The Swi/Snf chromatin remodeling complex is essential for hyphal development in Candida albicans
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The ability of dimorphic transition between yeast and hyphal forms in Candida albicans is one of the vital determinants for its pathogenicity and virulence. We isolated C. albicans SWI1 as a suppressor of the invasive growth defect in a Saccharomyces cerevisiae mutant. Expression of C. albicans SWI1 in S. cerevisiae partially complemented the growth defect of a swi1 mutant in the utilization of glycerol. Swi1 is in a complex with Snf2 in C. albicans, and both proteins are localized in the nucleus independent of the growth form. Deleting SWI1 or SNF2 in C. albicans prevented true hyphal formation and resulted in constitutive pseudohypha‐like growth in all media examined. Furthermore, swi1/swi1 mutant was defective in hypha‐specific gene expression and avirulent in a mouse model of systemic infection. These data strongly suggest the conserved Swi/Snf complex in C. albicans is required for hyphal development and pathogenicity.
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C. albicans Rtt106 and C. albicans SWI/SNF affect hyphae formation, which indirectly influences drug tolerance and pathogenicity.
“C. albicans Rtt106 and C. albicans SWI/SNF affect hyphae formation56,57, which indirectly influences drug tolerance and pathogenicity.”
From SWI/SNF and the histone chaperone Rtt106 drive expression of the Pleiotropic Drug Resistance network genes (2022) · cites this paper as [57]
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- Authors
- Mao, X., Cao, F., Nie, X., Liu, H., & Chen, J.
- Affiliations
- Chinese Academy of Sciences (CN)
- University of California, Irvine (US)
- Corresponding author
- Chen, Jiangye
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2006-04-21
- Volume
- 580
- Issue
- 11
- Pages
- 2615-2622
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2048179195
- Cited by
- 45
- References
- 47
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 3 · 2022: 4 · 2021: 2 · 2020: 4 · 2019: 2 · 2018: 2 · 2017: 3 · 2016: 1 · 2015: 3 · 2014: 1 · 2012: 2
- FWCI
- 1.36
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- FEBS Letters (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of General Medical Sciences (GM 55155, R01GM055155)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
- Keywords
- SWI/SNF complex, Candida albicans, hyphal development, Swi1, SnF2, dimorphic transition, pseudohyphae, fungal pathogenicity, virulence, invasive growth, systemic infection, Saccharomyces cerevisiae complementation
- MeSH terms
- Animals, Candida albicans, Cell Nucleus, Chromosomal Proteins, Non-Histone, Cloning, Molecular, Fungal Proteins, Mutation, Nuclear Proteins, Protein Binding, Saccharomyces cerevisiae, Transcription Factors, Trans-Activators, Gene Expression Regulation, Fungal, Gene Dosage, Hyphae, Saccharomyces cerevisiae Proteins, Chromatin Assembly and Disassembly, Mice
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