Polymorphisms in toll-like receptor genes and susceptibility to pulmonary aspergillosis
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Toll-like receptors (TLRs) are important components of innate immunity. We investigated the association between polymorphisms in the TLR2, TLR4, and TLR9 genes and susceptibility to noninvasive forms of pulmonary aspergillosis. A significant association was observed between allele G on Asp299Gly (TLR4) and chronic cavitary pulmonary aspergillosis (odds ratio [OR], 3.46; P =.003). Susceptibility to allergic bronchopulmonary aspergillosis was associated with allele C on T-1237C (TLR9) (OR, 2.49; P =. 043). No particular polymorphism was associated with severe asthma with fungal sensitization. These findings reinforce the importance of innate immunity in the pathogenesis of different forms of aspergillosis.
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Numerous single-nucleotide polymorphisms within human Toll-like receptors and C-type lectin receptors have been identified as risk factors for fungal disease.
“Numerous single-nucleotide polymorphisms (SNPs) within human TLRs (TLR1 [11], TLR4 [12–15], TLR6 [11], among others) and CLRs (Dectin-1—in particular the Y238X SNP [16–18]; DC-SIGN, mannose receptor and mannose-binding lectin [19–22]) have been identified as risk factors for fungal disease.”
From Race and ethnicity: Risk factors for fungal infections? (2023) · cites this paper as [14]
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- Authors
- Carvalho, A., Pasqualotto, A. C., Pitzurra, L., Romani, L., Denning, D. W., & Rodrigues, F.
- Affiliations
- University of Minho (PT)
- University of Manchester (GB)
- University of Perugia (IT)
- Corresponding author
- Rodrigues, F.
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-02-15
- Volume
- 197
- Issue
- 4
- Pages
- 618-621
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2098596185
- Cited by
- 255
- References
- 16
- Citations by year
- 2026: 7 · 2025: 6 · 2024: 11 · 2023: 10 · 2022: 10 · 2021: 17 · 2020: 16 · 2019: 5 · 2018: 11 · 2017: 13 · 2016: 13 · 2015: 14 · 2014: 18 · 2013: 14 · 2012: 19
- FWCI
- 15.29
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Infectious Diseases (publishedVersion)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (publishedVersion, other-oa)
- Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion, other-oa)
- Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Fundação para a Ciência e a Tecnologia (SFRH/BD/11837/2003)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Life Sciences › Immunology and Microbiology › Immunology › Immunodeficiency and Autoimmune Disorders
- Keywords
- Toll-like receptors, TLR2, TLR4, TLR9, genetic polymorphism, pulmonary aspergillosis, chronic cavitary pulmonary aspergillosis, allergic bronchopulmonary aspergillosis, innate immunity, disease susceptibility
- MeSH terms
- Aged, Aspergillosis, Aspergillosis, Allergic Bronchopulmonary, Aspergillus fumigatus, Female, Humans, Lung Diseases, Fungal, Male, Middle Aged, Cohort Studies, Case-Control Studies, Polymorphism, Single Nucleotide, Toll-Like Receptor 2, Toll-Like Receptor 4, Toll-Like Receptor 9
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