Dendritic arbor development and synaptogenesis
Abstract
In vivo studies indicate that synaptic activity promotes dendritic arbor elaboration at early stages of brain development. At later stages of development, synaptic activity stabilizes dendritic structure. The different roles of synaptic activity with respect to structural plasticity probably reflect the regulated spatiotemporal expression of key components within signaling pathways.
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Dendritic development is regulated by a combination of intrinsic programs and extrinsic factors.
“Dendritic development is regulated by a combination of intrinsic programs and extrinsic factors78.”
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- Authors
- Cline, H. T.
- Affiliations
- Cold Spring Harbor Laboratory (US)
- Corresponding author
- Cline, Hollis T
- ORCID
- Cline, Hollis T
- Venue
- Current Opinion in Neurobiology
- Publisher
- Elsevier BV
- Published
- 2001-02
- Volume
- 11
- Issue
- 1
- Pages
- 118-126
- ISSN
- 0959-4388 (ISSN-L)
- OpenAlex
- W2065958702
- Semantic Scholar
- 25da4cebd6ff01d6bed9db0c0f8e8329ba573e80
- Cited by
- 499
- References
- 58
- Citations by year
- 2026: 6 · 2025: 6 · 2024: 9 · 2023: 15 · 2022: 6 · 2021: 5 · 2020: 14 · 2019: 11 · 2018: 15 · 2017: 11 · 2016: 21 · 2015: 18 · 2014: 28 · 2013: 17 · 2012: 21
- FWCI
- 2.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Neurobiology (publishedVersion)
- PubMed (publishedVersion)
- Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) (acceptedVersion)
- Funders
- Cold Spring Harbor Laboratory
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- dendritic arbor development, synaptogenesis, synaptic activity, structural plasticity, brain development, signaling pathways, spatiotemporal gene expression
- MeSH terms
- Animals, Brain, Brain Chemistry, Dendrites, Humans, Nervous System, Synapses, GTP Phosphohydrolases
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