The DOI matches its Crossref record; 168 of the 168 references it cites were found in a registry or an index.
BMP signaling in vascular diseases
Open accessAbstract
Bone morphogenetic proteins (BMPs) are members of the transforming growth factor‐β (TGF‐β) family that signal via type I and type II serine/threonine kinase receptors and intracellular Smad transcription factors. BMPs are multifunctional regulators of development and tissue homeostasis and they were initially characterized as inducers of bone regeneration. Genetic studies in humans and mice showed that perturbations in BMP signaling lead to various diseases, such as skeletal diseases, vascular diseases and cancer. Mutations in BMP type II receptor and BMP type I receptor/activin receptor‐like kinase 1 have been linked to pulmonary arterial hypertension and hereditary hemorrhagic telangiectasia, respectively. BMPs have also been implicated in promoting vascular calcification and tumor angiogenesis. In this review we discuss the role of BMP signaling in vascular diseases and the value of BMP signaling as a vascular disease marker or a therapeutic target.
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Feedback regulation of TGF-β signaling
Yan, X., Xiong, X., & Chen, Y.-G. (2018) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmx129 · Cited by 128
Upregulation of ANGPTL4 messenger RNA and protein in severely calcified carotid plaques
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An avidity-driven mechanism of extracellular BMP regulation by Twisted gastrulation
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Metadata
- Authors
- Cai, J., Pardali, E., Sánchez-Duffhues, G., & ten Dijke, P.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2012-05-03
- Volume
- 586
- Issue
- 14
- Pages
- 1993-2002
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2020777546
- Cited by
- 269
- References
- 168
- FWCI
- 9.29
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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