CoChat
Sign Up
Cited by 345Mycotoxins in Agriculture and FoodProbiotics and Fermented FoodsPhytase and its Applications

The DOI matches its Crossref record; 72 of the 75 references it cites were found in a registry or an index.

Detoxification of patulin and ochratoxin A, two abundant mycotoxins, by lactic acid bacteria

Fuchs, S., Sontag, G., Stidl, R., Ehrlich, V., Kundi, M., Knasmüller, S.·2008·Food and Chemical Toxicology
DOI 10.1016/j.fct.2007.10.008
Open this paper in CoChat — free account

Abstract

Aim of the present study was to investigate the detoxification of two abundant mycotoxins, namely ochratoxin A (OTA) and patulin (PAT) which are frequently found in human foods, by lactic acid bacteria. The removal of the two mycotoxins from liquid medium by thirty different LAB strains was analyzed in a screening trial by the use of HPLC coupled with UV- or fluorescence detection. Two highly effective strains were identified; Lactobacillus acidophilus VM 20 caused a decrease of OTA by > or = 95% and Bifidobacterium animalis VM 12 reduced PAT levels by 80%. Subsequently experiments showed that the binding of these compounds depends on different parameters, i.e. the concentration of toxins, the cell density, the pH-value and on the viability of the bacteria. To proof that the decrease of the toxins by LAB from liquid medium results in a reduction of their toxic properties, micronucleus (MCN) assays were conducted with a human derived hepatoma cell line (HepG2). Indeed, a substantial decrease (39-59%) of OTA and PAT induced MCN formation was observed with the most effective strains detected in the chemical analyses. Furthermore, also the inhibition of the cell division rates by the toxins was significantly reduced. These findings indicate that certain LAB strains are able to detoxify the two toxins and may be useful to protect humans and/or animals against the adverse health effects of these compounds.

Overview

Integrity signals

Registry

Crossref · 10.1016/j.fct.2007.10.008

Cites

72 of 72 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Flagged first, then by citations

Show all 75 references

3 of the 75 references couldn’t be matched to a known paper.

Research works printed but not linked: 6

  1. Ehrlich, V., 2002. Untersuchung der gentoxischen Effekte von nahrungsrelevanten Mykotoxinen in Humanzellen. Masters Thesis.
  2. El-Nezami, 2002, Binding rather than metabolism may explain the interaction of two food-grade Lactobacillus strains with zearalenone and its derivative a-zearalenol, Appl. Environ. Microbiol., 68, 3449, 10.1128/AEM.68.7.3545-3549.2002 · DOI
  3. Hosoda, 1993, Inhibitory effect of milk cultured with Lactobacillus acidophilus LA 106 (LA2) on mutagenicity of aflatoxin B1, Jpn. J. Dairy Food Sci., 42, 1
  4. Kabak, 2004, Binding of aflatoxin M1 by Lactobacillus and Bifidobacterium strains, Milchwissenschaft, 59, 301
  5. Thurm, 1979, Zum hygienischen Vorkommen von Patulin in Obst und Gemüse, Die Nahrung, 23
  6. Umeda, 1977, Mutagenicity and inducibility of DNA single-strand breaks and chromosome abbreviations by various mycotoxins, Gann, 68, 619

Cited by

Sorted by citations

Items 301–345 of 345

Related

See all

Metadata

Authors
Fuchs, S., Sontag, G., Stidl, R., Ehrlich, V., Kundi, M., & Knasmüller, S.
Affiliations
  • University of Vienna (AT)
  • Medical University of Vienna (AT)
Corresponding author
Ehrlich, V.
ORCID
Venue
Food and Chemical Toxicology
Publisher
Elsevier BV
Published
2008-04
Volume
46
Issue
4
Pages
1398-1407
ISSN
0278-6915 (ISSN-L)
DOI
10.1016/j.fct.2007.10.008
OpenAlex
W2016865034
Cited by
345
References
75
Citations by year
2026: 7 · 2025: 11 · 2024: 16 · 2023: 17 · 2022: 28 · 2021: 26 · 2020: 22 · 2019: 22 · 2018: 29 · 2017: 24 · 2016: 15 · 2015: 17 · 2014: 27 · 2013: 14 · 2012: 20
FWCI
11.71
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Food and Chemical Toxicology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Mycotoxins in Agriculture and Food
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytase and its Applications
Keywords
mycotoxin detoxification, patulin, ochratoxin A, lactic acid bacteria, Lactobacillus acidophilus, Bifidobacterium animalis, toxin binding, bacterial viability, micronucleus formation, HepG2 cells, cell division inhibition, food safety
MeSH terms
Bifidobacterium, Cell Division, Cell Line, Chromatography, High Pressure Liquid, Culture Media, Humans, Hydrogen-Ion Concentration, Lactobacillus acidophilus, Inactivation, Metabolic, Ochratoxins, Patulin, Spectrophotometry, Ultraviolet, Micronucleus Tests, Chromosome Breakage

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review