The miR-29 family: genomics, cell biology, and relevance to renal and cardiovascular injury
Abstract
The human miR-29 family of microRNAs has three mature members, miR-29a, miR-29b, and miR-29c. miR-29s are encoded by two gene clusters. Binding sites for several transcriptional factors have been identified in the promoter regions of miR-29 genes. The miR-29 family members share a common seed region sequence and are predicted to target largely overlapping sets of genes. However, the miR-29 family members exhibit differential regulation in several cases and different subcellular distribution, suggesting their functional relevance may not be identical. miR-29s directly target at least 16 extracellular matrix genes, providing a dramatic example of a single microRNA targeting a large group of functionally related genes. Strong antifibrotic effects of miR-29s have been demonstrated in heart, kidney, and other organs. miR-29s have also been shown to be proapoptotic and involved in the regulation of cell differentiation. It remains to be explored how various cellular effects of miR-29s determine functional relevance of miR-29s to specific diseases and how the miR-29 family members may function cooperatively or separately.
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The gene encoding precursors of both miR-29b-1 and miR-29a is located on Chromosome 7, whereas the coding gene for both miR-29b-2 and miR-29c is on Chromosome 1.
“The gene encoding the precursors of both miR-29b-1 and miR-29a is located on Chromosome 7, whereas the coding gene for both miR-29b-2 and miR-29c is on Chromosome 1 [14].”
From Expression of miR-15/107 Family MicroRNAs in Human Tissues and Cultured Rat Brain Cells (2014) · cites this paper as [14]
The human miR-29 family includes three mature members, miR-29a, miR-29b and miR-29c, encoded by two gene clusters.
“The human miR-29 family includes three mature members, miR-29a, miR-29b and miR-29c, that are encoded by two gene clusters.”
From Expression of miR-15/107 Family MicroRNAs in Human Tissues and Cultured Rat Brain Cells (2014) · cites this paper as [14]
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Coenzyme Q<sub>10</sub>: From bench to clinic in aging diseases, a translational review
Gutierrez-Mariscal, F. M., Yubero-Serrano, E. M., Villalba, J. M., & Lopez-Miranda, J. (2019) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2018.1442316 · Cited by 92 · see citing works
Expression of miR-15/107 Family MicroRNAs in Human Tissues and Cultured Rat Brain Cells
Wang, W.-X., Danaher, R. J., Miller, C. S., Berger, J. R., Nubia, V. G., Wilfred, B. S., Neltner, J. H., Norris, C. M., & Nelson, P. T. (2014) · Genomics, Proteomics & Bioinformatics · doi:10.1016/j.gpb.2013.10.003 · Cited by 67 · see citing works
Bioinformatics analysis of microarray data to reveal the pathogenesis of brain ischemia
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- Authors
- Kriegel, A. J., Liu, Y., Fang, Y., Ding, X., & Liang, M.
- Affiliations
- Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin; and
- Division of Nephrology, Fudan University Zhongshan Hospital, Shanghai, People's Republic of China
- Venue
- Physiological Genomics
- Publisher
- American Physiological Society
- Published
- 2012-02-15
- Volume
- 44
- Issue
- 4
- Pages
- 237-244
- ISSN
- 1094-8341
- 1531-2267
- Cited by
- 461
- References
- 5
- Language
- en
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