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High glucose down‐regulates miR‐29a to increase collagen IV production in HK‐2 cells
Abstract
Deposition of collagen IV in proximal tubule cells (PTCs) plays an important role during diabetic nephropathy, but the mechanism underlying excessive production of collagen IV remains poorly understood. In this study, we examined the miRNA profile of HK‐2 cells and found that high glucose/TGF‐β1 induced significant down‐regulation of miR‐29a. We then showed that miR‐29a negatively regulated collagen IV by directly targeting the 3′UTRs of col4a1 and col4a2. These results suggest that miR‐29a acts as a repressor to fine‐tune collagen expression and that the reduction of miR‐29a caused by high glucose may increase the risk of excess collagen deposition in PTCs.
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Cites
The impact of microRNAs on protein output
Baek, D., Villén, J., Shin, C., Camargo, F. D., Gygi, S. P., & Bartel, D. P. (2008) · Nature · doi:10.1038/nature07242 · Cited by 3,592
Cited by
TGF-β/Smad signaling in renal fibrosis
Meng, X.-M., Tang, P. M.-K., Li, J., & Lan, H. Y. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00082 · Cited by 666
The miR-29 family: genomics, cell biology, and relevance to renal and cardiovascular injury
Kriegel, A. J., Liu, Y., Fang, Y., Ding, X., & Liang, M. (2012) · Physiological Genomics · doi:10.1152/physiolgenomics.00141.2011 · Cited by 533
Chen, L., Yang, T., Lu, D.-W., Zhao, H., Feng, Y.-L., Chen, H., Chen, D.-Q., Vaziri, N. D., & Zhao, Y.-Y. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.02.090 · Cited by 359
MicroRNAs in kidney physiology and disease
Trionfini, P., Benigni, A., & Remuzzi, G. (2015) · Nature Reviews Nephrology · doi:10.1038/nrneph.2014.202 · Cited by 353
Kuo, D. S., Labelle-Dumais, C., & Gould, D. B. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds346 · Cited by 320
Metadata
- Authors
- Du, B., Ma, L.-M., Huang, M.-B., Zhou, H., Huang, H.-L., Shao, P., Chen, Y.-Q., & Qu, L.-H.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2010-01-11
- Volume
- 584
- Issue
- 4
- Pages
- 811-816
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W1963767678
- Cited by
- 168
- References
- 1
- FWCI
- 11.04
- Type
- journal article
- Language
- en
- Open access
- closed
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- Du, B., Ma, L.-M., Huang, M.-B., Zhou, H., Huang, H.-L., Shao, P., Chen, Y.-Q., & Qu, L.-H. (2010). High glucose down‐regulates miR‐29a to increase collagen IV production in HK‐2 cells. FEBS Letters. https://doi.org/10.1016/j.febslet.2009.12.053
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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