Cited by 148Gut microbiota and healthGastrointestinal motility and disordersClinical Nutrition and Gastroenterology

Alterations of gut barrier and gut microbiota in food restriction, food deprivation and protein-energy wasting

Open access
Genton, L., Cani, P.D., Schrenzel, J.·2015·Clinical Nutrition

Abstract

Increasing evidence shows that gut microbiota composition is related to changes of gut barrier function including gut permeability and immune function. Gut microbiota is different in obese compared to lean subjects, suggesting that gut microbes are also involved in energy metabolism and subsequent nutritional state. While research on gut microbiota and gut barrier has presently mostly focused on intestinal inflammatory bowel diseases and more recently on obesity and type 2 diabetes, this review aims at summarizing the present knowledge regarding the impact, in vivo, of depleted nutritional states on structure and function of the gut epithelium, the gut-associated lymphoid tissue (GALT), the gut microbiota and the enteric nervous system. It highlights the complex interactions between the components of gut barrier in depleted states due to food deprivation, food restriction and protein energy wasting and shows that these interactions are multidirectional, implying the existence of feedbacks.

Integrity signals

Registry

Crossref · 10.1016/j.clnu.2014.10.003

Cites

113 of 113 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Genton, L., Cani, P. D., & Schrenzel, J.
Affiliations
  • University Hospital of Geneva (CH)
  • Walloon Excellence in Lifesciences and Biotechnology (BE)
Corresponding author
Genton, L.
Venue
Clinical Nutrition
Publisher
Elsevier BV
Published
2015-06
Volume
34
Issue
3
Pages
341-349
ISSN
0261-5614 (ISSN-L)
OpenAlex
W2055032087
Cited by
148
References
113
Citations by year
2026: 8 · 2025: 10 · 2024: 23 · 2023: 14 · 2022: 8 · 2021: 12 · 2020: 14 · 2019: 18 · 2018: 14 · 2017: 14 · 2016: 10 · 2015: 2 · 2012: 1
FWCI
0.82
Type
journal article
Language
en
Open access
Locations
  • Clinical Nutrition (publishedVersion)
  • PubMed (publishedVersion)
  • Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
  • Digital Access to Libraries (submittedVersion)
Funders
  • European Research Council (336452-ENIGMO)
  • Australian Research Council
  • Fonds De La Recherche Scientifique - FNRS
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
Keywords
intestinal barrier, gut microbiota, dietary restriction, food deprivation, protein-energy wasting, intestinal permeability, gut-associated lymphoid tissue, enteric nervous system, intestinal epithelium, nutritional status, energy metabolism, obesity
MeSH terms
Gastrointestinal Microbiome, Animals, Cachexia, Diabetes Mellitus, Type 2, Disease Models, Animal, Energy Metabolism, Food Deprivation, Humans, Intestinal Mucosa, Nutritional Status, Obesity, Protein-Energy Malnutrition, Gastrointestinal Tract

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review