Cited by 35Medicinal Plants and NeuroprotectionCholinesterase and Neurodegenerative DiseasesPhytochemistry and Biological Activities

Cognitive-enhancing and ameliorative effects of acanthoside B in a scopolamine-induced amnesic mouse model through regulation of oxidative/inflammatory/cholinergic systems and activation of the TrkB/CREB/BDNF pathway

Karthivashan, Govindarajan, Kweon, Mee-Hyang, Park, Shin-Young, Kim, Joon-Soo, Kim, Deuk-Hoi, Ganesan, Palanivel, Choi, Dong-Kug·2019·Food and Chemical Toxicology

Abstract

Recently, our research team reported the anti-amnesic potential of desalted-hydroethanolic extracts of Salicornia europaea L. (SE-EE). In this study, we performed bioactivity-guided isolation and identification of Acanthoside B (Aca.B), from SE-EE, as the potential bioactive candidate and examined anti-amnesic activity with its potential mechanism of action using an in vivo model. S7-L3-3 purified from SE-EE showed enhanced in vitro acetylcholinesterase (AChE) inhibitory activity. The isolated S7-L3-3 was identified and characterized as Aca.B using varied spectral analyses, i.e., Nuclear magnetic resonance (NMR), Ultraviolet-visible (UV-Vis), and Electrospray ionization-mass spectrometry (ESI-MS). In the in vitro studies, Aca.B exhibited negligible toxicity and showed a dose-dependent nitric oxide inhibitory potential in Lipopolysaccharide (LPS)-stimulated BV-2 microglial cells. In the in vivo studies, the oral administration of Aca.B to mice showed enhanced bioavailability and dose-dependent repression of the behavioral/cognitive impairment by regulating the cholinergic function, restoring the antioxidant status, attenuating the inflammatory cytokines/mediators and actively enriching neurotropic proteins in the hippocampal regions of the scopolamine-administered mice.

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Crossref · 10.1016/j.fct.2019.04.062

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  • Salicornia europaea ethanol extract containing Acanthoside B at 10-20 mg/kg significantly decreased AChE levels in hippocampus and cortical regions compared to the scopolamine-treated group (p<0.05).

    “oral administration (o.p.) of Salicornia europaea ethanol extract (SE-EE), which contains Acanthoside B (Aca.B), at doses of 10–20 mg/kg significantly decreased AChE levels in both the hippocampus and cortical regions compared to the scopolamine-treated group (p < 0.05) [27].”

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Authors
Karthivashan, G., Kweon, M.-H., Park, S.-Y., Kim, J.-S., Kim, D.-H., Ganesan, P., & Choi, D.-K.
Affiliations
Konkuk University (KR)
Corresponding author
Choi, Dong-Kug
Venue
Food and Chemical Toxicology
Publisher
Elsevier BV
Published
2019-07
Volume
129
Pages
444-457
ISSN
0278-6915 (ISSN-L)
OpenAlex
W2944218266
Cited by
34
References
61
Citations by year
2025: 5 · 2024: 3 · 2023: 9 · 2022: 6 · 2021: 7 · 2020: 3 · 2019: 1
FWCI
5.46
Type
journal article
Language
en
Open access
closed
Locations
  • Food and Chemical Toxicology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Konkuk University
Topics
  • Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
  • Health Sciences › Medicine › Pharmacology › Cholinesterase and Neurodegenerative Diseases
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
Keywords
Salicornia europaea, scopolamine-induced amnesia, antiamnesic activity, acetylcholinesterase inhibition, neuroinflammation, oxidative stress, nitric oxide, microglia, hippocampus, neuroprotection, bioactivity-guided isolation
MeSH terms
Amnesia, Animals, Disease Models, Animal, Furans, Glucosides, Inflammation, Membrane Glycoproteins, Oxidation-Reduction, Protein-Tyrosine Kinases, Receptors, Cholinergic, Scopolamine, Cyclic AMP Response Element-Binding Protein, Lignans, Brain-Derived Neurotrophic Factor, Receptor, trkB, Mice

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