390/genes15010057 · Cited by 3
“Subse-quently, in the terminal differentiation stage, precursor adipocytes gradually differentiate into mature adipocytes with lipid droplets accumulation [11].”
BackgroundFetal and Adult Leydig Cells Are of Common Orig
Davidoff, M. S., Middendorff, R., Müller, D., & Holstein, A. F. (2009) · Advances in anatomy, embryology and cell biology · doi:10.1007/978-3-642-00513-8_8 · Cited by 3
Participation of Mesenchymal Stromal Cells in Muscle Tissue Regeneration
Payushina, O. V., Domaratskaya, E. I., & Шевелева, О. Н. (2019) · Biology Bulletin Reviews · doi:10.1134/s2079086419050062 · Cited by 3
Барсуков, А. В., Shcherbakova, K. A., Maltsev, D. S., Burnasheva, M. A., & Kulikov, A. N. (2020) · Arterial’naya Gipertenziya (Arterial Hypertension) · doi:10.18705/1607-419x-2020-26-4-410-420 · Cited by 3
Toland, G., Makaram, N. S., Atzmon, R., Donohue, J. P., & Murray, I. R. (2023) · Orthopaedics and Trauma · doi:10.1016/j.mporth.2023.03.002 · Cited by 3
Aghazadeh, S., Peng, Q., Dardmeh, F., Hjortdal, J., Zachar, V., & Alipour, H. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25168684 · Cited by 3
“Different gene expression profiles can result in different phenotypical and functional properties [41,45–48].”
BackgroundRossetti, R., Rós, F. A., de Souza, L. E. B., Maçonetto, J. D. M., da Costa, P. N. M., Ferreira, F. U., Borges, J. S., de Carvalho, J. V., Morotti, N. P., Kashima, S. H., et al. (2020) · Experimental Cell Research · doi:10.1016/j.yexcr.2020.112434 · Cited by 4
Self-citationKordes, C., Sawitza, I., Götze, S., & Häussinger, D. (2015) · Digestive Diseases · doi:10.1159/000371673 · Cited by 3
Cell transplantation therapy for diabetes mellitus: endocrine pancreas and adipocyte [Review]
Fujikura, J., Hosoda, K., & Nakao, K. (2013) · Endocrine Journal · doi:10.1507/endocrj.ej13-0162 · Cited by 3
Isolation of CD146+ Resident Lung Mesenchymal Stromal Cells from Rat Lungs
Collins, J. J. P., Möbius, M. A., & Thébaud, B. (2016) · Journal of Visualized Experiments · doi:10.3791/53782 · Cited by 3
Mesenchymal Stem Cells: An Optimistic Cell Source in Tissue Engineering for Bone Regeneration
Hosseini, S., & Eslaminejad, M. B. (2016) · Stem cells in clinical applications · doi:10.1007/978-3-319-40144-7_10 · Cited by 3
Cell based therapeutic approach in vascular surgery: application and review
Rocca, A., Tafuri, D., Paccone, M., Giuliani, A., Zamboli, A. G. I., Surfaro, G., Paccone, A., Compagna, R., Amato, M., Serra, R., et al. (2017) · Open Medicine · doi:10.1515/med-2017-0045 · Cited by 3
“Important elements of AA are represented by chronic inflammation of the aortic wall induced by chemokines and aortic ECM degradation by MMP-2 and MMP-9, so MSCs that migrate toward MMPs and Chemokines can be useful for therapy of aortic aneurysm [222-225].”
BackgroundOrigin of tendon stem cells in situ
Harvey, T., & Fan, C. (2018) · Frontiers in Biology · doi:10.1007/s11515-018-1504-4 · Cited by 3
Pittenger, M. F., & Kerr, C. L. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-420145-3.00002-x · Cited by 3
Review and prospect of CD146 research
Liu, J., XinRan, M. A., Xu, Q., Yan, X., Xiong, C., Feng, J., Wang, D., Duan, H., Xiang, J., He, Z., et al. (2020) · Scientia Sinica Vitae · doi:10.1360/ssv-2020-0238 · Cited by 3
Cremona, M., Rusconi, G., Ferrario, A., Mariotta, L., Gola, M., & Soldati, G. (2023) · Preprints.org · doi:10.20944/preprints202305.1216.v1 · Cited by 3
High-density Lipoproteins Induce the Migration Capacity of Mesenchymal Stromal Cells
Spillmann, F. (2014) · Journal of Stem Cell Research & Therapy · doi:10.4172/2157-7633.1000176 · Cited by 2
“Therefore, we suggest that the HDLand apo A-I-induced improvement in MSC functionality facilitates circulating MSC to migrate towards the site of injury and to contribute to endothelial repair via their ability to render endothelial cells support as pericyte-like cell [41] and their capacity to induce angiogenesis in…”
BackgroundComparative study of bone marrow mesenchymal stromal cells at different stages of ontogeny
Payushina, O. V., Butorina, N. N., Шевелева, О. Н., Bukhinnik, S. S., Berezina, A. A., Ramazanova, S. G., & Domaratskaya, E. I. (2017) · Russian Journal of Developmental Biology · doi:10.1134/s1062360417040087 · Cited by 2
“Cells with the properties of MSCs are found in the majority of tissues and organs (da Silva Meirelles et al., 2006; Covas et al., 2008).”
Takahashi, T., Sato, F., & Shinkai, K. (2023) · Dentistry Journal · doi:10.3390/dj11120283 · Cited by 2
Berni, P., Andreoli, V., Conti, V., Ramoni, R., Basini, G., Scattini, G., Pascucci, L., Pellegrini, M., Bue, M. D., Squassino, G. P., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252111854 · Cited by 2
Zhang, Y.-L., Wen, D., Wang, S., Tan, Y., & Ma, H.-R. (2025) · World Journal of Stem Cells · doi:10.4252/wjsc.v17.i10.109284 · Cited by 2
Blazar, B. R. (2018) · Engineering · doi:10.1016/j.eng.2018.11.016 · Cited by 2
Use of Cancer/Testis Antigens in Immunotherapy: Potential Effect on Mesenchymal Stem Cells
Saldanha‐Araújo, F., & Haddad, R. (2012) · Stem cells and cancer stem cells · doi:10.1007/978-94-007-4798-2_11 · Cited by 2
Simon, L., Cooke, P. S., & Berry, S. E. (2013) · Cells Tissues Organs · doi:10.1159/000354900 · Cited by 2
Jung, Y.-H., Kim, J. G., Kim, B., Kim, E., Kang, M.-S., Jung, S. J., Yang, Y., & Khang, S. K. (2011) · Journal of Pathology and Translational Medicine · doi:10.4132/koreanjpathol.2011.45.6.564 · Cited by 2
Torres, C. (2016) · Journal of Tissue Science & Engineering · doi:10.4172/2157-7552.1000163 · Cited by 2
“With this combination of mAbs we guaranteed the identification of a welldefined EC population by their typical CD45- CD146+brightCD31+bright staining and we were able to exclude most of the cell populations that could be misinterpreted as EC, such as CD45+brightCD146+ lymphocyte subsets, perivascular cells, including…”
Mesenchymal Stem Cells During Tumor Formation and Dissemination
Correa, D. (2016) · Current Stem Cell Reports · doi:10.1007/s40778-016-0046-4 · Cited by 2
Analysis of TNF-alpha-Mediated Cerebral Pericyte Remodeling
Welser-Alves, J. V., Boroujerdi, A., Tigges, U., & Milner, R. (2014) · Methods in molecular biology · doi:10.1007/978-1-4939-0669-7_8 · Cited by 2
Enhancing the Potency of Mesenchymal Stem Cells for Tissue Regeneration
Müller, S. (2015) · International Journal of Stem cell Research & Therapy · doi:10.23937/2469-570x/1410013 · Cited by 1
“[172-174]”
Similarities and Differences in Stem Cells Between Cancer, Normal, and Injured Brain
Huang, L. H., & Huang, P. (2016) · Stem cell biology and regenerative medicine · doi:10.1007/978-3-319-46733-7_5 · Cited by 2
Mesenchymal stromal cells as a resource for regeneration of damaged skin
Domaratskaya, E. I., & Payushina, O. V. (2017) · Biology Bulletin Reviews · doi:10.1134/s207908641704003x · Cited by 2
“Aside from bone marrow, which is their basic source in postnatal ontogenesis, the spleen, thymus, lungs, heart, and blood vessels, as well as bone, fat, muscular, and other tissues, can be alternative sources (da Silva Meirelles et al., 2006; Beltrami et al., 2007; Yoshimura et al., 2007; Covas et al., 2008; Riekstina…”
Background
Metadata
- Authors
- Covas, D. T., Panepucci, R. A., Fontes, A. M., Silva, W. A., Orellana, M. D., Freitas, M. C. C., Neder, L., Santos, A. R. D., Peres, L. C., Jamur, M. C., & Zago, M. A.
- Affiliations
- Universidade de São Paulo (BR)
- Corresponding author
- Covas, Dimas T.
- ORCID
- Venue
- Experimental Hematology
- Publisher
- Elsevier BV
- Published
- 2008-05
- Volume
- 36
- Issue
- 5
- Pages
- 642-654
- ISSN
- 0301-472X (ISSN-L)
- OpenAlex
- W1979782761
- Cited by
- 610
- References
- 93
- Citations by year
- 2026: 4 · 2025: 10 · 2024: 15 · 2023: 14 · 2022: 19 · 2021: 25 · 2020: 31 · 2019: 31 · 2018: 32 · 2017: 32 · 2016: 48 · 2015: 58 · 2014: 49 · 2013: 60 · 2012: 63
- FWCI
- 18.19
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Experimental Hematology (publishedVersion)
- PubMed (publishedVersion)
- Scientific Electronic Library Online (São Paulo Research Foundation, Latin American and Caribbean Center on Health Sciences Information, Conselho Nacional de Desenvolvimento Científico e Tecnológico) (publishedVersion)
- Funders
- Scheme for Promotion of Academic and Research Collaboration
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
- Health Sciences › Dentistry › Periodontics › Periodontal Regeneration and Treatments
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Keywords
- mesenchymal stem cells, pericytes, fibroblasts, CD146, hepatic stellate cells, gene expression profiling, osteogenic differentiation, adipogenesis, chondrogenic differentiation, angiogenesis, S100A4, NG2, p75 neurotrophin receptor, PDGFRβ, vascular wall cells, tissue repair
- MeSH terms
- Cell Differentiation, Cell Separation, Cells, Cultured, Fibroblasts, Flow Cytometry, Humans, Transcription, Genetic, Umbilical Cord, Cluster Analysis, Immunophenotyping, Reverse Transcriptase Polymerase Chain Reaction, Pericytes, Gene Expression Profiling, CD146 Antigen, Mesenchymal Stem Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
