Poly(ADP-ribose) (PAR) binding to apoptosis-inducing factor is critical for PAR polymerase-1-dependent cell death (parthanatos)
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Poly(ADP-ribose) binds to apoptosis-inducing factor to trigger its release from mitochondria and induce cell death.
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“Excessive activation of PARP-1 leads to an intrinsic cell death program, which has been designated parthanatos (PARP-1–dependent cell death) to distinguish it from necrosis and apoptosis (1, 2).”
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- [25]Yu SW Wang Y Frydenlund DS Ottersen OP Dawson VL Dawson TM Outer mitochondrial membrane localization of apoptosis-inducing factor: mechanistic implications for release ASN Neuro 1 2009 PMC2784601 19863494
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- Authors
- Wang, Y., Kim, N. S., Haince, J.-F., Kang, H. C., David, K. K., Andrabi, S. A., Poirier, G. G., Dawson, V. L., & Dawson, T. M.
- Affiliations
- Johns Hopkins University (US)
- Health and Environment Unit, Laval University Medical Research Center, CHUQ, Ste-Foy, Quebec, Canada G1V 4G2.
- Centre hospitalier universitaire de Québec (CA)
- Corresponding author
- Kim, No Soo
- David, Karen K.
- Dawson, Valina L.
- Dawson, Ted M.
- Venue
- Science Signaling
- Published
- 2011-04-05
- Volume
- 4
- Issue
- 167
- Pages
- ra20-ra20
- ISSN
- 1937-9145 (ISSN-L)
- 1945-0877
- PMC
- PMC3086524
- OpenAlex
- W2049028195
- Cited by
- 476
- References
- 42
- Citations by year
- 2026: 31 · 2025: 33 · 2024: 32 · 2023: 42 · 2022: 34 · 2021: 37 · 2020: 34 · 2019: 33 · 2018: 23 · 2017: 24 · 2016: 29 · 2015: 25 · 2014: 29 · 2013: 33 · 2012: 25
- FWCI
- 12.45
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Signaling (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Canadian Institutes of Health Research
- National Institute on Drug Abuse (P50DA000266, DA.00266)
- National Institute of Neurological Disorders and Stroke (NS067525, R37NS067525, NS039148, R01NS067525, P01NS039148)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Health Sciences › Medicine › Oncology › PARP inhibition in cancer therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Keywords
- poly(ADP-ribose), apoptosis-inducing factor, PARP1, parthanatos, mitochondrial outer membrane, AIF nuclear translocation, cell death, NADH oxidase activity, FAD binding, DNA binding
- MeSH terms
- Amino Acid Sequence, Analysis of Variance, Animals, Arginine, Base Sequence, Genetic Vectors, Immunohistochemistry, Lysine, Models, Molecular, Molecular Sequence Data, Poly Adenosine Diphosphate Ribose, Poly(ADP-ribose) Polymerases, Transfection, Immunoblotting, Lentivirus, Cell Death, Sequence Analysis, DNA, Electrophoretic Mobility Shift Assay, Immunoprecipitation, Apoptosis Inducing Factor, Mice
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