The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
The plant P1B‐type ATPase AtHMA4 transports Zn and Cd and plays a role in detoxification of transition metals supplied at elevated levels
Abstract
The transition metal Zn is essential for many physiological processes in plants, yet at elevated concentrations this, and the related non‐essential metal Cd, can be toxic. Arabidopsis thaliana HMA4, belonging to the Type P 1B subfamily of P‐type ATPases, has recently been implicated in Zn nutrition, having a role in root to shoot Zn translocation. Using Arabidopsis insertional mutants, it is shown here that disruption of AtHMA4 function also results in increased sensitivity to elevated levels of Cd and Zn, suggesting that AtHMA4 serves an important role in metal detoxification at higher metal concentrations. AtHMA4 and a truncated form lacking the last 457 amino acids both confer Cd and Zn resistance to yeast but a mutant version of the full‐length AtHMA4 (AtHMA4‐C357G) does not; this demonstrates that the C‐terminal region is not essential for this function. Evidence is presented that AtHMA4 functions as an efflux pump.
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Cites
Molecular mechanisms of plant metal tolerance and homeostasis
Clemens, S. (2001) · Planta · doi:10.1007/s004250000458 · Cited by 1,417
Becher, M., Talke, I. N., Krall, L., & Krämer, U. (2004) · The Plant Journal · doi:10.1046/j.1365-313x.2003.01959.x · Cited by 568
A novel CPx‐ATPase from the cadmium hyperaccumulator Thlaspi caerulescens
Bernard, C., Roosens, N., Czernic, P., Lebrun, M., & Verbruggen, N. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.05.036 · Cited by 248
Cited by
Root responses to cadmium in the rhizosphere: a review
Lux, A., Martinka, M., Vaculik, M., & White, P. J. (2011) · Journal of Experimental Botany · doi:10.1093/jxb/erq281 · Cited by 1,100
Krämer, U., Talke, I. N., & Hanikenne, M. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.04.010 · Cited by 583
Talke, I. N., Hanikenne, M., & Krämer, U. (2006) · Plant Physiology · doi:10.1104/pp.105.076232 · Cited by 452
Wong, C. K. E., & Cobbett, C. S. (2009) · New Phytologist · doi:10.1111/j.1469-8137.2008.02638.x · Cited by 445
Yamaji, N., Xia, J., Mitani-Ueno, N., Yokosho, K., & Feng Ma, J. (2013) · Plant Physiology · doi:10.1104/pp.113.216564 · Cited by 438
Metadata
- Authors
- Mills, R. F., Francini, A., Ferreira da Rocha, P. S. C., Baccarini, P. J., Aylett, M., Krijger, G. C., & Williams, L. E.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2004-12-27
- Volume
- 579
- Issue
- 3
- Pages
- 783-791
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2072950818
- Cited by
- 247
- References
- 3
- FWCI
- 9.37
- Type
- journal article
- Language
- en
- Open access
- closed
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- Mills, R. F., Francini, A., Ferreira da Rocha, P. S. C., Baccarini, P. J., Aylett, M., Krijger, G. C., & Williams, L. E. (2005). The plant P1B‐type ATPase AtHMA4 transports Zn and Cd and plays a role in detoxification of transition metals supplied at elevated levels. FEBS Letters. https://doi.org/10.1016/j.febslet.2004.12.040
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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