Replication and reproducibility in spinal cord injury research

CONSORT 2010 Statement: updated guidelines for reporting parallel group randomised trials

the CONSORT Group, Schulz, K. F., Altman, D. G., & Moher, D. (2010) · BMC Medicine · doi:10.1186/1741-7015-8-18 · Cited by 13,371 · see citing works

Why Most Published Research Findings Are False

Ioannidis, J. P. A. (2005) · PLoS Medicine · doi:10.1371/journal.pmed.0020124 · Cited by 10,505 · see citing works

Why Most Published Research Findings Are False

Ioannidis, J. P. A. (2005) · CHANCE · doi:10.1080/09332480.2005.10722754 · Cited by 4,702 · see citing works

A Sensitive and Reliable Locomotor Rating Scale for Open Field Testing in Rats

Basso, D. M., Beattie, M. S., & Bresnahan, J. C. (1995) · Journal of Neurotrauma · doi:10.1089/neu.1995.12.1 · Cited by 4,481 · see citing works

Chondroitinase ABC promotes functional recovery after spinal cord injury

Bradbury, E. J., Moon, L. D. F., Popat, R. J., King, V. R., Bennett, G. S., Patel, P. N., Fawcett, J. W., & McMahon, S. B. (2002) · Nature · doi:10.1038/416636a · Cited by 2,357 · see citing works

CONSORT 2010 statement: updated guidelines for reporting parallel group randomised trials

Schulz, K. F., Altman, D. G., Moher, D., & for the CONSORT Group (2010) · PLoS Medicine · doi:10.1371/journal.pmed.1000251 · Cited by 2,296 · see citing works

Basso Mouse Scale for Locomotion Detects Differences in Recovery after Spinal Cord Injury in Five Common Mouse Strains

Basso, D., Fisher, L., Anderson, A., Jakeman, L., McTigue, D. M., & Popovich, P. (2006) · Journal of Neurotrauma · doi:10.1089/neu.2006.23.635 · Cited by 1,615 · see citing works

Cellular prion protein mediates impairment of synaptic plasticity by amyloid-β oligomers

Laurén, J., Gimbel, D. A., Nygaard, H. B., Gilbert, J. W., & Strittmatter, S. M. (2009) · Nature · doi:10.1038/nature07761 · Cited by 1,560 · see citing works

Recommendations for standards regarding preclinical neuroprotective and restorative drug development.

Roundtable, S. T. A. I. (1999) · Stroke · doi:10.1161/01.str.30.12.2752 · Cited by 1,258 · see citing works

Human Embryonic Stem Cell-Derived Oligodendrocyte Progenitor Cell Transplants Remyelinate and Restore Locomotion after Spinal Cord Injury

Keirstead, H. S., Nistor, G., Bernal, G. M., Totoiu, M. O., Cloutier, F., Sharp, K. L., & Steward, O. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0311-05.2005 · Cited by 1,253 · see citing works

PTEN deletion enhances the regenerative ability of adult corticospinal neurons

Liu, K., Lü, Y., Lee, J. K., Samara, R. F., Willenberg, R., Sears‐Kraxberger, I., Tedeschi, A., Park, K. K., Jin, D., Cai, B., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2603 · Cited by 987 · see citing works

Clinical trials in head injury

Narayan, R. K., Michel, M. E., Ansell, B., Baethmann, A., Biegon, A., Bracken, M. B., Bullock, M. R., Choi, S. C., Clifton, G. L., Contant, C. F., et al. (2002) · Journal of Neurotrauma · doi:10.1089/089771502753754037 · Cited by 913 · see citing works

cAMP and Schwann cells promote axonal growth and functional recovery after spinal cord injury

Pearse, D. D., Pereira, F. C., Marcillo, A. E., Bates, M. L., Berrocal, Y. A., Filbin, M. T., & Bunge, M. B. (2004) · Nature Medicine · doi:10.1038/nm1056 · Cited by 727 · see citing works

Publication bias in reports of animal stroke studies leads to major overstatement of efficacy

Sena, E. S., van der Worp, H. B., Bath, P. M. W., Howells, D. W., & Macleod, M. R. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000344 · Cited by 600 · see citing works

Experimental Modeling of Spinal Cord Injury: Characterization of a Force-Defined Injury Device

Scheff, S. W., Rabchevsky, A. G., Fugaccia, I., Main, J. A., & Lumpp, J. E. (2003) · Journal of Neurotrauma · doi:10.1089/08977150360547099 · Cited by 564 · see citing works

Design, power, and interpretation of studies in the standard murine model of ALS

Scott, S., Kranz, J. E., Cole, J., Lincecum, J. M., Thompson, K., Kelly, N., Bostrom, A., Theodoss, J., Al‐Nakhala, B. M., Vieira, F. G., et al. (2008) · Amyotrophic Lateral Sclerosis · doi:10.1080/17482960701856300 · Cited by 504 · see citing works

P2X7 receptor inhibition improves recovery after spinal cord injury

Wang, X., Arcuino, G., Takano, T., Lin, J. H.-C., Peng, W. G., Wan, P., Li, P., Xu, Q., Liu, Q. S., Goldman, S. A., et al. (2004) · Nature Medicine · doi:10.1038/nm1082 · Cited by 495 · see citing works

Bias as a threat to the validity of cancer molecular-marker research

Ransohoff, D. F. (2005) · Nature reviews. Cancer · doi:10.1038/nrc1550 · Cited by 480 · see citing works

MASCIS Evaluation of Open Field Locomotor Scores: Effects of Experience and Teamwork on Reliability

Basso, D. M., Beattie, M. S., Bresnahan, J. C., Anderson, D. K., Faden, A. I., Gruner, J. A., Holford, T. R., Hsu, C. Y., Noble‐Haeusslein, L. J., Nockels, R. P., et al. (1996) · Journal of Neurotrauma · doi:10.1089/neu.1996.13.343 · Cited by 449 · see citing works

Systemic administration of an antagonist of the ATP-sensitive receptor P2X7 improves recovery after spinal cord injury

Peng, W., Cotrina, M. L., Han, X., Yu, H., Bekar, L. K., Blum, L., Takano, T., Tian, G.-F., Goldman, S. A., & Nedergaard, M. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0902531106 · Cited by 425 · see citing works

Axon Regeneration in Young Adult Mice Lacking Nogo-A/B

Kim, J., Li, S., GrandPré, T., Qiu, D., & Strittmatter, S. M. (2003) · Neuron · doi:10.1016/s0896-6273(03)00147-8 · Cited by 413 · see citing works

The relationships among the severity of spinal cord injury, residual neurological function, axon counts, and counts of retrogradely labeled neurons after experimental spinal cord injury

Fehlings, M. G., & Tator, C. H. (1995) · Experimental Neurology · doi:10.1016/0014-4886(95)90027-6 · Cited by 405 · see citing works

Recombinant human erythropoietin counteracts secondary injury and markedly enhances neurological recovery from experimental spinal cord trauma

Gorio, A., Gökmen, N., Erbayraktar, S., Yılmaz, O., Madaschi, L., Cichetti, C., Giulio, A. M. D., Vardar, E., Cerami, A., & Brines, M. L. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.142287899 · Cited by 389 · see citing works

Adaptive Group Sequential Designs for Clinical Trials: Combining the Advantages of Adaptive and of Classical Group Sequential Approaches

Müller, H., & Schäfer, H. (2001) · Biometrics · doi:10.1111/j.0006-341x.2001.00886.x · Cited by 374 · see citing works

How can we improve the pre-clinical development of drugs for stroke?

Sena, E. S., van der Worp, H. B., Howells, D. W., & Macleod, M. R. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.06.009 · Cited by 365 · see citing works

Olfactory ensheathing cells promote locomotor recovery after delayed transplantation into transected spinal cord

Lu, J., Feron, F. P., Mackay‐Sim, A., & Waite, P. M. E. (2002) · Brain · doi:10.1093/brain/awf014 · Cited by 345 · see citing works

The effects of methylprednisolone and the ganglioside GM1 on acute spinal cord injury in rats

Constantini, S., & Young, W. (1994) · Journal of neurosurgery · doi:10.3171/jns.1994.80.1.0097 · Cited by 329 · see citing works

Transient Blockade of the CD11d/CD18 Integrin Reduces Secondary Damage after Spinal Cord Injury, Improving Sensory, Autonomic, and Motor Function

Gris, D., Marsh, D. R., Oatway, M. A., Chen, Y., Hamilton, E. F., Dekaban, G. A., & Weaver, L. C. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.5343-03.2004 · Cited by 320 · see citing works

Guidelines for preclinical animal research in ALS/MND: A consensus meeting

Ludolph, A. C., Bendotti, C., Blaugrund, E., Chiò, A., Greensmith, L., Loeffler, J., Mead, R. J., Niessen, H. G., Petri, S., Pradat, P., et al. (2010) · Amyotrophic Lateral Sclerosis · doi:10.3109/17482960903545334 · Cited by 315 · see citing works

Assessing Spinal Axon Regeneration and Sprouting in Nogo-, MAG-, and OMgp-Deficient Mice

Lee, J. K., Geoffroy, C. G., Chan, A. F., Tolentino, K. E., Crawford, M. J., Leal, M. A., Kang, B., & Zheng, B. (2010) · Neuron · doi:10.1016/j.neuron.2010.05.002 · Cited by 312 · see citing works

Minocycline Reduces Cell Death and Improves Functional Recovery after Traumatic Spinal Cord Injury in the Rat

Lee, S. M., Yune, T. Y., Kim, S. J., Park, D. W., Lee, Y. K., Kim, Y. C., Oh, Y. J., Markelonis, G. J., & Oh, T. H. (2003) · Journal of Neurotrauma · doi:10.1089/089771503770195867 · Cited by 305 · see citing works

Delayed Systemic Nogo-66 Receptor Antagonist Promotes Recovery from Spinal Cord Injury

Li, S., & Strittmatter, S. M. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-10-04219.2003 · Cited by 305 · see citing works

Sources of Bias in Specimens for Research About Molecular Markers for Cancer

Ransohoff, D. F., & Gourlay, M. L. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2009.25.6065 · Cited by 200 · see citing works

Endothelial sulfonylurea receptor 1–regulated NCCa-ATP channels mediate progressive hemorrhagic necrosis following spinal cord injury

Simard, J. M., Tsymbalyuk, O., Ivanov, A., Ivanova, S., Bhatta, S., Geng, Z., Woo, S. K., & Gerzanich, V. (2007) · Journal of Clinical Investigation · doi:10.1172/jci32041 · Cited by 197 · see citing works

Minocycline inhibits apoptotic cell death via attenuation of TNF‐α expression following iNOS/NO induction by lipopolysaccharide in neuron/glia co‐cultures

Lee, S. M., Yune, T. Y., Kim, S. J., Kim, Y. C., Oh, Y. J., Markelonis, G. J., & Oh, T. H. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02780.x · Cited by 139 · see citing works

Inosine stimulates extensive axon collateral growth in the rat corticospinal tract after injury

Benowitz, L. I., Goldberg, D. E., Madsen, J. R., Soni, D., & Irwin, N. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.23.13486 · Cited by 134 · see citing works

Translational Research in Spinal Cord Injury: A Survey of Opinion from the SCI Community

Kwon, B. K., Hillyer, J. E., & Tetzlaff, W. (2009) · Journal of Neurotrauma · doi:10.1089/neu.2009.1048 · Cited by 124 · see citing works

A re-assessment of the effects of a Nogo-66 receptor antagonist on regenerative growth of axons and locomotor recovery after spinal cord injury in mice

Steward, O., Sharp, K., Yee, K. M., & Hofstadter, M. (2007) · Experimental Neurology · doi:10.1016/j.expneurol.2007.12.010 · Cited by 124 · see citing works

Inhibiting Epidermal Growth Factor Receptor Improves Structural, Locomotor, Sensory, and Bladder Recovery from Experimental Spinal Cord Injury

Erschbamer, M., Pernold, K., & Olson, L. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.1037-07.2007 · Cited by 123 · see citing works

Key role for pregnenolone in combination therapy that promotes recovery after spinal cord injury.

Guth, L., Zhang, Z., & Roberts, E. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.25.12308 · Cited by 115 · see citing works

A re-assessment of the consequences of delayed transplantation of olfactory lamina propria following complete spinal cord transection in rats

Steward, O., Sharp, K., Selvan, G., Hadden, A., Hofstadter, M., Au, E., & Roskams, J. (2006) · Experimental Neurology · doi:10.1016/j.expneurol.2005.12.034 · Cited by 108 · see citing works

Bayesian clinical trials at the University of Texas M. D. Anderson Cancer Center

Biswas, S., Liu, D. D., Lee, J. J., & Berry, D. A. (2009) · Clinical Trials · doi:10.1177/1740774509104992 · Cited by 106 · see citing works

A re-assessment of minocycline as a neuroprotective agent in a rat spinal cord contusion model

Pinzón, A., Marcillo, A. E., Quintana, A., Stamler, S., Bunge, M. B., Bramlett, H. M., & Dietrich, W. D. (2008) · Brain Research · doi:10.1016/j.brainres.2008.09.047 · Cited by 95 · see citing works

Beyond Access vs. Protection in Trials of Innovative Therapies

London, A. J., Kimmelman, J., & Emborg, M. E. (2010) · Science · doi:10.1126/science.1189369 · Cited by 80 · see citing works

Regenerative Growth of Corticospinal Tract Axons via the Ventral Column after Spinal Cord Injury in Mice

Steward, O., Zheng, B., Tessier‐Lavigne, M., Hofstadter, M., Sharp, K., & Yee, K. M. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.5372-07.2008 · Cited by 73 · see citing works

A novel multicenter preclinical drug screening and biomarker consortium for experimental traumatic brain injury: operation brain trauma therapy.

Kochanek, P., Bramlett, H., Dietrich, W., Dixon, C., Hayes, R., Povlishock, J., Tortella, F., & Wang, K. K. W. (2011) · Journal of Trauma · doi:10.1097/ta.0b013e31822117fe · Cited by 58 · see citing works

Recommended guidelines for studies of human subjects with spinal cord injury

Anderson, D. K., Beattie, M. S., Blesch, A., Bresnahan, J. C., Bunge, M. B., Dietrich, D., Dietz, V., Dobkin, B. H., Fawcett, J. W., Fehlings, M. G., et al. (2005) · Spinal Cord · doi:10.1038/sj.sc.3101746 · Cited by 57 · see citing works

Response to: Kim et al., “Axon Regeneration in Young Adult Mice Lacking Nogo-A/B.” Neuron 38, 187–199

Steward, O., Zheng, B., Banos, K., & Yee, K. M. (2007) · Neuron · doi:10.1016/j.neuron.2007.04.004 · Cited by 53 · see citing works

A re-assessment of erythropoietin as a neuroprotective agent following rat spinal cord compression or contusion injury

Pinzón, A., Marcillo, A. E., Pabon, D., Bramlett, H. M., Bunge, M. B., & Dietrich, W. D. (2008) · Experimental Neurology · doi:10.1016/j.expneurol.2008.05.018 · Cited by 51 · see citing works

Article Commentary: The American Society for Neural Transplantation and Repair Considerations and Guidelines for Studies of Human Subjects the Practice Committee of the Society Approved by Council

Redmond, D. E., & Freeman, T. (2001) · Cell Transplantation · doi:10.3727/000000001783986170 · Cited by 21 · see citing works

The American Society for Neural Transplantation and Repair Considerations and guidelines for studies of human subjects. The practice committee of the society. Approved by council.

Redmond, D. E., & Freeman, T. P. (2001) · PubMed · Cited by 20 · see citing works

Key Alzheimer's findings questioned

Ledford, H. K. (2010) · Nature · doi:10.1038/4661031a · Cited by 11 · see citing works

A call for transparent reporting to optimize the predictive value of preclinical research

Landis, S. C., Amara, S. G., Asadullah, K., Austin, C. P., Blumenstein, R., Bradley, E. W., Crystal, R. G., Darnell, R. B., Ferrante, R. J., Fillit, H., et al. (2012) · Nature · doi:10.1038/nature11556 · Cited by 1,196 · see citing works

The economics of reproducibility in preclinical research

Freedman, L. P., Cockburn, I. M., & Simcoe, T. S. (2015) · PLOS Biology · doi:10.1371/journal.pbio.1002165 · Cited by 1,055 · see citing works

From basics to clinical: A comprehensive review on spinal cord injury

Silva, N. A., Sousa, N., Reis, R. L., & Salgado, A. J. (2013) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.11.002 · Cited by 814 · see citing works

Long-Term Consequences of Traumatic Brain Injury: Current Status of Potential Mechanisms of Injury and Neurological Outcomes

Bramlett, H. M., & Dietrich, W. D. (2014) · Journal of Neurotrauma · doi:10.1089/neu.2014.3352 · Cited by 554 · see citing works

Investigating the replicability of preclinical cancer biology

Errington, T. M., Mathur, M., Soderberg, C. K., Denis, A., Perfito, N., Iorns, E., & Nosek, B. A. (2021) · eLife · doi:10.7554/elife.71601 · Cited by 393 · see citing works

Restoring function after spinal cord injury: towards clinical translation of experimental strategies.

Ramer, L., Ramer, M., & Bradbury, E. (2014) · Lancet Neurology · doi:10.1016/s1474-4422(14)70144-9 · Cited by 280 · see citing works

Challenges for assessing replicability in preclinical cancer biology

Errington, T. M., Denis, A., Perfito, N., Iorns, E., & Nosek, B. A. (2021) · eLife · doi:10.7554/elife.67995 · Cited by 323 · see citing works

Concepts and Methods for the Study of Axonal Regeneration in the CNS

Tuszynski, M. H., & Steward, O. (2012) · Neuron · doi:10.1016/j.neuron.2012.05.006 · Cited by 305 · see citing works

Restoration of sensorimotor functions after spinal cord injury

Dietz, V., & Fouad, K. (2013) · Brain · doi:10.1093/brain/awt262 · Cited by 293 · see citing works

An open investigation of the reproducibility of cancer biology research

Errington, T. M., Iorns, E., Gunn, W., Tan, F. E., Lomax, J., & Nosek, B. A. (2014) · eLife · doi:10.7554/elife.04333 · Cited by 312 · see citing works

Distinguishing between exploratory and confirmatory preclinical research will improve translation

Kimmelman, J., Mogil, J. S., & Dirnagl, U. (2014) · PLoS Biology · doi:10.1371/journal.pbio.1001863 · Cited by 236 · see citing works

Therapeutic repair for spinal cord injury: combinatory approaches to address a multifaceted problem

Griffin, J. M., & Bradke, F. (2020) · EMBO Molecular Medicine · doi:10.15252/emmm.201911505 · Cited by 220 · see citing works

Preclinical research in Rett syndrome: setting the foundation for translational success

Katz, D. M., Berger-Sweeney, J. E., Eubanks, J. H., Justice, M. J., Neul, J. L., Pozzo-Miller, L., Blue, M. E., Christian, D., Crawley, J. N., Giustetto, M., et al. (2012) · Disease Models & Mechanisms · doi:10.1242/dmm.011007 · Cited by 206 · see citing works

Big data from small data: data-sharing in the 'long tail' of neuroscience

Ferguson, A. R., Nielson, J. L., Cragin, M. H., Bandrowski, A. E., & Martone, M. E. (2014) · Nature Neuroscience · doi:10.1038/nn.3838 · Cited by 211 · see citing works

Found in Translation

Dirnagl, U., & Endres, M. (2014) · Stroke · doi:10.1161/strokeaha.113.004075 · Cited by 194 · see citing works

Pain and laboratory animals: publication practices for better data reproducibility and better animal welfare

Carbone, L., & Austin, J. (2016) · PLOS ONE · doi:10.1371/journal.pone.0155001 · Cited by 191 · see citing works

Scientific Utopia III: Crowdsourcing Science

Uhlmann, E. L., Ebersole, C. R., Chartier, C. R., Errington, T. M., Kidwell, M. C., Lai, C. K., McCarthy, R. J., Riegelman, A., Silberzahn, R., & Nosek, B. A. (2019) · Perspectives on Psychological Science · doi:10.1177/1745691619850561 · Cited by 182 · see citing works

How to design preclinical studies in nanomedicine and cell therapy to maximize the prospects of clinical translation

Ioannidis, J. P. A., Kim, B. Y. S., & Trounson, A. (2018) · Nature Biomedical Engineering · doi:10.1038/s41551-018-0314-y · Cited by 175 · see citing works

The neuroanatomical–functional paradox in spinal cord injury

Fouad, K., Popovich, P. G., Kopp, M. A., & Schwab, J. M. (2020) · Nature Reviews Neurology · doi:10.1038/s41582-020-00436-x · Cited by 160 · see citing works

Bringing rigour to translational medicine

Howells, D. W., Sena, E. S., & Macleod, M. R. (2014) · Nature Reviews Neurology · doi:10.1038/nrneurol.2013.232 · Cited by 130 · see citing works

Olfactory Ensheathing Cell Transplantation in Experimental Spinal Cord Injury: Effect size and Reporting Bias of 62 Experimental Treatments: A Systematic Review and Meta-Analysis

Watzlawick, R., Rind, J., Sena, E., Brommer, B., Zhang, T., Kopp, M., Dirnagl, U., Macleod, M., Howells, D., & Schwab, J. (2016) · PLoS Biology · doi:10.1371/journal.pbio.1002468 · Cited by 101 · see citing works

Evaluating mesenchymal stem cell therapy for sepsis with preclinical meta-analyses prior to initiating a first-in-human trial

Lalu, M. M., Sullivan, K., Mei, S. H. J., Moher, D., Straus, A., Fergusson, D. A., Stewart, D. J., Jazi, M., Macleod, M. R., Winston, B. W., et al. (2016) · eLife · doi:10.7554/elife.17850 · Cited by 116 · see citing works

The challenge and promise of anti-epileptic therapy development in animal models

Simonato, M., Brooks‐Kayal, A. R., Engel, J., Galanopoulou, A. S., Jensen, F. E., Moshé, S. L., O'Brien, T. J., Pitkänen, A., Wilcox, K. S., & French, J. A. (2014) · The Lancet Neurology · doi:10.1016/s1474-4422(14)70076-6 · Cited by 114 · see citing works

Neurotrophic factors for spinal cord repair: Which, where, how and when to apply, and for what period of time?

Harvey, A. R., Lovett, S. J., Majda, B. T., Yoon, J. H., Wheeler, L. P. G., & Hodgetts, S. I. (2014) · Brain Research · doi:10.1016/j.brainres.2014.10.049 · Cited by 108 · see citing works

Large animal and primate models of spinal cord injury for the testing of novel therapies

Kwon, B. K., Streijger, F., Hill, C. E., Anderson, A. J., Bacon, M., Beattie, M. S., Blesch, A., Bradbury, E. J., Brown, A. M., Bresnahan, J. C., et al. (2015) · Experimental Neurology · doi:10.1016/j.expneurol.2015.04.008 · Cited by 97 · see citing works

Issues related to development of antiepileptogenic therapies

Pitkänen, A., Nehlig, A., Brooks‐Kayal, A. R., Dudek, F. E., Friedman, D. J., Galanopoulou, A. S., Jensen, F. E., Kaminski, R. M., Kapur, J., Klitgaard, H., et al. (2013) · Epilepsia · doi:10.1111/epi.12297 · Cited by 95 · see citing works

Effect and Reporting Bias of RhoA/ROCK-Blockade Intervention on Locomotor Recovery After Spinal Cord Injury

Watzlawick, R., Sena, E. S., Dirnagl, U., Brommer, B., Kopp, M. A., Macleod, M. R., Howells, D. W., & Schwab, J. M. (2013) · JAMA Neurology · doi:10.1001/jamaneurol.2013.4684 · Cited by 97 · see citing works

Data sharing in psychology.

Martone, M. E., García, A., & VandenBos, G. R. (2018) · American Psychologist · doi:10.1037/amp0000242 · Cited by 89 · see citing works

Minimum Information about a Spinal Cord Injury Experiment: A Proposed Reporting Standard for Spinal Cord Injury Experiments

Lemmon, V., Ferguson, A. R., Popovich, P. G., Xu, X., Snow, D. M., Igarashi, M., Beattie, C. E., & Bixby, J. L. (2014) · Journal of Neurotrauma · doi:10.1089/neu.2014.3400 · Cited by 77 · see citing works

Chondroitinase gene therapy improves upper limb function following cervical contusion injury

James, N. D., Shea, J. R., Muir, E. M., Verhaagen, J., Schneider, B. L., & Bradbury, E. J. (2015) · Experimental Neurology · doi:10.1016/j.expneurol.2015.05.022 · Cited by 73 · see citing works

Lymphocytes and autoimmunity after spinal cord injury

Jones, T. B. (2014) · Experimental Neurology · doi:10.1016/j.expneurol.2014.03.003 · Cited by 72 · see citing works

A re-assessment of long distance growth and connectivity of neural stem cells after severe spinal cord injury

Sharp, K., Yee, K. M., & Steward, O. (2014) · Experimental Neurology · doi:10.1016/j.expneurol.2014.04.008 · Cited by 71 · see citing works

Consider drug efficacy before first-in-human trials

Kimmelman, J., & Federico, C. A. (2017) · Nature · doi:10.1038/542025a · Cited by 68 · see citing works

Blockage of Lysophosphatidic Acid Signaling Improves Spinal Cord Injury Outcomes

Goldshmit, Y., Matteo, R., Sztal, T. E., Ellett, F. E., Frisca, F., Moreno, K. M., Crombie, D. E., Lieschke, G. J., Currie, P. D., Sabbadini, R. A., et al. (2012) · American Journal Of Pathology · doi:10.1016/j.ajpath.2012.06.007 · Cited by 66 · see citing works

Spinal Cord Repair: From Cells and Tissue Engineering to Extracellular Vesicles

Guo, S., Redenski, I., & Levenberg, S. (2021) · Cells · doi:10.3390/cells10081872 · Cited by 64 · see citing works

Demonstrating efficacy in preclinical studies of cellular therapies for spinal cord injury — How much is enough?

Kwon, B. K., Soril, L. J. J., Bacon, M., Beattie, M. S., Blesch, A., Bresnahan, J. C., Bunge, M. B., Dunlop, S. A., Fehlings, M. G., Ferguson, A. R., et al. (2013) · Experimental Neurology · doi:10.1016/j.expneurol.2013.05.012 · Cited by 59 · see citing works

Rigor or mortis: best practices for preclinical research in neuroscience.

Steward, O., & Balice-Gordon, R. (2014) · Neuron · doi:10.1016/j.neuron.2014.10.042 · Cited by 58 · see citing works

Preventing the ends from justifying the means: withholding results to address publication bias in peer-review

Button, K., Bal, L., Clark, A., & Shipley, T. (2016) · BMC Psychology · doi:10.1186/s40359-016-0167-7 · Cited by 51 · see citing works

Pharmacologic Management of Duchenne Muscular Dystrophy: Target Identification and Preclinical Trials

Kornegay, J. N., Spurney, C. F., Nghiem, P. P., Brinkmeyer‐Langford, C., Hoffman, E. P., & Nagaraju, K. (2014) · ILAR Journal · doi:10.1093/ilar/ilu011 · Cited by 57 · see citing works

Development of a Database for Translational Spinal Cord Injury Research

Nielson, J. L., Guandique, C. F., Liu, A. W., Burke, D. A., Lash, A. T., Moseanko, R., Hawbecker, S., Strand, S. C., Zdunowski, S., Irvine, K., et al. (2014) · Journal of Neurotrauma · doi:10.1089/neu.2014.3399 · Cited by 55 · see citing works

Developing a data sharing community for spinal cord injury research

Callahan, A., Anderson, K. D., Beattie, M. S., Bixby, J. L., Ferguson, A. R., Fouad, K., Jakeman, L. B., Nielson, J. L., Popovich, P. G., Schwab, J. M., et al. (2017) · Experimental Neurology · doi:10.1016/j.expneurol.2017.05.012 · Cited by 53 · see citing works

Harnessing QbD, Programming Languages, and Automation for Reproducible Biology

Sadowski, M. I., Grant, C., & Fell, T. S. (2015) · Trends in biotechnology · doi:10.1016/j.tibtech.2015.11.006 · Cited by 51 · see citing works

Delayed Intervention with Intermittent Hypoxia and Task Training Improves Forelimb Function in a Rat Model of Cervical Spinal Injury

Prosser-Loose, E. J., Hassan, A. U., Mitchell, G. S., & Muir, G. D. (2015) · Journal of Neurotrauma · doi:10.1089/neu.2014.3789 · Cited by 49 · see citing works

Critical appraisal of studies using laboratory animal models.

O'Connor, A., & Sargeant, J. (2014) · ILAR journal · doi:10.1093/ilar/ilu038 · Cited by 45 · see citing works

Epilepsy therapy development: Technical and methodologic issues in studies with animal models

Galanopoulou, A. S., Kokaia, M., Loeb, J. A., Nehlig, A., Pitkänen, A., Rogawski, M. A., Staley, K. J., Whittemore, V., & Dudek, F. E. (2013) · Epilepsia · doi:10.1111/epi.12295 · Cited by 50 · see citing works

A Direct Comparison of Three Clinically Relevant Treatments in a Rat Model of Cervical Spinal Cord Injury

Hosier, H., Peterson, D., Tsymbalyuk, O., Keledjian, K. M., Smith, B. R., Ivanova, S., Gerzanich, V., Popovich, P. G., & Simard, J. M. (2015) · Journal of Neurotrauma · doi:10.1089/neu.2015.3892 · Cited by 50 · see citing works

Evaluating the credibility of histopathology data in environmental endocrine toxicity studies

Wolf, J. C., & Maack, G. (2016) · Environmental Toxicology and Chemistry · doi:10.1002/etc.3695 · Cited by 49 · see citing works

Pathological Changes in the White Matter after Spinal Contusion Injury in the Rat

Ek, C. J., Habgood, M. D., Dennis, R., Dzięgielewska, K. M., Mallard, C. E., Wheaton, B. J., & Saunders, N. R. (2012) · PLoS ONE · doi:10.1371/journal.pone.0043484 · Cited by 48 · see citing works

Independent replication of motor cortex and cervical spinal cord electrical stimulation to promote forelimb motor function after spinal cord injury in rats

Yang, Q., Ramamurthy, A., Lall, S., Santos, J., Ratnadurai‐Giridharan, S., Lopane, M., Zareen, N., Alexander, H., Ryan, D., Martin, J. H., et al. (2019) · Experimental Neurology · doi:10.1016/j.expneurol.2019.112962 · Cited by 45 · see citing works

Cell transplantation and secretome based approaches in spinal cord injury regenerative medicine

Silva, R. C. A., Pinto, L., & Salgado, A. J. (2021) · Medicinal Research Reviews · doi:10.1002/med.21865 · Cited by 43 · see citing works

Comprehensive Corticospinal Labeling withmu-crystallinTransgene Reveals Axon Regeneration after Spinal Cord Trauma inngr1−/−Mice

Fink, K. L., Strittmatter, S. M., & Cafferty, W. B. J. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.3165-15.2015 · Cited by 43 · see citing works

Common data elements and data management: Remedy to cure underpowered preclinical studies

Lapinlampi, N., Melin, E., Aronica, E., Bankstahl, J. P., Becker, A. J., Bernard, C., Gorter, J. A., Gröhn, O. H. J., Lipsanen, A., Łukasiuk, K., et al. (2016) · Epilepsy Research · doi:10.1016/j.eplepsyres.2016.11.010 · Cited by 43 · see citing works

Validation study of neurotrophin-3-releasing chitosan facilitation of neural tissue generation in the severely injured adult rat spinal cord

Oudega, M., Hao, P., Shang, J., Haggerty, A. E., Wang, Z., Sun, J. H., Liebl, D. J., Shi, Y., Cheng, L., Duan, H., et al. (2018) · Experimental Neurology · doi:10.1016/j.expneurol.2018.11.003 · Cited by 41 · see citing works

A re-assessment of the effects of treatment with a non-steroidal anti-inflammatory (ibuprofen) on promoting axon regeneration via RhoA inhibition after spinal cord injury

Sharp, K., Yee, K. M., Stiles, T. L., Aguilar, R. M., & Steward, O. (2013) · Experimental Neurology · doi:10.1016/j.expneurol.2013.06.023 · Cited by 40 · see citing works

The Lesioned Spinal Cord Is a “New” Spinal Cord: Evidence from Functional Changes after Spinal Injury in Lamprey

Parker, D. (2017) · Frontiers in Neural Circuits · doi:10.3389/fncir.2017.00084 · Cited by 40 · see citing works

Outcome heterogeneity and bias in acute experimental spinal cord injury

Watzlawick, R., Antonić, A., Sena, E., Kopp, M., Rind, J., Dirnagl, U., Macleod, M., Howells, D., & Schwab, J. (2019) · Neurology · doi:10.1212/wnl.0000000000007718 · Cited by 37 · see citing works

FAIR SCI Ahead: The Evolution of the Open Data Commons for Pre-Clinical Spinal Cord Injury Research

Fouad, K., Bixby, J. L., Callahan, A., Grethe, J. S., Jakeman, L. B., Lemmon, V., Magnuson, D. S. K., Martone, M. E., Nielson, J. L., Schwab, J. M., et al. (2019) · Journal of Neurotrauma · doi:10.1089/neu.2019.6674 · Cited by 40 · see citing works

Biomaterial-based interventions for neuronal regeneration and functional recovery in rodent model of spinal cord injury: A systematic review

Krishna, V., Konakondla, S., Nicholas, J. S., Varma, A. K., Kindy, M. S., & Wen, X. (2013) · Journal of Spinal Cord Medicine · doi:10.1179/2045772313y.0000000095 · Cited by 40 · see citing works

A Preclinical Consortium Approach for Assessing the Efficacy of Combined Anti-CD3 Plus IL-1 Blockade in Reversing New-Onset Autoimmune Diabetes in NOD Mice

Gill, R. G., Pagni, P. P., Kupfer, T., Wasserfall, C. H., Deng, S., Posgai, A. L., Manenkova, Y., Hani, A. B., Straub, L., Bernstein, P., et al. (2015) · Diabetes · doi:10.2337/db15-0492 · Cited by 39 · see citing works

JMJD2 promotes acquired cisplatin resistance in non-small cell lung carcinoma cells

Duan, L., Perez, R. E., Chastain, P. D., Mathew, M. T., Bijukumar, D. R., & Maki, C. G. (2019) · Oncogene · doi:10.1038/s41388-019-0814-6 · Cited by 38 · see citing works

Promoting FAIR Data Through Community-driven Agile Design: the Open Data Commons for Spinal Cord Injury (odc-sci.org)

Espin, A. T., de Almeida, C., Chou, A., Huie, J. R., Chiu, M. W., Vavrek, R., Sacramento, J. A., Orr, M. B., Gensel, J. C., Grethe, J. S., et al. (2021) · Neuroinformatics · doi:10.1007/s12021-021-09533-8 · Cited by 36 · see citing works

Rho Signaling and Axon Regeneration

McKerracher, L. J., Ferraro, G. B., & Fournier, A. E. (2012) · International review of neurobiology · doi:10.1016/b978-0-12-398309-1.00007-x · Cited by 35 · see citing works

A review of animal models utilized in preclinical studies of approved gene therapy products: trends and insights

Soufizadeh, P., Mansouri, V., & Ahmadbeigi, N. (2024) · Laboratory Animal Research · doi:10.1186/s42826-024-00195-6 · Cited by 40 · see citing works

Evaluating the effectiveness of anti-Nogo treatment in spinal cord injuries

Mohammed, R., Opara, K., Lall, R., Ojha, U., & Xiang, J. (2020) · Neural Development · doi:10.1186/s13064-020-0138-9 · Cited by 34 · see citing works

Biomarkers for posttraumatic epilepsy

Pitkänen, A., Paananen, T., Kyyriäinen, J., Gupta, S. D., Heiskanen, M., Vuokila, N., Bañuelos‐Cabrera, I., Lapinlampi, N., Kajevu, N., Andrade, P., et al. (2020) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2020.107080 · Cited by 34 · see citing works

Brain-wide analysis of the supraspinal connectome reveals anatomical correlates to functional recovery after spinal injury

Wang, Z., Romanski, A., Mehra, V., Wang, Y., Brannigan, M., Campbell, B. C., Petsko, G. A., Tsoulfas, P., & Blackmore, M. G. (2022) · eLife · doi:10.7554/elife.76254 · Cited by 30 · see citing works

The roles of chemokine (C-X-C motif) ligand 13 in spinal cord ischemia-reperfusion injury in rats

Chen, F., Li, X., Li, Z., Zhou, Y., Qiang, Z., & Ma, H. (2019) · Brain Research · doi:10.1016/j.brainres.2019.146489 · Cited by 29 · see citing works

Experimental design and reporting standards for improving the internal validity of pre-clinical studies in the field of pain: Consensus of the IMI-Europain consortium

Knopp, K. L., Stenfors, C., Baastrup, C., Bannon, A. W., Calvo, M., Caspani, O., Currie, G. L., Finnerup, N. B., Huang, W., Kennedy, J. D., et al. (2015) · Scandinavian Journal of Pain · doi:10.1016/j.sjpain.2015.01.006 · Cited by 29 · see citing works

The methodological quality of animal research in critical care: the public face of science

Bara, M., & Joffe, A. R. (2014) · Annals of Intensive Care · doi:10.1186/s13613-014-0026-8 · Cited by 28 · see citing works

Examining the predictive validity of NIH peer review scores

Lindner, M. D., & Nakamura, R. K. (2015) · PLOS ONE · doi:10.1371/journal.pone.0126938 · Cited by 24 · see citing works

ProvCaRe: Characterizing scientific reproducibility of biomedical research studies using semantic provenance metadata

Sahoo, S. S., Valdez, J., Kim, M. J., Rueschman, M., & Redline, S. S. (2018) · International Journal of Medical Informatics · doi:10.1016/j.ijmedinf.2018.10.009 · Cited by 23 · see citing works

Bilateral cervical contusion spinal cord injury: A mouse model to evaluate sensorimotor function

Reinhardt, D. R., Stehlik, K. E., Satkunendrarajah, K., & Kroner, A. (2020) · Experimental Neurology · doi:10.1016/j.expneurol.2020.113381 · Cited by 24 · see citing works

Fighting for recovery on multiple fronts: The past, present, and future of clinical trials for spinal cord injury

Dietz, V. A., Roberts, N., Knox, K., Moore, S., Pitonak, M., Barr, C., Centeno, J., Leininger, S., New, K. C., Nowell̀, P. C., et al. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.977679 · Cited by 22 · see citing works

Cell Therapy for Spinal Cord Injuries

Granger, N. P., Franklin, R. J. M., & Jeffery, N. D. (2014) · The Neuroscientist · doi:10.1177/1073858413514635 · Cited by 22 · see citing works

Understanding the axonal response to injury by in vivo imaging in the mouse spinal cord: A tale of two branches

Zheng, B., Lorenzana, A. O., & Ma, L. (2019) · Experimental Neurology · doi:10.1016/j.expneurol.2019.04.008 · Cited by 22 · see citing works

Preclinical assessment for translation to humans: The PATH approach for assessing supporting evidence for early-phase trials and innovative care

Kimmelman, J., Kane, P. B., Bicer, S., & Carlisle, B. G. (2024) · Med · doi:10.1016/j.medj.2024.07.014 · Cited by 21 · see citing works

NIH Peer Review

Lindner, M. D., Vancea, A., Chen, M., & Chacko, G. W. (2015) · American Journal of Evaluation · doi:10.1177/1098214015582049 · Cited by 21 · see citing works

Leveraging biomedical informatics for assessing plasticity and repair in primate spinal cord injury

Nielson, J. L., Haefeli, J., Salegio, E. A., Liu, A. W., Guandique, C. F., Stück, E. D., Hawbecker, S., Moseanko, R., Strand, S. C., Zdunowski, S., et al. (2014) · Brain Research · doi:10.1016/j.brainres.2014.10.048 · Cited by 20 · see citing works

Protection and Repair After Spinal Cord Injury: Accomplishments and Future Directions

Dietrich, W. D. (2015) · Topics in Spinal Cord Injury Rehabilitation · doi:10.1310/sci2102-174 · Cited by 20 · see citing works

A Rhumba of “R’s”: Replication, Reproducibility, Rigor, Robustness: What Does a Failure to Replicate Mean?

Steward, O. (2016) · eNeuro · doi:10.1523/eneuro.0072-16.2016 · Cited by 18 · see citing works

Epilepsy phenotype and its reproducibility after lateral fluid percussion‐induced traumatic brain injury in rats: Multicenter EpiBioS4Rx study project 1

Ndode‐Ekane, X. E., Ali, I. Y., Santana‐Gomez, C., Andrade, P., Immonen, R. J., Casillas-Espinosa, P. M., Paananen, T., Manninen, E., Puhakka, N., Smith, G. S., et al. (2023) · Epilepsia · doi:10.1111/epi.17838 · Cited by 18 · see citing works

A re-assessment of treatment with a tyrosine kinase inhibitor (imatinib) on tissue sparing and functional recovery after spinal cord injury

Sharp, K., Yee, K. M., & Steward, O. (2014) · Experimental Neurology · doi:10.1016/j.expneurol.2013.12.019 · Cited by 18 · see citing works

RegenBase: a knowledge base of spinal cord injury biology for translational research

Callahan, A., Abeyruwan, S. W., Al‐Ali, H., Sakurai, K., Ferguson, A. R., Popovich, P. G., Shah, N. H., Visser, U., Bixby, J. L., & Lemmon, V. (2016) · Database · doi:10.1093/database/baw040 · Cited by 18 · see citing works

Developing a spinal cord injury research strategy using a structured process of evidence review and stakeholder dialogue. Part III: outcomes

Middleton, J. W., Piccenna, L. G., Gruen, R. L., Williams, S., Creasey, G. H., Dunlop, S. A., Brown, D., Batchelor, P., Berlowitz, D. J., Coates, S., et al. (2015) · Spinal Cord · doi:10.1038/sc.2015.87 · Cited by 17 · see citing works

Lentiviral-Mediated Netrin-1 Overexpression Improves Motor and Sensory Functions in SCT Rats Associated with SYP and GAP-43 Expressions

Han, X., Zhang, Y., Xiong, L.-L., Xu, Y. X. Z., Zhang, P., Xia, Q., Wang, T., & Ba, Y. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-9723-7 · Cited by 17 · see citing works

Measuring the effects of publication bias in political science

Esarey, J., & Wu, A. (2016) · Research & Politics · doi:10.1177/2053168016665856 · Cited by 17 · see citing works

Neurobiological reduction: From cellular explanations of behavior to interventions

Parker, D. (2022) · Frontiers in Psychology · doi:10.3389/fpsyg.2022.987101 · Cited by 18 · see citing works

Consequences of Common Data Analysis Inaccuracies in CNS Trauma Injury Basic Research

Burke, D. A., Whittemore, S. R., & Magnuson, D. S. K. (2012) · Journal of Neurotrauma · doi:10.1089/neu.2012.2704 · Cited by 16 · see citing works

Preface - Practical and theoretical considerations for performing a multi-center preclinical biomarker discovery study of post-traumatic epileptogenesis: lessons learned from the EpiBioS4Rx consortium

Pitkänen, A., O'Brien, T. J., & Staba, R. J. (2019) · Epilepsy Research · doi:10.1016/j.eplepsyres.2019.01.007 · Cited by 15 · see citing works

Advances and Challenges for Neural Regeneration Research

Wang, X., So, K., & Xu, X. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-801732-6.00001-x · Cited by 15 · see citing works

A Dynamic Balance between Neuronal Death and Clearance in an in Vitro Model of Acute Brain Injury

Balena, T., Lillis, K. P., Rahmati, N., Bahari, F., Dzhala, V. I., Berdichevsky, E., & Staley, K. J. (2023) · Journal of Neuroscience · doi:10.1523/jneurosci.0436-23.2023 · Cited by 14 · see citing works

Challenges in Translating Regenerative Therapies for Spinal Cord Injury

Stewart, A. N., Gensel, J. C., Jones, L., & Fouad, K. (2023) · Topics in Spinal Cord Injury Rehabilitation · doi:10.46292/sci23-00044s · Cited by 14 · see citing works

High-speed video analysis improves the accuracy of spinal cord compression measurement in a mouse contusion model

Fournely, M., Petit, Y., Wagnac, É., Laurin, J., Callot, V., & Arnoux, P. (2017) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2017.09.007 · Cited by 14 · see citing works

Co-targeting myelin inhibitors and CSPGs markedly enhances regeneration of GDNF-stimulated, but not conditioning-lesioned, sensory axons into the spinal cord

Zhai, J., Kim, H., Han, S. B., Manire, M., Yoo, R., Pang, S., Smith, G. M., & Son, Y. (2021) · eLife · doi:10.7554/elife.63050 · Cited by 14 · see citing works

Estimating the replicability of Brazilian biomedical science

Initiative, T. B. R., Amaral, O. B., Carneiro, C. F. D., Neves, K., Sampaio, A. P. W., Gomes, B. V., Abreu, M. B. D., Tan, P. B., Mota, G. P. S., Goulart, R. N., et al. (2025) · bioRxiv · doi:10.1101/2025.04.02.645026 · Cited by 13 · see citing works

Testing of putative antiseizure medications in a preclinical Dravet syndrome zebrafish model

Whyte‐Fagundes, P., Vance, A., Carroll, A., Figueroa, F., Manukyan, C., & Baraban, S. C. (2024) · Brain Communications · doi:10.1093/braincomms/fcae135 · Cited by 13 · see citing works

Prospective Harmonization, Common Data Elements, and Sharing Strategies for Multicenter Pre-Clinical Traumatic Brain Injury Research in the Translational Outcomes Project in Neurotrauma Consortium

Wanner, I. B., McCabe, J. T., Huie, J. R., Harris, N. G., Paydar, A., McMann-Chapman, C., Tobar, A., Korotcov, A. V., Burns, M. P., Koehler, R. C., et al. (2025) · Journal of Neurotrauma · doi:10.1089/neu.2023.0653 · Cited by 13 · see citing works

Weight-Bearing Locomotion in the Developing Opossum, Monodelphis domestica following Spinal Transection: Remodeling of Neuronal Circuits Caudal to Lesion

Wheaton, B. J., Noor, N. M., Whish, S. C., Truettner, J. S., Dietrich, W. D., Zhang, M., Crack, P. J., Dzięgielewska, K. M., & Saunders, N. R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0071181 · Cited by 14 · see citing works

Peptide Derivatives of Erythropoietin in the Treatment of Neuroinflammation and Neurodegeneration

Ercan, İ., Tüfekçi, K. U., Karaca, E., Genç, Ş., & Genç, K. (2018) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2018.01.007 · Cited by 13 · see citing works

Spinal cord injury – there is not just one way of treating it

Estrada, V., & Müller, H. W. (2014) · F1000Prime Reports · doi:10.12703/p6-84 · Cited by 12 · see citing works

Facilitating transparency in spinal cord injury studies using data standards and ontologies

Lemmon, V., Abeyruwan, S., Visser, U., & Bixby, J. (2014) · Neural Regeneration Research · doi:10.4103/1673-5374.125322 · Cited by 9 · see citing works

Peripheral Nerve Suicide Transport Generates a Reproducible SCI

Pagano, J. E., Liang, A. S., Chrzan, C. A., & McKinnon, R. D. (2017) · Spine Research · doi:10.21767/2471-8173.100038

Repair of spinal cord injury:advancement in methods

Tingbao, Z., Zhao-tong, L., Liu, S., & Jinan, P. (2006) · Academic Journal of Second Military Medical University

The rocky road to translation in spinal cord repair

Filli, L., & Schwab, M. E. (2012) · Annals of Neurology · doi:10.1002/ana.23630 · Cited by 70 · see citing works

Restoring function after spinal cord injury: towards clinical translation of experimental strategies.

Ramer, L., Ramer, M., & Bradbury, E. (2014) · Lancet Neurology · doi:10.1016/s1474-4422(14)70144-9 · Cited by 280 · see citing works