The DOI matches its Crossref record; 92 of the 92 references it cites were found in a registry or an index.
Poly(ADP-ribose) signals to mitochondrial AIF: A key event in parthanatos
Open accessAbstract
Poly(ADP-ribose) polymerase-1 (PARP-1) plays a pivotal role in multiple neurologic diseases by mediating caspase-independent cell death, which has recently been designated parthanatos to distinguish it from other forms of cell death such as apoptosis, necrosis and autophagy. Mitochondrial apoptosis-inducing factor (AIF) release and translocation to the nucleus is the commitment point for parthanatos. This process involves a pathogenic role of poly (ADP-ribose) (PAR) polymer. It generates in the nucleus and translocates to the mitochondria to mediate AIF release following lethal PARP-1 activation. PAR polymer itself is toxic to cells. Thus, PAR polymer signaling to mitochondrial AIF is the key event initiating the deadly crosstalk between the nucleus and the mitochondria in parthanatos. Targeting PAR-mediated AIF release could be a potential approach for the therapy of neurologic disorders.
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Cites
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Self-citationPoly(ADP-ribosyl)ation reactions in the regulation of nuclear functions
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Self-citationPoly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia
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Self-citationHeat-shock protein 70 antagonizes apoptosis-inducing factor
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Cited by
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
Dixon, S. J., Lemberg, K. M., Lamprecht, M. R., Skouta, R., Zaitsev, E. M., Gleason, C. E., Patel, D. N., Bauer, A. J., Cantley, A. M., Yang, W. S., et al. (2012) · Cell · doi:10.1016/j.cell.2012.03.042 · Cited by 18,691
Galluzzi, L., Vitale, I., Abrams, J. M., Alnemri, E. S., Baehrecke, E. H., Blagosklonny, M. V., Dawson, T. M., Dawson, V. L., El-Deiry, W. S., Fulda, S., et al. (2012) · Cell Death & Differentiation · doi:10.1038/cdd.2011.96 · Cited by 2,421
Self-citationFerroptosis in cancer and cancer immunotherapy
Zhao, L., Zhou, X., Xie, F., Zhang, L., Yan, H., Huang, J., Zhang, C., Zhou, F., Chen, J., & Zhang, L. (2022) · Cancer Communications · doi:10.1002/cac2.12250 · Cited by 684
Parthanatos: mitochondrial‐linked mechanisms and therapeutic opportunities
Fatokun, A. A., Dawson, V. L., & Dawson, T. M. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12416 · Cited by 594
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Metadata
- Authors
- Wang, Y., Dawson, V. L., & Dawson, T. M.
- Venue
- Experimental Neurology
- Publisher
- Elsevier BV
- Published
- 2009-08
- Volume
- 218
- Issue
- 2
- Pages
- 193-202
- ISSN
- 0014-4886 (ISSN-L)
- OpenAlex
- W2047230408
- Cited by
- 408
- References
- 92
- FWCI
- 12.24
- Type
- journal article
- Language
- en
- Open access
- green
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