Alterations of gut barrier and gut microbiota in food restriction, food deprivation and protein-energy wasting
Open accessAbstract
Increasing evidence shows that gut microbiota composition is related to changes of gut barrier function including gut permeability and immune function. Gut microbiota is different in obese compared to lean subjects, suggesting that gut microbes are also involved in energy metabolism and subsequent nutritional state. While research on gut microbiota and gut barrier has presently mostly focused on intestinal inflammatory bowel diseases and more recently on obesity and type 2 diabetes, this review aims at summarizing the present knowledge regarding the impact, in vivo, of depleted nutritional states on structure and function of the gut epithelium, the gut-associated lymphoid tissue (GALT), the gut microbiota and the enteric nervous system. It highlights the complex interactions between the components of gut barrier in depleted states due to food deprivation, food restriction and protein energy wasting and shows that these interactions are multidirectional, implying the existence of feedbacks.
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Obesity and undernutrition are associated with an altered composition and diversity of the gut microbiota compared to healthy individuals.
“In fact, it has been shown that this two conditions are associated with an altered composition and diversity of the gut microbiota compared to healthy individuals [96,97,98].”
From Autism, Gastrointestinal Symptoms and Modulation of Gut Microbiota by Nutritional Interventions (2019) · cites this paper as [97]
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- Authors
- Genton, L., Cani, P. D., & Schrenzel, J.
- Affiliations
- University Hospital of Geneva (CH)
- Walloon Excellence in Lifesciences and Biotechnology (BE)
- Corresponding author
- Genton, L.
- Venue
- Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2015-06
- Volume
- 34
- Issue
- 3
- Pages
- 341-349
- ISSN
- 0261-5614 (ISSN-L)
- OpenAlex
- W2055032087
- Cited by
- 148
- References
- 113
- Citations by year
- 2026: 8 · 2025: 10 · 2024: 23 · 2023: 14 · 2022: 8 · 2021: 12 · 2020: 14 · 2019: 18 · 2018: 14 · 2017: 14 · 2016: 10 · 2015: 2 · 2012: 1
- FWCI
- 0.82
- Type
- journal article
- Language
- en
- Open access
- Locations
- Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
- Digital Access to Libraries (submittedVersion)
- Funders
- European Research Council (336452-ENIGMO)
- Australian Research Council
- Fonds De La Recherche Scientifique - FNRS
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
- Keywords
- intestinal barrier, gut microbiota, dietary restriction, food deprivation, protein-energy wasting, intestinal permeability, gut-associated lymphoid tissue, enteric nervous system, intestinal epithelium, nutritional status, energy metabolism, obesity
- MeSH terms
- Gastrointestinal Microbiome, Animals, Cachexia, Diabetes Mellitus, Type 2, Disease Models, Animal, Energy Metabolism, Food Deprivation, Humans, Intestinal Mucosa, Nutritional Status, Obesity, Protein-Energy Malnutrition, Gastrointestinal Tract
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