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Cited by 45Aluminum toxicity and tolerance in plants and animalsLipid Membrane Structure and BehaviorErythrocyte Function and Pathophysiology

The DOI matches its Crossref record; 49 of the 54 references it cites were found in a registry or an index.

Aluminum fluoride affects the structure and functions of cell membranes

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Suwalsky, M., Norris, B., Villena, F., Cuevas, F., Sotomayor, P., Zatta, P.·2004·Food and Chemical Toxicology
DOI 10.1016/j.fct.2004.01.016
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Abstract

No useful biological function for aluminum has been found. To the contrary, it might play an important role in several pathologies, which could be related to its interactions with cell membranes. On the other hand, fluoride is a normal component of body fluids, soft tissues, bones and teeth. Its sodium salt is frequently added to drinking water to prevent dental caries. However, large doses cause severe pathological alterations. In view of the toxicity of Al(3+) and F(-) ions, it was thought of interest to explore the damaging effects that AlF(3) might induce in cell membranes. With this aim, it was incubated with human erythrocytes, which were examined by phase contrast and scanning electron microscopy, and molecular models of biomembranes. The latter consisted of large unilamellar vesicles (LUV) of dimyristoylphosphatidylcholine (DMPC) and bilayers of DMPC and dimyristoylphosphatidylethanolamine (DMPE) which were studied by fluorescence spectroscopy and X-ray diffraction, respectively. In order to understand the effects of AlF(3) on ion transport (principally sodium and chloride) we used the isolated toad skin to which electrophysiological measurements were applied. It was found that AlF(3) altered the shape of erythrocytes inducing the formation of echinocytes. This effect was explained by X-ray diffraction which revealed that AlF(3) perturbed the structure of DMPC, class of lipids located in the outer monolayer of the erythrocyte membrane. This result was confirmed by fluorescence spectroscopy on DMPC LUV. The biphasic (stimulatory followed by inhibitory) effects on the isolated skin suggested changes in apical Cl(-) secretion and moderate ATPase inactivation.

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Crossref · 10.1016/j.fct.2004.01.016

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49 of 49 references verified0 citation errors · 0 not checkable

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  • Al-induced change in erythrocyte size may be accompanied by change in erythrocyte shape resulting in formation of echinocytes, acanthocytes and stomatocytes in vitro due to altered membrane morphology.

    “The Al-induced change in erythrocyte size may also be accompanied by change in erythrocyte shape resulting in the formation of echinocytes (Suwalsky et al., 2004), acanthocytes and stomatocytes (Vittori et al., 2002) in vitro, due to altered membrane morphology (Lukyanenko et al., 2013).”

    From Aluminium toxicosis: a review of toxic actions and effects (2019) · cites this paper as Suwalsky et al., 2004

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5 of the 54 references couldn’t be matched to a known paper.

Research works printed but not linked: 2

  1. Bhatnagar, 2002, Neurotoxicity of fluoride, Indian Journal of Experimental Biology, 40, 546
  2. Strunecka, 1999, Pharmacological and toxicological effects of aluminofluoride complexes, Fluoride Journal, 32, 230

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Metadata

Authors
Suwalsky, M., Norris, B., Villena, F., Cuevas, F., Sotomayor, P., & Zatta, P.
Affiliations
  • University of Concepción (CL)
  • Pontificia Universidad Católica de Valparaíso (CL)
  • University of Padua (IT)
Corresponding author
Suwalsky, M.
ORCID
Venue
Food and Chemical Toxicology
Publisher
Elsevier BV
Published
2004-06
Volume
42
Issue
6
Pages
925-933
ISSN
0278-6915 (ISSN-L)
DOI
10.1016/j.fct.2004.01.016
OpenAlex
W2085637137
Cited by
45
References
54
Citations by year
2026: 1 · 2025: 1 · 2024: 1 · 2023: 2 · 2022: 3 · 2019: 3 · 2018: 1 · 2017: 5 · 2016: 4 · 2015: 5 · 2014: 1 · 2013: 2 · 2012: 1
FWCI
1.82
Type
journal article
Language
en
Open access
Licence
Locations
  • Food and Chemical Toxicology (publishedVersion)
  • PubMed (publishedVersion)
  • Americanae (AECID Library) (submittedVersion, other-oa)
  • LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Aluminum toxicity and tolerance in plants and animals
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
  • Health Sciences › Medicine › Physiology (medical) › Erythrocyte Function and Pathophysiology
Keywords
aluminum fluoride, erythrocytes, echinocytes, erythrocyte membrane structure, DMPC lipid bilayer, large unilamellar vesicles, ion transport, chloride secretion, sodium transport, ATPase inactivation, toad skin, aluminum toxicity, fluoride toxicity
MeSH terms
Adult, Cell Membrane, Electrophysiology, Erythrocytes, Fluorides, Humans, Male, Models, Molecular, Spectrometry, Fluorescence, X-Ray Diffraction, Aluminum Compounds, Cell Culture Techniques

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