Trends in the exploitation of novel drug targets

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Molecular Connections between Cancer Cell Metabolism and the Tumor Microenvironment

Justus, C., Sanderlin, E. J., & Yang, L. V. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms160511055 · Cited by 136 · see citing works

Learning from the past and looking to the future: emerging perspectives for improving the treatment of psychiatric disorders

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Pharmacological treatment of migraine: Drug classes, mechanisms of action, clinical trials and new treatments

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G-Protein-Coupled Receptor Signaling in CiliaPreprint

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Therapeutic target database update 2014: a resource for targeted therapeutics

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What Can Crystal Structures of Aminergic Receptors Tell Us about Designing Subtype-Selective Ligands?

Michino, M., Beuming, T., Donthamsetti, P., Newman, A. H., Javitch, J. A., & Shi, L. (2014) · Pharmacological Reviews · doi:10.1124/pr.114.009944 · Cited by 118 · see citing works

Chemosensing Ensembles for Monitoring Biomembrane Transport in Real Time

Ghale, G., Lanctôt, A. G., Kreissl, H. T., Jacob, M. H., Weingart, H., Winterhalter, M., & Nau, W. M. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201309583 · Cited by 116 · see citing works

Drug Target Protein-Protein Interaction Networks: A Systematic Perspective

Feng, Y., Wang, Q., & Wang, T. (2017) · BioMed Research International · doi:10.1155/2017/1289259 · Cited by 116 · see citing works

Dynamic tuneable G protein-coupled receptor monomer-dimer populations

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What makes a good drug target?

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Labeling and Single-Molecule Methods To Monitor G Protein-Coupled Receptor Dynamics

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Application of omics- and multi-omics-based techniques for natural product target discovery

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Treatment of ADHD: Drugs, psychological therapies, devices, complementary and alternative methods as well as the trends in clinical trials

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Ligand-Dependent Activation and Deactivation of the Human Adenosine A2AReceptor

Li, J., Jonsson, A. L., Beuming, T., Shelley, J. C., & Voth, G. A. (2013) · Journal of the American Chemical Society · doi:10.1021/ja404391q · Cited by 110 · see citing works

Target identification of natural products and bioactive compounds using affinity-based probes

Pan, S., Zhang, H., Wang, C., Yao, S. C. L., & Yao, S. Q. (2015) · Natural Product Reports · doi:10.1039/c5np00101c · Cited by 110 · see citing works

Marine natural products with anti-inflammatory activity

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Soluble ligands as drug targets

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PyDPI: Freely Available Python Package for Chemoinformatics, Bioinformatics, and Chemogenomics Studies

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Modular detergents tailor the purification and structural analysis of membrane proteins including G-protein coupled receptors

Urner, L. H., Liko, I., Yen, H.-Y., Hoi, K.-K., Bolla, J. R., Gault, J., Almeida, F. G., Schweder, M.-P., Shutin, D., Ehrmann, S., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-14424-8 · Cited by 107 · see citing works

Medium-chain fatty acids modulate myocardial function via a cardiac odorant receptor

Jovancevic, N., Dendorfer, A., Matzkies, M., Kovarova, M., Heckmann, J. C., Osterloh, M., Boehm, M., Weber, L., Nguemo, F., Semmler, J., et al. (2017) · Basic Research in Cardiology · doi:10.1007/s00395-017-0600-y · Cited by 106 · see citing works

Diindolylmethane Derivatives: Potent Agonists of the Immunostimulatory Orphan G Protein-Coupled Receptor GPR84

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Ligand Binding Ensembles Determine Graded Agonist Efficacies at a G Protein-coupled Receptor

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In this issue

(2011) · Nature Reviews Drug Discovery · doi:10.1038/nrd3513

The Druggable Genome: Evaluation of Drug Targets in Clinical Trials Suggests Major Shifts in Molecular Class and Indication

Rask-Andersen, M., Masuram, S., & Schiöth, H. B. (2014) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-011613-135943 · Cited by 282 · see citing works

The evolving landscape of drug targets

Halip, L., Avram, S. I., Overington, J. P., Al‐Lazikani, B., Curpan, R. F., Sirimulla, S., Pushechnikov, A. O., Beccari, A. R., Savchuk, N., & Oprea, T. I. (2026) · Nature Reviews Drug Discovery · doi:10.1038/s41573-026-01530-3

Network Analysis of Drug–target Interactions: A Study on FDA-approved New Molecular Entities Between 2000 to 2015

Lin, H.-H., Zhang, L., Yan, R., Lu, J., & Yuanjia, H. (2017) · Scientific Reports · doi:10.1038/s41598-017-12061-8 · Cited by 45 · see citing works

Network analysis of FDA approved drugs and their targets

Ma’ayan, A., Jenkins, S. L., Goldfarb, J., & Iyengar, R. (2007) · Mount Sinai Journal of Medicine A Journal of Translational and Personalized Medicine · doi:10.1002/msj.20002 · Cited by 115 · see citing works