Cited by 101Mitochondrial Function and PathologyCell death mechanisms and regulationPharmacological Receptor Mechanisms and Effects

Fluoxetine (Prozac) interaction with the mitochondrial voltage‐dependent anion channel and protection against apoptotic cell death

Nahon, Edna, Israelson, Adrian, Abu-Hamad, Salah, Shoshan-Barmatz, Varda·2005·FEBS Letters

Abstract

Here, we demonstrate that fluoxetine interacted with VDAC and decreased its conductance. Fluoxetine inhibited the opening of the mitochondrial permeability transition pore, the release of cytochrome c, and protected against staurosporine‐induced apoptotic cell death. These findings may explain some of the reported fluoxetine side effects.

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Crossref · 10.1016/j.febslet.2005.08.020

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35 of 35 references verified0 citation errors · 0 not checkable

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Authors
Nahon, E., Israelson, A., Abu-Hamad, S., & Shoshan-Barmatz, V.
Affiliations
Ben-Gurion University of the Negev (IL)
Venue
FEBS Letters
Publisher
Wiley
Published
2005-08-24
Volume
579
Issue
22
Pages
5105-5110
ISSN
  • 0014-5793 (ISSN-L)
  • 1873-3468
OpenAlex
W1983099105
Cited by
101
References
34
Citations by year
2026: 3 · 2025: 1 · 2024: 3 · 2023: 2 · 2022: 4 · 2021: 5 · 2020: 7 · 2019: 5 · 2018: 8 · 2017: 8 · 2016: 7 · 2015: 4 · 2014: 4 · 2013: 6 · 2012: 11
FWCI
1.51
Type
journal article
Language
en
Open access
closed
Locations
  • FEBS Letters (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pharmacological Receptor Mechanisms and Effects
Keywords
fluoxetine, mitochondrial voltage-dependent anion channel, voltage-dependent anion channel, mitochondrial permeability transition pore, cytochrome c release, staurosporine-induced apoptosis, apoptosis, adverse drug reactions, serotonin reuptake inhibition
MeSH terms
Animals, Cell Line, Enzyme Inhibitors, Fluoxetine, Humans, Mitochondria, Liver, Apoptosis, Selective Serotonin Reuptake Inhibitors, Porins, Staurosporine, Cytochromes c, Voltage-Dependent Anion Channels, Rats

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