Brain-derived neurotrophic factor regulates AMPA receptor trafficking to post-synaptic densities via IP3R and TRPC calcium signaling
Abstract
The change in the number of post-synaptic alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA)-type glutamatergic receptors (AMPARs) by neuronal activity is recognized as a molecular basis of synaptic plasticity. Here, we show that Ca(2+) transients evoked by brain-derived neurotrophic factor (BDNF) induce translocation of a subunit of AMPAR, GluR1, but not NMDAR, to the post-synaptic membrane in cultured cortical pyramidal neurons. Among BDNF-induced Ca(2+) transients, that dependent on IP3R was fully required, while store-operated calcium influx through the non-selective cation channel TRPC (transient receptor potential canonical) was partially required for the GluR1 up-regulation, suggesting that spatial and temporal calcium signaling regulate translocation of GluR1 to the polarized membrane domain.
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Increased BDNF expression robustly promotes in vivo proliferation, triggering of differentiation, axonal path migration, and maturation of neural stem cells in the dentate gyrus.
“In fact, many individual studies have found that increased BDNF expression robustly promotes the in vivo proliferation, triggering of differentiation, axonal path migration, and maturation of the neural stem cells in the dentate gyrus (Korte et al., 1995; Reichardt, 2006; Nakata and Nakamura, 2007; Waterhouse et al., 2012).”
From Exercise-Mediated Neurogenesis in the Hippocampus via BDNF (2018) · cites this paper as Nakata and Nakamura, 2007
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- Authors
- Nakata, H., & Nakamura, S.
- Affiliations
- Tokyo Institute of Psychiatry (JP)
- National Center of Neurology and Psychiatry (JP)
- Corresponding author
- Nakata, Hiroko
- ORCID
- Nakamura, Shun
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2007-04-25
- Volume
- 581
- Issue
- 10
- Pages
- 2047-2054
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W1977539668
- Cited by
- 117
- References
- 11
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 4 · 2023: 9 · 2022: 7 · 2021: 3 · 2020: 5 · 2019: 2 · 2018: 7 · 2017: 8 · 2016: 5 · 2015: 5 · 2014: 12 · 2013: 8 · 2012: 8
- FWCI
- 2.63
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- FEBS Letters (publishedVersion)
- PubMed (publishedVersion)
- Funders
- RIKEN Brain Science Institute
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Keywords
- brain-derived neurotrophic factor, AMPA receptor trafficking, GluR1, postsynaptic density, IP3 receptor, store-operated calcium entry, calcium transients, synaptic plasticity, cortical pyramidal neurons
- MeSH terms
- Disks Large Homolog 4 Protein, Animals, Humans, Membrane Glycoproteins, Membrane Proteins, Synaptic Membranes, Time Factors, Calcium Channels, Pyramidal Cells, Receptors, AMPA, Receptors, Cytoplasmic and Nuclear, Brain-Derived Neurotrophic Factor, Calcium Signaling, Protein Transport, Intracellular Signaling Peptides and Proteins, Dendritic Spines, TRPC Cation Channels, Mice, Guanylate Kinases, Inositol 1,4,5-Trisphosphate Receptors
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