Cited by 610Mesenchymal stem cell researchPeriodontal Regeneration and TreatmentsHematopoietic Stem Cell Transplantation

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Multipotent mesenchymal stromal cells obtained from diverse human tissues share functional properties and gene-expression profile with CD146(+) perivascular cells and fibroblasts

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Covas, Dimas T., Panepucci, Rodrigo A., Fontes, Aparecida M., Silva, Wilson A., Orellana, Maristela D., Freitas, Marcela C.C., Neder, Luciano, Santos, Anemari R.D., Peres, Luiz C., Jamur, Maria C., Zago, Marco A.·2008·Experimental Hematology

DOI 10.1016/j.exphem.2007.12.015

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Abstract

Objective The relationship of multipotent mesenchymal stromal cells (MSC) with pericytes and fibroblasts has not been established thus far, although they share many markers of primitive marrow stromal cells and the osteogenic, adipogenic, and chondrogenic differentiation potentials.Materials and methods We compared MSCs from adult or fetal tissues, MSC differentiated in vitro, fibroblasts and cultures of retinal pericytes obtained either by separation with anti-CD146 or adhesion. The characterizations included morphological, immunophenotypic, gene-expression profile, and differentiation potential.Results Osteogenic, adipocytic, and chondrocytic differentiation was demonstrated for MSC, retinal perivascular cells, and fibroblasts. Cell morphology and the phenotypes defined by 22 markers were very similar. Analysis of the global gene expression obtained by serial analysis of gene expression for 17 libraries and by reverse transcription polymerase chain reaction of 39 selected genes from 31 different cell cultures, revealed similarities among MSC, retinal perivascular cells, and hepatic stellate cells. Despite this overall similarity, there was a heterogeneous expression of genes related to angiogenesis, in MSC derived from veins, artery, perivascular cells, and fibroblasts. Evaluation of typical pericyte and MSC transcripts, such as NG2, CD146, CD271, and CD140B on CD146 selected perivascular cells and MSC by real-time polymerase chain reaction confirm the relationship between these two cell types. Furthermore, the inverse correlation between fibroblast-specific protein-1 and CD146 transcripts observed on pericytes, MSC, and fibroblasts highlight their potential use as markers of this differentiation pathway.Conclusion Our results indicate that human MSC and pericytes are similar cells located in the wall of the vasculature, where they function as cell sources for repair and tissue maintenance, whereas fibroblasts are more differentiated cells with more restricted differentiation potential.

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Authors: Covas, D. T., Panepucci, R. A., Fontes, A. M., Silva, W. A., Orellana, M. D., Freitas, M. C. C., Neder, L., Santos, A. R. D., Peres, L. C., Jamur, M. C., & Zago, M. A.
Affiliations: Universidade de São Paulo (BR)
Corresponding author: Covas, Dimas T.
ORCID: Covas, Dimas T.
Panepucci, Rodrigo A.
Fontes, Aparecida M.
Silva, Wilson A.
Orellana, Maristela D.
Freitas, Marcela C.C.
Neder, Luciano
Jamur, Maria C.
Zago, Marco A.
Venue: Experimental Hematology
Publisher: Elsevier BV
Published: 2008-05
Volume: 36
Issue: 5
Pages: 642-654
ISSN: 0301-472X (ISSN-L)
DOI: 10.1016/j.exphem.2007.12.015
OpenAlex: W1979782761
Cited by: 610
References: 93
Citations by year: 2026: 4 · 2025: 10 · 2024: 15 · 2023: 14 · 2022: 19 · 2021: 25 · 2020: 31 · 2019: 31 · 2018: 32 · 2017: 32 · 2016: 48 · 2015: 58 · 2014: 49 · 2013: 60 · 2012: 63
FWCI: 18.19
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 5151 d)
Locations: Experimental Hematology (publishedVersion)
PubMed (publishedVersion)
Scientific Electronic Library Online (São Paulo Research Foundation, Latin American and Caribbean Center on Health Sciences Information, Conselho Nacional de Desenvolvimento Científico e Tecnológico) (publishedVersion)
Funders: Scheme for Promotion of Academic and Research Collaboration
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
Health Sciences › Dentistry › Periodontics › Periodontal Regeneration and Treatments
Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
Keywords: mesenchymal stem cells, pericytes, fibroblasts, CD146, hepatic stellate cells, gene expression profiling, osteogenic differentiation, adipogenesis, chondrogenic differentiation, angiogenesis, S100A4, NG2, p75 neurotrophin receptor, PDGFRβ, vascular wall cells, tissue repair
MeSH terms: Cell Differentiation, Cell Separation, Cells, Cultured, Fibroblasts, Flow Cytometry, Humans, Transcription, Genetic, Umbilical Cord, Cluster Analysis, Immunophenotyping, Reverse Transcriptase Polymerase Chain Reaction, Pericytes, Gene Expression Profiling, CD146 Antigen, Mesenchymal Stem Cells

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Multipotent mesenchymal stromal cells obtained from diverse human tissues share functional properties and gene-expression profile with CD146(+) perivascular cells and fibroblasts

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