The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Role of AMP‐activated protein kinase in the metabolic syndrome and in heart disease
Abstract
Obesity, type 2 diabetes and the metabolic syndrome are disorders of energy balance, which the AMP‐activated protein kinase (AMPK) regulates both at the cellular and whole body levels. AMPK switches cells from an anabolic state where nutrients are taken up and stored, to a catabolic state where they are oxidized. Drugs that activate AMPK indirectly (metformin and thiazolidinediones) are now the mainstay of treatment for type 2 diabetes, but more direct AMPK activators may have fewer side effects. However, activating mutations in AMPK can cause heart disease, and it will be important to look for adverse effects in the heart.
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Cites
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Cited by
MTOR: a pharmacologic target for autophagy regulation
Kim, Y. C., & Guan, K.-L. (2015) · Journal of Clinical Investigation · doi:10.1172/jci73939 · Cited by 2,126
Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner
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Trends in the exploitation of novel drug targets
Rask-Andersen, M., Almén, M. S., & Schiöth, H. B. (2011) · Nature Reviews Drug Discovery · doi:10.1038/nrd3478 · Cited by 853
Molecular Mechanisms of the Anti-Obesity and Anti-Diabetic Properties of Flavonoids
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AMPK and the biochemistry of exercise: implications for human health and disease
Richter, E. A., & Ruderman, N. B. (2009) · Biochemical Journal · doi:10.1042/bj20082055 · Cited by 481
Metadata
- Authors
- Hardie, D. G.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2007-11-20
- Volume
- 582
- Issue
- 1
- Pages
- 81-89
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2127632261
- Cited by
- 217
- References
- 26
- FWCI
- 7.42
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
