Tau deficiency leads to the upregulation of BAF‐57, a protein involved in neuron‐specific gene repression
Abstract
Although tau is mainly located in the cell cytoplasm, mostly bound to tubulin, it may also be found in the nucleus of neurons. Hence, we tested whether tau might play a role in regulating the expression of certain genes by comparing gene expression in mice containing or lacking the tau protein. Our results identified a significant difference in the expression of the smarce1 gene, which codes for the BAF‐57 protein, a protein involved in the repression of neuron specific genes. These data suggest a role for tau in neuron maturation.
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Genetic deletion studies indicate that endogenous tau participates in neuronal processes including cytoskeletal regulation, mitochondrial dynamics, synaptic plasticity, network activity, and DNA/RNA stability.
“Genetic deletion studies indicate that endogenous tau participates in a range of neuronal processes, including cytoskeletal regulation, mitochondrial dynamics, synaptic plasticity, network activity [10–22], and stability of DNA and RNA stability [23].”
From Tau Ablation Rewires Brain Cell Programs in Health and Restores Function in Disease (2026) · cites this paper as [14]
Cites
Rat hippocampal neurons in dispersed cell culture.
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Tau protein binds to pericentromeric DNA: a putative role for nuclear tau in nucleolar organization
Sjöberg, M. K., Shestakova, E., Mansuroglu, Z., Maccioni, R. B., & Bonnefoy, E. (2006) · Journal of Cell Science · doi:10.1242/jcs.02907 · Cited by 166 · see citing works
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Roles of tau protein in health and disease
Guo, T., Noble, W., & Hanger, D. P. (2017) · Acta Neuropathologica · doi:10.1007/s00401-017-1707-9 · Cited by 1,003 · see citing works
Nuclear Tau and Its Potential Role in Alzheimer’s Disease
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Loss of tau rescues inflammation-mediated neurodegeneration
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Tau Ablation Rewires Brain Cell Programs in Health and Restores Function in Disease
Chimal-Juárez, E., Patel, H., Jury-Garfe, N., Dabin, L. C., Vidal, R., Kim, J., & Lasagna-Reeves, C. A. (2026) · bioRxiv · doi:10.64898/2026.05.12.724684
- Authors
- Gómez de Barreda, E., Dawson, H. N., Vitek, M. P., & Avila, J.
- Affiliations
- Duke University (US)
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2010-03-23
- Volume
- 584
- Issue
- 11
- Pages
- 2265-2270
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2060831684
- Cited by
- 32
- References
- 2
- Citations by year
- 2026: 2 · 2025: 1 · 2023: 2 · 2021: 5 · 2020: 1 · 2019: 1 · 2018: 4 · 2017: 1 · 2016: 2 · 2015: 3 · 2014: 1 · 2013: 1 · 2012: 3
- FWCI
- 1.95
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- FEBS Letters (publishedVersion)
- PubMed (publishedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
- Funders
- Comunidad de Madrid
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- tau protein, SMARCE1, gene repression, neuron-specific gene expression, neuronal maturation, gene expression regulation
- MeSH terms
- Animals, Cell Nucleus, Chromosomal Proteins, Non-Histone, Cytoplasm, Cytoskeletal Proteins, Neurons, Tubulin, Up-Regulation, Gene Expression, tau Proteins, Mice, Knockout, Mice
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