The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Panax ginseng and Panax quinquefolius: From pharmacology to toxicology
Open accessAbstract
The use of Panax ginseng and Panax quinquefolius in traditional Chinese medicine dates back to about 5000 years ago thanks to its several beneficial and healing properties. Over the past few years, extensive preclinical and clinical evidence in the scientific literature worldwide has supported the beneficial effects of P. ginseng and P. quinquefolius in significant central nervous system, metabolic, infectious and neoplastic diseases. There has been growing research on ginseng because of its favorable pharmacokinetics, including the intestinal biotransformation which is responsible for the processing of ginsenosides - contained in the roots or extracts of ginseng - into metabolites with high pharmacological activity and how such principles act on numerous cell targets. The aim of this review is to provide a simple and extensive overview of the pharmacokinetics and pharmacodynamics of P. ginseng and P. quinquefolius, focusing on the clinical evidence which has shown particular effectiveness in specific diseases, such as dementia, diabetes mellitus, respiratory infections, and cancer. Furthermore, the review will also provide data on toxicological factors to support the favorable safety profile of these medicinal plants.
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Cites
The world ginseng market and the ginseng (Korea)
Baeg, I.-H., & So, S.-H. (2013) · Journal of Ginseng Research · doi:10.5142/jgr.2013.37.1 · Cited by 392
Metabolomics View on Gut Microbiome Modulation by Polyphenol-Rich Foods
Moco, S., Martin, F.-P. J., & Rezzi, S. (2012) · Journal of Proteome Research · doi:10.1021/pr300581s · Cited by 234
Genton, L., Cani, P. D., & Schrenzel, J. (2015) · Clinical Nutrition · doi:10.1016/j.clnu.2014.10.003 · Cited by 148
Oh, S.-J., Kim, K., & Lim, C.-J. (2015) · Pharmacology · doi:10.1159/000431154 · Cited by 18
Cited by
Phytotherapy in the management of diabetes: A review
Governa, P., Baini, G., Borgonetti, V., Cettolin, G., Giachetti, D., Magnano, A., Miraldi, E., & Biagi, M. (2018) · Molecules · doi:10.3390/molecules23010105 · Cited by 182
Todorova, V., Ivanov, K., & Ivanova, S. (2021) · Plants · doi:10.3390/plants11010064 · Cited by 56
Metadata
- Authors
- Mancuso, C., & Santangelo, R.
- Venue
- Food and Chemical Toxicology
- Publisher
- Elsevier BV
- Published
- 2017-09
- Volume
- 107
- Issue
- Pt A
- Pages
- 362-372
- ISSN
- 0278-6915 (ISSN-L)
- OpenAlex
- W2724098821
- Cited by
- 382
- References
- 4
- FWCI
- 7.18
- Type
- journal article
- Language
- en
- Open access
- green
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