Positive selection on apoptosis related genes
Abstract
Apoptosis is a form of programmed cell death crucial for development, homeostasis, immunity, spermatogenesis, and prevention of cancer. Positive selection acting on mammalian apoptosis related genes targets protein interfaces that interact with pathogens and also elements of signaling complexes. Selection appears primarily to be driven by the immune/defense related function of these genes. Moreover, competitive interactions could be driving positive selection among sperm cells, as well as the need for protection against female anti‐sperm immune responses. Trade‐offs in fitness are expected out of these selective pressures, which could explain the involvement of these genes in various diseases, including cancer.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Genes involved in cancer and apoptosis, including BRCA1 and BRCA2, are common targets of positive selection.
“Previous works reported that genes involved in cancer and apoptosis, including BRCA1 and BRCA2, are common targets of positive selection66, 67.”
From Distinct selective forces and Neanderthal introgression shaped genetic diversity at genes involved in neurodevelopmental disorders (2017) · cites this paper as [67]
Cites
Gene Ontology: tool for the unification of biology
Ashburner, M., Ball, C. A., Blake, J. A., Botstein, D., Butler, H., Cherry, J. M., Davis, A. P., Dolinski, K., Dwight, S. S., Eppig, J. T., et al. (2000) · Nature Genetics · doi:10.1038/75556 · Cited by 43,206 · see citing works
PAML 4: Phylogenetic Analysis by Maximum Likelihood
Yang, Z. (2007) · Molecular Biology and Evolution · doi:10.1093/molbev/msm088 · Cited by 13,879 · see citing works
Comparative Protein Modelling by Satisfaction of Spatial Restraints
Šali, A., & Blundell, T. L. (1993) · Journal of Molecular Biology · doi:10.1006/jmbi.1993.1626 · Cited by 12,977 · see citing works
Inhibition of death receptor signals by cellular FLIP
Irmler, M., Thome, M., Hahne, M., Schneider, P., Hofmann, K., Steiner, V., Bodmer, J.-L., Schröter, M., Burns, K., Mattmann, C., et al. (1997) · Nature · doi:10.1038/40657 · Cited by 2,548 · see citing works
ROLE OF CYTOKINES IN RHEUMATOID ARTHRITIS
Feldmann, M., Brennan, F. M., & Maini, R. N. (1996) · Annual Review of Immunology · doi:10.1146/annurev.immunol.14.1.397 · Cited by 2,486 · see citing works
IgE, mast cells, basophils, and eosinophils
Stone, K. D., Prussin, C., & Metcalfe, D. D. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.11.017 · Cited by 1,702 · see citing works
Molecular Signatures of Natural Selection
Nielsen, R. (2005) · Annual Review of Genetics · doi:10.1146/annurev.genet.39.073003.112420 · Cited by 1,660 · see citing works
Self-citationViruses and interferon: a fight for supremacy
Katze, M. G., He, Y., & Gale, M. (2002) · Nature Reviews Immunology · doi:10.1038/nri888 · Cited by 1,419 · see citing works
Mutations in Fas associated with human lymphoproliferative syndrome and autoimmunity.
Rieux-Laucat, F., Deist, F. L., Hivroz, C., Roberts, I., Debatin, K., Fischer, A., & de Villartay, J. (1995) · Science · doi:10.1126/science.7539157 · Cited by 1,405 · see citing works
Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors
Thome, M., Schneider, P., Hofmann, K., Fickenscher, H., Meinl, E., Neipel, F., Mattmann, C., Burns, K., Bodmer, J.-L., Schröter, M., et al. (1997) · Nature · doi:10.1038/386517a0 · Cited by 1,316 · see citing works
Lymphocyte-Mediated Cytotoxicity
Russell, J. H., & Ley, T. J. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.100201.131730 · Cited by 1,122 · see citing works
A Scan for Positively Selected Genes in the Genomes of Humans and Chimpanzees
Nielsen, R., Bustamante, C. D., Clark, A. G., Glanowski, S., Sackton, T. B., Hubisz, M. J., Fledel-Alon, A., Tanenbaum, D. M., Civello, D., White, T. J., et al. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030170 · Cited by 998 · see citing works
Self-citationIKK/NF- B signaling: balancing life and death - a new approach to cancer therapy
Luo, J. (2005) · Journal of Clinical Investigation · doi:10.1172/jci26322 · Cited by 879 · see citing works
Viral Subversion of the Immune System
Tortorella, D., Gewurz, B. E., Furman, M. H., Schust, D. J., & Ploegh, H. L. (2000) · Annual Review of Immunology · doi:10.1146/annurev.immunol.18.1.861 · Cited by 828 · see citing works
The tumour microenvironment as a target for chemoprevention
Albini, A., & Sporn, M. B. (2007) · Nature reviews. Cancer · doi:10.1038/nrc2067 · Cited by 823 · see citing works
Positive Darwinian selection after gene duplication in primate ribonuclease genes
Zhang, J., Rosenberg, H. F., & Nei, M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.7.3708 · Cited by 736 · see citing works
Takahata, N., & Nei, M. (1990) · Genetics · doi:10.1093/genetics/124.4.967 · Cited by 680 · see citing works
Thomas, P. D. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkg115 · Cited by 660 · see citing works
Fas Preassociation Required for Apoptosis Signaling and Dominant Inhibition by Pathogenic Mutations
Siegel, R. M., Frederiksen, J. K., Zacharias, D. A., Chan, F. K.-M., Johnson, M. M., Lynch, D. H., Tsien, R. Y., & Lenardo, M. J. (2000) · Science · doi:10.1126/science.288.5475.2354 · Cited by 659 · see citing works
The P53 pathway: what questions remain to be explored?
Levine, A. J., Hu, W., & Feng, Z. (2006) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401910 · Cited by 654 · see citing works
Rodríguez, I., Ody, C., Araki, K., Garcia, I., & VASSALLI, P. (1997) · The EMBO Journal · doi:10.1093/emboj/16.9.2262 · Cited by 601 · see citing works
Patterns of Positive Selection in Six Mammalian Genomes
Kosiol, C., Vinař, T., da Fonseca, R. R., Hubisz, M. J., Bustamante, C. D., Nielsen, R., & Siepel, A. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000144 · Cited by 576 · see citing works
Self-citationThe role of the mast cell in the pathophysiology of asthma
Bradding, P., Walls, A. F., & Holgate, S. T. (2006) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2006.02.039 · Cited by 573 · see citing works
The Death Domain Superfamily in Intracellular Signaling of Apoptosis and Inflammation
Park, H. H., Lo, Y.-C., Lin, S., Wang, L., Yang, J. K., & Wu, H. (2007) · Annual Review of Immunology · doi:10.1146/annurev.immunol.25.022106.141656 · Cited by 523 · see citing works
Taniguchi, T., & Takaoka, A. (2002) · Current Opinion in Immunology · doi:10.1016/s0952-7915(01)00305-3 · Cited by 476 · see citing works
Mast cell tryptases and chymases in inflammation and host defense.
Caughey, G. H. (2007) · Immunological Reviews · doi:10.1111/j.1600-065x.2007.00509.x · Cited by 442 · see citing works
Bertin, J., Armstrong, R. C., Ottilie, S., Martin, D. A., Wang, Y., Banks, S., Wang, G.-H., Senkevich, T. G., Alnemri, E. S., Moss, B., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.4.1172 · Cited by 435 · see citing works
Tumstatin, an Endothelial Cell-Specific Inhibitor of Protein Synthesis
Maeshima, Y., Sudhakar, A., Lively, J. C., Ueki, K., Kharbanda, S. M., Kahn, C. R., Sonenberg, N., Hynes, R. O., & Kalluri, R. (2002) · Science · doi:10.1126/science.1065298 · Cited by 434 · see citing works
Origin and evolution of eukaryotic apoptosis: the bacterial connection
Koonin, E. V., & Aravind, L. (2002) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4400991 · Cited by 431 · see citing works
The Fas–FADD death domain complex structure unravels signalling by receptor clustering
Scott, F. L., Stec, B., Pop, C., Dobaczewska, M. K., Lee, J. J., Monosov, E., Robinson, H., Salvesen, G. S., Schwarzenbacher, R., & Riedl, S. J. (2009) · Nature · doi:10.1038/nature07606 · Cited by 384 · see citing works
Byth, K. F., Conroy, L. A., Howlett, S., Smith, A. J., May, J., Alexander, D. R., & Holmes, N. J. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.183.4.1707 · Cited by 373 · see citing works
Mammalian Housekeeping Genes Evolve More Slowly than Tissue-Specific Genes
Zhang, L., & Li, W. (2004) · Molecular Biology and Evolution · doi:10.1093/molbev/msh010 · Cited by 354 · see citing works
Perspectives on mammalian cell death
Schwartz, L. M. (1988) · Cell · doi:10.1016/0092-8674(88)90084-0 · Cited by 339 · see citing works
Fine Tuning of TCR Signaling by CD5
Azzam, H. S., Dejarnette, J. B., Huang, K. L., Emmons, R. P., Park, C., Sommers, C. L., El‐Khoury, D., Shores, E. W., & Love, P. E. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.9.5464 · Cited by 279 · see citing works
4. IgE, mast cells, basophils, and eosinophils
Prussin, C., & Metcalfe, D. D. (2003) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2003.120 · Cited by 253 · see citing works
Signaling Life and Death in the Thymus: Timing Is Everything
Werlen, G., Hausmann, B., Naeher, D., & Palmer, E. (2003) · Science · doi:10.1126/science.1067833 · Cited by 251 · see citing works
A worm's eye view of the immune system: consequences for evolution of human autoimmune disease
Dunne, D. W., & Cooke, A. (2005) · Nature reviews. Immunology · doi:10.1038/nri1601 · Cited by 245 · see citing works
Autoimmune lymphoproliferative syndromes: genetic defects of apoptosis pathways
Rieux‐Laucat, F., Deist, F. L., & Fischer, A. (2003) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401190 · Cited by 229 · see citing works
Inverse Interference: How Viruses Fight the Interferon System
Weber, F., Kochs, G., & Haller, O. (2004) · Viral Immunology · doi:10.1089/vim.2004.17.498 · Cited by 212 · see citing works
Modulation of Tumor Necrosis Factor by Microbial Pathogens
Rahman, M. M., & McFadden, G. (2006) · PLoS Pathogens · doi:10.1371/journal.ppat.0020004 · Cited by 209 · see citing works
The interplay between the Bcl-2 family and death receptor-mediated apoptosis
Sprick, M. R., & Walczak, H. (2003) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2003.11.002 · Cited by 206 · see citing works
The major human and mouse granzymes are structurally and functionally divergent
Kaiserman, D., Bird, C. H., Sun, J., Matthews, A. Y., Ung, K. S., Whisstock, J. C., Thompson, P. E., Trapani, J. A., & Bird, P. I. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200606073 · Cited by 197 · see citing works
Kjer‐Nielsen, L., Dunstone, M. A., Kostenko, L., Ely, L. K., Beddoe, T., Mifsud, N. A., Purcell, A. W., Brööks, A. G., McCluskey, J., & Rossjohn, J. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402295101 · Cited by 182 · see citing works
Perspectives on mammalian cell death.
Potten, C. S. (1987) · Oxford University Press eBooks · Cited by 180 · see citing works
Fas regulates germ cell apoptosis in the human testis in vitro
Pentikäinen, V., Erkkilä, K., & Dunkel, L. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.276.2.e310 · Cited by 174 · see citing works
Allan, D. (1987) · Medical Entomology and Zoology · Cited by 170 · see citing works
Viral Subversion of Apoptotic Enzymes: Escape from Death Row
Best, S. M. (2008) · Annual Review of Microbiology · doi:10.1146/annurev.micro.62.081307.163009 · Cited by 168 · see citing works
Crystal structure of a human CD3-ε/δ dimer in complex with a UCHT1 single-chain antibody fragment
Arnett, K. L., Harrison, S. C., & Wiley, D. C. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407359101 · Cited by 153 · see citing works
Duplication and selection in the evolution of primate β-defensin genes
Semple, C. A. M., Rolfe, M., & Dorin, J. R. (2003) · Genome biology · doi:10.1186/gb-2003-4-5-r31 · Cited by 149 · see citing works
Testicular FasL is expressed by sperm cells
D’Alessio, A., Anna Riccioli, A., Lauretti, P., Padula, F., Muciaccia, B., Cesaris, P. D., Filippini, A., Nagata, S., & Elio Ziparo, A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.051566098 · Cited by 143 · see citing works
Schneider, A., Souvorov, A. E., Sabath, N., Landan, G., Gonnet, G. H., & Graur, D. (2009) · Genome Biology and Evolution · doi:10.1093/gbe/evp012 · Cited by 138 · see citing works
Apoptosis and the homeostatic control of immune responses
Hildeman, D. A., Jørgensen, T. N., Kappler, J. W., & Marrack, P. (2007) · Current Opinion in Immunology · doi:10.1016/j.coi.2007.05.005 · Cited by 129 · see citing works
Dying for NF-κB? Control of cell death by transcriptional regulation of the apoptotic machinery
Burstein, E., & Duckett, C. S. (2003) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2003.10.005 · Cited by 126 · see citing works
A matter of death and life: the significance of germ cell death during spermatogenesis
BLANCO‐RODRÍGUEZ (1998) · International Journal of Andrology · doi:10.1046/j.1365-2605.1998.00133.x · Cited by 116 · see citing works
Delineation of the cell-extrinsic apoptosis pathway in the zebrafish
Eimon, P. M., Kratz, E., Varfolomeev, E. E., Hymowitz, S. G., Stern, H. M., Zha, J., & Ashkenazi, A. (2006) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4402015 · Cited by 115 · see citing works
Specific requirement for CD3ɛ in T cell development
Dejarnette, J. B., Sommers, C. L., Huang, K. L., Woodside, K. J., Emmons, R. P., Katz, K., Shores, E. W., & Love, P. E. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.25.14909 · Cited by 114 · see citing works
White, S. N., Taylor, K. H., Abbey, C. A., Gill, C. A., & Womack, J. E. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1333957100 · Cited by 107 · see citing works
Epstein-Barr Virus BALF1 Is a BCL-2-Like Antagonist of the Herpesvirus Antiapoptotic BCL-2 Proteins
Bellows, D. S., Howell, M., Pearson, C. K., Hazlewood, S. A., & Hardwick, J. M. (2002) · Journal of Virology · doi:10.1128/jvi.76.5.2469-2479.2002 · Cited by 102 · see citing works
Zhu, N., Ware, C. F., & Lai, M. M. C. (2001) · Virology · doi:10.1006/viro.2001.0896 · Cited by 98 · see citing works
Epithelial membrane protein-1 is a biomarker of gefitinib resistance
Jain, A., Tindell, C., Laux, I., Hunter, J. B., Curran, J. A., Galkin, A., Afar, D., Aronson, N., Shak, S., Natale, R. B., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502113102 · Cited by 87 · see citing works
Ryan, A. E., Shanahan, F., O’Connell, J., & Houston, A. M. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-1462 · Cited by 86 · see citing works
Evidence of Positively Selected Sites in Mammalian α-Defensins
Lynn, D. J., Lloyd, A. T., Fares, M. A., & O’Farrelly, C. (2004) · Molecular Biology and Evolution · doi:10.1093/molbev/msh084 · Cited by 75 · see citing works
(2003) · Nucleic Acids Research · doi:10.1093/nar/gkg290 · Cited by 74 · see citing works
Hesslein, D. G. T., Takaki, R., Hermiston, M. L., Weiss, A., & Lanier, L. L. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601851103 · Cited by 68 · see citing works
Francavilla, S. (2002) · Molecular Human Reproduction · doi:10.1093/molehr/8.3.213 · Cited by 67 · see citing works
Fas Ligand as a Tool for Immunosuppression and Generation of Immune Tolerance
Bohana‐Kashtan, O., & Civin, C. I. (2004) · Stem Cells · doi:10.1634/stemcells.22-6-908 · Cited by 54 · see citing works
Tan, Y., Lim, S. G., & Hong, W. (2007) · Cellular Microbiology · doi:10.1111/j.1462-5822.2007.01034.x · Cited by 40 · see citing works
FLIP is expressed in mouse testis and protects germ cells from apoptosis
Giampietri, C., Petrungaro, S., Coluccia, P., D’Alessio, A., Starace, D., Anna Riccioli, A., Padula, F., Srinivasula, S. M., Alnemri, E. S., Palombi, F., et al. (2003) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401137 · Cited by 37 · see citing works
Blanco‐Rodríguez, J., Martinez-Garcia, C., & Porrás, A. (2003) · Reproduction · doi:10.1530/rep.0.1260661 · Cited by 25 · see citing works
Touma, M., Sun, Z., Clayton, L. K., Marissen, W. E., Kruisbeek, A. M., Wagner, G., & Reinherz, E. L. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.6.3668 · Cited by 21 · see citing works
Starling, G. C., Kiener, P. A., Aruffo, A. A., & Bajorath, J. (1998) · Biochemistry · doi:10.1021/bi972959d · Cited by 21 · see citing works
A primate-specific acceleration in the evolution of the caspase-dependent apoptosis pathway
Vallender, E. J., & Lahn, B. T. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl245 · Cited by 21 · see citing works
Dodging the CTL response: viral evasion of Fas and granzyme induced apoptosis
Keckler, M. S. (2006) · Frontiers in bioscience · doi:10.2741/2096 · Cited by 19 · see citing works
c‐FlipLis expressed in undifferentiated mouse male germ cells
Giampietri, C., Petrungaro, S., Coluccia, P., Antonangeli, F., Paone, A., Padula, F., Cesaris, P. D., Elio Ziparo, A., & Filippini, A. (2006) · FEBS Letters · doi:10.1016/j.febslet.2006.10.010 · Cited by 12 · see citing works
An internet database on genetics in oncology
Huret, J., Dessen, P., & Bernheim, A. (2003) · Oncogene · doi:10.1038/sj.onc.1206225 · Cited by 9 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Ferroptosis, a new form of cell death, and its relationships with tumourous diseases
Yu, H., Guo, P., Xie, X., Wang, Y., & Chen, G. (2016) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13008 · Cited by 712 · see citing works
Targeting ferroptosis in breast cancer
Li, Z., Chen, L., Chen, C., Zhou, Y., Hu, D., Yang, J., Chen, Y., Zhuo, W., Mao, M., Zhang, X., et al. (2020) · Biomarker Research · doi:10.1186/s40364-020-00230-3 · Cited by 204 · see citing works
A Model-Based Approach for Identifying Signatures of Ancient Balancing Selection in Genetic Data
DeGiorgio, M., Lohmueller, K. E., & Nielsen, R. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004561 · Cited by 187 · see citing works
Self-citationHuang, J. Y., & Bargh, J. A. (2014) · Behavioral and Brain Sciences · doi:10.1017/s0140525x13000290 · Cited by 157 · see citing works
Zhang, L., Li, L., & Zhang, G. (2011) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2011.01.005 · Cited by 111 · see citing works
From molecules to mating: Rapid evolution and biochemical studies of reproductive proteins
Wilburn, D. B., & Swanson, W. J. (2015) · Journal of Proteomics · doi:10.1016/j.jprot.2015.06.007 · Cited by 110 · see citing works
Functional Comparison of Innate Immune Signaling Pathways in Primates
Barreiro, L. B., Marioni, J. C., Blekhman, R., Stephens, M., & Gilad, Y. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1001249 · Cited by 103 · see citing works
da Fonseca, R. R., Johnson, W. E., O’Brien, S. J., Vasconcelos, V. M., & Antunes, A. (2010) · BMC Evolutionary Biology · doi:10.1186/1471-2148-10-281 · Cited by 77 · see citing works
Atrazine-induced apoptosis of splenocytes in BALB/C mice
Zhang, X., Wang, M., Gao, S., Ren, R., Zheng, J., & Zhang, Y. (2011) · BMC Medicine · doi:10.1186/1741-7015-9-117 · Cited by 76 · see citing works
Thumma, B. R., Sharma, N. K., & Southerton, S. G. (2012) · BMC Genomics · doi:10.1186/1471-2164-13-364 · Cited by 70 · see citing works
Long-Read Sequencing Reveals Rapid Evolution of Immunity- and Cancer-Related Genes in Bats
Scheben, A., Ramos, O. M., Kramer, M., Goodwin, S., Oppenheim, S. J., Becker, D. J., Schatz, M. C., Simmons, N. B., Siepel, A. C., & McCombie, W. R. (2023) · Genome Biology and Evolution · doi:10.1093/gbe/evad148 · Cited by 63 · see citing works
Self-citationApoptosis detection: a purpose-dependent approach selection
Guo, M., Lu, B., Gan, J., Wang, S., Jiang, X., & Li, H. (2021) · Cell Cycle · doi:10.1080/15384101.2021.1919830 · Cited by 56 · see citing works
Selective Pressures on Human Cancer Genes along the Evolution of Mammals
Vicens, A., & Posada, D. (2018) · Genes · doi:10.3390/genes9120582 · Cited by 43 · see citing works
Host-specific sensing of coronaviruses and picornaviruses by the CARD8 inflammasome
Tsu, B. V., Agarwal, R., Gokhale, N. S., Kulsuptrakul, J., Ryan, A. P., Fay, E. J., Castro, L. K., Beierschmitt, C., Yap, C., Turcotte, E. A., et al. (2023) · PLoS Biology · doi:10.1371/journal.pbio.3002144 · Cited by 42 · see citing works
Leiva, C., Taboada, S., Kenny, N. J., Combosch, D. J., Giribet, G., Jombart, T., & Riesgo, A. (2019) · Molecular Ecology · doi:10.1111/mec.15135 · Cited by 38 · see citing works
Nguyen, T. H. P., Mahalakshmi, B., & Velmurugan, B. K. (2019) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2019.108930 · Cited by 37 · see citing works
Pinhu, L., Qin, Y., Xiong, B., You, Y., Li, J., & Sooranna, S. R. (2014) · Inflammation · doi:10.1007/s10753-014-9847-8 · Cited by 32 · see citing works
Montoya‐Burgos, J. I. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024800 · Cited by 31 · see citing works
Mandal, A. K., Pandey, R., Jha, V., & Mukerji, M. (2013) · Nucleic Acids Research · doi:10.1093/nar/gks1457 · Cited by 32 · see citing works
Vatsiou, A. I., Bazin, É., & Gaggiotti, O. E. (2016) · BMC Genomics · doi:10.1186/s12864-016-2783-2 · Cited by 28 · see citing works
O’Connell, M. J. (2010) · Journal of Molecular Evolution · doi:10.1007/s00239-010-9399-y · Cited by 25 · see citing works
Thavamanikumar, S., Southerton, S. G., & Thumma, B. R. (2014) · PLoS ONE · doi:10.1371/journal.pone.0101104 · Cited by 24 · see citing works
A refined model of the genomic basis for phenotypic variation in vertebrate hemostasis
Ribeiro, Â. M., Mendoza, M. L. Z., Bertelsen, M. F., Kristensen, A. T., Jarvis, E. D., Gilbert, M. T. P., & da Fonseca, R. R. (2015) · BMC Evolutionary Biology · doi:10.1186/s12862-015-0409-y · Cited by 22 · see citing works
Mozzi, A., Forni, D., Cagliani, R., Pozzoli, U., Clerici, M., & Sironi, M. (2017) · Scientific Reports · doi:10.1038/s41598-017-06440-4 · Cited by 19 · see citing works
Applied & translational genomics
ScienceDirect (2012) · Cited by 20 · see citing works
Disease consequences of human adaptation
Fay, J. C. (2013) · Applied & Translational Genomics · doi:10.1016/j.atg.2013.08.001 · Cited by 18 · see citing works
Wilburn, D. B., Tuttle, L. M., Klevit, R. E., & Swanson, W. J. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1709061115 · Cited by 18 · see citing works
Ezawa, K., & Innan, H. (2013) · Genetics · doi:10.1534/genetics.113.152066 · Cited by 15 · see citing works
Shilpa, M., Selvaraju, S., GirishKumar, V., Parthipan, S., Binsila, K. B., Arangasamy, A., & Ravindra, J. P. (2017) · Reproduction Fertility and Development · doi:10.1071/rd16290 · Cited by 15 · see citing works
Adaptive Evolution and Divergence of SERPINB3: A Young Duplicate in Great Apes
Gomes, S. C. V., Marques, P., Matthiesen, R., & Seixas, S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0104935 · Cited by 13 · see citing works
Darwish, A. M., Khattab, A. E.-N. A., El‐Razik, K. A. A., Othman, S. I., Allam, A. A., & Abu-Taweel, G. M. (2022) · Inflammopharmacology · doi:10.1007/s10787-022-01064-1 · Cited by 7 · see citing works
Genetic correlates of the evolving primate brain
Vallender, E. J. (2012) · Progress in brain research · doi:10.1016/b978-0-444-53860-4.00002-7 · Cited by 6 · see citing works
Shulkina, A., Hacker, K., Ehrmann, J. F., Budroni, V., Mandlbauer, A., Bock, J., Grabarczyk, D. B., Edobor, G., Cochella, L., Clausen, T., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-59129-y · Cited by 4 · see citing works
Comparative Oncology: Evolutionary Perspectives, Emerging Discoveries, and Analytical Advances
Fard, V. N., & Tollis, M. (2026) · Annual Review of Biomedical Data Science · doi:10.1146/annurev-biodatasci-092724-030138 · Cited by 2 · see citing works
The Human SERPIN Repertoire and the Evolution of 14q32.1 and 18q21.3 Gene Clusters
Seixas, S. (2015) · Springer eBooks · doi:10.1007/978-3-319-22711-5_1 · Cited by 2 · see citing works
Scheben, A., Ramos, O. M., Kramer, M., Goodwin, S., Oppenheim, S. J., Becker, D. J., Schatz, M. C., Simmons, N. B., Siepel, A. C., & McCombie, W. R. (2020) · Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) · doi:10.1101/2020.09.09.290502 · Cited by 2 · see citing works
Self-citationShulkina, A., Hacker, K., Ehrmann, J. F., Budroni, V., Mandlbauer, A., Bock, J., Grabarczyk, D. B., Cochella, L., Clausen, T., & Versteeg, G. A. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.05.16.594269 · Cited by 2 · see citing works
Rethinking the design process, rethinking the curriculum
Corsi, M., & Rossi, P. G. (2018) · EDUCATION SCIENCES AND SOCIETY · doi:10.3280/ess2-2017oa5733 · Cited by 1 · see citing works
Huang, S., Girdner, J., Nguyen, L. P., Enard, D., & Li, M. M. H. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.11.20.567784 · Cited by 1 · see citing works
The validity of Dawkins's selfish gene theory and the role of the unconscious in decision making
Mattei, T. A. (2014) · Behavioral and Brain Sciences · doi:10.1017/s0140525x13002070
A model-based approach for identifying signatures of balancing selection in genetic dataPreprint
DeGiorgio, M., Lohmueller, K. E., & Nielsen, R. (2013) · arXiv (Cornell University) · doi:10.48550/arxiv.1307.4137
Self-citation
- Authors
- da Fonseca, R. R., Kosiol, C., Vinař, T., Siepel, A., & Nielsen, R.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2009-12-22
- Volume
- 584
- Issue
- 3
- Pages
- 469-476
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2148301706
- Cited by
- 42
- References
- 75
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 3 · 2022: 1 · 2021: 1 · 2020: 3 · 2019: 2 · 2018: 3 · 2017: 2 · 2016: 2 · 2015: 3 · 2014: 6 · 2013: 4 · 2012: 3
- FWCI
- 0.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- FEBS Letters (publishedVersion)
- PubMed (publishedVersion)
- Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) (acceptedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Funders
- EMBO
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and phenotypic traits in livestock
- Keywords
- positive selection, apoptosis, programmed cell death, immune-related genes, protein interfaces, pathogen interactions, signaling complexes, sperm competition, fitness trade-offs, cancer, mammalian evolution
- MeSH terms
- Animals, Female, Humans, Male, Models, Biological, Proteins, Selection, Genetic, Signal Transduction, Apoptosis, Evolution, Molecular
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review