Nuclear Tau and Its Potential Role in Alzheimer’s Disease

Bukar Maina, Mahmoud; Al-Hilaly, Youssra; Serpell, Louise

doi:10.3390/biom6010009

Cited by 161Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchAldose Reductase and Taurine

Nuclear Tau and Its Potential Role in Alzheimer’s Disease

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Bukar Maina, Mahmoud, Al-Hilaly, Youssra, Serpell, Louise·2016·Biomolecules

DOI 10.3390/biom6010009PMC PMC4808803

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Abstract

Tau protein, found in both neuronal and non-neuronal cells, forms aggregates in neurons that constitutes one of the hallmarks of Alzheimer’s disease (AD). For nearly four decades, research efforts have focused more on tau’s role in physiology and pathology in the context of the microtubules, even though, for over three decades, tau has been localised in the nucleus and the nucleolus. Its nuclear and nucleolar localisation had stimulated many questions regarding its role in these compartments. Data from cell culture, mouse brain, and the human brain suggests that nuclear tau could be essential for genome defense against cellular distress. However, its nature of translocation to the nucleus, its nuclear conformation and interaction with the DNA and other nuclear proteins highly suggest it could play multiple roles in the nucleus. To find efficient tau-based therapies, there is a need to understand more about the functional relevance of the varied cellular distribution of tau, identify whether specific tau transcripts or isoforms could predict tau’s localisation and function and how they are altered in diseases like AD. Here, we explore the cellular distribution of tau, its nuclear localisation and function and its possible involvement in neurodegeneration.

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Tau protein has been found to be normally expressed within the nucleus of neurons.
“Tau protein, most well-known as a structural molecule of the cytoskeleton in the axons and for its involvement in AD pathogenesis in its hyperphosphorylated form, has been found to be normally expressed within the nucleus of neurons [12].”
From DNA repair deficiency and senescence in concussed professional athletes involved in contact sports (2019) · cites this paper as [12]
Intranuclear tau has been shown to interact with nucleic acid proteins and other nuclear proteins, and various studies have suggested that it is essential for genome integrity.
“Intranuclear tau has been shown to interact with nucleic acid proteins and other nuclear proteins, and various studies ranging from cell culture to human brain have suggested that it is essential for genome integrity [12].”
From DNA repair deficiency and senescence in concussed professional athletes involved in contact sports (2019) · cites this paper as [12]

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Authors: Bukar Maina, M., Al-Hilaly, Y., & Serpell, L.
Affiliations: School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QG, East Sussex, UK
University of Sussex (GB)
Corresponding author: Serpell, Louise
ORCID: Bukar Maina, Mahmoud
Serpell, Louise
Venue: Biomolecules
Publisher: MDPI AG
Published: 2016-01-07
Volume: 6
Issue: 1
Pages: 9
ISSN: 2218-273X (ISSN-L)
DOI: 10.3390/biom6010009
PMC: PMC4808803
OpenAlex: W2226786300
Cited by: 161
References: 129
Citations by year: 2026: 7 · 2025: 15 · 2024: 10 · 2023: 13 · 2022: 26 · 2021: 24 · 2020: 19 · 2019: 14 · 2018: 19 · 2017: 10 · 2016: 4
FWCI: 1.84
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Biomolecules (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Figshare (submittedVersion, cc-by)
Sussex Research Online (University of Sussex) (submittedVersion, cc-by)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: Alzheimer's Society
University of Sussex
Medical Research Council
Topics: Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Aldose Reductase and Taurine
Keywords: tau protein, Alzheimer's disease, nucleolus, nuclear localization, tau isoforms, genome defense, neurodegeneration, tau aggregation
MeSH terms: Alzheimer Disease, Animals, Cell Nucleus, DNA, Humans, Phosphorylation, Protein Binding, tau Proteins, Protein Isoforms

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Nuclear Tau and Its Potential Role in Alzheimer’s Disease

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