AXL-mediate GEF-H1 phosphorylation was involved in microglia synapse phagocytosis in 5xFAD mice

Morris water maze: procedures for assessing spatial and related forms of learning and memory

Vorhees, C. V., & Williams, M. T. (2006) · Nature Protocols · doi:10.1038/nprot.2006.116 · Cited by 4,629 · see citing works

Physiology of Microglia

Kettenmann, H., Hanisch, U.-K., Noda, M., & Verkhratsky, A. (2011) · Physiological Reviews · doi:10.1152/physrev.00011.2010 · Cited by 3,547 · see citing works

Complement and microglia mediate early synapse loss in Alzheimer mouse models

Hong, S., Beja-Glasser, V. F., Nfonoyim, B. M., Frouin, A., Li, S., Ramakrishnan, S., Merry, K. M., Shi, Q., Rosenthal, A., Barres, B. A., et al. (2016) · Science · doi:10.1126/science.aad8373 · Cited by 3,343 · see citing works

Alzheimer Disease: An Update on Pathobiology and Treatment Strategies

Long, J. M., & Holtzman, D. M. (2019) · Cell · doi:10.1016/j.cell.2019.09.001 · Cited by 3,204 · see citing works

Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?

Leng, F., & Edison, P. (2021) · Nature Reviews Neurology · doi:10.1038/s41582-020-00435-y · Cited by 3,179 · see citing works

Alzheimer disease

Knopman, D. S., Amieva, H., Petersen, R. C., Chételat, G., Holtzman, D. M., Hyman, B. T., Nixon, R. A., & Jones, D. T. (2021) · Nature Reviews Disease Primers · doi:10.1038/s41572-021-00269-y · Cited by 2,606 · see citing works

Disease-Associated Microglia: A Universal Immune Sensor of Neurodegeneration

Deczkowska, A., Keren-Shaul, H., Weiner, A., Colonna, M., Schwartz, M., & Amit, I. (2018) · Cell · doi:10.1016/j.cell.2018.05.003 · Cited by 1,474 · see citing works

The SYK tyrosine kinase: A crucial player in diverse biological functions

Mócsai, A., Ruland, J., & Tybulewicz, V. L. J. (2010) · Nature Reviews Immunology · doi:10.1038/nri2765 · Cited by 1,368 · see citing works

Object recognition test in mice

Leger, M., Quiedeville, A., Bouet, V., Haelewyn, B., Boulouard, M., Schumann-Bard, P., & Freret, T. (2013) · Nature Protocols · doi:10.1038/nprot.2013.155 · Cited by 1,357 · see citing works

The TAM family: phosphatidylserine-sensing receptor tyrosine kinases gone awry in cancer

Graham, D. K., DeRyckere, D., Davies, K. D., & Earp, H. S. (2014) · Nature reviews. Cancer · doi:10.1038/nrc3847 · Cited by 708 · see citing works

Complement C3 deficiency protects against neurodegeneration in aged plaque-rich APP/PS1 mice

Shi, Q., Chowdhury, S., Ma, R., Le, K. X., Hong, S., Caldarone, B. J., Stevens, B., & Lemere, C. A. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aaf6295 · Cited by 593 · see citing works

Synaptic degeneration in Alzheimer disease

Tzioras, M., McGeachan, R. I., Durrant, C. S., & Spires-Jones, T. L. (2023) · Nature Reviews Neurology · doi:10.1038/s41582-022-00749-z · Cited by 504 · see citing works

Microglia use TAM receptors to detect and engulf amyloid β plaques

Huang, Y., Happonen, K. E., Burrola, P. G., O’Connor, C., Hah, N., Huang, L., Nimmerjahn, A., & Lemke, G. (2021) · Nature Immunology · doi:10.1038/s41590-021-00913-5 · Cited by 483 · see citing works

TREM2 drives microglia response to amyloid-β via SYK-dependent and -independent pathways

Wang, S., Sudan, R., Peng, V., Zhou, Y., Du, S., Yuede, C. M., Lei, T., Hou, J., Cai, Z., Cella, M., et al. (2022) · Cell · doi:10.1016/j.cell.2022.09.033 · Cited by 471 · see citing works

Rab family of small GTPases: an updated view on their regulation and functions

Homma, Y., Hiragi, S., & Fukuda, M. (2020) · FEBS Journal · doi:10.1111/febs.15453 · Cited by 468 · see citing works

Complement C3 Is Activated in Human AD Brain and Is Required for Neurodegeneration in Mouse Models of Amyloidosis and Tauopathy

Wu, T., Dejanovic, B., Gandham, V. D., Gogineni, A., Edmonds, R., Schauer, S., Srinivasan, K., Huntley, M. A., Wang, Y., Wang, T.-M., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.07.060 · Cited by 466 · see citing works

Synapses and Alzheimer's Disease

Sheng, M., Sabatini, B. L., & Sudhof, T. C. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005777 · Cited by 436 · see citing works

Diversification of TAM receptor tyrosine kinase function

Zagórska, A., Través, P. G., Lew, E. D., Dransfield, I., & Lemke, G. (2014) · Nature Immunology · doi:10.1038/ni.2986 · Cited by 430 · see citing works

Complement C1q-dependent excitatory and inhibitory synapse elimination by astrocytes and microglia in Alzheimer’s disease mouse models

Dejanovic, B., Wu, T., Tsai, M.-C., Graykowski, D., Gandham, V. D., Rose, C. M., Bakalarski, C. E., Ngu, H., Wang, Y., Pandey, S., et al. (2022) · Nature Aging · doi:10.1038/s43587-022-00281-1 · Cited by 341 · see citing works

SYK coordinates neuroprotective microglial responses in neurodegenerative disease

Ennerfelt, H., Frost, E. L., Shapiro, D. A., Holliday, C., Zengeler, K. E., Voithofer, G., Bolte, A. C., Lammert, C. R., Kulas, J. A., Ulland, T. K., et al. (2022) · Cell · doi:10.1016/j.cell.2022.09.030 · Cited by 329 · see citing works

Function of Rho family proteins in actin dynamics during phagocytosis and engulfment

Chimini, G., & Chavrier, P. (2000) · Nature Cell Biology · doi:10.1038/35036454 · Cited by 329 · see citing works

The neuroimmune axis of Alzheimer’s disease

Jorfi, M., Maaser‐Hecker, A., & Tanzi, R. E. (2023) · Genome Medicine · doi:10.1186/s13073-023-01155-w · Cited by 299 · see citing works

Microglial phagocytosis of neurons in neurodegeneration, and its regulation

Butler, C. A., Popescu, A. S., Kitchener, E. J. A., Allendorf, D. H., Puigdellívol, M., & Brown, G. C. (2021) · Journal of Neurochemistry · doi:10.1111/jnc.15327 · Cited by 293 · see citing works

TREM2 haplodeficiency in mice and humans impairs the microglia barrier function leading to decreased amyloid compaction and severe axonal dystrophy

Yuan, P., Condello, C., Keene, C. D., Wang, Y., Bird, T. D., Paul, S. M., Luo, W., Colonna, M., Baddeley, D., & Grutzendler, J. (2016) · Neuron · doi:10.1016/j.neuron.2016.09.016 · Cited by 219 · see citing works

Trem2 Deletion Reduces Late-Stage Amyloid Plaque Accumulation, Elevates the Aβ42:Aβ40 Ratio, and Exacerbates Axonal Dystrophy and Dendritic Spine Loss in the PS2APP Alzheimer's Mouse Model

Meilandt, W. J., Ngu, H., Gogineni, A., Lalehzadeh, G., Lee, S.-H., Srinivasan, K., Imperio, J., Wu, T., Weber, M., Kruse, A. J., et al. (2020) · The Journal of Neuroscience · doi:10.1523/jneurosci.1871-19.2019 · Cited by 210 · see citing works

Local apoptotic-like mechanisms underlie complement-mediated synaptic pruning

Györffy, B. A., Kun, J., Török, G., Bulyáki, É., Borhegyi, Z., Gulyássy, P., Kis, V., Szocsics, P., Micsonai, A., Matkó, J., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1722613115 · Cited by 186 · see citing works

Microglial efferocytosis: Diving into the Alzheimer’s disease gene pool

Romero-Molina, C., Garretti, F., Andrews, S. J., Marcora, E., & Goate, A. M. (2022) · Neuron · doi:10.1016/j.neuron.2022.10.015 · Cited by 111 · see citing works

Human astrocytes and microglia show augmented ingestion of synapses in Alzheimer’s disease via MFG-E8

Tzioras, M., Daniels, M. J. D., Davies, C., Baxter, P. S., King, D., McKay, S., Varga, B. V., Popovic, K., Hernandez, M., Stevenson, A. J., et al. (2023) · Cell Reports Medicine · doi:10.1016/j.xcrm.2023.101175 · Cited by 109 · see citing works

An Engulfment Assay: A Protocol to Assess Interactions Between CNS Phagocytes and Neurons

Schafer, D. P., Lehrman, E. K., Heller, C. T., & Stevens, B. (2014) · Journal of Visualized Experiments · doi:10.3791/51482 · Cited by 108 · see citing works

In vivo tau pathology is associated with synaptic loss and altered synaptic function

Coomans, E. M., Schoonhoven, D. N., Tuncel, H., Verfaillie, S. C. J., Wolters, E. E., Boellaard, R., Ossenkoppele, R., den Braber, A., Scheper, W., Schober, P. R., et al. (2021) · Alzheimer s Research & Therapy · doi:10.1186/s13195-021-00772-0 · Cited by 101 · see citing works

Three-dimensional morphometric analysis reveals time-dependent structural changes in microglia and astrocytes in the central amygdala and hypothalamic paraventricular nucleus of heart failure rats

Althammer, F., Ferreira‐Neto, H. C., Rubaharan, M., Roy, R. K., Patel, A. A., Murphy, A. Z., Cox, D. N., & Stern, J. E. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01892-4 · Cited by 85 · see citing works

Regulation and functions of the RhoA regulatory guanine nucleotide exchange factor GEF-H1

Joo, E., & Olson, M. F. (2021) · Small GTPases · doi:10.1080/21541248.2020.1840889 · Cited by 56 · see citing works

Microglial clearance of focal apoptotic synapses

Nonaka, S., & Nakanishi, H. (2019) · Neuroscience Letters · doi:10.1016/j.neulet.2019.134317 · Cited by 55 · see citing works

Microglial VPS35 deficiency impairs Aβ phagocytosis and Aβ-induced disease-associated microglia, and enhances Aβ associated pathology

Ren, X., Yao, L., Wang, Y., Mei, L., & Xiong, W. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02422-0 · Cited by 44 · see citing works

Apoptotic neurons and amyloid-beta clearance by phagocytosis in Alzheimer's disease: Pathological mechanisms and therapeutic outlooks

Tajbakhsh, A., Read, M. I., Barreto, G. E., Ávila-Rodriguez, M., Hayat, S. M. G., & Sahebkar, A. (2021) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2021.173873 · Cited by 41 · see citing works

An Engulfment Assay: A Protocol to Assess Interactions Between CNS Phagocytes and Neurons

Schafer, D. P., Lehrman, E. K., Heller, C. T., et al. (2014) · Journal of Visualized Experiments · doi:10.3791/51482-v · Cited by 31 · see citing works

VAV1 as a putative therapeutic target in autoimmune and chronic inflammatory diseases

Neurath, M. F., & Berg, L. J. (2024) · Trends in Immunology · doi:10.1016/j.it.2024.06.004 · Cited by 30 · see citing works

Soluble Fc Fusion Proteins for Biomedical Research

Flanagan, M. L., Arias, R. S., Hu, P., Khawli, L. A., & Epstein, A. L. (2007) · Methods in molecular biology · doi:10.1007/978-1-59745-323-3_3 · Cited by 25 · see citing works

Generation of Transgenic Drosophila Expressing shRNAs in the miR-1 BackbonePreprint

Chang, K., Marran, K., Valentine, A., & Hannon, G. J. (2014) · Cold Spring Harbor Protocols · doi:10.1101/pdb.prot080762 · Cited by 7 · see citing works

AXL activation leads to reduced amyloid plaque deposition in APP/PS‐1 mice

Owlett, L. D., Olschowka, J. A., Elliott, M. R., & O’Banion, M. K. (2020) · Alzheimer s & Dementia · doi:10.1002/alz.046330 · Cited by 3 · see citing works

Microglial phagocytosis in Alzheimer disease

Brown, G. C., St George-Hyslop, P., Paolicelli, R. C., & Lemke, G. (2026) · Nature Reviews Neurology · doi:10.1038/s41582-025-01162-y · Cited by 36 · see citing works

Human astrocytes and microglia show augmented ingestion of synapses in Alzheimer’s disease via MFG-E8

Tzioras, M., Daniels, M. J. D., Davies, C., Baxter, P. S., King, D., McKay, S., Varga, B. V., Popovic, K., Hernandez, M., Stevenson, A. J., et al. (2023) · Cell Reports Medicine · doi:10.1016/j.xcrm.2023.101175 · Cited by 109 · see citing works

Phagocytosis promotes plaque

Hurtley, S. M. (2021) · Science · doi:10.1126/science.372.6544.804-f

Microglial Deletion of Hrh4 Alleviates Alzheimer's Disease Pathologies by Enhancing Microglial Phagocytosis of Amyloid‐β and Tau

Xu, Y., Wu, T., Lo, L. T., Ko, C., Wang, X., & Ma, C. H. E. (2025) · Advanced Science · doi:10.1002/advs.202505421 · Cited by 2 · see citing works