The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Δ160p53 is a novel N‐terminal p53 isoform encoded by Δ133p53 transcript
Abstract
p53 gene expresses several protein isoforms modulating p53‐mediated responses through regulation of gene expression. Here, we identify a novel p53 isoform, Δ160p53, lacking the first 159 residues. By knockdown experiments and site‐directed mutagenesis, we show that Δ160p53 is encoded by Δ133p53 transcript using ATG160 as translational initiation site. This hypothesis is supported by endogenous expression of Δ160p53 in U2OS, T47D and K562 cells, the latter ones carrying a premature stop codon that impairs p53 and Δ133p53 protein expression but not the one of Δ160p53. Overall, these results show that the Δ133p53 transcript generates two different p53 isoforms, Δ133p53 and Δ160p53.
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“Fourteen isoforms of p53 have been identified: p53, p53β, p53γ, Δ40p53, Δ40p53β, Δ40p53γ, Δ133p53, Δ133p53β, Δ133p53γ, Δ160p53, Δ160p53β, Δ160p53γ, Δp53, and p53ψ.563–568”
From Targeting p53 pathways: mechanisms, structures, and advances in therapy (2023) · cites this paper as [568]
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The first 30 years of p53: growing ever more complex.
Levine, A. J., & Oren, M. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2723 · Cited by 1,967
Petitjean, A., Mathe, E., Kato, S., Ishioka, C., Tavtigian, S. V., Hainaut, P., & Olivier, M. (2007) · Human Mutation · doi:10.1002/humu.20495 · Cited by 1,598
p53 isoforms can regulate p53 transcriptional activity
Bourdon, J.-C., Fernandes, K., Murray-Zmijewski, F., Liu, G., Diot, A., Xirodimas, D. P., Saville, M. K., & Lane, D. P. (2005) · Genes & Development · doi:10.1101/gad.1339905 · Cited by 810
Self-citationp53 isoforms Δ133p53 and p53β are endogenous regulators of replicative cellular senescence
Fujita, K., Mondal, A. M., Horikawa, I., Nguyen, G. H., Kumamoto, K., Sohn, J. J., Bowman, E. D., Mathe, E. A., Schetter, A. J., Pine, S. R., et al. (2009) · Nature Cell Biology · doi:10.1038/ncb1928 · Cited by 336
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Research works printed but not linked: 10
- 10.1007/s00018-008-8336-3 · DOI
- 10.1038/sj.onc.1205874 · DOI · Paper page
- 10.1101/cshperspect.a000927 · DOI · Paper page
- 10.1016/j.semcancer.2010.02.005 · DOI
- 10.1101/gad.1761609 · DOI · Paper page
- Aoubala M. Murray-Zmijewski F. Khoury M.P. Fernandes K. Perrier S. Bernard H. Prats A.C. Lane D.P. and Bourdon J.C. (2010) p53 directly transactivates Δ133p53α regulating cell fate outcome in response to DNA damage. Cell Death Diff. PMID 20689555 (Epub ahead of print). · DOI
- 10.1038/onc.2010.26 · DOI
- 10.1016/0022-2836(87)90418-9 · DOI · Paper page
- Neubauer A., 1993, Genetic alterations in the p53 gene in the blast crisis of chronic myelogenous leukemia: analysis by polymerase chain reaction based techniques, Leukemia, 7, 593
- 10.1248/bpb.17.586 · DOI
Cited by
Targeting p53 pathways: mechanisms, structures, and advances in therapy
Wang, H., Guo, M., Wei, H., & Chen, Y. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01347-1 · Cited by 1,016
TP53 Mutation in Acute Myeloid Leukemia: An Old Foe Revisited
Shin, D.-Y. (2023) · Cancers · doi:10.3390/cancers15194816 · Cited by 46
The Elephant Evolved p53 Isoforms that Escape MDM2-Mediated Repression and Cancer
Padariya, M., Jooste, M.-L., Hupp, T., Fåhraeus, R., Vojtesek, B., Vollrath, F., Kalathiya, U., & Karakostis, K. (2022) · Molecular Biology and Evolution · doi:10.1093/molbev/msac149 · Cited by 33
p53 is an important regulator of CCL2 gene expression
Tang, X., Asano, M., O’Reilly, A., Farquhar, A., Yang, Y., & Amar, S. (2012) · Current Molecular Medicine · doi:10.2174/156652412802480844 · Cited by 30
Detecting p53 Isoforms at Protein Level
Marcel, V., Khoury, M. P., Fernandes, K., Diot, A., Lane, D. P., & Bourdon, J.-C. (2013) · Methods in Molecular Biology · doi:10.1007/978-1-62703-236-0_2 · Cited by 22
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Metadata
- Authors
- Marcel, V., Perrier, S., Aoubala, M., Ageorges, S., Groves, M. J., Diot, A., Fernandes, K., Tauro, S., & Bourdon, J.-C.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2010-10-13
- Volume
- 584
- Issue
- 21
- Pages
- 4463-4468
- ISSN
- 0014-5793
- 1873-3468
- Cited by
- 125
- References
- 4
- Language
- en
- Funders
- l’Institut National de la Sante et de la Recherche Medicale (INSERM)
- Breast Cancer Campaign
- Cancer Research UK (C8/A6613)
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- Marcel, V., Perrier, S., Aoubala, M., Ageorges, S., Groves, M. J., Diot, A., Fernandes, K., Tauro, S., & Bourdon, J.-C. (2010). Δ160p53 is a novel N‐terminal p53 isoform encoded by Δ133p53 transcript. FEBS Letters. https://doi.org/10.1016/j.febslet.2010.10.005
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