Cited by 42Evolution and Genetic DynamicsCell death mechanisms and regulationGenetic and phenotypic traits in livestock

Positive selection on apoptosis related genes

da Fonseca, Rute R., Kosiol, Carolin, Vinař, Tomáš, Siepel, Adam, Nielsen, Rasmus·2010·FEBS Letters

Abstract

Apoptosis is a form of programmed cell death crucial for development, homeostasis, immunity, spermatogenesis, and prevention of cancer. Positive selection acting on mammalian apoptosis related genes targets protein interfaces that interact with pathogens and also elements of signaling complexes. Selection appears primarily to be driven by the immune/defense related function of these genes. Moreover, competitive interactions could be driving positive selection among sperm cells, as well as the need for protection against female anti‐sperm immune responses. Trade‐offs in fitness are expected out of these selective pressures, which could explain the involvement of these genes in various diseases, including cancer.

Integrity signals

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Crossref · 10.1016/j.febslet.2009.12.022

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75 of 75 references verified0 citation errors · 0 not checkable

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Authors
da Fonseca, R. R., Kosiol, C., Vinař, T., Siepel, A., & Nielsen, R.
Venue
FEBS Letters
Publisher
Wiley
Published
2009-12-22
Volume
584
Issue
3
Pages
469-476
ISSN
  • 0014-5793 (ISSN-L)
  • 1873-3468
OpenAlex
W2148301706
Cited by
42
References
75
Citations by year
2026: 1 · 2025: 1 · 2024: 1 · 2023: 3 · 2022: 1 · 2021: 1 · 2020: 3 · 2019: 2 · 2018: 3 · 2017: 2 · 2016: 2 · 2015: 3 · 2014: 6 · 2013: 4 · 2012: 3
FWCI
0.28
Type
journal article
Language
en
Open access
closed
Locations
  • FEBS Letters (publishedVersion)
  • PubMed (publishedVersion)
  • Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) (acceptedVersion)
  • Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
Funders
EMBO
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and phenotypic traits in livestock
Keywords
positive selection, apoptosis, programmed cell death, immune-related genes, protein interfaces, pathogen interactions, signaling complexes, sperm competition, fitness trade-offs, cancer, mammalian evolution
MeSH terms
Animals, Female, Humans, Male, Models, Biological, Proteins, Selection, Genetic, Signal Transduction, Apoptosis, Evolution, Molecular

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