BDNF polymorphism predicts the rate of decline in skilled task performance and hippocampal volume in healthy individuals
Open accessAbstract
Numerous studies have indicated a link between the presence of polymorphism in brain-derived neurotrophic factor (BDNF) and cognitive and affective disorders. However, only a few have studied these effects longitudinally along with structural changes in the brain. This study was carried out to investigate whether valine-to-methionine substitution at position 66 (val66met) of pro-BDNF could be linked to alterations in the rate of decline in skilled task performance and structural changes in hippocampal volume. Participants consisted of 144 healthy Caucasian pilots (aged 40-69 years) who completed a minimum of 3 consecutive annual visits. Standardized flight simulator score (SFSS) was measured as a reliable and quantifiable indicator for skilled task performance. In addition, a subset of these individuals was assessed for hippocampal volume alterations using magnetic resonance imaging. We found that val66met substitution in BDNF correlated longitudinally with the rate of decline in SFSS. Structurally, age-dependent hippocampal volume changes were also significantly altered by this substitution. Our study suggests that val66met polymorphism in BDNF can be linked to the rate of decline in skilled task performance. Furthermore, this polymorphism could be used as a predictor of the effects of age on the structure of the hippocampus in healthy individuals. Such results have implications for understanding possible disabilities in older adults performing skilled tasks who are at a higher risk for cognitive and affective disorders.Translational Psychiatry (2011) 1, e51; doi:10.1038/tp.2011.47; published online 25 October 2011.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In an extensive longitudinal study, the presence of rs6265 robustly predicted the gradual decline of hippocampal volume and subsequent skilled task performance.
“In an extensive longitudinal study, the presence of rs6265 robustly predicted the gradual decline of hippocampal volume and also subsequent skilled task performance (Sanchez et al., 2011).”
From Exercise-Mediated Neurogenesis in the Hippocampus via BDNF (2018) · cites this paper as Sanchez et al., 2011
The Results (Standard flight simulator score; page not provided) report significantly faster decline in skilled-task performance among met carriers. But the longitudinal hippocampal-volume analysis found no significant effect of the polymorphism on the rate of volume decline, and the paper found no significant correlation between hippocampal volume and task performance. The claim overstates the volume finding and implies a sequence the study did not establish. (LLM, conf=0.90)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
(1992) · Applied Ergonomics · doi:10.1016/0003-6870(92)90338-v · Cited by 7,153 · see citing works
Egan, M. F., Kojima, M., Callicott, J. H., Goldberg, T. E., Kolachana, B. S., Bertolino, A., Zaitsev, E., Gold, B., Goldman, D., Dean, M., et al. (2003) · Cell · doi:10.1016/s0092-8674(03)00035-7 · Cited by 3,888 · see citing works
Neurotrophin-regulated signalling pathways
Reichardt, L. F. (2006) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2006.1894 · Cited by 2,195 · see citing works
Hippocampal long-term potentiation is impaired in mice lacking brain-derived neurotrophic factor.
Korte, M., Carroll, P., Wolf, E., Brem, G., Thoenen, H., & Bonhoeffer, T. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.19.8856 · Cited by 1,426 · see citing works
Fritsch, B., Reis, J., Martinowich, K., Schambra, H. M., Ji, Y., Cohen, L. G., & Lu, B. (2010) · Neuron · doi:10.1016/j.neuron.2010.03.035 · Cited by 1,420 · see citing works
N-Acetylaspartate in the CNS: From neurodiagnostics to neurobiology
MOFFETT, J., Ross, B., Arun, P., Madhavarao, C. N., & Namboodiri, A. M. (2007) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2006.12.003 · Cited by 1,413 · see citing works
Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior
Chen, Z.-Y., Jing, D., Bath, K. G., Ieraci, A., Khan, T., Siao, C.-J., Herrera, D. G., Toth, M., Yang, C., McEwen, B. S., et al. (2006) · Science · doi:10.1126/science.1129663 · Cited by 1,340 · see citing works
Nagahara, A. H., Merrill, D. A., Coppola, G., Tsukada, S., Schroeder, B. E., Shaked, G. M., Wang, L., Blesch, A., Kim, A., Conner, J. M., et al. (2009) · Nature Medicine · doi:10.1038/nm.1912 · Cited by 1,034 · see citing works
Pezawas, L., Verchinski, B. A., Mattay, V. S., Callicott, J. H., Kolachana, B. S., Straub, R. E., Egan, M. F., Meyer-Lindenberg, A., & Weinberger, D. R. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.2680-04.2004 · Cited by 890 · see citing works
Schuff, N., Woerner, N., Boreta, L., Kornfield, T., Shaw, L. M., Trojanowski, J. Q., Thompson, P. M., Jack, C. R., Weiner, M. W., & Initiative, T. A. D. N. (2008) · Brain · doi:10.1093/brain/awp007 · Cited by 679 · see citing works
An, J. J., Gharami, K., Liao, G., Woo, N. H., Lau, A. G., Vanevski, F., Torre, E. R., Jones, K. R., Feng, Y., Lu, B., et al. (2008) · Cell · doi:10.1016/j.cell.2008.05.045 · Cited by 670 · see citing works
Hippocampal morphometry in schizophrenia by high dimensional brain mapping
Csernansky, J. G., Joshi, S. C., Wang, L., Haller, J. W., Gado, M. H., Miller, J. P., Grenander, U., & Miller, M. I. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.19.11406 · Cited by 469 · see citing works
BDNF Val66Met Allele Is Associated with Reduced Hippocampal Volume in Healthy Subjects
Bueller, J. A., Aftab, M., Sen, S., Gomez‐Hassan, D. M., Burmeister, M., & Zubieta, J. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.09.022 · Cited by 458 · see citing works
Volumetric transformation of brain anatomy
Christensen, G. E., Joshi, S. C., & Miller, M. I. (1997) · IEEE Transactions on Medical Imaging · doi:10.1109/42.650882 · Cited by 441 · see citing works
Gratacòs, M., González, J. R., Mercader, J. M., de Cid, R., Urretavizcaya, M., & Estivill, X. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.08.025 · Cited by 428 · see citing works
High-throughput SNP genotyping on universal bead arrays
Shen, R., Fan, J., Campbell, D., Chang, W., Chen, J., Doucet, D., Yeakley, J. M., Bibikova, M. V., Wickham‐Garcia, E., McBride, C., et al. (2005) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2004.07.022 · Cited by 415 · see citing works
Exercise, Antidepressant Medications, and Enhanced Brain Derived Neurotrophic Factor Expression
Russo-Neustadt, A. (1999) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00059-7 · Cited by 411 · see citing works
Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents
Massa, S. M., Yang, T., Xie, Y., Shi, J., Bilgen, M., Joyce, J. N., Nehama, D., Rajadas, J., & Longo, F. M. (2010) · Journal of Clinical Investigation · doi:10.1172/jci41356 · Cited by 406 · see citing works
Chen, Z.-Y., Ieraci, A., Teng, H. K., Dall, H., Meng, C.-X., Herrera, D. G., Nykjær, A., Hempstead, B. L., & Lee, F. S. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1017-05.2005 · Cited by 399 · see citing works
Frodl, T., Schüle, C., Schmitt, G., Born, C., Baghai, T., Zill, P., Bottlender, R., Rupprecht, R., Bondy, B., Reiser, M., et al. (2007) · Archives of General Psychiatry · doi:10.1001/archpsyc.64.4.410 · Cited by 394 · see citing works
Hashimoto, K. (2010) · Psychiatry and Clinical Neurosciences · doi:10.1111/j.1440-1819.2010.02113.x · Cited by 388 · see citing works
Brain-derived neurotrophic factor Val66met polymorphism and volume of the hippocampal formation
Szeszko, P. R., Lipsky, R. H., Mentschel, C., Robinson, D. G., Gunduz‐Bruce, H., Sevy, S. M., Ashtari, M., Napolitano, B. A., Bilder, R. M., Kane, J. M., et al. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001656 · Cited by 373 · see citing works
Marie Chupin, A., Gérardin, E., Cuingnet, R., Boutet, C., Lemieux, L., Lehéricy, S., Benali, H., Garnero, L., & Colliot, O. (2009) · Hippocampus · doi:10.1002/hipo.20626 · Cited by 341 · see citing works
Holsinger, R. M. D., Schnarr, J., Henry, P., Castelo, V. T., & Fahnestock, M. L. (2000) · Molecular Brain Research · doi:10.1016/s0169-328x(00)00023-1 · Cited by 328 · see citing works
Shimizu, E., Hashimoto, K., & Iyo, M. (2003) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.20118 · Cited by 328 · see citing works
Hippocampal volume in normal aging and traumatic brain injury.
Bigler, E. D., Blatter, D. D., Anderson, C. V., Johnson, S. C., Gale, S. D., Hopkins, R. O., & Burnett, B. (1997) · PubMed Central · Cited by 311 · see citing works
Müller, M. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00099-3 · Cited by 292 · see citing works
Pro-brain-derived neurotrophic factor is decreased in parietal cortex in Alzheimer's disease.
Michalski, B., & Fahnestock, M. (2003) · Brain Research. Molecular Brain Research · doi:10.1016/s0169-328x(03)00003-2 · Cited by 269 · see citing works
Population genetic study of the brain-derived neurotrophic factor (BDNF) gene
Petryshen, T. L., Sabeti, P. C., Aldinger, K. A., Fry, B., Fan, J. B., Schaffner, S. F., Waggoner, S. G., Tahl, A. R., & Sklar, P. (2010) · Molecular Psychiatry · doi:10.1038/mp.2009.24 · Cited by 267 · see citing works
Hwang, J., Tsai, S., Hong, C., Yang, C.-H., Lirng, J., & Yang, Y.-M. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.10.013 · Cited by 253 · see citing works
Age effects on atrophy rates of entorhinal cortex and hippocampus
Du, A., Schuff, N. W., Chao, L. L., Kornak, J., Jagust, W. J., Kramer, J. H., Reed, B., Miller, B. L., Norman, D. M., Chui, H. C., et al. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.03.021 · Cited by 223 · see citing works
Kunugi, H., Ueki, A., Otsuka, M., Isse, K., Hirasawa, H., Kato, N., Nabika, T., Kobayashi, S., & Nanko, S. (2000) · Molecular Psychiatry · doi:10.1038/sj.mp.4000792 · Cited by 220 · see citing works
Chiaruttini, C., Vicario, A., Li, Z., Baj, G., Braiuca, P., Wu, Y., Lee, F. S., Gardossi, L., Baraban, J. M., & Tongiorgi, E. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0902833106 · Cited by 217 · see citing works
Peng, S., Garzon, D. J., Marchese, M., Klein, W. L., Ginsberg, S. D., Francis, B. M., Mount, H. T. J., Mufson, E. J., Salehi, A., & Fahnestock, M. L. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.4736-08.2009 · Cited by 216 · see citing works
Self-citationComparison of automated and manual MRI volumetry of hippocampus in normal aging and dementia
Hsu, Y., Schuff, N. W., Du, A., Mark, K. E., Zhu, X., Hardin, D., & Weiner, M. W. (2002) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.10163 · Cited by 213 · see citing works
Localized Synaptic Potentiation by BDNF Requires Local Protein Synthesis in the Developing Axon
Zhang, X.-H., & Poo, M. (2002) · Neuron · doi:10.1016/s0896-6273(02)01023-1 · Cited by 209 · see citing works
Ribasés, M., Gratacòs, M., Armengol, L., de Cid, R., Badía, A., Jiménez, L., Solano, R., Vallejo, J., Fernández, F., & Estivill, X. (2003) · Molecular Psychiatry · doi:10.1038/sj.mp.4001281 · Cited by 200 · see citing works
Neurotrophins, synaptic plasticity and dementia
Arancio, O., & Chao, M. V. (2007) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2007.03.013 · Cited by 193 · see citing works
Association between BDNF val66 met genotype and episodic memory
Dempster, E. L., Toulopoulou, T., McDonald, C., Bramon, E., Walshe, M., Filbey, F. M., Wickham, H., Sham, P. C., Murray, R. M., & Collier, D. A. (2005) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30150 · Cited by 179 · see citing works
Signaling Mechanisms Mediating BDNF Modulation of Synaptic Plasticity in the HippocampusPreprint
Gottschalk, W., Jiang, H., Tartaglia, N. R., Feng, L., Figurov, A., & Lu, B. (1999) · Learning & Memory · doi:10.1101/lm.6.3.243 · Cited by 165 · see citing works
Donepezil and flight simulator performance: Effects on retention of complex skills
Yesavage, J. A., Mumenthaler, M. S., Taylor, J. L., Friedman, L., O'Hara, R. M., Sheikh, J. I., Tinklenberg, J. R., & Whitehouse, P. J. (2002) · Neurology · doi:10.1212/wnl.59.1.123 · Cited by 161 · see citing works
Self-citationNemoto, K., Ohnishi, T., Mori, T., Moriguchi, Y., Hashimoto, R., Asada, T., & Kunugi, H. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2005.11.067 · Cited by 131 · see citing works
Nakata, H., & Nakamura, S. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.04.041 · Cited by 117 · see citing works
Sarchiapone, M., Carli, V., Roy, A., Iacoviello, L., Cuomo, C., Latella, M. C., di Giannantonio, M., Janiri, L., de Gaetano, M., & Janal, M. N. (2008) · Neuropsychobiology · doi:10.1159/000142361 · Cited by 115 · see citing works
Lyons, L., ELBeltagy, M., Umka, J., Markwick, R., Startin, C. M., Bennett, G., & Wigmore, P. M. (2010) · Psychopharmacology · doi:10.1007/s00213-010-2122-2 · Cited by 108 · see citing works
Local Effects of BDNF on Dendritic Growth
Horch, H. W. (2004) · Reviews in the Neurosciences · doi:10.1515/revneuro.2004.15.2.117 · Cited by 103 · see citing works
Hajek, T., Kopecek, M., & Höschl, C. (2012) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2011.580005 · Cited by 99 · see citing works
Pilot age and expertise predict flight simulator performance
Taylor, J. L., Kennedy, Q., Noda, A. M., & Yesavage, J. A. (2007) · Neurology · doi:10.1212/01.wnl.0000255943.10045.c0 · Cited by 97 · see citing works
Self-citationBrain-derived neurotrophic factor gene polymorphisms and Alzheimer?s disease
Matsushita, S., Arai, H., Matsui, T., Yuzuriha, T., Urakami, K., Masaki, T., & Higuchi, S. (2004) · Journal of Neural Transmission · doi:10.1007/s00702-004-0210-3 · Cited by 93 · see citing works
Genetic association study of BDNF in depression: Finding from two cohort studies and a meta‐analysis
Chen, L., Lawlor, D. A., Lewis, S. J., Yuan, W., Abdollahi, M. R., Timpson, N. J., Day, I. N. M., Ebrahim, S. B. J., Smith, G. D., & Shugart, Y. Y. (2008) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30686 · Cited by 90 · see citing works
Stressful life events and the brain-derived neurotrophic factor gene in bipolar disorder
Hosang, G. M., Uher, R., Keers, R., Cohen‐Woods, S., Craig, I., Korszun, A., Perry, J., Tozzi, F., Muglia, P., McGuffin, P., et al. (2010) · Journal of Affective Disorders · doi:10.1016/j.jad.2010.01.071 · Cited by 79 · see citing works
Götz, R., Raulf, F., & Schartl, M. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb09389.x · Cited by 77 · see citing works
Sleep/Wake Disruption in Alzheimer’s Disease: APOE Status and Longitudinal Course
Yesavage, J. A., Friedman, L., KRAEMER, H. C., Tinklenberg, J. R., Salehi, A., Noda, A. M., Taylor, J. L., O'Hara, R. M., & Murphy, G. M. (2004) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/0891988703261994 · Cited by 74 · see citing works
Self-citationCombarros, O., Infante, J., Llorca, J., & Berciano, J. (2004) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000077736 · Cited by 68 · see citing works
Role of BDNF Val66Met functional polymorphism in Alzheimer's disease-related depression
Borroni, B., Archetti, S., Costanzi, C., Grassi, M., FERRARI, M. M. H., Radeghieri, A., Caimi, L., Caltagirone, C., Luca, M. D., & Padovani, A. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.11.023 · Cited by 67 · see citing works
Goodyer, I. M., Croudace, T., Dudbridge, F., Ban, M., & Herbert, J. (2010) · British Journal of Psychiatry · doi:10.1192/bjp.bp.110.077750 · Cited by 67 · see citing works
Pringle, A. K., Sundström, L., Wilde, G. J. C., Williams, L. R., & lannotti, F. (1996) · Neuroscience Letters · doi:10.1016/0304-3940(96)12745-2 · Cited by 66 · see citing works
BDNF genotype potentially modifying the association between incident stroke and depression
Kim, J.-M., Stewart, R., Kim, S.-W., Yang, S.-J., Shin, I.-S., Kim, Y.-H., & Yoon, J.-S. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.11.021 · Cited by 64 · see citing works
Plasma BDNF concentration, Val66Met genetic variant and depression- related personality traits
Terracciano, A., Martin, B., Ansari, D., Tanaka, T., Ferrucci, L., Maudsley, S., Mattson, M. P., & Costa, P. T. (2010) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2010.00579.x · Cited by 63 · see citing works
Relationship of CogScreen-AE to flight simulator performance and pilot age.
Taylor, J. L., O'Hara, R. M., Mumenthaler, M. S., & Yesavage, J. A. (2000) · PubMed · Cited by 56 · see citing works
Self-citationKarnik, M. S., Wang, L., Barch, D. M., Morris, J. C., & Csernansky, J. G. (2010) · Psychiatry Research · doi:10.1016/j.psychres.2009.09.008 · Cited by 51 · see citing works
Forero, D. A., Benítez, B. A., Arboleda, G., Yunis, J. J., Pardo, R., & Arboleda, H. (2006) · Neuroscience Research · doi:10.1016/j.neures.2006.04.006 · Cited by 49 · see citing works
Effect of BDNF val66met polymorphism on age-related amygdala volume changes in healthy subjects
Sublette, M. E., Baca‐García, E., Parsey, R. V., Oquendo, M. A., Rodrigues, S. M., Galfalvy, H., Huang, Y., Arango, V., & Mann, J. J. (2008) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2008.06.009 · Cited by 48 · see citing works
Bian, J.-T., Zhang, J., Zhang, Z., & Zhao, H.-L. (2005) · Neuroscience Letters · doi:10.1016/j.neulet.2005.07.009 · Cited by 47 · see citing works
Bagnoli, S., Nacmias, B., Tedde, A., Guarnieri, B., Cellini, E., Petruzzi, C., Bartoli, A., Ortenzi, L., & Sorbi, S. (2004) · Annals of Neurology · doi:10.1002/ana.10842 · Cited by 44 · see citing works
Stern, A., Farmer, A. S., Goldman, A. L., Barnett, A. S., van der Veen, J. W. C., Callicott, J. H., Mattay, V. S., Weinberger, D. R., & Marenco, S. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.07.009 · Cited by 41 · see citing works
Cathomas, F., Vogler, C., Sigmund, J., de Quervain, D. J. ‐., & Papassotiropoulos, A. (2010) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145710000519 · Cited by 40 · see citing works
Relationship of Age and Simulated Flight Performance
Yesavage, J. A., Taylor, J. L., Mumenthaler, M. S., Noda, A. M., & O'Hara, R. M. (1999) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1999.tb03838.x · Cited by 35 · see citing works
Self-citationXiao-ming, H., Zhang, Z., Zhang, J., Zhou, Y., Tang, M., Wu, C., & Hong, Z. (2007) · Neuropsychobiology · doi:10.1159/000106473 · Cited by 32 · see citing works
Apolipoprotein E ɛ4 influences on episodic recall and brain structures in aging pilots
Adamson, M. M., Landy, K. M., Duong, S., Fox‐Bosetti, S., Ashford, J. W., Murphy, G. M., Weiner, M. W., & Taylor, J. L. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.07.017 · Cited by 31 · see citing works
Self-citationKim, J., Gale, K., & Kondratyev, A. D. (2010) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2010.02.003 · Cited by 24 · see citing works
Elucidating the Role of Brain-Derived Neurotrophic Factor in the Brain
Monteggia, L. M. (2007) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2007.07101634 · Cited by 20 · see citing works
Cheng, J. D., & de Vellis, J. (2000) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(20000201)59:3
Flagged first, then by citations
Research works printed but not linked: 2
- Chao MV Trophic factors: an evolutionary cul-de-sac or door into higher neuronal function J Neurosci Res 2000 59 353 355 10679770
- Kay GG CogScreen Aeromedical Edition Professional Manual Psychological Assessment Resources, Inc: Odessa, FL 1995
Cited by
Sorted by citations
BDNF-based synaptic repair as a disease-modifying strategy for neurodegenerative diseases
Lu, B., Nagappan, G., Guan, X.-M., Nathan, P. J., & Wren, P. B. (2013) · Nature reviews. Neuroscience · doi:10.1038/nrn3505 · Cited by 747 · see citing works
The effects of aging in the hippocampus and cognitive decline
Bettio, L. E. B., Rajendran, L., & Gil‐Mohapel, J. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.04.030 · Cited by 654 · see citing works
Exercise-Mediated Neurogenesis in the Hippocampus via BDNF
Liu, P. Z., & Nusslock, R. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00052 · Cited by 533 · see citing works
Neuroprotective effects of physical activity on the brain: a closer look at trophic factor signaling
Phillips, C., Baktir, M. A., Srivatsan, M., & Salehi, A. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00170 · Cited by 330 · see citing works
Self-citationKennedy, G., Hardman, R. J., Macpherson, H., Scholey, A. B., & Pipingas, A. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-160665 · Cited by 187 · see citing works
Walsh, E., Smith, L. M., Northey, J. M., Rattray, B., & Cherbuin, N. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101044 · Cited by 163 · see citing works
Molendijk, M. L., Bus, B. A. A., Spinhoven, P., Kaimatzoglou, A., Voshaar, R. C. O., Penninx, B. W. J. H., van IJzendoorn, M. H., & Elzinga, B. M. (2012) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32078 · Cited by 107 · see citing works
Gibbons, T. E., Pence, B. D., Petr, G. T., Ossyra, J. M., Mach, H. C., Bhattacharya, T. K., Perez, S., Martin, S. A., McCusker, R. H., Kelley, K. W., et al. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.05.049 · Cited by 80 · see citing works
Aging-related magnification of genetic effects on cognitive and brain integrity
Papenberg, G., Lindenberger, U., & Bäckman, L. (2015) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2015.06.008 · Cited by 77 · see citing works
Balkaya, M., & Cho, S. (2018) · Neurobiology of Disease · doi:10.1016/j.nbd.2018.08.009 · Cited by 73 · see citing works
Harrisberger, F., Spalek, K., Smieskova, R., Schmidt, A., Coynel, D., Milnik, A., Fastenrath, M., Freytag, V., Gschwind, L., Walter, A., et al. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.03.011 · Cited by 67 · see citing works
The Potential Role of Genetic Markers in Talent Identification and Athlete Assessment in Elite Sport
Jacob, Y., Spiteri, T., Hart, N. H., & Anderton, R. S. (2018) · Sports · doi:10.3390/sports6030088 · Cited by 71 · see citing works
Boschen, K. E., & Klintsova, A. Y. (2016) · Vitamins and hormones · doi:10.1016/bs.vh.2016.10.008 · Cited by 57 · see citing works
Investigating Predictors of Cognitive Decline Using Machine Learning
Casanova, R., Saldana, S. J., Lutz, M. W., Plassman, B. L., Kuchibhatla, M. N., & Hayden, K. M. (2018) · The Journals of Gerontology Series B · doi:10.1093/geronb/gby054 · Cited by 56 · see citing works
DNA methylation and cognitive aging
Xu, X. Z. S. (2015) · Oncotarget · doi:10.18632/oncotarget.4215 · Cited by 54 · see citing works
Genetics and Functional Imaging: Effects of APOE, BDNF, COMT, and KIBRA in Aging
Papenberg, G., Salami, A., Persson, J., Lindenberger, U., & Bäckman, L. (2015) · Neuropsychology Review · doi:10.1007/s11065-015-9279-8 · Cited by 39 · see citing works
Jiang, R., Babyak, M. A., Brummett, B. H., Siegler, I. C., Kuhn, C. M., & Williams, R. B. (2017) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2017.02.005 · Cited by 39 · see citing works
Brain-derived neurotrophic factor Val66Met polymorphism, human memory, and synaptic neuroplasticity.
Lamb, Y. N., Mckay, N. S., Thompson, C., Hamm, J., Waldie, K., & Kirk, I. (2015) · Wiley Interdisciplinary Reviews: Cognitive Science · doi:10.1002/wcs.1334 · Cited by 37 · see citing works
Lopes, I. S., Oliveira, I. C. M., Capibaribe, V. C. C., Valentim, J. T., da Silva, D. M. A., de Souza, A. G., de Araújo, M. A., Chaves, R. D. C., Gutierrez, S. J. C., Barbosa‐Filho, J. M., et al. (2018) · Neurochemistry International · doi:10.1016/j.neuint.2018.07.007 · Cited by 37 · see citing works
Weaver, S. M., Tremont, J. N. P., Chau, A., Cristofori, I., Moretti, L., & Grafman, J. H. (2012) · Brain Imaging and Behavior · doi:10.1007/s11682-012-9197-9 · Cited by 33 · see citing works
Graves, A. R., Moore, S. J., Spruston, N., Tryba, A. K., & Kaczorowski, C. C. (2016) · Journal of Neurophysiology · doi:10.1152/jn.00186.2016 · Cited by 29 · see citing works
Soltész, F., John Suckling, A., Lawrence, P., Tait, R. J., Ooi, C., Bentley, G., Dodds, C. M., Miller, S. R., Willé, D. R., Byrne, M., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0095558 · Cited by 25 · see citing works
BDNF genotype is associated with hippocampal volume in mild traumatic brain injury
Hayes, J. P., Reagan, A., Logue, M. W., Hayes, S. M., Sadeh, N., Miller, D. R., Verfaellie, M. H., Wolf, E. J., McGlinchey, R. E., Milberg, W., et al. (2017) · Genes Brain & Behavior · doi:10.1111/gbb.12403 · Cited by 26 · see citing works
Nees, F., Witt, S. H., & Flor, H. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.12.015 · Cited by 26 · see citing works
The link between BDNF and platelets in neurological disorders
Bouhaddou, N., Mabrouk, M., Atifi, F., Bouyahya, A., & Zaid, Y. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e39278 · Cited by 23 · see citing works
The Impact of the Brain-Derived Neurotrophic Factor Gene on Trauma and Spatial Processing
Miller, J. K., McDougall, S. J. P., Thomas, S., & Wiener, J. M. (2017) · Journal of Clinical Medicine · doi:10.3390/jcm6120108 · Cited by 18 · see citing works
de Araújo, C. M., Zugman, A., Swardfager, W., Belangero, S. I., Ota, V., Spíndola, L., Hakonarson, H. H., Pellegrino, R., Gadelha, A., Salum, G. A., et al. (2017) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2017.12.008 · Cited by 15 · see citing works
de Faria, R. S., Sartori, C. R., Canova, F. B., & Ferrari, E. A. M. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.09.054 · Cited by 14 · see citing works
Impact of Strength Training Intensity on Brain-derived Neurotrophic Factor
Júnior, M. B., Tavares, L. F. J., Nagata, G. Y., Barroso, L. S. S., Fernandes, H. D. B., Souza-Gomes, A. F., de Miranda, A. S., & Nunes-Silva, A. (2023) · International Journal of Sports Medicine · doi:10.1055/a-2197-1201 · Cited by 11 · see citing works
Paolini, M., Fortaner-Uyà, L., Lorenzi, C., Spadini, S., Maccario, M., Zanardi, R., Colombo, C., Poletti, S., & Benedetti, F. (2023) · Genes · doi:10.3390/genes14112037 · Cited by 10 · see citing works
Testing influences of APOE and BDNF genes and heart failure on cognitive function
Jung, M., Apostolova, L. G., Gao, S., Burney, H. N., Lai, D., Foroud, T., Saykin, A. J., & Pressler, S. J. (2020) · Heart & Lung · doi:10.1016/j.hrtlng.2020.06.014 · Cited by 8 · see citing works
Cheng, Y., Chen, T., & Hu, J. (2023) · Scientific Reports · doi:10.1038/s41598-023-41066-9 · Cited by 8 · see citing works
Kim, D., Chung, S., Lee, S., Choi, S., Kim, S. M., Koo, J., Lee, J., & Jahng, J. W. (2017) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13284 · Cited by 7 · see citing works
Takeuchi, H., Tomita, H., Taki, Y., Kikuchi, Y., Ono, C., Yu, Z., Sekiguchi, A., Nouchi, R., Kotozaki, Y., Nakagawa, S., et al. (2019) · Brain Imaging and Behavior · doi:10.1007/s11682-018-0025-8 · Cited by 7 · see citing works
Khitrinskaia, I. I., Khar'kov, V. N., Voevoda, M. I., & Stepanova, V. A. (2014) · PubMed · Cited by 6 · see citing works
Голимбет, В. Е., Алфимова, М. В., Коровайцева, Г. И., & Лежейко, Т. В. (2014) · Molecular Biology · doi:10.1134/s0026893314010038 · Cited by 5 · see citing works
Malykhin, N. V., Travis, S. G., Fujiwara, E., Huang, Y., Camicioli, R. M., & Olsen, F. (2020) · Hippocampus · doi:10.1002/hipo.23217 · Cited by 4 · see citing works
The Role of BDNF Gene Polymorphism in Formation of Clinical Characteristics of Migraine
Климов, Е. А. (2016) · Journal of Neurology & Stroke · doi:10.15406/jnsk.2016.04.00123 · Cited by 3 · see citing works
Pence, B. D., Bhattacharya, T. K., Park, P., Rytych, J. L., Allen, J. M., Sun, Y., McCusker, R. H., Kelley, K. W., Johnson, R. W., Rhodes, J. S., et al. (2017) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2016-0530 · Cited by 3 · see citing works
GENETİK YAPININ SPORTİF PERFORMANSA ETKİSİ
Karaca, D. (2018) · R&S - Research Studies Anatolia Journal · doi:10.33723/rs.470847
Cheng, Y., Liu, Y., Wu, R., Xu, Y., Sun, M., Wang, F., Geng, X., & Wang, F. (2023) · The Journals of Gerontology Series A · doi:10.1093/gerona/glad267 · Cited by 2 · see citing works
Epigenetics of Brain/Cognitive Aging
Xu, X. Z. S. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-811060-7.00016-4
The role for DNA/RNA methylation on neurocognitive dysfunctions
Xu, X. Z. S. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-816843-1.00006-0
The Genetics of Cognitive Abilities
Papenberg, G., & Bäckman, L. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108552684.034
Pavlova, L. E., Тимина, М. Ф., Анзорович, А. А., & Panchenko, A. V. (2023) · Bulletin of Experimental Biology and Medicine · doi:10.1007/s10517-023-05873-4
- Authors
- Sanchez, M. M., Das, D., Taylor, J. L., Noda, A., Yesavage, J. A., & Salehi, A.
- Affiliations
- VA Palo Alto Health Care System (US)
- Corresponding author
- Salehi, A
- Venue
- Translational Psychiatry
- Published
- 2011-10-25
- Volume
- 1
- Issue
- 10
- Pages
- e51-e51
- ISSN
- 2158-3188 (ISSN-L)
- PMC
- PMC3309489
- OpenAlex
- W2155400471
- Cited by
- 45
- References
- 73
- Citations by year
- 2024: 1 · 2023: 5 · 2020: 4 · 2019: 2 · 2018: 7 · 2017: 8 · 2016: 4 · 2015: 3 · 2014: 7 · 2013: 2 · 2012: 2
- FWCI
- 1.46
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc-nd
- www.springer.com/tdm (unspecified)
- Locations
- Translational Psychiatry (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Veterans Affairs
- McMaster University
- War Related Illness and Injury Study Center
- National Institute on Aging (AG-17824, R01AG021632, P30AG017824, R37 AG12713, R37AG012713, P30 AG17824)
- National Center for Research Resources (P41RR023953)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- brain-derived neurotrophic factor, BDNF Val66Met polymorphism, hippocampal volume, cognitive decline, aging, pilots, healthy older adults
- MeSH terms
- Workforce, Adult, Aerospace Medicine, Aged, Cross-Sectional Studies, Female, Hippocampus, Humans, Longitudinal Studies, Male, Middle Aged, Motor Skills, Polymorphism, Genetic, Predictive Value of Tests, Psychomotor Performance, United States, Brain-Derived Neurotrophic Factor, Amino Acid Substitution
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
