Lipid droplets: A dynamic organelle moves into focus
Open accessAbstract
Lipid droplets (LDs) were perceived as static storage deposits, which passively participate in the energy homeostasis of both cells and entire organisms. However, this view has changed recently after the realization of a complex and highly dynamic LD proteome. The proteome contains key components of the fat mobilization system and proteins that suggest LD interactions with a variety of cell organelles, including the endoplasmic reticulum, mitochondria and peroxisomes. The study of LD cell biology, including cross‐talk with other organelles, the trafficking of LDs in the cell and regulatory events involving the LD coat proteins is now on the verge of leaving its infancy and unfolds that LDs are highly dynamic cellular organelles.
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These genes control the storage and decomposition of sterols in lipid droplets, which in S. cerevisiae contain a neutral lipid core consisting of triacylglycerols and sterol esters surrounded by phospholipid.
“These genes control the storage and decomposition of sterols in lipid droplets, which in S. cerevisiae contain a neutral lipid core consisting of triacylglycerols (TG) and sterol esters (SE) surrounded by phospholipid.”
From The synthesis, regulation, and functions of sterols in<i>Candida albicans</i>: Well-known but still lots to learn (2016) · cites this paper as [48]
The Abstract (page unavailable) describes lipid droplets as having a core containing triacylglycerols and sterol esters, surrounded by a phospholipid hemimembrane, and says this structure is highly conserved. It does not establish that the unspecified genes control sterol storage and decomposition in S. cerevisiae; its yeast discussion in section 4 concerns lipid-droplet breakdown and peroxisomes. (LLM, conf=0.86)
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- Authors
- Beller, M., Thiel, K., Thul, P. J., & Jäckle, H.
- Affiliations
- Max Planck Institute for Biophysical Chemistry (DE)
- Corresponding author
- Beller, Mathias
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2010-03-18
- Volume
- 584
- Issue
- 11
- Pages
- 2176-2182
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2012296410
- Cited by
- 263
- References
- 68
- Citations by year
- 2026: 6 · 2025: 8 · 2024: 11 · 2023: 7 · 2022: 10 · 2021: 18 · 2020: 15 · 2019: 18 · 2018: 16 · 2017: 23 · 2016: 21 · 2015: 15 · 2014: 18 · 2013: 28 · 2012: 24
- FWCI
- 2.34
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- FEBS Letters (publishedVersion)
- PubMed (publishedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
- Funders
- Max-Planck-Gesellschaft
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Keywords
- lipid droplets, lipid droplet proteome, organelle dynamics, lipid mobilization, endoplasmic reticulum, mitochondria, peroxisomes, energy homeostasis
- MeSH terms
- Animals, Inclusion Bodies, Endoplasmic Reticulum, Lipids, Mitochondria, Proteins, Organelles, Proteome, Protein Transport
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