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Polymorphisms in Toll-like receptor genes and susceptibility to infections in allogeneic stem cell transplantation
Open accessAbstract
Objective Discovery of genetic variations in the genes encoding for Toll-like receptors (TLRs) has highlighted a potential link between genomic variation of the host and susceptibility to infections.Materials and methods We investigated the association between polymorphisms in the TLR2, TLR4, and TLR9 genes in recipients of allogeneic hematopoietic stem cell transplant and susceptibility to infections caused by cytomegalovirus and filamentous fungi.Results A significant association was observed between the presence of the T-1237C polymorphism (TLR9) and susceptibility to viral pneumonia (p=0.04; odds ratio [OR]: 1.73). For fungi, a significant association was observed between the presence of the cosegregating Asp299Gly/Thr399Ile polymorphisms (TLR4) and fungal colonization (p=0.003; OR: 10.6). However, susceptibility to fungal infections, predominantly fungal pneumonia, was instead significantly decreased in the presence of the same polymorphisms (p=0.03; OR: 0.23).Conclusion Thus, fungal colonization may not predict susceptibility to infection in the presence of these single nucleotide polymorphisms. The finding that defective viral but not fungal sensing may predict susceptibility to infection highlights the divergent function of TLRs in the pathogenesis of opportunistic infections.
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“Numerous single-nucleotide polymorphisms (SNPs) within human TLRs (TLR1 [11], TLR4 [12–15], TLR6 [11], among others) and CLRs (Dectin-1—in particular the Y238X SNP [16–18]; DC-SIGN, mannose receptor and mannose-binding lectin [19–22]) have been identified as risk factors for fungal disease.”
From Race and ethnicity: Risk factors for fungal infections? (2023) · cites this paper as [13]
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Cites
Pathogen Recognition and Innate Immunity
Akira, S., Uematsu, S., & Takeuchi, O. (2006) · Cell · doi:10.1016/j.cell.2006.02.015 · Cited by 12,401
De Pauw, B., Walsh, T. J., Donnelly, J. P., Stevens, D. A., Edwards, J. E., Calandra, T., Pappas, P. G., Maertens, J., Lortholary, O., Kauffman, C. A., et al. (2008) · Clinical Infectious Diseases · doi:10.1086/588660 · Cited by 4,917
Aşçıoğlu, S., Rex, J. H., de Pauw, B., Bennett, J. E., Billé, J., Crokaert, F., Denning, D. W., Donnelly, J. P., Edwards, J. E., Erjavec, Z., et al. (2002) · Clinical Infectious Diseases · doi:10.1086/323335 · Cited by 2,315
TLR4 mutations are associated with endotoxin hyporesponsiveness in humans
Arbour, N. C., Lorenz, E., Schutte, B. C., Zabner, J., Kline, J. N., Jones, M., Frees, K., Watt, J. L., & Schwartz, D. A. (2000) · Nature Genetics · doi:10.1038/76048 · Cited by 2,024
Romani, L. (2011) · Nature Reviews Immunology · doi:10.1038/nri2939 · Cited by 1,793
Self-citationCooperation of Toll-like receptor signals in innate immune defence
Trinchieri, G., & Sher, A. (2007) · Nature reviews. Immunology · doi:10.1038/nri2038 · Cited by 1,394
Therapeutic potential of Toll-like receptor 9 activation
Krieg, A. Μ. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd2059 · Cited by 1,244
Definitions of Cytomegalovirus Infection and Disease in Transplant Recipients
Ljungman, P. T., Griffiths, P., & Payá, C. V. (2002) · Clinical Infectious Diseases · doi:10.1086/339329 · Cited by 1,236
Aversa, F., Tabilio, A., Velardi, A., Cunningham, I. B., Terenzi, A., Falzetti, F., Ruggeri, L., Barbabietola, G., Aristei, C., Latini, P., et al. (1998) · New England Journal of Medicine · doi:10.1056/nejm199810223391702 · Cited by 1,164
Self-citationTabeta, K., Georgel, P., Janssen, E. M., Du, X., Hoebe, K. H. N., Crozat, K., Mudd, S., Shamel, L., Sovath, S., Goode, J., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400525101 · Cited by 956
Romani, L. R. (2003) · Nature reviews. Immunology · doi:10.1038/nri1255 · Cited by 759
Self-citationAversa, F., Terenzi, A., Tabilio, A., Falzetti, F., Carotti, A., Ballanti, S., Felicini, R., Falcinelli, F., Velardi, A., Ruggeri, L., et al. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.09.117 · Cited by 699
Self-citationSingle nucleotide polymorphisms of Toll-like receptors and susceptibility to infectious disease
Schröder, N. W. J., & Schumann, R. R. (2005) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(05)01308-3 · Cited by 638
Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease
Romani, L., Fallarino, F., De Luca, A., Montagnoli, C., D’Angelo, C., Zelante, T., Vacca, C., Bistoni, F., Fioretti, M. C., Grohmann, U., et al. (2008) · Nature · doi:10.1038/nature06471 · Cited by 535
Self-citationImmunobiology of Allogeneic Hematopoietic Stem Cell Transplantation
Welniak, L. A., Blazar, B. R., & Murphy, W. J. (2006) · Annual Review of Immunology · doi:10.1146/annurev.immunol.25.022106.141606 · Cited by 535
Bellocchio, S., Montagnoli, C., Bozza, S., Gaziano, R., Rossi, G., Mambula, S. S., Vecchi, A., Mantovani, A., Levitz, S. M., & Romani, L. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.5.3059 · Cited by 515
Self-citationToll-like receptor 4 polymorphisms and aspergillosis in stem-cell transplantation
Bochud, P.-Y., Chien, J. W., Marr, K. A., Leisenring, W. M., Upton, A., Janer, M., Rodrigues, S. D., Li, S., Hansen, J. A., Zhao, L. P., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0802629 · Cited by 453
Pagano, L., Caira, M., Nosari, A., Lint, M. T. V., Candoni, A., Offidani, M., Aloisi, T., Irrera, G., Bonini, A., Picardi, M., et al. (2007) · Clinical Infectious Diseases · doi:10.1086/522189 · Cited by 413
Self-citationExtrathymic T-cell differentiation in vitro
Pawelec, G. (2004) · Nature reviews. Immunology · doi:10.1038/nri1257-c1 · Cited by 363
TLR4 polymorphisms, infectious diseases, and evolutionary pressure during migration of modern humans
Ferwerda, B., McCall, M. B. B., Alonso, S., Giamarellos‐Bourboulis, E. J., Mouktaroudi, M., Izagirre, N., Syafruddin, D., Kibiki, G. S., Cristea, T., Hijmans, A., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0704828104 · Cited by 329
Reverse signaling through GITR ligand enables dexamethasone to activate IDO in allergy
Grohmann, U., Volpi, C., Fallarino, F., Bozza, S., Bianchi, R., Vacca, C., Orabona, C., Belladonna, M. L., Ayroldi, E., Nocentini, G., et al. (2007) · Nature Medicine · doi:10.1038/nm1563 · Cited by 326
Self-citationToll-like Receptor (TLR) Signaling in Response toAspergillus fumigatus
Mambula, S. S., Sau, K., Henneke, P., Golenbock, D. T., & Levitz, S. M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201683200 · Cited by 296
Netea, M. G., Warris, A., van der Meer, J. W. M., Fenton, M. J., Verver-Jansen, T. J. G., Jacobs, L., Andresen, T. K., Verweij, P. E., & Kullberg, B. J. (2003) · The Journal of Infectious Diseases · doi:10.1086/376456 · Cited by 284
Polymorphisms in toll-like receptor genes and susceptibility to pulmonary aspergillosis
Carvalho, A., Pasqualotto, A. C., Pitzurra, L., Romani, L., Denning, D. W., & Rodrigues, F. (2008) · The Journal of Infectious Diseases · doi:10.1086/526500 · Cited by 255
Self-citationLazarus, R. M., Vercelli, D., Palmer, L. J., Klimecki, W. J., Silverman, E. K., Richter, B. G., Riva, A., Ramoni, M. F., Martínez, F. D., Weiss, S. T., et al. (2002) · Immunological Reviews · doi:10.1034/j.1600-065x.2002.19002.x · Cited by 215
TLR Engagement Prevents Transplantation Tolerance
Chen, L., Wang, T., Zhou, P., Ma, L., Yin, D., Shen, J., Molinero, L. L., Nozaki, T., Phillips, T. L., Uematsu, S., et al. (2006) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2006.01489.x · Cited by 213
KESH, S., MENSAH, N. Y., PETERLONGO, P., JAFFE, D., HSU, K., VAN DEN BRINK, M., O'REILLY, R., PAMER, E., SATAGOPAN, J., & PAPANICOLAOU, G. A. (2005) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1358.012 · Cited by 208
Lazarus, R. M., Klimecki, W. T., Raby, B. A., Vercelli, D., Palmer, L. J., Kwiatkowski, D. J., Silverman, E. K., Martinez, F., & Weiss, S. T. (2003) · Genomics · doi:10.1016/s0888-7543(02)00022-8 · Cited by 206
Delale, T., Paquin, A., Asselin‐Paturel, C., Dalod, M., Brizard, G., Bates, E. E. M., Kastner, P., Chan, S. H., Akira, S., Vicari, A. P., et al. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.10.6723 · Cited by 206
Crohn’s disease is associated with a toll-like receptor-9 polymorphism
Török, H., Glas, J., Tonenchi, L., Brünnler, G., Folwaczny, M., & Folwaczny, C. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.05.051 · Cited by 187
The Importance of Toll-Like Receptor 2 Polymorphisms in Severe Infections
Texereau, J., Chiche, J., Taylor, W., Choukroun, G., Comba, B., & Mira, J. P. (2005) · Clinical Infectious Diseases · doi:10.1086/431990 · Cited by 183
Aspergillus fumigatus antigens activate innate immune cells via toll‐like receptors 2 and 4
Braedel-Ruoff, S., Radsak, M. P., Einsele, H., Latgé, J., Michan, A., Loeffler, J., Haddad, Z., Grigoleit, U., Schild, H., & Hebart, H. F. (2004) · British Journal of Haematology · doi:10.1111/j.1365-2141.2004.04922.x · Cited by 180
Putative association of a TLR9 promoter polymorphism with atopic eczema
Novak, N., Yu, C., Bußmann, C., Maintz, L., Peng, W., Hart, J., Hagemann, T., Diaz-Lacava, A. N., Baurecht, H., Klopp, N., et al. (2007) · Allergy · doi:10.1111/j.1398-9995.2007.01358.x · Cited by 174
LUCA, A. D., Montagnoli, C., Zelante, T., Bonifazi, P., Bozza, S., Moretti, S., D’Angelo, C., Vacca, C., Boon, L., Bistoni, F., et al. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.9.5999 · Cited by 163
Self-citationvan der Graaf, C. A. A., Netea, M. G., Morré, S. A., den Heijer, M., Verweij, P. E., van der Meer, J. W. M., & Kullberg, B. J. (2006) · PubMed · Cited by 160
Ramirez‐Ortiz, Z. G., Specht, C. A., Wang, J. P., Lee, C. K., Bartholomeu, D. C., Gazzinelli, R. T., & Levitz, S. M. (2008) · Infection and Immunity · doi:10.1128/iai.00047-08 · Cited by 150
Michel, O., LeVan, T. D., Stern, D., Dentener, M., Thorn, J., Gnat, D., Beijer, M. L., Cochaux, P., Holt, P. G., Martinez, F. D., et al. (2003) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2003.05.001 · Cited by 147
Kijpittayarit, S., Eid, A. J., Brown, R. A., Paya, C. V., & Razonable, R. R. (2007) · Clinical Infectious Diseases · doi:10.1086/514339 · Cited by 147
Protective tolerance to fungi: the role of IL-10 and tryptophan catabolism
Romani, L. R., & Puccetti, P. (2006) · Trends in Microbiology · doi:10.1016/j.tim.2006.02.003 · Cited by 140
Self-citationAntequera, F., Tamame, M., Villanueva, J. R., & Santos, T. A. D. S. (1984) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)39681-3 · Cited by 136
Toll‐like receptor 4 in atherosclerosis
Li, H., & Sun, B. (2007) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2007.00011.x · Cited by 136
TLR7/9 Antagonists as Therapeutics for Immune-Mediated Inflammatory Disorders
Karlsson, L., Sun, S., Rao, N. L., Venable, J. D., & Thurmond, R. L. (2007) · Inflammation & Allergy - Drug Targets · doi:10.2174/187152807783334300 · Cited by 133
IL-17 and Therapeutic Kynurenines in Pathogenic Inflammation to Fungi
Romani, L. R., Zelante, T., LUCA, A. D., Fallarino, F., & Puccetti, P. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.8.5157 · Cited by 123
Self-citationLorenz, E., Schwartz, D. A., Martin, P. J., Gooley, T. A., Lin, M.-T., Chien, J. W., Hansen, J. A., & Clark, J. G. (2001) · Transplantation and Cellular Therapy · doi:10.1053/bbmt.2001.v7.pm11529488 · Cited by 109
Dessing, M. C., Schouten, M., Draing, C., Levi, M. M., von Aulock, S., & van der Poll, T. (2008) · The Journal of Infectious Diseases · doi:10.1086/524873 · Cited by 86
Vollmer, J. (2006) · International Reviews of Immunology · doi:10.1080/08830180600743107 · Cited by 73
Inflammation, Longevity, and Cardiovascular Diseases
Candore, G., Aquino, A., Balistreri, C. R., Bulati, M., Carlo, D. D., Grimaldi, M. P., Listı̀, F., ORLANDO, V., Vasto, S., Caruso, M., et al. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1354.037 · Cited by 67
Polymorphisms of the Toll-Like Receptors and Human Disease
Sutherland, A. M., & Cook, D. N. (2005) · Clinical Infectious Diseases · doi:10.1086/431985 · Cited by 66
Mayor, N. P., Shaw, B. E., Hughes, D. A., Maldonado-Torres, H., Madrigal, J. A., Keshav, S., & Marsh, S. G. E. (2007) · Journal of Clinical Oncology · doi:10.1200/jco.2007.12.1897 · Cited by 65
Cappellano, P., Viscoli, C., Bruzzi, P., Lint, M. T. V., Pereira, C. A. P., & Bacigalupo, A. P. (2007) · PubMed · Cited by 63
Controlling pathogenic inflammation to fungi
Romani, L. R., & Puccetti, P. (2007) · Expert Review of Anti-infective Therapy · doi:10.1586/14787210.5.6.1007 · Cited by 62
Self-citationChignard, M., Balloy, V., Sallenave, J., & Si‐Tahar, M. (2007) · Clinical Immunology · doi:10.1016/j.clim.2007.05.004 · Cited by 61
Innate Immunity-Mediated Allograft Rejection and Strategies to Prevent It
Land, W. G. (2007) · Transplantation Proceedings · doi:10.1016/j.transproceed.2007.01.052 · Cited by 58
Bozza, S., Gaziano, R., Bonifazi, P., Zelante, T., Pitzurra, L., Montagnoli, C., Moretti, S., Castronari, R., Sinibaldi, P., Rasi, G., et al. (2007) · International Immunology · doi:10.1093/intimm/dxm097 · Cited by 58
Self-citationRole of the Toll‐Like Receptor 4 Asp299Gly Polymorphism in Susceptibility toCandidaalbicansInfection
Morré, S. A., Murillo, L. S., Spaargaren, J., Fennema, H., & Peña, A. S. (2002) · The Journal of Infectious Diseases · doi:10.1086/344328 · Cited by 45
Intracellular TLR Signaling: A Structural Perspective on Human Disease
Lasker, M. V., & Nair, S. K. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.1.11 · Cited by 44
Stem Cell Mobilization in Normal Donors
Tabilio, A., Falzetti, F., Giannoni, C., Aversa, F., Martelli, M. P., ROSSETTI, M., CAPUTO, P., Chionne, F., GAMBELUNGHE, C., & MARTELLI, M. F. (1997) · Journal of Hematotherapy · doi:10.1089/scd.1.1997.6.227 · Cited by 38
Self-citationCarvalho, A., Marques, A. G., Maciel, P., & Rodrigues, F. J. S. (2007) · Molecular and Cellular Probes · doi:10.1016/j.mcp.2007.03.005 · Cited by 28
Self-citationReduction of TLR2 gene expression in allergic and nonallergic rhinitis
Vanhinsbergh, L., Powe, D. G., & Jones, N. S. (2007) · Annals of Allergy Asthma & Immunology · doi:10.1016/s1081-1206(10)60379-1 · Cited by 18
Non-HLA Gene Polymorphisms and the Outcome of Allogeneic Hematopoietic Stem Cell Transplantation
Bogunia‐Kubik, K., Wysoczańska, B., & Lange, A. (2006) · Current Stem Cell Research & Therapy · doi:10.2174/157488806776956850 · Cited by 10
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Metadata
- Authors
- Carvalho, A., Cunha, C., Carotti, A., Aloisi, T., Guarrera, O., Di Ianni, M., Falzetti, F., Bistoni, F., Aversa, F., Pitzurra, L., Rodrigues, F., & Romani, L.
- Affiliations
- University of Perugia (IT)
- University of Minho (PT)
- Corresponding author
- Carvalho, Agostinho
- ORCID
- Venue
- Experimental Hematology
- Publisher
- Elsevier BV
- Published
- 2009-09
- Volume
- 37
- Issue
- 9
- Pages
- 1022-1029
- ISSN
- 0301-472X (ISSN-L)
- OpenAlex
- W2031814949
- Cited by
- 104
- References
- 60
- Citations by year
- 2026: 2 · 2024: 2 · 2023: 2 · 2022: 6 · 2021: 3 · 2020: 4 · 2019: 5 · 2018: 6 · 2017: 6 · 2016: 9 · 2015: 6 · 2014: 10 · 2013: 7 · 2012: 8
- FWCI
- 5.18
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Experimental Hematology (publishedVersion)
- PubMed (publishedVersion)
- RepositóriUM (Universidade do Minho) (submittedVersion)
- Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion, cc-by-nc-nd)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Immunology and Microbiology › Immunology › Immunodeficiency and Autoimmune Disorders
- Health Sciences › Medicine › Epidemiology › Cytomegalovirus and herpesvirus research
- Keywords
- Toll-like receptors, TLR2, TLR4, TLR9, single nucleotide polymorphisms, allogeneic hematopoietic stem cell transplantation, infection susceptibility, cytomegalovirus infection, fungal infection, fungal pneumonia, viral pneumonia, fungal colonization, opportunistic infections
- MeSH terms
- Adult, Cytomegalovirus Infections, Cytomegalovirus, Female, Humans, Infections, Male, Middle Aged, Mycoses, Retrospective Studies, Transplantation, Homologous, Hematologic Neoplasms, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Stem Cell Transplantation, Toll-Like Receptor 2, Toll-Like Receptor 4, Toll-Like Receptor 9
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