Neuroprotective effect of Ro5-4864 following brain injury
Abstract
The 18 kDa translocator protein (TSPO) is a protein complex located at the outer mitochondrial membrane and interacting with the mitochondrial permeability transition pore (mPTP), indicating its involvement in the control of mPTP opening. We intended to explore the effect of TSPO ligands, PK 11195 and Ro5-4864 on apoptosis in a rat model of cortical injury. Sprague-Dawley rats received a daily intraperitoneal injection of dimethylsulfoxide (vehicle), PK 11195, or Ro5-4864, starting 2 days prior the injury and a third injection after the injury. At 6 weeks, immunohistochemistry analysis showed that Ro5-4864 resulted in a significant increase in the number of surviving neurons and in the density of the neurofilament network in the perilesional cortex in comparison with animals of the vehicle and PK 11195 groups. In tissue samples dissected from the injured area, Ro5-4864 caused a significant reduction in activation of caspases 3 and 9 but not of caspase 8 in comparison with the vehicle and PK 11195 groups. In addition, measurements of transmembrane mitochondrial potential of mitochondria (Deltapsi(M)) isolated from normal rat brain showed that loss of Deltapsi(M) induced by recombinant Bax could be significantly reduced by Ro5-4864 in a concentration-dependent manner. Our findings indicate that the neuroprotective effect shown by Ro5-4864 in the present model of brain injury involves the mitochondrial pathway of apoptosis modulation of mPTP.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
TSPO ligands have been shown to prevent neuronal loss in several animal models.
“TSPO ligands have been shown to prevent neuronal loss in several animal models [13;67–69].”
From Expression of the translocator protein of 18 kDa by microglia, macrophages and astrocytes based on immunohistochemical localization in abnormal human brain (2009) · cites this paper as [69]
Cites
Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c
Liu, X., Kim, C. N., Yang, J., Jemmerson, R., & Wang, X. (1996) · Cell · doi:10.1016/s0092-8674(00)80085-9 · Cited by 5,167 · see citing works
Mitochondrial membrane permeabilization in cell death
Kroemer, G., Galluzzi, L., & Brenner, C. (2007) · Physiological Reviews · doi:10.1152/physrev.00013.2006 · Cited by 3,598 · see citing works
Du, C., Fang, M., Li, Y., Li, L., & Wang, X. (2000) · Cell · doi:10.1016/s0092-8674(00)00008-8 · Cited by 3,513 · see citing works
Verhagen, A. M., Ekert, P. G., Pakusch, M., Silke, J., Connolly, L. M., Reid, G. E., Moritz, R. L., Simpson, R. J., & Vaux, D. L. (2000) · Cell · doi:10.1016/s0092-8674(00)00009-x · Cited by 2,372 · see citing works
An APAF-1·Cytochrome c Multimeric Complex Is a Functional Apoptosome That Activates Procaspase-9
Zou, H., Li, Y., Liu, X., & Wang, X. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.17.11549 · Cited by 2,089 · see citing works
THE MITOCHONDRIAL DEATH/LIFE REGULATOR IN APOPTOSIS AND NECROSIS
Kroemer, G., Dallaporta, B., & Resche-Rigon, M. (1998) · Annual Review of Physiology · doi:10.1146/annurev.physiol.60.1.619 · Cited by 1,971 · see citing works
Bax directly induces release of cytochrome c from isolated mitochondria
Jürgensmeier, J. M., Xie, Z., Deveraux, Q. L., Ellerby, L., Bredesen, D. E., & Reed, J. C. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.9.4997 · Cited by 1,523 · see citing works
Specific benzodiazepine receptors in rat brain characterized by high-affinity (3H)diazepam binding
Braestrup, C., & Squires, R. F. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.9.3805 · Cited by 1,264 · see citing works
Reers, M., Smith, T. W., & Chen, L. B. (1991) · Biochemistry · doi:10.1021/bi00232a015 · Cited by 1,052 · see citing works
Two Distinct Pathways Leading to Nuclear Apoptosis
Susín, S. A., Daugas, É., Ravagnan, L., Samejima, K., Zamzami, N., Loeffler, M. W., Costantini, P., Ferri, K. F., Irinopoulou, T., Prévost, M., et al. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.4.571 · Cited by 736 · see citing works
McEnery, M. W., Snowman, A. M., Trifiletti, R. R., & Snyder, S. H. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.8.3170 · Cited by 708 · see citing works
Cytochrome c Promotes Caspase-9 Activation by Inducing Nucleotide Binding to Apaf-1
Jiang, X., & Wang, X. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.c000405200 · Cited by 506 · see citing works
Waterhouse, N. J., Goldstein, J. C., von Ahsen, O., Schüler, M., Newmeyer, D. D., & Green, D. R. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.153.2.319 · Cited by 452 · see citing works
Programmed cell death via mitochondria: Different modes of dying
Bras, M., Queenan, B., & Susín, S. A. (2005) · Biochemistry (Moscow) · doi:10.1007/s10541-005-0105-4 · Cited by 404 · see citing works
Cyclosporin A Attenuates Acute Mitochondrial Dysfunction Following Traumatic Brain Injury
Sullivan, P. G., Thompson, M. B., & Scheff, S. W. (1999) · Experimental Neurology · doi:10.1006/exnr.1999.7197 · Cited by 344 · see citing works
Fur, G. L., Vaucher, N., Perrier, M. L., Flamier, A., Bénavidès, J., Renault, C., Dubroeucq, M. C., Gueremy, C., & Uzan, A. (1983) · Life Sciences · doi:10.1016/0024-3205(83)90794-4 · Cited by 268 · see citing works
Okonkwo, D. O., & Povlishock, J. T. (1999) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199904000-00010 · Cited by 265 · see citing works
Hirsch, T., Decaudin, D., Susín, S. A., Marchetti, P., Larochette, N., Resche-Rigon, M., & Kroemer, G. (1998) · Experimental Cell Research · doi:10.1006/excr.1998.4084 · Cited by 254 · see citing works
Dominant cell death induction by extramitochondrially targeted apoptosis‐inducing factor
Loeffler, M. W., Daugas, É., Susín, S. A., Zamzami, N., Métivier, D., Nieminen, A., Brothers, G. M., Penninger, J. M., & Kroemer, G. (2001) · The FASEB Journal · doi:10.1096/fj.00-0388com · Cited by 241 · see citing works
Pharmacological manipulation of cell death: clinical applications in sight?
Green, D. R. (2005) · Journal of Clinical Investigation · doi:10.1172/jci26321 · Cited by 239 · see citing works
Decaudin, D., Castedo, M., Némati, F., Beurdeley‐Thomas, A., Pinieux, G. D. B. D., Caron, A., Pouillart, P., Wijdenes, J., Rouillard, D., Kroemer, G., et al. (2002) · PubMed · Cited by 155 · see citing works
Maaser, K., Höpfner, M., Jansen, A., Weisinger, G., Gavish, M., Kozikowski, A. P., Weizman, A., Carayon, P., Riecken, E.-O., Zeitz, M., et al. (2001) · British Journal of Cancer · doi:10.1054/bjoc.2001.2181 · Cited by 120 · see citing works
Self-citationPeripheral Benzodiazepine Receptor Agonists Exhibit Potent Antiapoptotic Activities
Bono, F., Lamarche, I., Prabonnaud, V., Fur, G. L., & Herbert, J. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.1683 · Cited by 118 · see citing works
Azarashvili, T., Grachev, D., Krestinina, O. V., Evtodienko, Y. V., Yurkov, I. S., Papadopoulos, V., & Reiser, G. (2006) · Cell Calcium · doi:10.1016/j.ceca.2006.11.004 · Cited by 112 · see citing works
Veiga, S., Azcoitia, I., & Garcia-Segura, L. M. (2005) · Journal of Neuroscience Research · doi:10.1002/jnr.20430 · Cited by 101 · see citing works
Carmel, I., Fares, F., Leschiner, S., Scherübl, H., Weisinger, G., & Gavish, M. (1999) · Biochemical Pharmacology · doi:10.1016/s0006-2952(99)00093-3 · Cited by 90 · see citing works
Self-citationGonzález‐Polo, R. A., Carvalho, G., Braun, T., Decaudin, D., Fabre, C., Larochette, N., Perfettini, J., Djavaheri‐Mergny, M., Youlyouz‐Marfak, I., Codogno, P., et al. (2005) · Oncogene · doi:10.1038/sj.onc.1208907 · Cited by 88 · see citing works
Chelli, B., Lena, A., Vanacore, R., Pozzo, E. D., Costa, B., Rossi, L., Salvetti, A., Scatena, F., Ceruti, S., Abbracchio, M. P., et al. (2004) · Biochemical Pharmacology · doi:10.1016/j.bcp.2004.03.008 · Cited by 87 · see citing works
Palzur, E., Vlodavsky, E., Mulla, H., Arieli, R., D, M. F. M., & Soustiel, J. F. (2004) · Journal of Neurotrauma · doi:10.1089/089771504772695931 · Cited by 79 · see citing works
Self-citationNeuroprotective Anti-Apoptosis Effect of Estrogens in Traumatic Brain Injury
Soustiel, J. F., Palzur, E., Nevo, O., Thaler, I., & Vlodavsky, E. (2005) · Journal of Neurotrauma · doi:10.1089/neu.2005.22.345 · Cited by 78 · see citing works
Self-citationFennell, D. A., Corbo, M., Pallaska, A., & Cotter, F. E. (2001) · British Journal of Cancer · doi:10.1054/bjoc.2001.1788 · Cited by 72 · see citing works
Veenman, L. S., Leschiner, S., Spanier, I., Weisinger, G., Weizman, A., & Gavish, M. (2002) · Journal of Neurochemistry · doi:10.1046/j.0022-3042.2002.00769.x · Cited by 67 · see citing works
Self-citationShreiber, D. I., Bain, A. C., Ross, D. T., Smith, D. H., Gennarelli, T. A., McIntosh, T. K., & Meaney, D. F. (1999) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199902000-00005 · Cited by 63 · see citing works
Peripheral benzodiazepine receptor and its clinical targeting
Decaudin, D. (2004) · Anti-Cancer Drugs · doi:10.1097/00001813-200409000-00001 · Cited by 57 · see citing works
Jord�, E. G., Jim�nez, A. J., Verdaguer, E., Canudas, A. M., Folch, J., Sureda, F. X., Camins, A., & Pall�s, M. (2005) · APOPTOSIS · doi:10.1007/s10495-005-6064-9 · Cited by 56 · see citing works
Mitochondrial Apoptosis and the Peripheral Benzodiazepine Receptor
Castedo, M., Perfettini, J., & Kroemer, G. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20021758 · Cited by 49 · see citing works
Banker, D. E., Cooper, J. J., Fennell, D. A., Willman, C. L., Appelbaum, F. R., & Cotter, F. E. (2002) · Leukemia Research · doi:10.1016/s0145-2126(01)00112-6 · Cited by 44 · see citing works
Role of the peripheral benzodiazepine receptor in sensory neuron regeneration
Mills, C. D., Bitler, J. L., & Woolf, C. J. (2005) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2005.07.010 · Cited by 42 · see citing works
Clinical treatments for mitochondrial dysfunctions after brain injury
Merenda, A., & Bullock, R. M. (2006) · Current Opinion in Critical Care · doi:10.1097/01.ccx.0000216573.26686.27 · Cited by 38 · see citing works
Maaser, K., Sutter, A. P., & Scherübl, H. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.05.005 · Cited by 33 · see citing works
Peripheral-type benzodiazepine receptors in association with epileptic seizures in EL mice
Nakamoto, Y., Watabe, S., Shiotani, T., & Yoshii, M. (1996) · Brain Research · doi:10.1016/0006-8993(96)00033-9 · Cited by 18 · see citing works
Shiotani, T., Nakamoto, Y., Watabe, S., Yoshii, M., & Nabeshima, T. (2000) · Brain Research · doi:10.1016/s0006-8993(00)01971-5 · Cited by 17 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Rupprecht, R., Papadopoulos, V., Rammes, G., Baghai, T. C., Fan, J., Akula, N., Groyer, G., Adams, D., & Schumacher, M. (2010) · Nature Reviews Drug Discovery · doi:10.1038/nrd3295 · Cited by 930 · see citing works
Cosenza‐Nashat, M., Zhao, M. ‐., Suh, H. ‐., Morgan, J., Natividad, R., Morgello, S., & Lee, S. C. (2009) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2008.01006.x · Cited by 459 · see citing works
Cheng, G., Kong, R., Zhang, L., & Zhang, J. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2012.02025.x · Cited by 345 · see citing works
Wang, M., Wang, X., Zhao, L., Ma, W., Rodríguez, I. R., Fariss, R. N., & Wong, W. T. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.3153-13.2014 · Cited by 201 · see citing works
Cerebral microvascular endothelium and the pathogenesis of neurodegenerative diseases
Grammas, P., Martinez, J. M., & Miller, B. B. (2011) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399411001918 · Cited by 203 · see citing works
Translocator protein (18 kDa) TSPO: An emerging therapeutic target in neurotrauma
Papadopoulos, V., & Lecanu, L. (2009) · Experimental Neurology · doi:10.1016/j.expneurol.2009.04.016 · Cited by 178 · see citing works
Mazzeo, A. T., Alessandri, B., Singh, A., & Bullock, M. R. (2009) · Experimental Neurology · doi:10.1016/j.expneurol.2009.05.026 · Cited by 137 · see citing works
Choi, J., Ifuku, M., Noda, M., & Guilarte, T. R. (2010) · Glia · doi:10.1002/glia.21091 · Cited by 124 · see citing works
‘New/Designer Benzodiazepines’: An Analysis of the Literature and Psychonauts’ Trip Reports
Orsolini, L., Corkery, J., Chiappini, S., Guirguis, A., Vento, A. E., Berardis, D. D., Papanti, D., & Schifano, F. (2020) · Current Neuropharmacology · doi:10.2174/1570159x18666200110121333 · Cited by 82 · see citing works
Axonal Regeneration and Neuroinflammation: Roles for the Translocator Protein 18 kDa
Girard, C., Liu, S., Adams, D., Lacroix, C., Sinéus, M., Boucher, C., Papadopoulos, V., Rupprecht, R., Schumacher, M., & Groyer, G. (2012) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2011.02215.x · Cited by 75 · see citing works
Oxidative Imbalance and Anxiety Disorders
Krolow, R., Arcego, D. M., Noschang, C. G., Weis, S. N., & Dalmaz, C. (2014) · Current Neuropharmacology · doi:10.2174/1570159x11666131120223530 · Cited by 74 · see citing works
Zheng, J., Boisgard, R., Siquier-Pernet, K., Decaudin, D., Dollé, F., & Tavitian, B. (2011) · Molecular Pharmaceutics · doi:10.1021/mp100433c · Cited by 54 · see citing works
Singh, P., Adhikari, A., Singh, D., Gond, C., & Tiwari, A. K. (2022) · ACS Omega · doi:10.1021/acsomega.2c00588 · Cited by 47 · see citing works
Kim, T., & Pae, A. N. (2016) · Expert Opinion on Therapeutic Patents · doi:10.1080/13543776.2016.1230606 · Cited by 43 · see citing works
Targeting the 18-kDa translocator protein: recent perspectives for neuroprotection
Pozzo, E. D., Giacomelli, C., Barresi, E., Costa, B., Taliani, S., Settimo, F. D., & Martini, C. (2015) · Biochemical Society Transactions · doi:10.1042/bst20150028 · Cited by 41 · see citing works
GABA(A) receptor-targeted drug development -New perspectives in perioperative anesthesia
Antkowiak, B., & Rammes, G. (2019) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2019.1599356 · Cited by 39 · see citing works
Arbo, B. D., Benetti, F., García-Segura, L., & Ribeiro, M. (2015) · Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2015.07.007 · Cited by 35 · see citing works
Palzur, E., Edelman, D., Sakas, R., & Soustiel, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222312881 · Cited by 32 · see citing works
Self-citationMitochondrial Damage: A Target for New Therapeutic Horizons
Soustiel, J. F., & Larisch, S. (2010) · Neurotherapeutics · doi:10.1016/j.nurt.2009.11.001 · Cited by 29 · see citing works
Self-citationProgesterone: Synthesis, Metabolism, Mechanism of Action, and Effects in the Nervous System
Schumacher, M., Zhu, X., & Guennoun, R. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-803592-4.00054-7 · Cited by 28 · see citing works
Reduction of Traumatic Brain Damage by Tspo Ligand Etifoxine
Shehadeh, M., Palzur, E., Apel, L., & Soustiel, J. F. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20112639 · Cited by 26 · see citing works
Self-citationInvestigation of the mechanisms of neuroprotection mediated by Ro5-4864 in brain injury
Palzur, E., Sharon, A., Shehadeh, M., & Soustiel, J. F. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.05.014 · Cited by 26 · see citing works
Self-citationThe translocator protein as a drug target in Alzheimer’s disease
Chua, S. W., Kassiou, M., & Ittner, L. M. (2014) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.2014.896201 · Cited by 20 · see citing works
Etifoxine promotes glial-derived neurotrophic factor-induced neurite outgrowth in PC12 cells
Zhou, X., HE, X., He, B., Zhu, Z., Zheng, C., Xu, J., Jiang, L., Gu, L., Zhu, J., Zhu, Q., et al. (2013) · Molecular Medicine Reports · doi:10.3892/mmr.2013.1474 · Cited by 20 · see citing works
4′-Chlorodiazepam Protects Mitochondria in T98G Astrocyte Cell Line from Glucose Deprivation
Báez-Jurado, E., Guio-Vega, G. P., Echeverrı́a, V., Sandoval-Rueda, D. A., & Barreto, G. E. (2017) · Neurotoxicity Research · doi:10.1007/s12640-017-9733-x · Cited by 19 · see citing works
The Ligands of Translocator Protein: Design and Biological Properties
Мокров, Г. В., Деева, О. А., & Гудашева, Т. А. (2020) · Current Pharmaceutical Design · doi:10.2174/1381612826666200903122025 · Cited by 17 · see citing works
TSPO regulation in reactive gliotic diseases
McNeela, A. M., Bernick, C. B., Hines, R. M., & Hines, D. J. (2018) · Journal of Neuroscience Research · doi:10.1002/jnr.24212 · Cited by 18 · see citing works
A Protective Role of Translocator Protein in Alzheimer’s Disease Brain
Jung, M. E. (2020) · Current Alzheimer Research · doi:10.2174/1567205017666200217105950 · Cited by 15 · see citing works
Soustiel, J. F., Vlodavsky, E., Milman, F., Gavish, M., & Zaaroor, M. (2011) · Pharmaceutical Research · doi:10.1007/s11095-011-0463-0 · Cited by 15 · see citing works
Self-citationChronic benzodiazepine suppresses translocator protein and elevates amyloid β in mice
Tan, S., Metzger, D. B., & Jung, M. E. (2018) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2018.07.005 · Cited by 13 · see citing works
Yusuying, S., Yusuyin, S., & Cheng, X. (2021) · Neuroscience · doi:10.1016/j.neuroscience.2021.09.024 · Cited by 12 · see citing works
Döndaş, H. A., Belveren, S., Poyraz, S., Grigg, R., Kilner, C. A., Ferrándiz-Saperas, M., Selva, E., & Sansano, J. M. (2017) · Tetrahedron · doi:10.1016/j.tet.2017.11.017 · Cited by 13 · see citing works
Suto, F., Wood, A., Kobayashi, M., Komaba, J., Duffy, K. J., & Bruce, M. (2015) · Clinical Therapeutics · doi:10.1016/j.clinthera.2015.07.010 · Cited by 11 · see citing works
Kim, T.-H., Son, W. S., Morshed, M. N., Londhe, A. M., Jung, S. Y., Park, J., Park, W., Lim, S. M., Park, K. D., Cho, S. J., et al. (2017) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2017.09.033 · Cited by 11 · see citing works
Huang, Y. L., Su, M., Zhang, C., Zhan, H., Yang, F., Gao, Z., Zhou, X., & Liu, B. (2022) · European Journal of Pain · doi:10.1002/ejp.1942 · Cited by 10 · see citing works
Comparative Assessment of TSPO Modulators on Electroencephalogram Activity and Exploratory Behavior
Hines, R. M., Aquino, E. A., Khumnark, M., Dávila, M. P., & Hines, D. J. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.750554 · Cited by 6 · see citing works
Bonsack, F., Foss, C. A., Arbab, A. S., Alleyne, C. H., Pomper, M. G., & Sukumari‐Ramesh, S. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00066 · Cited by 5 · see citing works
The 18 kDa Translocator Protein as a Potential Participant in Atherosclerosis
Dimitrova‐Shumkovska, J., Veenman, L., & Gavish, M. (2012) · InTech eBooks · doi:10.5772/25781 · Cited by 3 · see citing works
Self-citationWolfe, C. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-818788-3.00013-9 · Cited by 3 · see citing works
Sakas, R., Fishboom, T., Ben-Menashe, A., Awad-Igbaria, Y., Nasra, R., Samson, A. O., Palzur, E., & Soustiel, J. F. (2025) · Neurotherapeutics · doi:10.1016/j.neurot.2025.e00803 · Cited by 1 · see citing works
Self-citationHead Injury: Metabolic, Nutritional, and Energy Considerations
Charrueau, C., Morio, B., & Moinard, C. (2011) · Springer eBooks · doi:10.1007/978-0-387-92271-3_103 · Cited by 1 · see citing works
Yue, Y., Wang, Y., Liao, Z., Hu, F., Liu, Q., Dong, J., Zhong, M., Chen, M., Pan, Y., Zhong, H., et al. (2022) · The FASEB Journal · doi:10.1096/fj.202101746rr · Cited by 1 · see citing works
The translocator protein as a drug target in Alzheimer's
Chua, S. W., Kassiou, M., & Ittner, L. M. (2014)
Ziablitsev, S. V., Aleksandrenko, N. O., Yevstifeiev, D. I., Babenko, M., & Likhodiievskyi, V. V. (2026) · Research Square · doi:10.21203/rs.3.rs-10044242/v1
- Authors
- Soustiel, J. F., Zaaroor, M., Vlodavsky, E., Veenman, L., Weizman, A., & Gavish, M.
- Affiliations
- Technion – Israel Institute of Technology (IL)
- Tel Aviv University (IL)
- Corresponding author
- Soustiel, Jean F.
- Gavish, Moshe
- Venue
- Experimental Neurology
- Publisher
- Elsevier BV
- Published
- 2008-12
- Volume
- 214
- Issue
- 2
- Pages
- 201-208
- ISSN
- 0014-4886 (ISSN-L)
- OpenAlex
- W2064170262
- Cited by
- 44
- References
- 42
- Citations by year
- 2026: 1 · 2025: 1 · 2022: 4 · 2021: 3 · 2020: 3 · 2019: 2 · 2018: 3 · 2017: 3 · 2016: 3 · 2015: 3 · 2014: 4 · 2013: 1 · 2012: 2
- FWCI
- 1.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Experimental Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Neuroscience › Neurology › Neurological Disorders and Treatments
- Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Keywords
- Ro5-4864, translocator protein (TSPO), PK11195, neuroprotection, brain injury, cortical injury, apoptosis, mitochondrial permeability transition pore, caspase-3, caspase-9, caspase-8, Bax, dimethyl sulfoxide
- MeSH terms
- Animals, Antineoplastic Agents, Benzodiazepinones, Brain Injuries, Carrier Proteins, Convulsants, Disease Models, Animal, Isoquinolines, Ligands, Male, Mitochondria, Neurons, Receptors, GABA-A, Rats, Sprague-Dawley, Apoptosis, Neuroprotective Agents, Caspases, Rats, Membrane Potential, Mitochondrial
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review