Molecular evidence on the protective effect of ellagic acid on phosalone-induced senescence in rat embryonic fibroblast cells
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Salient evidence testifies the link between organophosphorus (OPs) exposure and the formation of free radical oxidants; and it is well accepted that free radicals are one of the basic concerns of senescence. To show the oxidative features of phosalone (PLN) as a key member of OPs, to induce senescence in rat embryonic fibroblast (REF) cells and to demonstrate the beneficial effects of the known antioxidant ellagic acid (EA) in diminishing the PLN-induced toxic effects, the levels of cell viability, oxidative stress markers, inflammatory cytokines, telomerase activity, and the expression of the genes related to senescence were investigated. Our results lend support to the hypothesis that PLN enhances the entire premature senescence parameters of REF cells. This accounts for the mechanistic approval of the role of OPs in induction of senescence in rat fibroblasts. Moreover, incorporation of EA diminished PLN toxicity mainly through suppression of p38 and p53 at gene and protein levels, and tempered the inflammation factors (TNF-α, IL-1β, IL-6 and NF-κB), which further affected cell division. Analysis of cell cycle showed that the percentage of G0/G1 arrest, in REF cells treated by EA was elevated as compared to control and PLN treated cells.
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As an antioxidant agent, EA can activate cellular antioxidant enzymes like SOD, CAT and GPx, protect DNA from ROS and chelate metal ions.
“As an antioxidant agent, EA can activate cellular antioxidant enzymes, like SOD, CAT and GPx, protect DNA from ROS and chelate metal ions [365].”
From The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence (2022) · cites this paper as [365]
Cites
Analyzing real-time PCR data by the comparative CT method
Schmittgen, T. D., & Livak, K. J. (2008) · Nature Protocols · doi:10.1038/nprot.2008.73 · Cited by 26,190 · see citing works
The Ferric Reducing Ability of Plasma (FRAP) as a Measure of “Antioxidant Power”: The FRAP Assay
Benzie, I. F. F., & Strain, J. (1996) · Analytical Biochemistry · doi:10.1006/abio.1996.0292 · Cited by 23,027 · see citing works
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
Serrano, M., Lin, A. W., McCurrach, M. E., Beach, D., & Lowe, S. W. (1997) · Cell · doi:10.1016/s0092-8674(00)81902-9 · Cited by 5,178 · see citing works
A DNA damage checkpoint response in telomere-initiated senescence
Fagagna, F. D. D., Reaper, P. M., Clay-Farrace, L., Fiegler, H., Carr, P., von Zglinicki, T., Saretzki, G., Carter, N. P., & Jackson, S. P. (2003) · Nature · doi:10.1038/nature02118 · Cited by 2,855 · cited 1× · see citing works
“…mutated/ATM-and Rad3-Related, DNA-dependent protein kinase) (ATM/ATR, DNA-PK) are activated and then DNA damage occurs and ultimately cell cycle arrest is induced via checkpoint proteins, Tumor prtein (TP53) and the cyclin-dependent kinase inhibitor p21 (CDKN1A) (Di Fagagna et al., 2003).”
BackgroundOxidative stress shortens telomeres
von Zglinicki, T. (2002) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(02)02110-2 · Cited by 2,524 · see citing works
Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence
Narita, M., Nuñez, S., Heard, E., Narita, M., Lin, A. W., Hearn, S. A., Spector, D. L., Hannon, G. J., & Lowe, S. W. (2003) · Cell · doi:10.1016/s0092-8674(03)00401-x · Cited by 2,278 · see citing works
The essence of senescence: Figure 1.
Kuilman, T., Michaloglou, C., Mooi, W. J., & Peeper, D. S. (2010) · Genes & Development · doi:10.1101/gad.1971610 · Cited by 2,038 · see citing works
Pesticides and human chronic diseases: Evidences, mechanisms, and perspectives
Mostafalou, S., & Abdollahi, M. R. (2013) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2013.01.025 · Cited by 1,266 · see citing works
Self-citationHaupt, S., Berger, M., Goldberg, Z., & Haupt, Y. (2003) · Journal of Cell Science · doi:10.1242/jcs.00739 · Cited by 1,136 · see citing works
The antioxidant function of the p53 tumor suppressor
Sablina, A. A., Budanov, A. V., Ilyinskaya, G. V., Agapova, L. S., Kravchenko, J. E., & Chumakov, P. M. (2005) · Nature Medicine · doi:10.1038/nm1320 · Cited by 1,110 · see citing works
Feedback between p21 and reactive oxygen production is necessary for cell senescence
Passos, J. F., Nelson, G., Wang, C., Richter, T., Simillion, C., Proctor, C. J., Miwa, S., Olijslagers, S., Hallinan, J., Wipat, A., et al. (2010) · Molecular Systems Biology · doi:10.1038/msb.2010.5 · Cited by 1,019 · cited 1× · see citing works
“ROS cause the activation of p53 and transcription of p21, and thereby leading to senescence (Passos et al., 2010).”
Background[41] Measurement of protein thiol groups and glutathione in plasma
Hu, M. (1994) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(94)33044-1 · Cited by 962 · see citing works
Cellular senescence as a tumor-suppressor mechanism
Campisi, J. (2001) · Trends in Cell Biology · doi:10.1016/s0962-8924(01)02151-1 · Cited by 936 · see citing works
Kregel, K. C., & Zhang, H. J. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00327.2006 · Cited by 883 · see citing works
ROS and p53: A versatile partnership
Liu, B., Chen, Y., & Clair, D. K. S. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.01.011 · Cited by 829 · see citing works
Pesticides: an update of human exposure and toxicity
Mostafalou, S., & Abdollahi, M. R. (2016) · Archives of Toxicology · doi:10.1007/s00204-016-1849-x · Cited by 787 · see citing works
Self-citationFulton, M. H., & Key, P. B. (2001) · Environmental Toxicology and Chemistry · doi:10.1002/etc.5620200104 · Cited by 737 · see citing works
Ras Proteins Induce Senescence by Altering the Intracellular Levels of Reactive Oxygen Species
Lee, A. C., Fenster, B. E., Ito, H., Takeda, K., Bae, N. S., Hirai, T., Yu, Z.-X., Ferrans, V. J., Howard, B. H., & Finkel, T. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.12.7936 · Cited by 691 · see citing works
DNA damage, cellular senescence and organismal ageing: causal or correlative?
Chen, J.-H., Hales, C. N., & Ozanne, S. E. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm681 · Cited by 481 · see citing works
Seeram, N. P., Lee, R., & Heber, D. (2004) · Clinica Chimica Acta · doi:10.1016/j.cccn.2004.04.029 · Cited by 454 · see citing works
Cellular senescence as a tumor-suppressor mechanism
Campisi, J. (2001) · Trends in Cell Biology · doi:10.1016/s0962-8924(01)82148-6 · Cited by 390 · see citing works
Mitogen‐activated protein kinase p38 defines the common senescence‐signalling pathway
Iwasa, H., Han, J., & Ishikawa, F. (2003) · Genes to Cells · doi:10.1046/j.1365-2443.2003.00620.x · Cited by 388 · see citing works
Armstrong, D., & Browne, R. W. (1994) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-1833-4_4 · Cited by 360 · see citing works
Wu, H., & Lozano, G. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)32128-2 · Cited by 354 · see citing works
Maqbool, F., Mostafalou, S., Bahadar, H., & Abdollahi, M. R. (2015) · Life Sciences · doi:10.1016/j.lfs.2015.10.022 · Cited by 328 · see citing works
Self-citationAnti-Inflammatory Treatments for Chronic Diseases: A Review
Laveti, D., Kumar, M., Hemalatha, R., Sistla, R., Naidu, V. G. M., Talla, V., Verma, V., Kaur, N., & Nagpal, R. (2013) · Inflammation & Allergy - Drug Targets · doi:10.2174/18715281113129990053 · Cited by 327 · see citing works
BIOLOGICAL FUNCTIONALITY OF ELLAGIC ACID: A REVIEW
Vattem, D. A., & Shetty, K. (2005) · Journal of Food Biochemistry · doi:10.1111/j.1745-4514.2005.00031.x · Cited by 313 · see citing works
In vitro anti-proliferative activities of ellagic acid
Losso, J. N., Bansode, R. R., TRAPPEYII, A., Bawadi, H. A., & Truax, R. E. (2004) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2004.06.004 · Cited by 310 · see citing works
Narayanan, B. A., Geoffroy, O. J., Willingham, M. C., Re, G. G., & Nixon, D. W. (1999) · Cancer Letters · doi:10.1016/s0304-3835(98)00323-1 · Cited by 284 · see citing works
Emerging roles of the p38 MAPK and PI3K/AKT/mTOR pathways in oncogene-induced senescence
Xu, Y., Li, N., Xiang, R., & Sun, P. (2014) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2014.04.004 · Cited by 282 · see citing works
The pathways to tumor suppression via route p38
Han, J., & Sun, P. (2007) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2007.06.007 · Cited by 268 · see citing works
Ghorbanzadeh, B., Mansouri, M. T., Hemmati, A. A., Naghizadeh, B., Mard, S. A., & Rezaie, A. (2015) · Indian Journal of Pharmacology · doi:10.4103/0253-7613.157127 · Cited by 259 · see citing works
Toxicological and pharmacological concerns on oxidative stress and related diseases
Saeidnia, S., & Abdollahi, M. R. (2013) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2013.09.031 · Cited by 257 · see citing works
Self-citationDuan, J., Duan, J., Zhang, Z., & Tong, T. (2005) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2005.01.010 · Cited by 229 · see citing works
Antioxidant and apoptosis-inducing activities of ellagic acid.
Han, D. H., Lee, M. J., & Kim, J. H. (2006) · PubMed · Cited by 210 · see citing works
Current opinion on the science of organophosphate pesticides and toxic stress: a systematic review.
Soltaninejad, K., & Abdollahi, M. R. (2009) · PubMed · Cited by 207 · see citing works
Self-citationActivation of nuclear factor-kappa B signalling promotes cellular senescence
Rovillain, E. M. I., Mansfield, L., Caetano, C., Álvarez‐Fernández, M., Caballero, O. L., Medema, R. H., Hummerich, H., & Jat, P. (2011) · Oncogene · doi:10.1038/onc.2010.611 · Cited by 197 · see citing works
Antioxidants: Friends or foe in prevention or treatment of cancer: The debate of the century
Saeidnia, S., & Abdollahi, M. R. (2013) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2013.05.004 · Cited by 190 · see citing works
Self-citationChen, Q. M. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06640.x · Cited by 176 · see citing works
Rosillo, M. Á., Sánchéz‐Hidalgo, M., Cárdeno, A., Aparicio‐Soto, M., Sánchez‐Fidalgo, S., Villegas, I., & Alarcón‐de‐la‐Lastra, C. (2012) · Pharmacological Research · doi:10.1016/j.phrs.2012.05.006 · Cited by 175 · see citing works
Kim, S. J., Hwang, S., Shin, D. Y., Kang, S., & Chun, J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202862200 · Cited by 168 · see citing works
Ellagic acid induced p53/p21 expression, G1 arrest and apoptosis in human bladder cancer T24 cells.
Li, T., Chen, G.-W., Su, C., Lin, J.-G., Yeh, C.-C., Cheng, K.-C., & Chung, J. (2005) · PubMed · Cited by 153 · see citing works
Research progress on the anticarcinogenic actions and mechanisms of ellagic acid.
Zhang, H., Zhao, L., Li, H., Xu, H., Chen, W., & Tao, L. (2014) · Europe PMC (PubMed Central) · doi:10.7497/j.issn.2095-3941.2014.02.004 · Cited by 151 · see citing works
El‐Shitany, N. A., El-Bastawissy, E. A., & El-desoky, K. (2014) · International Immunopharmacology · doi:10.1016/j.intimp.2014.02.004 · Cited by 149 · see citing works
Inflammatory signaling and cellular senescence
Ren, J., Pan, J., Lu, Y.-P., Sun, P., & Han, J. (2008) · Cellular Signalling · doi:10.1016/j.cellsig.2008.10.011 · Cited by 149 · see citing works
Morris, S., & Lee, T. H. (1984) · Cited by 148 · see citing works
Enhancement of radiation-induced oxidative stress and cytotoxicity in tumor cells by ellagic acid
Bhosle, S. M., Huilgol, N., & Mishra, K. P. (2005) · Clinica Chimica Acta · doi:10.1016/j.cccn.2005.03.037 · Cited by 141 · see citing works
KHANDUJA, K. L., Avti, P., Kumar, S., Mittal, N., Sohi, K. K., & Pathak, C. M. (2006) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2005.12.017 · Cited by 139 · see citing works
Protective effects of ellagic and chlorogenic acids against oxidative stress in PC12 cells
Pavlica, S., & Gebhardt, R. (2005) · Free Radical Research · doi:10.1080/09670260500197660 · Cited by 107 · see citing works
Role of oxidative stress in osteoporosis
Abdollahi, M. R., Larijani, B. A., Rahimi, R., & Salari, P. (2005) · Therapy · doi:10.2217/14750708.2.5.787 · Cited by 106 · see citing works
Self-citationVicinanza, R., Zhang, Y., Henning, S. M., & Heber, D. (2013) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2013/247504 · Cited by 97 · see citing works
Rocha, A., Wang, L., Penichet, M. L., & Martins‐Green, M. M. (2012) · Breast Cancer Research and Treatment · doi:10.1007/s10549-012-2264-5 · Cited by 90 · see citing works
Altuntaş, I., Delibaş, N., Doğuç, D. K., Özmen, S., & Gültekin, F. (2003) · Toxicology in Vitro · doi:10.1016/s0887-2333(02)00133-9 · Cited by 86 · see citing works
Fitzgerald, A. L., Osman, A. A., Xie, T.-X., Patel, A. A., Skinner, H., Sandulache, V. C., & Myers, J. N. (2015) · Cell Death and Disease · doi:10.1038/cddis.2015.44 · Cited by 82 · see citing works
p38MAPK in the Senescence of Human and Murine Fibroblasts
Debacq‐Chainiaux, F., Boilan, E., Moutier, J. D. L., Weemaels, G., & Toussaint, O. (2010) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-7002-2_10 · Cited by 79 · see citing works
Ellagic acid protects Lipopolysaccharide/d-galactosamine-induced acute hepatic injury in mice
Gu, L., Deng, W.-S., Liu, Y., Jiang, C., Sun, L.-C., Sun, X., Xu, Q., & Zhou, H. Y. (2014) · International Immunopharmacology · doi:10.1016/j.intimp.2014.07.005 · Cited by 75 · see citing works
Mechanisms underlying stress-induced hyperglycemia in critically ill patients
Kajbaf, F., Mojtahedzadeh, M., & Abdollahi, M. R. (2006) · Therapy · doi:10.2217/14750708.4.1.97 · Cited by 65 · see citing works
Self-citationChen, J., Ozanne, S. E., & Hales, C. N. (2005) · DNA repair · doi:10.1016/j.dnarep.2005.06.003 · Cited by 60 · see citing works
Li, H.-L. (2002) · World Journal of Gastroenterology · doi:10.3748/wjg.v8.i3.431 · Cited by 52 · see citing works
A systematic review on the role of environmental toxicants in stem cells aging
Hodjat, M., Rezvanfar, M. A., & Abdollahi, M. R. (2015) · Food and Chemical Toxicology · doi:10.1016/j.fct.2015.11.002 · Cited by 49 · see citing works
Self-citationEmbryonic fibroblasts represent a connecting link between mesenchymal and embryonic stem cells
Yusuf, B., Gopurappilly, R., Dadheech, N., Gupta, S. S., Bhonde, R. R., & Pal, R. (2013) · Development Growth & Differentiation · doi:10.1111/dgd.12043 · Cited by 41 · see citing works
Bahadar, H., Maqbool, F., Mostafalou, S., Baeeri, M., Rahimifard, M., Nigjeh, M. N., & Abdollahi, M. R. (2015) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2015.04.010 · Cited by 40 · see citing works
Self-citationEllagic Acid, a Dietary Polyphenol, Selectively Cytotoxic to HSC-2 Oral Carcinoma Cells.
Weisburg, J. H., Schuck, A. G., Reiss, S. E., Wolf, B. J., Fertel, S. R., Zuckerbraun, H. L., & Babich, H. (2013) · PubMed · Cited by 40 · see citing works
Esmaily, H., Vaziri-Bami, A., Miroliaee, A. E., Baeeri, M., & Abdollahi, M. R. (2010) · Fundamental and Clinical Pharmacology · doi:10.1111/j.1472-8206.2010.00893.x · Cited by 39 · see citing works
Self-citationRahimifard, M., Nigjeh, M. N., Baeeri, M., Maqbool, F., & Abdollahi, M. R. (2015) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-015-2348-8 · Cited by 39 · see citing works
Self-citationMethods for the discovery of new anti-aging products – targeted approaches
Manayi, A., Saeidnia, S., Gohari, A. R., & Abdollahi, M. R. (2014) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.2014.885014 · Cited by 32 · see citing works
Self-citationGrowth inhibition and induction of apoptosis in human cancerous HeLa cells by Maytenus procumbens
Momtaz, S., Hussein, A. A., Ostad, S. N., Abdollahi, M. R., & Lall, N. (2012) · Food and Chemical Toxicology · doi:10.1016/j.fct.2012.09.005 · Cited by 32 · see citing works
Self-citationRezvanfar, M. A., Hodjat, M., & Abdollahi, M. R. (2016) · Life Sciences · doi:10.1016/j.lfs.2016.05.027 · Cited by 32 · see citing works
Self-citationEllagic acid: Characterization as substrate of polyphenol oxidase
Muñoz-Muñoz, J., Garcı́a-Molina, F., García‐Molina, M. D. M., Tudela, J., Garcı́a-Cánovas, F., & Rodríguez‐López, J. N. (2008) · IUBMB Life · doi:10.1002/iub.143 · Cited by 28 · see citing works
Mechanistic Overview of Immune Modulatory Effects of Environmental Toxicants
Bahadar, H., Abdollahi, M. R., Maqbool, F., Baeeri, M., & Niaz, K. (2015) · Inflammation & Allergy - Drug Targets · doi:10.2174/1871528114666150529103003 · Cited by 28 · see citing works
Self-citationEllagic Acid – Chemopreventive Role in Oral Cancer
Bisen, P. S., Bundela, S., & Sharma, A. (2012) · Journal of Cancer Science & Therapy · doi:10.4172/1948-5956.1000106 · Cited by 26 · see citing works
Moeinian, M. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i31.10876 · Cited by 25 · see citing works
Pasquet, J., Mazuret, A., Fournel, J., & Koenig, F. H. (1976) · Toxicology and Applied Pharmacology · doi:10.1016/s0041-008x(76)80010-5 · Cited by 24 · see citing works
Phosalone-induced inflammation and oxidative stress in the colon: evaluation and treatment
Ghasemi‐Niri, S. F., Maqbool, F., Baeeri, M., Gholami, M., & Abdollahi, M. R. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i21.4999 · Cited by 23 · see citing works
Self-citationSanadgol, N., Mostafaie, A., Mansouri, K., & Bahrami, G. (2012) · Archives of Medical Science · doi:10.5114/aoms.2012.28544 · Cited by 17 · see citing works
Self-citationEffect of N-acetylcysteine on microalbuminuria in patients with acute respiratory distress syndrome
Najafi, A., Mojtahedzadeh, M., Mahmoodpoor, A., Aghamohammadi, M., Ahmadi, A., Nahreini, S., Pazuki, M., Khajavi, M. R., & Abdollahi, M. R. (2009) · Archives of Medical Science · Cited by 12 · see citing works
Self-citationNajafi, A., Mojtahedzadeh, M., Mahmoodpoor, A., Aghamohammadi, M., Ahmadi, A., Nahreini, S., Pazuki, M., Khajavi, M. R., & Abdollahi, M. R. (2009) · Archives of Medical Science · Cited by 9 · see citing works
Self-citation
Flagged first, then by citations
2 of the 79 references couldn’t be matched to a known paper.
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Varesi, A., Chirumbolo, S., Campagnoli, L. I. M., Pierella, E., Piccini, G. B., Carrara, A., Ricevuti, G., Scassellati, C., Bonvicini, C., & Pascale, A. (2022) · Antioxidants · doi:10.3390/antiox11071224 · Cited by 145 · see citing works
The role of melatonin on doxorubicin-induced cardiotoxicity: A systematic review
Najafi, M., Shayesteh, M. R. H., Mortezaee, K., Farhood, B., & Haghi‐Aminjan, H. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.117173 · Cited by 96 · see citing works
Rahimi, V. B., Askari, V. R., & Mousavi, S. H. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.10.024 · Cited by 75 · see citing works
Sanadgol, N., Barati, M., Houshmand, F., Hassani, S., Clarner, T., Shahlaei, M., & Golab, F. (2019) · Pharmacological Reports · doi:10.1007/s43440-019-00019-8 · Cited by 74 · see citing works
Self-citationJalili‐Baleh, L., Forootanfar, H., Küçükkılınç, T. T., Nadri, H., Abdolahi, Z., Ameri, A., Jafari, M., Ayazgök, B., Baeeri, M., Rahimifard, M., et al. (2018) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2018.04.058 · Cited by 73 · see citing works
Self-citationThe possible neuroprotective effect of ellagic acid on sodium arsenate-induced neurotoxicity in rats
Goudarzi, M., Amiri, S., Nesari, A., Hosseinzadeh, A., Mansouri, E., & Mehrzadi, S. (2018) · Life Sciences · doi:10.1016/j.lfs.2018.02.022 · Cited by 68 · see citing works
Najafi, M., Mortezaee, K., Rahimifard, M., Farhood, B., & Haghi‐Aminjan, H. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118051 · Cited by 65 · see citing works
Self-citationEllagic Acid and Cancer Hallmarks: Insights from Experimental Evidence
Čižmáriková, M., Michalková, R., Mirossay, L., Mojžišová, G., Zigová, M., Bardelčíková, A., & Mojžíš, J. (2023) · Biomolecules · doi:10.3390/biom13111653 · Cited by 61 · see citing works
Sanadgol, N., Golab, F., Tashakkor, Z., Taki, N., Kouchi, S. M., Mostafaie, A., Mehdizadeh, M., Abdollahi, M. R., Taghizadeh, G., & Sharifzadeh, M. S. (2017) · Pharmaceutical Biology · doi:10.1080/13880209.2017.1319867 · Cited by 57 · see citing works
Self-citationRetractedJalili‐Baleh, L., Nadri, H., Forootanfar, H., Samzadeh‐Kermani, A., Küçükkılınç, T. T., Ayazgök, B., Rahimifard, M., Baeeri, M., Doostmohammadi, M., Firoozpour, L., et al. (2018) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2018.04.030 · Cited by 53 · see citing works
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Self-citationRetractedEllagic acid prolongs the lifespan of Drosophila melanogaster
Kharat, P., Sarkar, P. A., Sekar, M., Tiwary, V., Priya, V. B. R., Sree, N. Y., Annapoorna, H. V., Saikia, D. K., Mahanta, K., & Thirumurugan, K. (2019) · GeroScience · doi:10.1007/s11357-019-00135-6 · Cited by 38 · see citing works
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Renu, K., Mukherjee, A. G., Gopalakrishnan, A. V., Wanjari, U. R., Kannampuzha, S., Murali, R., Veeraraghavan, V. P., Vinayagam, S., Paz, S., George, A., et al. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.126715 · Cited by 26 · see citing works
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Zhao, Y., Chen, Y., Miao, C., Wang, R., Yang, L., Liu, J., Chen, Z., Zhang, Q., & Ma, J. (2022) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2022/7705194 · Cited by 10 · see citing works
Khodabandeh, Z., Etebari, M., & Aliomrani, M. (2021) · Genes and Environment · doi:10.1186/s41021-021-00191-5 · Cited by 9 · see citing works
Farag, A. A., Mostafa, M., Abdelfatah, R. M., Eldahshan, A. E., Gad, S. F., Mohamed, S. K., Alawam, M. K., Elzeer, A. A., Ismail, N. S., Elsharkawey, S., et al. (2025) · Toxics · doi:10.3390/toxics13050355 · Cited by 8 · see citing works
Nigjeh, M. N., Mirzababaei, S., Ghiass, M. A., Roshanbinfar, K., Gholami, M., & Abdollahi, M. R. (2022) · Biofabrication · doi:10.1088/1758-5090/ac9d04 · Cited by 8 · see citing works
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Eslami, S. M., Khorshidi, L., Ghasemi, M., Rashidian, A., Mirghazanfari, S. M., Nezhadi, A., Chamanara, M., & Mirjani, R. (2021) · Inflammopharmacology · doi:10.1007/s10787-021-00891-y · Cited by 6 · see citing works
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Mahdizade, E., Baeeri, M., Hodjat, M., Rahimifard, M., Nigjeh, M. N., Haghi‐Aminjan, H., Moeini‐Nodeh, S., Hassani, S., Dehghan, G., Feizi, M. A. H., et al. (2021) · PubMed Central · doi:10.22037/ijpr.2021.115117.15206 · Cited by 5 · see citing works
Self-citationTerry, A. V., Beck, W. D., Zona, V., Itokazu, Y., Tripathi, A., Madeshiya, A. K., & Pillai, A. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1498350 · Cited by 5 · see citing works
Liu, Y., Li, W., Gong, J., Yin, B., & Zheng, Z. (2025) · Food Bioscience · doi:10.1016/j.fbio.2025.108062 · Cited by 4 · see citing works
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Self-citationSheikh, S., Dehghani, H., & Kazerani, H. R. (2024) · PubMed Central · doi:10.22038/ajp.2023.22910 · Cited by 2 · see citing works
Landucci, E., Castellacci, R., Puente-Sanz, A., Mazzantini, C., Pellegrini-Giampietro, D. E., Bilia, A. R., & Bergonzi, M. C. (2026) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2026.108648 · Cited by 1 · see citing works
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Self-citation
- Authors
- Baeeri, M., Momtaz, S., Navaei-Nigjeh, M., Niaz, K., Rahimifard, M., Ghasemi-Niri, S. F., Sanadgol, N., Hodjat, M., Sharifzadeh, M., & Abdollahi, M.
- Affiliations
- Tehran University of Medical Sciences (IR)
- Academic Center for Education, Culture and Research (IR)
- Zabol University (IR)
- University of Tehran (IR)
- Corresponding author
- Abdollahi, Mohammad
- ORCID
- Venue
- Food and Chemical Toxicology
- Publisher
- Elsevier BV
- Published
- 2017-02
- Volume
- 100
- Pages
- 8-23
- ISSN
- 0278-6915 (ISSN-L)
- OpenAlex
- W2560331608
- Cited by
- 54
- References
- 79
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 2 · 2023: 6 · 2022: 6 · 2021: 8 · 2020: 7 · 2019: 6 · 2018: 12 · 2017: 2
- FWCI
- 5.36
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (am, 314 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Food and Chemical Toxicology (acceptedVersion)
- PubMed (publishedVersion)
- Funders
- Tehran University of Medical Sciences (94-04-45-31137)
- Iran National Science Foundation
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Pesticide Exposure and Toxicity
- Health Sciences › Nursing › Nutrition and Dietetics › Pomegranate: compositions and health benefits
- Keywords
- ellagic acid, phosalone, organophosphorus pesticides, cellular senescence, premature senescence, rat embryonic fibroblasts, oxidative stress, antioxidant defense, p38 MAPK, p53, inflammatory cytokines, NF-κB, telomerase activity, G0/G1 cell cycle arrest, pesticide toxicity
- MeSH terms
- Animals, Antioxidants, Cell Cycle, Cell Survival, Cells, Cultured, Ellagic Acid, Embryo, Mammalian, Female, Fibroblasts, Insecticides, Organothiophosphorus Compounds, Pregnancy, Cellular Senescence, Rats, Wistar, Oxidative Stress, Rats
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